stem cells tissue engineering and regenerative medicine

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Stem Cells Tissue Engineering And Regenerative Medicine

Author : David Warburton
ISBN : 9789814612791
Genre : Science
File Size : 28. 60 MB
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Stem cells, tissue engineering and regenerative medicine are fast moving fields with vastly transformative implications for the future of health care and capital markets. This book will show the state of the art in the translational fields of stem cell biology, tissue engineering and regenerative medicine. The state of developments in specific organ systems, where novel solutions to organ failure are badly needed such as the lungs, kidney and so forth, are discussed in various chapters. These present and future advances are placed in the context of the overall field, offering a comprehensive and quick up-to-date drink from the fountain of knowledge in this rapidly emerging field. This book provides an investigator-level overview of the current field accessible to the educated scientific generalist as well as a college educated readership, undergraduates and science writers, educators and professionals of all kinds. Contents:Developmental Biology, Regenerative Medicine and Stem Cells: The Hope Machine is Justified (David Warburton)Towards Broader Approaches to Stem Cell Signaling and Therapeutics (Edwin Jesudason)Pluripotent Stem Cells from the Early Embryo (Claire E Cuddy and Martin F Pera)The First Cell Fate Decision During Mammalian Development (Melanie D White and Nicolas Plachta)Asymmetric Cell Divisions of Stem/Progenitor Cells (Ahmed HK El-Hashash)Microenvironmental Modulation of Stem Cell Differentiation with Focus on the Lung (Shimon Lecht, Collin T Stabler, Seda Karamil, Athanasios Mantalaris, Ali Samadikuchaksaraei, Julia M Polak and Peter I Lelkes)Smart Matrices for Distal Lung Tissue Engineering (Mark J Mondrinos and Peter I Lelkes)Skin Stem Cells and Their Roles in Skin Regeneration and Disorders (Chao-Kai Hsu, Chao-Chun Yang and Shyh-Jou Shieh)Stem Cell Recruitment and Impact in Skin Repair and Regeneration (Tim Hsu, Tai-Lan Tuan and Yun-Shain Lee)Epigenetic and Environmental Regulation of Skin Appendage Regeneration (Ting-Xin Jiang, Chih-Chiang Chen, Michael W Hughes, Cheng-Ming Chuong and Randall Widelitz)Cranial Neural Crest: An Extraordinarily Migratory and Multipotent Embryonic Cell Population (Samuel G Cox and J Gage Crump)Modeling Neurodegenerative Diseases and Neurodevelopmental Disorders with Reprogrammed Cells (Kate E Galloway and Justin K Ichida)Cytokine Regulation of Intestinal Stem Cells (Philip E Dubé, Unice J K Soh and D Brent Polk)The Intestinal Stem Cell Niche and Its Regulation by ErbB Growth Factor Receptors (Dana Almohazey and Mark R Frey)Tissue Engineering: Intestine (Avafia Y Dossa, Kathy A Schall, Tracy C Grikscheit and Christopher P Gayer)Liver Stem and Progenitor Cells in Development, Disease and Regenerative Medicine (Nirmala Mavila and Kasper S Wang)Lung Mesenchymal Stem Cells (Wei Shi)FGF Signaling in Lung Stem and Progenitor Cells (Soula Danopoulos and Denise Al Alam)Bioengineering Distal Airways (Christine Finck and Todd Jensen)The Isolation and Molecular Characterization of Cancer Stem Cells (Aggressive Endophenotypes) in Individual Lung Cancers (Raj K Batra, Scott Oh and Saroj Basak)Mesenchymal Stromal Cell-Based Therapies for Lung Diseases and Critical Illnesses (Fernanda Cruz, Patricia RM Rocco and Daniel J Weiss)Heart Regeneration and Repair: What We Have Learned from Model Organisms (Laurent Gamba, Michael R Harrison and Ching-Ling Lien)Leveraging Structure-Based Rational Drug Design and Nanotechnology to Destroy Leukemic Stem Cells (Fatih M Uckun, Jianjun Cheng, Cheney Mao and Sanjive Qazi)Placenta-Derived Stem Cells: Development and Preclinical Applications for Regenerative Medicine (Jennifer Izumi Divine, Hee Kyung Jung and Toshio Miki)Stem Cells in the Real World: Environmental Impacts (Theresa M Bastain, Lu Gao and Frank D Gilliland)Establishing a Research Grade Human Pluripotent Stem Cell Laboratory (Laura-Marie Nucho and Victoria Fox) Readership: Stem cell and tissue engineering scientists, patient advocates, educated laypeople, high school science students, undergraduate students, graduate students, physicians and surgeons. Key Features:This book presents up-to-date latest breakthroughs and near future applicationsBench to bedsideThis book features potential curesKeywords:Stem Cells;Tissue Engineering;Regenerative Medicine

