new trends in genetic risk assessment

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New Trends In Genetic Risk Assessment

Author : G. Jolles
ISBN : 9781483265674
Genre : Social Science
File Size : 42. 97 MB
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New Trends in Genetic Risk Assessment is based on the Fifth International Round Table of the Rhône-Poulenc Santé Foundation, held in Nice 1987. The conference was an attempt to review the latest theories and mechanisms stipulated for the various aspects of genotoxicity; it was above all an open forum to discuss the new trends, the new tests, and the new battery of tests for assessing the genetic risk of chemicals and especially drugs. This volume is actually not a proceedings of the meeting but a monograph specially edited to report the reviews which were presented and the discussions which took place; it was designed to provide a better understanding of the knowledge obtained in the most recent years and to help in the practical choice of approaches or tests for the prediction of the various forms of genotoxicity. The main subjects of this review concern molecular analysis of mutagenesis, detection of DNA damage, gene mutation, clastogenesis, aneuploidy, and germ cells. Each theme is preceded by a short overview summarizing the state of the art and the contributions of each author. Finally, special attention was given to the personal views of some leading toxicologists as to the battery of tests presently available or recommended.

Human Gene Therapy Current Opportunities And Future Trends

Author : G. M. Rubanyi
ISBN : 3540004130
Genre : Medical
File Size : 63. 23 MB
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Advances in genetics, molecular biology and gene delivery technologies in recent years have led to new gene therapy strategies for treatment of a variety of diseases. This book gives a comprehensive overview of the present status and future directions of gene delivery systems and therapeutic strategies for the clinical application of gene therapy in cancer, cardiovascular and central nervous system diseases. Stem cell-based therapies and gene expression regulatory systems as novel platform technologies for various gene therapy applications are also discussed. Leading experts give excellent overviews of basic molecular aspects and clinical applications in this new emerging biomedical field.

Risk Assessment And Decision Making Using Test Results

Author : V. Chankong
ISBN : 9781468455953
Genre : Science
File Size : 77. 30 MB
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The difficulties associated with making risk assessments on the basis of experimental results are familiar to practitioners in many fields engineering, epidemiology, chemistry, etc. These difficulties are particularly common in problems that have dynamic and stochastic characteristics driven by multiple purposes and goals, with complex interconnections and inter dependencies. Acquiring an appropriate data base, processing and analyzing model results, and transmitting these results at an appropriate technical, social, political, and institutional level are additional difficulties that must be addressed. This book is grounded on the premise that risks are best assessed on the basis of experimental results and sound mathematical analyses, coupled with the knowledge of experts. The carcinogenicity prediction and battery selection (ePBS) approach described herein provides a systematic mechan ism-a synthesis of systems and statistical and decision analyses-to aid researchers and decision makers in the critical field of carcinogenicity prediction in selecting an appropriate battery of tests to use and in translating experimental results into information that can be used as an aid to decision making.

Genetics And Genomics In Nursing

Author : Dr. Quannetta T Edwards, PhD, FNP-BC, WHNP-BC, FAANP
ISBN : 9780826145628
Genre : Medical
File Size : 69. 35 MB
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Delivers complex information in an easy-to-read, step-by-step format The genomic era encompasses the entire spectrum of DNA -- all of the genes, and the interaction and inter-relationship of genes (genome) to the environment. Rapidly changing research has led to numerous advances in genetic testing, diagnosis, and treatments, and it is essential that APRNs be able to integrate genetic risk assessment into clinical care. This quick reference delivers complex information in an easy-to-read, step-by-step format with bitesize info boxes and bulleted information to provide the tools necessary to understand genetics/genomics and identify "red flags" that can appear in patient assessments. In an age of personalized and precision medicine, genetic risk assessment has never been more important. Genetics and Genomics in Nursing begins with an overview of genetics and the science behind inheritance. Chapters then break down the processes that make up risk assessment, and walk the reader through data collection and review, identification and calculation of risk, and patient communication. Finally, the last section of this text discusses special populations and key facts nurses need to know about their risk assessment. Key Features: Provides a clear introduction to a complex topic Describes important elements of the genomic risk assessment process for use in clinical settings when evaluating patients Illustrates how to develop a three-generation pedigree Applies commonly-used standardized pedigree symbols and familial patterns to aid in risk interpretation Discusses the challenges and limitations of pedigree interpretation Explains common concepts and includes helpful genomic resources Incorporates genomic risk assessment into patient evaluation

