physicochemical and biomimetic properties in drug discovery enhanced edition chromatographic techniques for lead optimization

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Physicochemical And Biomimetic Properties In Drug Discovery

Author : Klara Valko
ISBN : 9781118770320
Genre : Medical
File Size : 83. 74 MB
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Demonstrating how and why to measure physicochemical and biomimetic properties in early stages of drug discovery for lead optimization, Physicochemical and Biomimetic Properties in Drug Discovery encourages readers to discover relationships between various measurements and develop a sense of interdisciplinary thinking that will add to new research in drug discovery. This practical guide includes detailed descriptions of state-of-the-art chromatographic techniques and uses real-life examples and models to help medicinal chemists and scientists and advanced graduate students apply measurement data for optimal drug discovery.

Optimization In Drug Discovery

Author : Zhengyin Yan
ISBN : 9781592598007
Genre : Medical
File Size : 55. 60 MB
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Recent reports of drug attrition rates have revealed that a significant number of drug candidates fail in the later stage of clinical development due to absorption, distribution, metabolism, elimination and toxicity issues. Lead optimization in drug discovery, a process of attempting to uncover and correct these defects, is highly beneficial in lowering the cost and time to develop therapeutic drugs by reducing drug candidate failures in development. This book provides the assays utilized in drug discovery to rapidly screen for compounds with favorable drug-like properties. A total of 25 chapters, contributed by many experts in the field, cover a wide spectrum of subjects including physicochemical properties, absorption, plasma binding, metabolism, drug interactions, and toxicity, making this an essential book for all pharmacologists and pharmaceutical scientists.

Physico Chemical Methods In Drug Discovery And Development

Author : Zoran Mandic
ISBN : 9789535694205
Genre :
File Size : 49. 21 MB
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Plant Bioactives And Drug Discovery

Author : Valdir Cechinel-Filho
ISBN : 9781118259924
Genre : Science
File Size : 41. 34 MB
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An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.

Natural Based Polymers For Biomedical Applications

Author : Rui L. Reis
ISBN : 9781845694814
Genre : Technology & Engineering
File Size : 54. 14 MB
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Polymers from natural sources are particularly useful as biomaterials and in regenerative medicine, given their similarity to the extracellular matrix and other polymers in the human body. This important book reviews the wealth of research on both tried and promising new natural-based biomedical polymers, together with their applications as implantable biomaterials, controlled-release carriers or scaffolds for tissue engineering. The first part of the book reviews the sources, processing and properties of natural-based polymers for biomedical applications. Part two describes how the surfaces of polymer-based biomaterials can be modified to improve their functionality. The third part of the book discusses the use of natural-based polymers for biodegradable scaffolds and hydrogels in tissue engineering. Building on this foundation, Part four looks at the particular use of natural-gelling polymers for encapsulation, tissue engineering and regenerative medicine. The penultimate group of chapters reviews the use of natural-based polymers as delivery systems for drugs, hormones, enzymes and growth factors. The final part of the book summarises research on the key issue of biocompatibility. Natural-based polymers for biomedical applications is a standard reference for biomedical engineers, those studying and researching in this important area, and the medical community. Examines the sources, processing and properties of natural based polymers for biomedical applications Explains how the surfaces of polymer based biomaterials can be modified to improve their functionality Discusses the use of natural based polymers for hydrogels in tissue engineering, and in particular natural gelling polymers for encapsulation and regenerative medicine

Chromatographic Determination Of Molecular Interactions Applications In Biochemistry Chemistry And Biophysics

Author : Tibor Cserhati
ISBN : 0849344379
Genre : Science
File Size : 61. 20 MB
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Chromatographic Determination of Molecular Interactions describes the theory and practice of the measurement of molecular interactions by thin-layer, high performance liquid, and gas chromatography. Methods and various procedures used for the calculation of complex stability constants are compiled, and the stability constants of a wide variety of interactions determined by the various chromatographic techniques are included. New results of molecular interactions are covered, including those for protein-peptide and amino acid-nucleic acid bases. The book will appeal to biochemists, analytical chemists, molecular biologists, biotechnologists, biophysicists, and medicinal chemists.

Separation Methods In Drug Synthesis And Purification

Author : Klara Valko
ISBN : 0080541097
Genre : Science
File Size : 25. 73 MB
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Separation Methods in Drug Synthesis and Purification

40 Days Of Dating

Author : Jessica Walsh
ISBN : 9781613127155
Genre : Self-Help
File Size : 65. 55 MB
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When New York–based graphic designers and long-time friends Timothy Goodman and Jessica Walsh found themselves single at the same time, they decided to try an experiment. The old adage says that it takes 40 days to change a habit—could the same be said for love? So they agreed to date each other for 40 days, record their experiences in questionnaires, photographs, videos, texts, and artworks, and post the material on a website they would create for this purpose. What began as a small experiment between two friends became an Internet sensation, drawing 5 million unique (and obsessed) visitors from around the globe to their site and their story since it was launched in July 2013. 40 Days of Dating: An Experiment is a beautifully designed, expanded look at the experiment and the results, including a great deal of material that never made it onto the site, such as who they were as friends and individuals before the 40 days and who they have become since. Note: 40 Days of Dating has a special binding that allows it to open very flat by attaching the endpapers to the inside covers.

Process Scale Purification Of Antibodies

Author : Uwe Gottschalk
ISBN : 9781119126911
Genre : Medical
File Size : 43. 40 MB
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Promoting a continued and much-needed renaissance in biopharmaceutical manufacturing, this book covers the different strategies and assembles top-tier technology experts to address the challenges of antibody purification. • Updates existing topics and adds new ones that include purification of antibodies produced in novel production systems, novel separation technologies, novel antibody formats and alternative scaffolds, and strategies for ton-scale manufacturing • Presents new and updated discussions of different purification technologies, focusing on how they can address the capacity crunch in antibody purification • Emphasizes antibodies and innovative chromatography methods for processing

Polymer Nanoparticles For Nanomedicines

Author : Christine Vauthier
ISBN : 9783319414218
Genre : Medical
File Size : 40. 22 MB
Format : PDF
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This volume serves as a valuable handbook for the development of nanomedicines made of polymer nanoparticles because it provides researchers, students, and entrepreneurs with all the material necessary to begin their own projects in this field. Readers will find protocols to prepare polymer nanoparticles using different methods, since these are based on the variety of experiences that experts encounter in the field. In addition, complex topics such as, the optimal characterization of polymer nanoparticles is discussed, as well as practical guidelines on how to formulate polymer nanoparticles into nanomedicines, and how to modify the properties of nanoparticles to give them the different functionalities required to become an efficient nanomedicine for different clinical applications. The book also discusses the translation of technology from research to practice, considering aspects related to industrialization of preparation and aspects of regulatory and clinical development.

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