Stem Cells Regenerative Medicine

Author : Krishnarao Appasani
ISBN : 1607618605
Genre : Science
File Size : 73. 15 MB
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Defined as, “The science about the development of an embryo from the fertilization of the ovum to the fetus stage,” embryology has been a mainstay at universities throughout the world for many years. Throughout the last century, embryology became overshadowed by experimental-based genetics and cell biology, transforming the field into developmental biology, which replaced embryology in Biology departments in many universities. Major contributions in this young century in the fields of molecular biology, biochemistry and genomics were integrated with both embryology and developmental biology to provide an understanding of the molecular portrait of a “development cell.” That new integrated approach is known as stem-cell biology; it is an understanding of the embryology and development together at the molecular level using engineering, imaging and cell culture principles, and it is at the heart of this seminal book. Stem Cells and Regenerative Medicine: From Molecular Embryology to Tissue Engineering is completely devoted to the basic developmental, cellular and molecular biological aspects of stem cells as well as their clinical applications in tissue engineering and regenerative medicine. It focuses on the basic biology of embryonic and cancer cells plus their key involvement in self-renewal, muscle repair, epigenetic processes, and therapeutic applications. In addition, it covers other key relevant topics such as nuclear reprogramming induced pluripotency and stem cell culture techniques using novel biomaterials. A thorough introduction to stem-cell biology, this reference is aimed at graduate students, post-docs, and professors as well as executives and scientists in biotech and pharmaceutical companies.

Stem Cell And Tissue Engineering

Author : Song Li
ISBN : 9789814317054
Genre : Science
File Size : 67. 95 MB
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Tissue engineering integrates knowledge and tools from biological sciences and engineering for tissue regeneration. A challenge for tissue engineering is to identify appropriate cell sources. The recent advancement of stem cell biology provides enormous opportunities to engineer stem cells for tissue engineering. The impact of stem cell technology on tissue engineering will be revolutionary. This book covers state-of-the-art knowledge on the potential of stem cells for the regeneration of a wide range of tissues and organs and the technologies for studying and engineering stem cells. It serves as a valuable reference book for researchers and students.

Tissue Engineering And Regenerative Medicine

Author : Murugan Ramalingam
ISBN : 9781439881866
Genre : Medical
File Size : 31. 86 MB
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Through the integration of strategies from life science, engineering, and clinical medicine, tissue engineering and regenerative medicine hold the promise of new solutions to current health challenges. This rapidly developing field requires continual updates to the state-of-the-art knowledge in all of the aforementioned sciences. Tissue Engineering and Regenerative Medicine: A Nano Approach provides a compilation of the important aspects of tissue engineering and regenerative medicine, including dentistry, from fundamental principles to current advances and future trends. Written by internationally renowned scientists, engineers, and clinicians, the chapters cover the following areas: Nanobiomaterials and scaffolds—including nanocomposites and electrospun nanofibers Tissue mechanics Stem cells and nanobiomaterials Oral and cranial implants and regeneration of bone Cartilage tissue engineering Controlled release—DNA, RNA, and protein delivery Animal science and clinical medicine The editors designed this textbook with a distinctive theme focusing on the utilization of nanotechnology, biomaterials science in tissue engineering, and regenerative medicine with the inclusion of important clinical aspects. In addition to injured veterans and other individuals, increased life expectancy in the industrialized world is creating a growing population that will require regenerative medicine, producing greater pressure to develop procedures and treatments to improve quality of life. This book bridges the gap between nanotechnology and tissue engineering and regenerative medicine, facilitating the merger of these two fields and the important transition from laboratory discoveries to clinical applications.

