progress in the chemistry of organic natural products 102

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Progress In The Chemistry Of Organic Natural Products 102

Author : A. Douglas Kinghorn
ISBN : 9783319331720
Genre : Science
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The first contribution reviews the phytochemical, chemical, and biological literature on members of the ingenane class of diterpenoids from their first isolation in 1968 through 2015, highlighting unresolved issues both common to phorboids and specific to ingenol derivatives. The biogenesis of ingenol is discussed in the light of the Jakupovic proposal of a dissection between the formation of the macrocyclic Euphorbia diterpenoids and the phorboids, and the clinical development of ingenol mebutate is chronicled in the light of its “reverse-pharmacology” focus. The second contribution offers a comprehensive view of the chemical wealth and the taxonomic problems currently impeding chemical and biological investigations of the genus Laurencia. It addresses the botanical description and the growth and population dynamics of the genus, as well as its chemical diversity and ecological relations; the secondary metabolites as well as their sources of isolation; and finally the biological activity.

Progress In The Chemistry Of Organic Natural Products Fortschritte Der Chemie Organischer Naturstoffe Progr S Dans La Chimie Des Substances Organiques Naturelles

Author : P. R. Ashurst
ISBN : 3211808116
Genre : Science
File Size : 78. 84 MB
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Mit Beiträgen zahlreicher Fachwissenschaftler

Fortschritte Der Chemie Organischer Naturstoffe Progress In The Chemistry Of Organic Natural Products

Author :
ISBN : 9783709165270
Genre : Science
File Size : 56. 54 MB
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The volumes of this classic series, now referred to simply as "Zechmeister” after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series’ inauguration in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.

Fortschritte Der Chemie Organischer Naturstoffe Progress In The Chemistry Of Organic Natural Products

Author : W. Herz
ISBN : 3211828508
Genre : Medical
File Size : 22. 2 MB
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In order to make further progress in elucidating the mechanism of NOS catalysis it will be essential to throw light on the interaction between the enzyme and its substrate. An understanding of the catalytic site will also assist the development of therapeutically important NOS inhibitors. In particular. it will be useful to uncover any differences that exist between the substrate binding sites of the three NOS isozymes which might be exploited for the development of isoform selective NOS inhibitors. A comparison of NOS to other Arg-binding proteins has shown no significant sequence homology (159). Moreover, the lack of a 3D structure and absence of significant sequence homology between the NOS oxygenase domain and known cytochromes P450 has made it difficult to identify residues and construct a model of the distal heme pocket responsible for substrate binding. However, a number of groups are currently working towards crystallisation of the separate NOS reductase and oxygenase domains of the three isoforms for X-ray diffraction studies; the first X-ray structure is likely to be forthcoming within a matter of months. * The results of these studies are expected to resolve many of the uncertainties surrounding the structure of the NOS catalytic site. Preliminary X-ray diffraction analysis of CPR from rat liver has already been reported by MASTERS et al. (524) and the future emergence of a detailed structure for this protein should throw light on the structure and function of the NOS reductase domain.

Fortschritte Der Chemie Organischer Naturstoffe Progress In The Chemistry Of Organic Natural Products

Author : L. Zechmeister
ISBN : 3211830537
Genre : Medical
File Size : 72. 55 MB
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The volumes of this classic series, now referred to simply as "Zechmeister” after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series’ inauguration in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists, and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.

Progress In The Chemistry Of Organic Natural Products 100

Author : A. D. Kinghorn
ISBN : 9783319052755
Genre : Science
File Size : 57. 42 MB
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The volumes of this classic series, now referred to simply as "Zechmeister" after its founder, L. Zechmeister, have appeared under the Springer Imprint ever since the series' inauguration in 1938. It is therefore not really surprising to find out that the list of contributing authors, who were awarded a Nobel Prize, is quite long: Kurt Alder, Derek H.R. Barton, George Wells Beadle, Dorothy Crowfoot-Hodgkin, Otto Diels, Hans von Euler-Chelpin, Paul Karrer, Luis Federico Leloir, Linus Pauling, Vladimir Prelog, with Walter Norman Haworth and Adolf F.J. Butenandt serving as members of the editorial board. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority in his field and provides a comprehensive and up-to-date review of the topic in question. Addressed to biologists, technologists and chemists alike, the series can be used by the expert as a source of information and literature citations and by the non-expert as a means of orientation in a rapidly developing discipline.

Fortschritte Der Chemie Organischer Naturstoffe Progress In The Chemistry Of Organic Natural Products Progr S Dans La Chimie Des Substances Organiques Naturelles

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ISBN : 9783709171622
Genre : Science
File Size : 74. 31 MB
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Fortschritte Der Chemie Organischer Naturstoffe Progress In The Chemistry Of Organic Natural Products

Author : W. Herz
ISBN : 3211830332
Genre : Medical
File Size : 61. 35 MB
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The volumes of this classic series have appeared under the Springer Imprint ever since the series' inauguration in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority to provide an up-to-date review of the topic in question.

Progress In The Chemistry Of Organic Natural Products

Author : H. Budzikiewicz
ISBN : 3211027807
Genre : Science
File Size : 82. 39 MB
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Fortschritte Der Chemie Organischer Naturstoffe Progress In The Chemistry Of Organic Natural Products

Author : Bernhard Kräutler
ISBN : 9783211740194
Genre : Science
File Size : 48. 60 MB
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The volumes of this classic series have appeared under the Springer Imprint ever since the series' inauguration in 1938. The volumes contain contributions on various topics related to the origin, distribution, chemistry, synthesis, biochemistry, function or use of various classes of naturally occurring substances ranging from small molecules to biopolymers. Each contribution is written by a recognized authority to provide an up-to-date review of the topic in question.

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