neurobiology of mental illness

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Neurobiology Of Mental Illness

Author : Dennis S. Charney
ISBN : 9780199934959
Genre : Medical
File Size : 41. 51 MB
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Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections' 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers and doctoral students in neurochemistry and the neurosciences.

Neurobiology Of Mental Illness

Author : Dennis S. Charney
ISBN : 9780195189803
Genre : Medical
File Size : 48. 27 MB
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The new edition of this definitive textbook reflects the continuing reintegration of psychiatry into the mainstream of biomedical science. The research tools that are transforming other branches of medicine - epidemiology, genetics, molecular biology, imaging, and medicinal chemistry - are also transforming psychiatry. The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and more effective treatments, and ultimately preventing psychiatric disorders. The Neurobiology of Mental Illness is written by world-renowned experts in basic neuroscience and the pathophysiology and treatment of psychiatric disorders. It begins with a succint overview of the basic neurosciences followed by and evaluation of the tools that are available for the study of mental disorders in humans. The core of the book is a series of consistently organized sections on the major psychiatric disorders that cover their diagnostic classification, molecular genetics, functional neuroanatomy, neurochemistry and pharmacology, neuroimaging, and principles of pharmacotherapy. Chapters are written in a clear style that is easily accessible to practicing psychiatrists, and yet they are detailed enough to interest researchers and academics.For this second edition, every section has been thoroughly updated, and 13 new chapters have been added in areas where significant advances have been made, including functional genomics and animal models of illness; epidemiology; cognitive neuroscience; postmortem investigation of human brain; drug discovery methods for psychiatric disorders; the neurobiology of schizophrenia; animal models of anxiety disorders; neuroimaging studies of anxiety disorders; developmental neurobiology and childhood onset of psychiatric disorders; the neurobiology of mental retardation; the interface between neurological and psychiatric disorders; the neurobiology of circadian rhythms; and the neurobiology of sleep disorders. Both as a textbook and a reference work, Neurobiology of Mental Illness represents a uniquely valuable resource for psychiatrists, neuroscientists, and their students or trainees.

Neurobiology Of Psychiatric Disorders

Author : Thomas E. Schlaepfer
ISBN : 9780444520029
Genre : Medical
File Size : 48. 71 MB
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This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment. Provides a comprehensive review of the scientific foundations of psychiatric disorders and psychiatric treatment Includes detailed results from genetics, molecular biology, brain imaging, and neuropathological, immunological, epidemiological, metabolic, therapeutic and historical aspects of the major psychiatric disorders A "must have" reference and resource for neuroscientists, neurologists, psychiatrists, and clinical psychologists as well as all research scientists investigating disorders of the brain

Charney And Nestler S Neurobiology Of Mental Illness

Author : Dennis S. Charney
ISBN : 9780190681425
Genre : Medical
File Size : 50. 40 MB
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In the years following publication of the DSM-5RG, the field of psychiatry has seen vigorous debate between the DSM's more traditional, diagnosis-oriented approach and the NIMH's more biological, dimension-based RDoC (research domain criteria) approach. Charney and Nestler's Neurobiology ofMental Illness is an authoritative foundation for translating information from the laboratory to clinical treatment, and its fifth edition extends beyond this reference function to acknowledge and examine the controversies, different camps, and thoughts on the future of psychiatric diagnosis.In this wider context, this book provides information from numerous levels of analysis, including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. Sections and chapters are edited and authored by experts at the top of their fields. Noother book distills the basic science and underpinnings of mental disorders - and highlights practical clinical significance - to the scope and breadth of this classic text. In this edition, Section 1, which reviews the methods used to examine the biological basis of mental illness in animal and cell models and in humans, has been expanded to reflect critically important technical advances in complex genetics (including powerful sequencing technologies and relatedbioinformatics), epigenetics, stem cell biology, optogenetics, neural circuit functioning, cognitive neuroscience, and brain imaging. This range of established and emerging methodologies offer groundbreaking advances in our ability to study the brain as well as unique opportunities for thetranslation of preclinical and clinical research into badly needed breakthroughs in our therapeutic toolkit.Sections 2 through 7 cover the neurobiology and genetics of major psychiatric disorders: psychoses (including bipolar disorder), mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood onset. Also covered within these sections is a summary of currenttherapeutic approaches for these illnesses as well as the ways in which research advances are now guiding the search for new treatments. Each of these parts has been augmented in several different areas as a reflection of research progress. The last section, Section 8, reconfigured in this new edition, now focuses on diagnostic schemes for mental illness. This includes an overview of the unique challenges that remain in diagnosing these disorders given our still limited knowledge of disease etiology and pathophysiology. The sectionthen provides reviews of DSM-5RG, which forms the basis of psychiatric diagnosis in the United States for all clinical work, and of RDoC, which provides an alternative perspective on diagnosis in heavy use in the research community. Also included are chapters on future efforts toward precision andcomputational psychiatry, which promise to someday align diagnosis with underlying biological abnormalities.