Fundamentals Of Tissue Engineering And Regenerative Medicine

Author : Ulrich Meyer
ISBN : 9783540777557
Genre : Medical
File Size : 44. 19 MB
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"Fundamentals of Tissue Engineering and Regenerative Medicine" provides a complete overview of the state of the art in tissue engineering and regenerative medicine. Tissue engineering has grown tremendously during the past decade. Advances in genetic medicine and stem cell technology have significantly improved the potential to influence cell and tissue performance, and have recently expanded the field towards regenerative medicine. In recent years a number of approaches have been used routinely in daily clinical practice, others have been introduced in clinical studies, and multitudes are in the preclinical testing phase. Because of these developments, there is a need to provide comprehensive and detailed information for researchers and clinicians on this rapidly expanding field. This book offers, in a single volume, the prerequisites of a comprehensive understanding of tissue engineering and regenerative medicine. The book is conceptualized according to a didactic approach (general aspects: social, economic, and ethical considerations; basic biological aspects of regenerative medicine: stem cell medicine, biomolecules, genetic engineering; classic methods of tissue engineering: cell, tissue, organ culture; biotechnological issues: scaffolds; bioreactors, laboratory work; and an extended medical discipline oriented approach: review of clinical use in the various medical specialties). The content of the book, written in 68 chapters by the world’s leading research and clinical specialists in their discipline, represents therefore the recent intellect, experience, and state of this bio-medical field.

Stem Cell Anthology

Author :
ISBN : 0123756839
Genre : Science
File Size : 36. 47 MB
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The fields of stem cell research, regenerative medicine, tissue engineering, and cloning are very closely related. It is important for researchers in each of these disciplines to be aware of the methods and principles in the others. Elsevier publishes some of the highest individual references in these areas. Bringing together the principles, applications, and basic understanding in these related areas of science will provide a new reference which is serve the needs of a variety of researchers. Edited by Dr. Bruce Carlson, Stem Cell Anthology will be valuable to researchers and students who need to save time and link concepts to principles, applications, and methods in order to work more effectively and see links for potential collaborations. Includes a collection of chapters by leaders in the stem cell field including the first researchers to discover iPS cells and multiple Nobel Laureates Provides the most detailed introduction to basic properties of major embryonic and adult stem cells by highlighting breakthrough discoveries in the nervous system, spinal cord, heart, pancreas, epidermis, musculo-skeletal, retina - leading areas of stem cell research in human application Details technical laboratory set up for practitioners, technicians, and administrators

Principles Of Regenerative Medicine

Author : Anthony Atala
ISBN : 9780128098936
Genre : Medical
File Size : 67. 32 MB
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Principles of Regenerative Medicine, Third Edition, details the technologies and advances applied in recent years to strategies for healing and generating tissue. Contributions from a stellar cast of researchers cover the biological and molecular basis of regenerative medicine, highlighting stem cells, wound healing and cell and tissue development. Advances in cell and tissue therapy, including replacement of tissues and organs damaged by disease and previously untreatable conditions, such as diabetes, heart disease, liver disease and renal failure are also incorporated to provide a view to the future and framework for additional studies. Comprehensively covers the interdisciplinary field of regenerative medicine with contributions from leaders in tissue engineering, cell and developmental biology, biomaterials sciences, nanotechnology, physics, chemistry, bioengineering and surgery Includes new chapters devoted to iPS cells and other alternative sources for generating stem cells as written by the scientists who made the breakthroughs Edited by a world-renowned team to present a complete story of the development and promise of regenerative medicine

