progress in heritable soft connective tissue diseases 802 advances in experimental medicine and biology

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Progress In Heritable Soft Connective Tissue Diseases

Author : Jaroslava Halper
ISBN : 9789400778931
Genre : Medical
File Size : 40. 95 MB
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This volume is a reference handbook focusing on diseases like Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome and other heritable soft connective tissue diseases. The book presents detailed information for both basic scientists and for clinicians seeing patients. It is also a stepping stone for new investigations and studies that goes beyond the facts about the composition and biochemistry of the connective tissue and extracellular matrix, as the authors connect individual components to specific aspects of various soft tissue disorders and to the actual or potential treatment of them. Progress in Heritable Soft Connective Tissue Diseases features very prominent physicians and scientists as contributors who bring their most recent discoveries to the benefit of readers. Their expertise will help clinicians with proper diagnosis of sometimes elusive and uncommon heritable diseases of soft connective tissues. This book also offers an update on the pathophysiology of these diseases, including an emphasis on unifying aspects such as connections between embryonic development of the different types of connective tissues and systems, and the role of TGF-beta in development and physiology of soft tissues. This new set of data explains, at least in part, why many of these disorders are interconnected, though the primary pathophysiological events, such as gene mutations, may be different for each disorder.

The Multiple Therapeutic Targets Of A20

Author : Christiane Ferran
ISBN : 9781493903986
Genre : Medical
File Size : 33. 93 MB
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This book is meant to provide the most current knowledge regarding the mechanisms of action of A20, if its versatile functions and their validation in animal models of human disease and its promise as a diagnostic biomarker and therapeutic target.

Sunlight Vitamin D And Skin Cancer

Author : Jörg Reichrath
ISBN : 9781493904372
Genre : Medical
File Size : 35. 42 MB
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The goal of this volume is to comprehensively cover a highly readable, updated and extended, overview on our present knowledge of positive and negative effects of UV‐exposure, with a focus on vitamin D and skin cancer. Topics that are discussed in‐depth by leading researchers and clinicians range from the newest findings in endocrinology, epidemiology, histology, photobiology, immunology, cytogenetics and molecular pathology to new concepts for prophylaxis and treatment. Experts in the field as well as health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of the second edition of this book to summarize essential up‐to‐date information for every clinician or scientist interested in how to balance between positive and negative effects of UV‐exposure to minimize the risks of developing vitamin D deficiency and skin cancer.

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