Neurobiology Of Mental Disorders

Author : Marcus Lira Brandão
ISBN : 1594549141
Genre : Medical
File Size : 70. 70 MB
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In writing this book, the authors have emphasised current perspectives on the neurobiology of mental disorders, not attempting to provide an exhaustive coverage of the field. Each chapter of the book represents a synthesis of the subject's state of the art. The first and third chapters were written by one of the Editors (FGG) and the sixth by the other (MLB). Each of the remaining chapters was extensively revised by one the authors. The book is a single-volume overview on the neurobiology of mental disorders, and was written for a broad audience. The authors aimed at the generally educated reader, who enjoys science and is interested in becoming acquainted with the remarkable new discoveries about how the nervous system executes mental functions. For this reason, they have provided, inside text boxes, background knowledge on the most relevant topics of each field. The authors hope that students from many areas will find here a clear and readable introduction to the present topic.

Brave New Brain

Author : Nancy C. Andreasen
ISBN : 9783642559518
Genre : Psychology
File Size : 64. 29 MB
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Nancy Andreasen, führende Neurowissenschaftlerin, Herausgeberin des angesehenen American Journal of Psychiatry und ausgezeichnet mit der National Medal of Science, zeigt uns in ihrem neuen Buch die Zusammenhänge zwischen Gehirn und Genom. Dank modernster Methoden und Entdeckungen in Neurowissenschaften und Molekularbiologie wissen Forscher mehr denn je über die Funktionen des Gehirns. Die Autorin beschreibt auf faszinierende und verständliche Weise, wie alles zusammenhängt - von Milliarden kleinster Neuronen im Thalamus bis hin zur moralischen Kontrollinstanz im präfrontalen Kortex. Sie erklärt die Entschlüsselung des Genoms, dessen 30000-40000 Gene fast alle in irgendeiner Form in unserem Gehirn aktiv sind. In fesselnden Geschichten beleuchtet sie aber auch, wie sich psychische Störungen entwickeln und welche Auswirkungen sie auf Patienten und Angehörige haben. Nancy Andreasen gelingt der Brückenschlag zwischen hochkomplexen Inhalten und spannender Lektüre.

