neuronal and glial proteins structure function and clinical application neurobiological research

Download Book Neuronal And Glial Proteins Structure Function And Clinical Application Neurobiological Research in PDF format. You can Read Online Neuronal And Glial Proteins Structure Function And Clinical Application Neurobiological Research here in PDF, EPUB, Mobi or Docx formats.

Neuronal And Glial Proteins

Author : Paul Marangos
ISBN : 9780323151566
Genre : Nature
File Size : 31. 88 MB
Format : PDF, ePub
Download : 476
Read : 688

Download Now


Neuronal and Glial Proteins: Structure, Function, and Clinical Application focuses on the basic and clinical information relating to a number of proteins that are either enriched in or unique to nervous tissue. This book discusses the structural and functional characteristics of cell-specific proteins, which provide a better understanding of the molecular mechanisms involved in processes that are specific to glia or neurons. Organized into three sections encompassing 15 chapters, this book starts with an overview of the fundamental principles and strategies involved in studying the anatomical, structural, functional, and immunological aspects of brain protein. This text then discusses the techniques, including the preparation of brain tissues as well as the preparation of neural and glial cells in purified form. Other chapters review the two-dimensional gel electrophoresis, which is recognized as a significant technique for discovering brain molecules. The final chapter deals with the membrane-associated nervous system proteins. Neurochemists and clinical researchers will find this book useful.

Gene Expression In The Central Nervous System

Author : A.C.H. Yu
ISBN : 9780080862309
Genre : Science
File Size : 75. 28 MB
Format : PDF, ePub, Mobi
Download : 195
Read : 445

Download Now


Gene expression is an active ongoing process that maintains a functional CNS, as proteins are being made on a continual basis. Processes such as learning and memory, nerve cell repair and regeneration and its response to stress are critically dependent on gene expression. This volume highlights the role of gene expression in normal CNS function, and presents many research methods at the cutting edge of neuroscience, which will provide insight into therapeutic approaches through which the control of gene expression may be used in the treatment of many nervous system diseases.

The Role Of Glia In Neurotoxicity

Author : Michael Aschner
ISBN : 0849347920
Genre : Medical
File Size : 76. 7 MB
Format : PDF
Download : 525
Read : 1070

Download Now


It is well established that glial cells represent more than mere passive cytoskeletal support elements of the central and peripheral nervous system. A reciprocal relationship exists between neurons and glia that is vital for mutual differentiation, development, and functioning of both cell types. It also has become apparent that perturbations in glial function may lead to deleterious consequences in juxtaposed neurons. It is therefore possible that neuronal damage induced by chemicals or neuropathic disease involves dissociation of glial-neuronal interactions. The Role of Glia in Neurotoxicity brings together experts in the neurosciences to provide a more complete understanding of the effects of chemicals on nervous system function. This book explores potential sites of glial-neuronal interactions both in the central and peripheral nervous system, focusing on potential sites of neurotoxicant actions. Text introduces basic aspects of neuroscience, the first step toward understanding the mechanisms at work in normal physiology. The ways in which these processes are disturbed in pathological conditions are discussed. Distinguished authors examine the functional interactions between glial cells and neurons during development, adulthood, and senescence. The roles of glia in the normal CNS and PNS are described. The book offers specific, in-depth examples of directly (via diffusive and cell surface signals) or indirectly (via effects on the extracellular fluid or the blood-brain barrier) mediated glial neurotoxicity. This reference includes different techniques, conceptual frameworks, and approaches that are currently used in the study of the role of glia in neurotoxicity. This timely review not only presents an excellent overview of the state of the science but also provides direction for future research into the consequences of an altered glial-neuronal unit.

Astrocytes

Author : Gerard Meurant
ISBN : 9780323139878
Genre : Science
File Size : 84. 27 MB
Format : PDF, ePub
Download : 278
Read : 289

Download Now


Interest in the functional roles of astrocytes in the nervous system has grown significantly as it is recognized that these cells not only have their own pharmacology but also release neuro- and vaso-active factors. This book relates astrocyte pharmacology to cell function for the first time, making it an attractive text across the neuroscience community. * Discusses the pharmacological regulation of specific astrocyte functions * Covers functional interactions between these and adjacent CNS cell types * Examines regional heterogeneity of astrocytes with respect to receptor expression * Compares in vitro and in vivo approaches

Cerebral Reorganization Of Function After Brain Damage

Author : Harvey S. Levin
ISBN : 0198028202
Genre : Medical
File Size : 37. 9 MB
Format : PDF, ePub, Mobi
Download : 804
Read : 847

