protein degradation in health and disease progress in molecular and subcellular biology

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Protein Degradation In Health And Disease

Author : Michèle Reboud-Ravaux
ISBN : 3540425942
Genre : Medical
File Size : 28. 31 MB
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Protein degradation has been identified as a major mechanism for the regulation of cellular functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated.

Protein Degradation In Health And Disease

Author : Michele Reboud-Ravaux
ISBN : 9783642563737
Genre : Science
File Size : 27. 20 MB
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Protein degradation has been identified as a major mechanism for the regulation of cellular functions. Not surprisingly, its deregulation is implied in almost any pathological condition. This book describes how aged proteins are eliminated during cell metabolism, how cell proliferation is regulated by protein degradation and how its deregulation can contribute to the development of cancer, how protein degradation is modified during normal and abnormal aging, in particular with regard to Alzheimer's disease and other degenerative diseases of the brain and central nervous system. Attempts aiming at correcting these pathologies by interfering with deviations of the normal pathway of protein degradation are also treated.

Biology Of Aging

Author : Alvaro Macieira-Coelho
ISBN : 9783642189944
Genre : Medical
File Size : 46. 85 MB
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The survival of the human species has improved significantly in modern times. During the last century, the mean survival of human populations in developed countries has increased more than during the preceding 5000 years. This improvement in survival was accompanied by an increase in the number of active years. In other words, the increase in mean life span was accompanied by an increase in health span. This is now accentuated by progress in medicine reducing the impact of physiologic events such as menopause and of patho logical processes such as atherosclerosis. Up to now,research on aging, whether theoretical or experimental, has not contributed to improvement in human survival. Actually, there is a striking contrast between these significant modifications in survival and the present knowledge of the mechanisms of human aging. Revealed by this state of affairs are the profound disagreements between gerontologists in regard to the way oflooking at the aging process. The definition of aging itself is difficult to begin with because of the variability of how it occurs in different organisms.

Alternative Splicing And Disease

Author : Philippe Jeanteur
ISBN : 9783540344490
Genre : Science
File Size : 60. 33 MB
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Splicing of primary RNA transcript is a quasi-systematic step of gene expression in higher organisms. This is the first book to highlight the medical implications, i.e. diseases, caused by alternative splicing. Alternative splicing not only vastly increases protein diversity but also offers numerous opportunities for aberrant splicing events with pathological consequences. The book also outlines possible targets for therapy.

Journal Of Cell Science

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ISBN : UOM:39015055724200
Genre : Cytology
File Size : 56. 48 MB
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American Book Publishing Record

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ISBN : STANFORD:36105111052911
Genre : Books
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Subject Guide To Books In Print

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ISBN : STANFORD:36105025888533
Genre : American literature
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Directory Of Periodicals Online

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ISBN : NWU:35556020511200
Genre : Information storage and retrieval systems
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Molecular Biology Of The Cell

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ISBN : UOM:39015057375563
Genre : Cells
File Size : 30. 57 MB
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Phosphoinositides I Enzymes Of Synthesis And Degradation

Author : Tamas Balla
ISBN : 9789400730120
Genre : Medical
File Size : 50. 30 MB
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Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

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