Neuroscience For Psychologists And Other Mental Health Professionals

Author : Dr. Jill Littrell, PhD, LCSW
ISBN : 9780826122780
Genre : Psychology
File Size : 52. 5 MB
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Harnesses new research about the link between neuroscience and immunology that underlies promising nonpharmacological treatment for mental disorders As researchers learn more about the neuroscience and neurobiology of mental disorders, the prevailing understanding of how to treat these conditions-often favoring the use of psychotropic medications-is changing rapidly. This book harnesses cutting-edge research about how neuroscience integrated with recent findings in immunology can explain behavioral syndromes and describes nonpharmacological approaches for ameliorating psychic distress and promoting wellbeing. The text discusses the pros and cons of using pharmaceuticals for treating different categories of mental distress in adults and children while illuminating key developments in alternative approaches to treatment-encompassing lifestyle changes related to diet, exercise, and strong interpersonal relationships-that have value and can lead to improved outcomes without medication. These new approaches are discussed as additions to the other research-validated techniques that are already offered in the therapeutic community. The book presents the latest neuroscience and physiological explanations behind the major diagnostic categories of mental illness-including schizophrenia, depression, anxiety, and addiction-that underlie traditional pharmaceutical treatment interventions and describe how and why non-pharmaceutical treatment strategies can be effective. It integrates current information about brain function and its chemical underpinnings with new research about immunology that identifies the mechanism through which lifestyle changes can obviate stress and offer new avenues for wellbeing. Of particular note is cutting-edge information about fast-spiking GABA interneurons and the role of NMDA receptors in psychosis, the role of inflammatory processes in mood disorders, and gut microbiota' s influence on inflammation. The book also explores the physiology undergirding health and resilience, offering a research-based rationale for viewing the mind and body as inseparable for treatment purposes. Students and mental health professionals in social work, counseling, and psychology will learn the benefits of delivering treatment interventions geared toward prevention and amelioration of distress, through lifestyle changes such as diet, exercise, and maintaining regular sleep and daily routines. Key Features: Presents the latest information on the neuroscience behind disorders such as schizophrenia, major depression, anxiety disorders, and addictions Explains the mechanisms through which diet and exercise can influence mood disorders and psychosis Covers the latest on the efficacy and side effects of antidepressants, antipsychotics, anxiolytics, mood stabilizers, and stimulants Discusses ADHD, depression, pediatric bipolar, issues for children in the child welfare system, and advocacy efforts Prepares mental health professionals to provide services in a primary health care setting in the role of the behavioral health professional

Molecular Neurobiology For The Clinician

Author : Dennis S. Charney
ISBN : 158562733X
Genre : Medical
File Size : 56. 23 MB
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In this authoritative volume you'll find today's most important molecular neurobiological advances and their relevance to clinicians treating patients with mental illness. Molecular Neurobiology for the Clinician, Review of Psychiatry, Volume 22, will update you on the latest findings -- and their impact on psychiatry. You'll learn about Discoveries with the potential to revolutionize your clinical approach by changing the ways in which you diagnose and treat patients The effects on psychiatry of advances in the molecular basis of neuronal network function, particularly in relation to abnormalities in cognitive and emotional regulation, and the identification of novel molecular targets for drug development How to apply these discoveries to diagnosing and treating major psychiatric disorders, including childhood- and adolescent-onset disorders, schizophrenia, drug addiction, and severe mood and anxiety disorders Molecular Neurobiology for the Clinician is an outstanding compilation of the best research by top names in the field. Psychiatrists, psychologists, psychiatric residents, and graduate students in neuroscience, psychiatry, and psychology will gain knowledge, understanding, and techniques for better diagnosis and treatment.

Neuroscience For The Mental Health Clinician

Author : Steven R. Pliszka
ISBN : 1593850786
Genre : Psychology
File Size : 29. 92 MB
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As scientific knowledge grows about the role of the brain in mental disorder, no clinician can afford to be uninformed about neurobiology. This accessible primer provides the basic grounding in neuroscience that all contemporary mental health professionals need. Readers are first guided through the fundamentals of neuroanatomy, neurochemistry, and psychiatric genetics. Chapters then illuminate the neurobiological underpinnings of a range of frequently encountered disorders--including ADHD, substance abuse, mood and anxiety disorders, schizophrenia, and learning and cognitive problems--giving particular attention to the impact of psychosocial risk factors on the brain. Also examined are ways that both pharmacological and psychological interventions have been shown to alter brain chemistry as they bring about a reduction in symptoms.

The Neuropsychology Of Mental Illness

Author : Stephen J. Wood
ISBN : 9780521862899
Genre : Medical
File Size : 48. 30 MB
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Describes neuropsychological approaches to the investigation, description, measurement and management of a wide range of mental illnesses.

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