neurobiology of brain disorders

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Neurobiology Of Brain Disorders

Author : Michael J. Zigmond
ISBN : 9780123982803
Genre : Science
File Size : 68. 3 MB
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Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions. This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases. Links basic, translational, and clinical research on disorders of the nervous system, creating a format for study that will accelerate disease prevention and treatment Covers a vast array of neurological disorders, including ADHD, Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson, Huntington, Alzheimer, OCD, PTSD, schizophrenia, depression, and pain Illustrated in full color Each chapter provides in-text summary points, special feature boxes, and research questions Provides an up-to-date synthesis of primary source material

Viral Vector Approaches In Neurobiology And Brain Diseases

Author : Riccardo Brambilla
ISBN : 1493959433
Genre : Medical
File Size : 50. 8 MB
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Aiming toward improvement in the safety, efficiency, and specificity of viral vectors for neurobiological research and clinical applications, Viral Vector Approaches in Neurobiology and Brain Diseases covers key aspects related to the use of viral vectors in neuroscience, with a major emphasis on basic mechanisms of synaptic plasticity, learning, and memory, as well as molecular neuropharmacology and experimental animal models of brain disorders. The volume begins by delving into features of the viral vectors currently available in neuroscience and their production methods, and it then continues onward to examples of successful applications of viral vector technology to psychiatric and memory research, current applications of viral vector technology in the context of neurological disorders, as well as various cutting-edge applications of viral vector technology to neuroscience, including optogenetics. Written for the Neuromethods series, the chapters of this book contain the kind of detailed description and implementation advice that promotes successful, repeatable results. Practical and up to date, Viral Vector Approaches in Neurobiology and Brain Diseases will be useful not only to neurobiologists wishing to routinely use viral vectors in the laboratory but also to experienced scientists needing detailed new protocols for a variety of experimental applications.

Neurobiology Of Psychiatric Disorders

Author : Thomas E. Schlaepfer
ISBN : 9780444520029
Genre : Medical
File Size : 28. 92 MB
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This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment. Provides a comprehensive review of the scientific foundations of psychiatric disorders and psychiatric treatment Includes detailed results from genetics, molecular biology, brain imaging, and neuropathological, immunological, epidemiological, metabolic, therapeutic and historical aspects of the major psychiatric disorders A "must have" reference and resource for neuroscientists, neurologists, psychiatrists, and clinical psychologists as well as all research scientists investigating disorders of the brain

Gene Expression To Neurobiology And Behaviour

Author :
ISBN : 9780444538857
Genre : Science
File Size : 58. 37 MB
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How does the genome, interacting with the multi-faceted environment, translate into the development by which the human brain achieves its astonishing, adaptive array of cognitive and behavioral capacities? Why and how does this process sometimes lead to neurodevelopmental disorders with a major, lifelong personal and social impact? This volume of Progress in Brain Research links findings on the structural development of the human brain, the expression of genes in behavioral and cognitive phenotypes, environmental effects on brain development, and developmental processes in perception, action, attention, cognitive control, social cognition, and language, in an attempt to answer these questions. Leading authors review the state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Neurobiology Of Mental Illness

Author : Dennis S. Charney
ISBN : 9780199934959
Genre : Medical
File Size : 84. 53 MB
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Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections' 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers and doctoral students in neurochemistry and the neurosciences.

Brain Norepinephrine

Author : Gregory A. Ordway
ISBN : 9781139461702
Genre : Medical
File Size : 56. 23 MB
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This book was first published in 2007. Norepinephrine is a chemical neurotransmitter. Drugs that directly manipulate central nervous system (CNS) norepinephrine are being developed targeting noradrenergic neurons to deliver therapeutic effects. Noradrenergic drugs have been proven effective for depression and ADHD, and new disease indications are being identified. A team of experts provides the reader with a thorough understanding of the anatomy, physiology, molecular biology, pharmacology and therapeutics of norepinephrine in the brain, including an extensive review of the role of norepinephrine in brain diseases. The book is divided into four sections: the basic biology of norepinephrine; the role that norepinephrine plays in behavior; evidence of norepinephrine's role in CNS diseases, and the pharmacology and therapeutics of noradrenergic drugs in the treatment of psychiatric and neurological disorders.