Micro And Nanotechnologies In Engineering Stem Cells And Tissues

Author : Murugan Ramalingam
ISBN : 9781118574805
Genre : Science
File Size : 88. 29 MB
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A cutting-edge look at the application of micro and nanotechnologies in regenerative medicine The area at the interface of micro/nanotechnology and stem cells/tissue engineering has seen an explosion of activity in recent years. This book provides a much-needed overview of these exciting developments, covering all aspects of micro and nanotechnologies, from the fundamental principles to the latest research to applications in regenerative medicine. Written and edited by the top researchers in the field, Micro and Nanotechnologies in Engineering Stem Cells and Tissues describes advances in material systems along with current techniques available for cell, tissue, and organ studies. Readers will gain tremendous insight into the state of the art of stem cells and tissue engineering, and learn how to use the technology in their own research or clinical trials. Coverage includes: Technologies for controlling or regulating stem cell and tissue growth Various engineering approaches for stem cell, vascular tissue, and bone regeneration The design and processing of biocompatible polymers and other biomaterials Characterization of the interactions between cells and biomaterials Unrivaled among books of this kind, Micro and Nanotechnologies in Engineering Stem Cells and Tissues is the ultimate forward-looking reference for researchers in numerous disciplines, from engineering and materials science to biomedicine, and for anyone wishing to understand the trends in this transformative field.

Skin Tissue Engineering And Regenerative Medicine

Author : Mohammad Albanna
ISBN : 9780128017975
Genre : Technology & Engineering
File Size : 36. 83 MB
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The skin is the largest human organ system. Loss of skin integrity due to injury or illness results in a substantial physiologic imbalance and ultimately in severe disability or death. From burn victims to surgical scars and plastic surgery, the therapies resulting from skin tissue engineering and regenerative medicine are important to a broad spectrum of patients. Skin Tissue Engineering and Regenerative Medicine provides a translational link for biomedical researchers across fields to understand the inter-disciplinary approaches which expanded available therapies for patients and additional research collaboration. This work expands on the primary literature on the state of the art of cell therapies and biomaterials to review the most widely used surgical therapies for the specific clinical scenarios. Explores cellular and molecular processes of wound healing, scar formation, and dermal repair Includes examples of animal models for wound healing and translation to the clinical world Presents the current state of, and clinical opportunities for, extracellular matrices, natural biomaterials, synthetic biomaterials, biologic skin substitutes, and adult and fetal stem and skin cells for skin regenerative therapies and wound management Discusses new innovative approaches for wound healing including skin bioprinting and directed cellular therapies

Biomaterials And Stem Cells In Regenerative Medicine

Author : Murugan Ramalingam
ISBN : 9781439879252
Genre : Medical
File Size : 60. 95 MB
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Work in the area of biomaterials and stem cell therapy has revealed great potential for many applications, from the treatment of localized defects and diseases to the repair and replacement of whole organs. Researchers have also begun to develop a better understanding of the cellular environment needed for optimal tissue repair and regeneration. Biomaterials and Stem Cells in Regenerative Medicine explores a range of applications for biomaterials and stem cell therapy and describes recent research on suitable cell scaffolds and substrates for tissue repair and reconstruction. Featuring contributions by experts in the field, the book explores important scientific and clinical aspects. It covers the basic science involved in structure and properties, techniques and technological innovations in processing and characterization, and applications of biomaterials and stem cells. Topics include: Polymeric systems for stem cell delivery The potential of membranes and porous scaffolds in tissue repair, including myocardial, periodontal, ophthalmic, and bone tissues The optimization of the interaction between stem cells and biomaterial substrates The source and nature of stem cells for tissue engineering applications The clinical translation of stem cell–based tissue engineering for regenerative medicine From fundamental principles to recent advances at the macro, micro, nano, and molecular scales, the book brings together current knowledge on biomaterials and stem cells in the context of regenerative medicine. It also stimulates discussion about future research directions. This unique book offers a valuable benchmark for the current status of clinically relevant research and development in stem cells and regenerative medicine. It bridges the gaps in experimental approaches and understanding among the materials science and engineering, biological sciences, and biomedical science and engineering communities, making it a valuable reference for graduate students, researchers, and practitioners working in the multidisciplinary field of biomedical research.

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