Genetic Erosion And Pollution Assessment Methodologies

Author :
ISBN : 9789290437109
Genre : Plant diversity
File Size : 87. 38 MB
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Methods For Risk Assessment Of Transgenic Plants

Author : Klaus Ammann
ISBN : 9783034880336
Genre : Science
File Size : 77. 18 MB
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For centuries, TK has been used almost exclusively by its creators, that is, indigenous and local communities. Access to, use of and handing down of TK has been regulated by local laws, customs and tmditions. Some TK has been freely accessible by all members of an indigenous or local community and has been freely exchanged with other communities; other TK has only been known to particular individuals within these communities such as shamans, and has been handed down only to particular individuals of thc next generation. Over many generations, indigenous and local communities have accumulated a great deal of TK which has generally been adapted, developed and improved by the generations that followed. For a long time, Western anthropologists and other scientists have generally been able to freely access TK and have documented it in their works. Still, this TK was only seldom used outside the indigenous and local communities that created it. More recently, however, Western scientists have become aware that TK is neither outdated nor valueless knowledge, but, instead, 1 can be useful to solve some of the problems facing today's world. Modem science, for example, has shown an increased interest in some fornls ofTK as knowledge that can be used in 4 research and development (R&D) activities and be integrated in modem innovations. This holds especially true for TK regarding genetic resources, which has been integrated in modem 6 phannaceuticals,s agro-chemicals and seed.

Annual Review Of Nursing Research Volume 29

Author : Ginette A. Pepper, PhD, RN, FAAN
ISBN : 9780826157553
Genre : Medical
File Size : 71. 68 MB
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This landmark annual review has provided three decades of knowledge, insight, and research on topics critical to the continued advancement of the nursing profession. This latest edition is a compilation of the most significant nursing research in genetics and genomics. Articles have been carefully selected by the editors, highly respected scholars and researchers in the field of genetics, to bring together current research that has particular relevance for translation into a clinical setting or expansion into other research areas. The review provides authoritative information of the highest caliber not only to researchers, but also to clinicians and undergraduate and graduate nursing students. Key Topics: The current status of genomic molecular science Ethical, legal, and social issues in genomics Genetics of diseases and symptoms Genomics across the lifespan

New Trends In Brain Research

Author : F. J. Chen
ISBN : 159454834X
Genre : Medical
File Size : 73. 26 MB
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The brain is omnipresent in bodily functions. Its vast array of responsibilities includes the regulation of all physical movements, memory, learning and emotions, as well as the reception and interpretation of all sensory inputs. These numerous responsibilities require the facility of a very complex organ, and the brain is complex, to say the least. The brain's complexity provides a constant challenge for scientists to explore new theories. Because of the brain's wide-ranging role in bodily functions these studies have an impact on many other realms of science, such as psychology, neurology, and genetics. This book features recent studies from this important field of scientific research.

Handbook Of Breast Cancer Risk Assessment

Author : Victor G. Vogel
ISBN : 0763718602
Genre : Medical
File Size : 32. 93 MB
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This Essential Book Provides On-The-Spot Clinical Guidelines For Assessing And Advising Patients On Their Risk Of Breast Cancer, Therapeutic Options, And Other Issues Of Critical Importance To Women Concerned About Their Breast Health. In Highly-Condensed, Outline Format, The Handbook Provides Extensive, Authoritative, And Current Recommendations On Such Critical Issues As Hormone Replacement Therapy, Chemoprevention, Lifestyle Factors, Genetic Counseling, Imaging Of High-Risk Patients, Economic Factors, And Much More.

Genetic Screening And Counseling An Issue Of Obstetrics And Gynecology Clinics

Author : Anthony R. Gregg
ISBN : 9781455700479
Genre : Medical
File Size : 83. 88 MB
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Genetic Screening and Counseling is reviewed in this issue of Obstetrics and Gynecology Clinics, guest edited by Drs. Anthony R. Gregg and Joe Leigh Simpson. Authorities in the field have come together to pen articles on Contemporary Genetics Counseling: New Frontiers and Challenges, Newborn Screening, SMA Carrier Screening, Fragile X, Ashkenazi Jewish Screening in the 21st Century, Thrombophilia in Obstetric Practice, Microarrays in the Practice of Obstetrics and Gynecology, Cancer Genetic Screening, and Cystic Fibrosis.

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