Neurobiology Of Mental Illness

Author : Eric J. Nestler
ISBN : 9780199725250
Genre : Medical
File Size : 48. 9 MB
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The new edition of this definitive textbook reflects the continuing reintegration of psychiatry into the mainstream of biomedical science. The research tools that are transforming other branches of medicine - epidemiology, genetics, molecular biology, imaging, and medicinal chemistry - are also transforming psychiatry. The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and more effective treatments, and ultimately preventing psychiatric disorders. The Neurobiology of Mental Illness is written by world-renowned experts in basic neuroscience and the pathophysiology and treatment of psychiatric disorders. It begins with a succint overview of the basic neurosciences followed by and evaluation of the tools that are available for the study of mental disorders in humans. The core of the book is a series of consistently organized sections on the major psychiatric disorders that cover their diagnostic classification, molecular genetics, functional neuroanatomy, neurochemistry and pharmacology, neuroimaging, and principles of pharmacotherapy. Chapters are written in a clear style that is easily accessible to practicing psychiatrists, and yet they are detailed enough to interest researchers and academics. For this second edition, every section has been thoroughly updated, and 13 new chapters have been added in areas where significant advances have been made, including functional genomics and animal models of illness; epidemiology; cognitive neuroscience; postmortem investigation of human brain; drug discovery methods for psychiatric disorders; the neurobiology of schizophrenia; animal models of anxiety disorders; neuroimaging studies of anxiety disorders; developmental neurobiology and childhood onset of psychiatric disorders; the neurobiology of mental retardation; the interface between neurological and psychiatric disorders; the neurobiology of circadian rhythms; and the neurobiology of sleep disorders. Both as a textbook and a reference work, Neurobiology of Mental Illness represents a uniquely valuable resource for psychiatrists, neuroscientists, and their students or trainees.

The Neurobiology Of Painting

Author : Ronald J. Bradley
ISBN : 0080463614
Genre : Science
File Size : 58. 73 MB
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The book presents a basis for the interaction of the brain and nervous system with painting, music and literature, and a discussion of art from multiple facets – such as anatomy, migraine, illusion and evolutionary biology. The book explores several aspects of the neurobiology of painting, including evolutionary neurobiology, sensation vs. perception, the visual brain and how the mind works, and also explores the affects of brain disorders and trauma on artist, with a concluding chapter on Frida Kahlo and the spinal cord injury that influenced her painting.

Neurobiology Of Ptsd

Author : Israel Liberzon
ISBN : 9780190215422
Genre :
File Size : 81. 14 MB
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Neurobiology of PTSD outlines the basic neural mechanisms that mediate complex responses and adaptations to psychological trauma, describing how these biological processes are impaired in individuals with posttraumatic stress disorder (PTSD). Throughout three comprehensive sections, expert authors present detailed analysis of the neural circuitry of emotion, biological findings in post-traumatic stress disorder, and neuroscience informed treatment and prevention. This book is a foundational resource for psychiatrists, neuroscientists, psychologists, and allied health professionals.

The Neurobiology Of Painting

Author : F. Clifford Rose
ISBN : 0123668751
Genre : Medical
File Size : 74. 51 MB
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This book presents a basis for the interaction of the brain and nervous system with painting, music and literature, and a discussion of art from multiple facets - such as anatomy, migraine, illusion and evolutionary biology. The book explores several aspects of the neurobiology of painting, including evolutionary neurobiology, sensation vs. perception, the visual brain and how the mind works, and also explores the affects of brain disorders and trauma on artist, with a concluding chapter on Frida Kahlo and the spinal cord injury that influenced her painting.

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