plasminogen related growth factors novartis foundation symposia

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Plasminogen Related Growth Factors

Author : Gregory Bock
ISBN : 0471974560
Genre : Medical
File Size : 85. 20 MB
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Plasminogen is the inactive precursor of the blood proteinase plasmin, the enzyme responsible for the dissolution of fibrin clots. It has been recognized for several years, however, that plasmin has a broad substrate specificity and can cleave a number of other proteins, including several components of the extracellular matrix. Specific cell surface receptors for the two major plasminogen activators exist on a number of cell types and probably play an important role in controlling plasminogen activation. The identification of plasminogen fragments that lack enzymic activity but affect cell growth and migration, and the discovery of the plasminogenrelated growth factors, has highlighted previously unsuspected links between blood coagulation and fibrinolysis on the one hand, and regulation of cell behaviour on the other. This book brings together these two lines of work and discusses two main areas: first, the evolutionary and structural relationship between plasminogen-related growth factors and second, the role of plasminogen activation in cell regulation. Chapters in the book deal specifically with the evolutionary and structural links between the clotting and fibrinolytic proteins and the plasminogenrelated growth factors; the role of individual domains for enzymic or receptor binding activity; general features of the receptors for plasminogen-related growth factors and signalling via these receptors; the role of plasmin and the plasminogen-activators in cell regulation and organogenesis; the role of plasminogen-related growth factors in development, in the regeneration of epithelial organs and in angiogenesis; and the role of these growth factors in cancer and in atherogenesis

Plasminogen Related Growth Factors

Author : CIBA Foundation Symposium
ISBN : 9780470515471
Genre : Science
File Size : 81. 8 MB
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A timely volume dealing with the evolutionary and structural links between the clotting and fibrinolytic proteins and plasminogen-related growth factors. The role of individual domains for enzymatic proteins and plasminogen-related growth factors is also comprehensively examined.

Klotho

Author :
ISBN : 9780128052358
Genre : Science
File Size : 27. 95 MB
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Klotho is the latest edition of a series first published in 1943 on Vitamins and Hormones and the longest-running serial published by Academic Press. It provides up-to-date information on vitamin and hormone research spanning data from molecular biology to the clinic, with volumes focusing on a single molecule or on a disease that is related to vitamins or hormones that are interpreted broadly so that related substances, such as transmitters, cytokines, growth factors, and others can be reviewed. Contains contributions from experts in the field of vitamins and hormones Covers a vast array of subjects In-depth, current information at the molecular to clinical levels

Parvoviruses

Author : Jonathan Kerr
ISBN : 9780340811986
Genre : Medical
File Size : 30. 93 MB
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This comprehensive reference work brings together for the first time information on every aspect of the parvoviruses in a single volume. It presents the new system of parvovirus classification, as agreed by the International Committee for the Taxonomy of Viruses (ICTV), and includes cutting edge information on the virology, molecular and cellular biology, immunology and clinical manifestations of infection with each known and proposed member of the family Parvoviridae. The book also describes the rapidly expanding basic and clinical science which underpins gene therapy applications using helper-dependent and helper-independent parvoviruses. The respected editorial group has drawn together renowned contributors from around the world to produce what will undoubtedly become the standard reference on the subject. It is essential reading for clinical or research virologists and microbiologists, infectious disease specialists, and public health specialists and laboratories.

Moderate Alcohol Consumption And Cardiovascular Disease

Author : Rodolfo Paoletti
ISBN : 0792365720
Genre : Medical
File Size : 72. 5 MB
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The complex relationships between alcohol use and human health represent an area of increasing interest to specialists interested in preventive cardiology. The inverse relationship between alcohol consumption and the incidence of cardiovascular diseases, especially myocardial infarction and ischemic stroke, has in fact gained sound scientific support in recent years. This book, based in an international symposium on the topic held in Venice, October 30-31, 1999, analyzes in depth the epidemiological association between alcohol consumption and human diseases and discusses the possible mechanisms involved in alcohol-associated protection from atherosclerotic diseases. The oxidative effects of different amounts of alcohol intake and of various alcoholic beverages in the production of these effects - subjects of considerable debate - are also analyzed. This book will be of interest to clinicians and researchers active in the areas of atherosclerosis, public health, preventive medicine, and preventive cardiology. It is intended to specifically help practising clinicians provide their patients with evidence-based answers to the most commonly asked questions regarding alcohol use.

Protein Turnover

Author : CIBA Foundation Symposium
ISBN : 9780470717592
Genre : Science
File Size : 27. 30 MB
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The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Pharmacology Of Purine And Pyrimidine Receptors

Author : Kenneth A. Jacobson
ISBN : 9780123855268
Genre : Medical
File Size : 75. 31 MB
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This is an overview of the fast-moving field of purinergic signalling through adenosine and ATP receptors. Authors are the leading authorities in their fields Subject matter is important for understanding tissue protection Subject matter is of intense interest for new drug development.

Protein Degradation In Health And Disease

Author : CIBA Foundation Symposium
ISBN : 9780470718261
Genre : Science
File Size : 58. 9 MB
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The Novartis Foundation Series is a popular collection of the proceedings from Novartis Foundation Symposia, in which groups of leading scientists from a range of topics across biology, chemistry and medicine assembled to present papers and discuss results. The Novartis Foundation, originally known as the Ciba Foundation, is well known to scientists and clinicians around the world.

Books In Print 2004 2005

Author :
ISBN : 0835246477
Genre : Literature
File Size : 21. 40 MB
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Metastasis

Author : CIBA Foundation Symposium
ISBN : 9780470513743
Genre : Science
File Size : 81. 37 MB
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An international group of researchers addresses basic mechanism involved in the metastatic spread of tumors and considers new methods of prevention and treatment. Compares behavior of normal and abnormal cells, with emphasis on cell surface mechanisms--especially invasive processes--and inhibitors that might prevent metastasis. Also discusses determination of the metastatic genotype, the role of the immune system, and reduction of metastasis via liposome-activated macrophages.

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