Download Now


Cerebral Reorganization of Function After Brain Damage integrates basic research on neuroplasticity and clinical research on reorganization of function after brain injury, with a view toward translating the findings to rehabilitation. Historical foundations of research on neuroplasticity are presented to provide a perspective on recent findings. Leading investigators synthesize their work with results from other laboratories to provide a current update on neuroanatomic features that enhance neuroplasticity and provide a substrate for reorganization of function. The capacity for recovery from brain injury associated with focal lesions as compared to diffuse cerebral insult is discussed. Interventions such as environmental enrichment and drugs to enhance reorganization of function after brain injury have been studied in animal models and in human studies. Methodologies to study neuroplasticity are discussed including functional magnetic resonance imaging, neurophysiological measures, transcranial magnetic stimulation, and computational modeling. Implications of neuroplasticity research for innovations in rehabilitation of persons with brain injury are critically reviewed. This text will be particularly appealing to neuropsychologists, neurologists, psychologists, neuroscientists, psychiatrists, speech scientists, and other health professionals engaged in rehabilitation-related research.

Basic Neurochemistry

Author : George J. Siegel
ISBN : UOM:39015026955735
Genre : Neurochemistry
File Size : 71. 19 MB
Format : PDF
Download : 980
Read : 906

Download Now



The Dentate Gyrus A Comprehensive Guide To Structure Function And Clinical Implications

Author : Helen E. Scharfman
ISBN : 0080551750
Genre : Science
File Size : 40. 89 MB
Format : PDF, ePub, Docs
Download : 631
Read : 906

Download Now


The dentate gyrus is a part of the brain that has been a topic of intense interest since the beginning of neuroscience, and pioneering studies from the distant and recent past attest to this. One of the reasons for such interest is that this structure provides some of the most remarkable examples of plasticity within the nervous system. In addition, it is critical to normal cognitive function, although exactly how and when is still a question that eludes answers. Furthermore, abnormalities within the dentate gyrus appear to play a role in diverse clinical conditions, from depression to epilepsy and traumatic brain injury. The primary goal of this book is to provide a context, or background, upon which the detailed knowledge of the current era can be appreciated. A series of overviews are provided to clarify essentials related to structural organization and development, cellular components, neurotransmitters and neuromodulators, plasticity, and clinical relevance. * Covers the topic comprehensively from anatomy to cellular and systems perspectives * Includes basic research and addresses translational implications, so it will be useful to both researchers in the laboratory and clinicians who conduct experiments in humans * Chapters provide fundamentals, but also details and ample references for further review of the topic

Current Catalog

Author :
ISBN : UOM:39015074107577
Genre : Medicine
File Size : 64. 68 MB
Format : PDF
Download : 483
Read : 1151

Download Now


First multi-year cumulation covers six years: 1965-70.

National Library Of Medicine Current Catalog

Author :
ISBN : MINN:31951000310403S
Genre : Medicine
File Size : 44. 21 MB
Format : PDF, ePub
Download : 452
Read : 172

Download Now



The Clinical Neurobiology Of The Hippocampus

Author : Thorsten Bartsch
ISBN : 9780191628962
Genre : Medical
File Size : 22. 68 MB
Format : PDF, Docs
Download : 847
Read : 671

Download Now


The hippocampus is one of the most studied structures in the human brain and plays a pivotal role in human memory function. Its recognized function is reflected by the presence of an extensive body of neurophysiological, neuropsychological, anatomical and neurocomputational literature that presents basic mechanisms, theoretical models and psychological concepts. However, in the rapidly growing field of hippocampal research, the clinical aspects of diseases that affect the hippocampus are greatly under-represented in current literature, and clinical approaches and concepts are scattered throughout various clinical and basic scientific disciplines. The Clinical Neurobiology of the Hippocampus explores clinical approaches to the range of diseases that affect the hippocampus. It brings together and reviews the common methods, clinical findings, concepts, mechanisms and, where applicable, therapeutic strategies for these clinical approaches. The clinical spectrum of hippocampal dysfunction encompasses a wide range of neurological, behavioural and psychiatric symptoms and surpasses the ability to encode, store and retrieve information. The relevance of hippocampal involvement in clinical diseases goes beyond mere neuropsychological deficits and includes psychopathological states in various conditions, such as acute amnesic syndromes, Alzheimer's disease, temporal lobe epilepsy (TLE), sleep, stroke medicine, limbic encephalitis, neurodevelopmental disorders, stress- and trauma-related disorders, depression, and schizophrenia. The first part of the book covers the basic and integrative features of the hippocampus, such as the anatomy and imaging of this structure, and the basic mechanisms of hippocampal function, including the principles of hippocampus-dependent memory processing in amnesia and sleep, the mechanisms of vulnerability and adult neurogenesis as well as the effects of stress. The second part covers the various clinical manifestations in which the hippocampus is involved and in which the preceding basic mechanisms are reflected. Bringing together a broad team of experts on the basic and clinical aspects of the hippocampus, the book provides an integrative view of the hippocampus. It is invaluable for neurologists, neuroscientists, and psychiatrists, and will stimulate interdisciplinary discussions in clinical neuroscience.

Top Download:

Best Books