nucleophilic aromatic substitution of hydrogen

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Nucleophilic Aromatic Substitution Of Hydrogen

Author : Oleg N. Chupakhin
ISBN : 9780323140591
Genre : Science
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Nucleophilic aromatic substitution in carbo- and heteroaromatic systems is a subject of considerable interest to chemists. This book uniquely addresses the systematic analysis of a vast range of nucleophilic substitutions of aromatic hydrogen. * This text provides coverage of: * Nucleophilic displacement of hydrogen (the S N/H reactions) in pi-deficient aromatics, such as nitroarenes, arene-metal complexes, and the like. * Nucleophilic displacement of hydrogen in heterocyclic substrates such as pyridines, their aza and benzo analogs, pyrylium and thiapyrylium cations, and other heterocycles * Mechanisms for the S N/H reactions (S N/H(AE), vicarious nucleophilic substitutions, and radical S N/H substitutions

Modern Nucleophilic Aromatic Substitution

Author : Francois Terrier
ISBN : 9783527656165
Genre : Science
File Size : 73. 89 MB
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This book provides a comprehensive overview of nucleophilic aromatic substitutions, focusing on the mechanistic and synthetic features that govern these reactions. The first chapter presents a detailed mechanistic analysis of the factors determining the feasibility of SNAr substitutions, providing decisive information to predict regioselectivity of many reactions and to define the conditions for concerted SNAr processes. Reflecting the key role played by these species as intermediates in most SNAr reactions, chapter 2 then discusses the chemistry of anionic sigma-complexes. Chapter 3 describes the concept of superelectrophilicity in SNAr substitutions, as it has recently emerged from the reactivity of strongly electron-deficient aromatic and heteroaromatic structures. The numerous synthetic applications are considered in depth in the chapters 4 and 5 that follow on intermolecular and intramolecular nucleophilic aromatic substitutions. Then, chapter 6 focuses on substitutions proceeding formally through displacement of a hydride ion, a hot topic in the field. The final chapter brings together concise yet comprehensive discussions surrounding SNAr photosubstitutions, radical substitutions, and ANRORC substitutions. Authored by a highly respected chemist who has contributed greatly to the field over the past two decades, this is a valuable information source for all organic chemists working in academia or the pharmaceutical and agrochemical industries.

Metal Free C H Functionalization Of Aromatics

Author : Valery Charushin
ISBN : 9783319070193
Genre : Science
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The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field.

Arene Chemistry

Author : Jacques Mortier
ISBN : 9781118752012
Genre : Science
File Size : 56. 16 MB
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Organized to enable students and synthetic chemists to understand and expand on aromatic reactions covered in foundation courses, the book offers a thorough and accessible mechanistic explanation of aromatic reactions involving arene compounds. Surveys methods used for preparing arene compounds and their transformations Connects reactivity and methodology with mechanism Helps readers apply aromatic reactions in a practical context by designing syntheses Provides essential information about techniques used to determine reaction mechanisms

Nucleophilic Aromatic Substitution Using Carbanion And N6 Arene Tricarbonylchromium Complexes

Author : Glenn Richard Clark
ISBN : CORNELL:31924004746248
Genre : Science
File Size : 50. 46 MB
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Nucleophilic Aromatic Displacement

Author : F. Terrier
ISBN : 047118697X
Genre : Science
File Size : 61. 59 MB
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The first truly comprehensive account of this versatile field. Classified and well-documented, it covers: * the chemistry of SNAr substitutions and anionic o-complexes * nucleophilic aromatic photosubstitutions * the possible role of electron transfer in some substitution processes * the ANRORC reactions The volume also discusses for the first time the whole field of nucleophilic aromatic substitutions of hydrogen, a subject of considerable recent interest. Researchers and students alike will appreciate the book's balanced presentation of mechanistic and synthetic features.

New Methods For Forming Carbon Carbon Bonds By Nucleophilic Aromatic Substitution

Author : Thomas Merton Bargar
ISBN : CORNELL:31924004743146
Genre : Science
File Size : 68. 74 MB
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Current Trends In Organic Synthesis

Author : Hitosi Nozaki
ISBN : 9781483279121
Genre : Science
File Size : 72. 30 MB
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Current Trends in Organic Synthesis is a collection of papers presented at the Fourth International Conference on Organic Synthesis, held in Tokyo, Japan on August 22-27, 1982. This conference brings together the significant achievements in the diversified frontier fields of organic synthesis. This book is composed of 33 chapters. The first chapters focus on the synthesis of biologically active natural compounds, including metabolites of arachidonic acid, erythromycin A, verrucarins, steroids, anthracyclines, terpenes, yeast alanine t-RNA, beta-lactam antibiotics, and palitoxin. Other chapters deal with the central problems in stereoselective and chiral synthesis, as well as processes of high degree of stereochemical control and asymmetric induction. These chapters also describe chiral pool synthesis by means of carbohydrate precursors. This book also examines the methodologies in organic synthesis using reagents with boron, aluminum, transition metals, silicon, phosphorus, and sulfur. The remaining chapters are devoted to reactions involving radical initiated ring closure, small ring hydrogenolysis, annulene synthesis, vicarious nucleophilic substitution of aromatic hydrogen, and dichlorine monoxide mediated powerful chlorination. This book is of value to organic chemists and allied scientists.

Organic Reaction Mechanisms 2005

Author : A. C. Knipe
ISBN : 0470066636
Genre : Science
File Size : 89. 37 MB
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Organic Reaction Mechanisms, 2005 is the 41st volume in this classical series. In every volume, the content is divided in the different classes of organic reaction mechanisms. An experienced team of authors compiles these reviews every year, so that the reader can rely on a continuing quality of selection and presentation. As a new service to the reader, all reaction mechanisms leading to stereospecific products are highlighted. This reflects the needs of the organic synthetic community with leads to chiral reactions.

Chemosensors

Author : Binghe Wang
ISBN : 1118019571
Genre : Science
File Size : 82. 61 MB
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A thorough, accessible, and general overview of chemosensors Providing a comprehensive overview of chemosensors—organic molecules designed to bind and sense small molecules or metal ions—and their applications, Chemosensors: Principles, Strategies, and Applications is an accessible one-stop resource for analysts, clinicians, and graduate students studying advanced chemistry and chemosensing. Chemosensors function on a molecular level, generating a signal upon binding. The book reviews their synthesis, design, and applications for detecting biological and organic molecules as well as metal ions. The text highlights applications in drug discovery and catalyses that have not been well covered elsewhere. Covering such topics as molecular recognition, detection methods, design strategies, and important biological issues, the book is broken into four sections that examine intermolecular interactions, strategies in sensor design, detection methods, and case studies in metal, saccharide, and amino acid sensing. An indispensable source of information for chemical and biomedical experts using sensors, Chemosensors includes case studies to make the material both accessible and understandable to chemists of all backgrounds.

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