the biostatistics of aging from gompertzian mortality to an index of aging relatedness

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The Biostatistics Of Aging

Author : Gilberto Levy
ISBN : 9781118645857
Genre : Mathematics
File Size : 40. 73 MB
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A practical and clarifying approach to aging and aging-related diseases Providing a thorough and extensive theoretical framework, The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness addresses the surprisingly subtlenotion—with consequential biomedical and public health relevance—of what it means for acondition to be related to aging. In this pursuit, the book presents a new quantitative methodto examine the relative contributions of genetic and environmental factors to mortality anddisease incidence in a population. With input from evolutionary biology, population genetics, demography, and epidemiology, this medically motivated book describes an index of aging-relatedness and also features: Original results on the asymptotic behavior of the minimum of time-to-event random variables, which extends those of the classical statistical theory of extreme values A comprehensive and satisfactory explanation based on biological principles of the Gompertz pattern of mortality in human populations The development of an evolution-based model of causation relevant to mortality and aging-related diseases of complex etiology An explanation of how and why the description of human mortality by the Gompertz distribution can be improved upon from first principles The amply illustrated analysis of real-world data, including a program for conducting the analysis written in the freely available R statistical software Technical appendices including mathematical material as well as an extensive and multidisciplinary bibliography on aging and aging-related diseases The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness is an excellent resource for practitioners and researchers with an interest in aging and aging-related diseases from the fields of medicine, biology, gerontology, biostatistics, epidemiology, demography, and public health.

Statistics For Lawyers

Author : Michael O. Finkelstein
ISBN : 9781441959850
Genre : Social Science
File Size : 31. 12 MB
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This classic text, first published in 1990, is designed to introduce law students, law teachers, practitioners, and judges to the basic ideas of mathematical probability and statistics as they have been applied in the law. The third edition includes over twenty new sections, including the addition of timely topics, like New York City police stops, exonerations in death-sentence cases, projecting airline costs, and new material on various statistical techniques such as the randomized response survey technique, rare-events meta-analysis, competing risks, and negative binomial regression. The book consists of sections of exposition followed by real-world cases and case studies in which statistical data have played a role. The reader is asked to apply the theory to the facts, to calculate results (a hand calculator is sufficient), and to explore legal issues raised by quantitative findings. The authors' calculations and comments are given in the back of the book. As with previous editions, the cases and case studies reflect a broad variety of legal subjects, including antidiscrimination, mass torts, taxation, school finance, identification evidence, preventive detention, handwriting disputes, voting, environmental protection, antitrust, sampling for insurance audits, and the death penalty. A chapter on epidemiology was added in the second edition. In 1991, the first edition was selected by the University of Michigan Law Review as one of the important law books of the year.

Between Zeus And The Salmon

Author : Kenneth W. Wachter
ISBN : 0309057876
Genre : Health & Fitness
File Size : 28. 20 MB
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Demographers and public health specialists have been surprised by the rapid increases in life expectancy, especially at the oldest ages, that have occurred since the early 1960s. Some scientists are calling into question the idea of a fixed upper limit for the human life span. There is new evidence about the genetic bases for both humans and other species. There are also new theories and models of the role of mutations accumulating over the life span and the possible evolutionary advantages of survival after the reproductive years. This volume deals with such diverse topics as the role of the elderly in other species and among human societies past and present, the contribution of evolutionary theory to our understanding of human longevity and intergenerational transfers, mathematical models for survival, and the potential for collecting genetic material in household surveys. It will be particularly valuable for promoting communication between the social and life sciences.

Demography In Archaeology

Author : Andrew T. Chamberlain
ISBN : 9781139455343
Genre : Social Science
File Size : 37. 84 MB
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Demography in Archaeology, first published in 2006, is a review of current theory and method in the reconstruction of populations from archaeological data. Starting with a summary of demographic concepts and methods, the book examines historical and ethnographic sources of demographic evidence before addressing the methods by which reliable demographic estimates can be made from skeletal remains, settlement evidence and modern and ancient biomolecules. Recent debates in palaeodemography are evaluated, new statistical methods for palaeodemographic reconstruction are explained, and the notion that past demographic structures and processes were substantially different from those pertaining today is critiqued. The book covers a wide span of evidence, from the evolutionary background of human demography to the influence of natural and human-induced catastrophes on population growth and survival. This is essential reading for any archaeologist or anthropologist with an interest in relating the results of field and laboratory studies to broader questions of population structure and dynamics.

Handbook Of Pain And Aging

Author : David I. Mostofsky
ISBN : 0306454580
Genre : Medical
File Size : 70. 24 MB
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This comprehensive text examines the physical and mental repercussions of pain among the elderly, finding theoretical bases in such fields as dynamic psychology, psychophysics, behavior modification, pharmacology, and nutrition. The book covers the basic topics of biobehaviorism, psychosocial and psychodynamic aspects, and clinical techniques as they pertain to treatment of elderly patients. The authors of the book's 17 chapters are all esteemed specialists on particular aspects of pain and aging, and all provide state-of-the-science solutions to quality-of-life problems associated with the elderly.

The Molecular Genetics Of Aging

Author : Siegfried Hekimi
ISBN : 9783540480037
Genre : Science
File Size : 42. 80 MB
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The molecular genetics of aging or life-span determination is an expanding field. One reason is because many people would consider it desirable if hu man life span could be extended. Indeed, it is difficult not to be fascinated by tales of the life and death of people who have succeeded in living a very long life. Because of this, we have placed at the head of this book the chapter by Perls et al. on Centenerians and the Genetics of Longevity. Perls and his coauthors convincingly argue that, while the average life expectancy might be mostly determined by environmental factors because the average person has an average genotype, extremely long life spans are genetically determined. Of course, studying humans to uncover the genetics of aging is not ideal, not so much because one cannot easily perform experiments as because they live such a long time. This is why most of this book describes the current state of research with model organisms such as yeast, worms, flies, and mice. J aswinski focuses on yeast and how metabolic activity and stress resistance affect the longevity of Saccharomyces cerevisiae. In the process, he discusses the concept of aging as applied to a unicellular organism such as yeast and the importance of metabolism and stress resistance for aging in all organisms.

Methods In Human Growth Research

Author : Roland C. Hauspie
ISBN : 1139451685
Genre : Social Science
File Size : 78. 70 MB
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In order to gain an understanding of the dynamics of human individual and average growth patterns it is essential that the right methods are selected. There are a variety of methods available to analyse individual growth patterns, to estimate variation in different growth measures in populations and to relate genetic and environmental factors to individual and average growth. This 2004 volume provides an overview of modern techniques for the assessment and collection of growth data and methods of analysis for individual and population growth data. The book contains the basic mathematical and statistical tools required to understand the concepts of the methods under discussion and worked examples of analyses, but it is neither a mathematical treatise, nor a recipe book for growth data analysis. Aimed at junior and senior researchers involved in the analysis of human growth data, this book will be an essential reference for anthropologists, auxologists and paediatricians.

Systems Biology Of Metabolic And Signaling Networks

Author : Miguel A. Aon
ISBN : 9783642385056
Genre : Science
File Size : 76. 37 MB
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Systems Biology represents a new paradigm aiming at a whole-organism-level understanding of biological phenomena, emphasizing interconnections and functional interrelationships rather than component parts. The study of network properties, and how they control and regulate behavior from the cellular to organism level, constitutes a main focus of Systems Biology. This book addresses from a novel perspective a major unsolved biological problem: understanding how a cell works and what goes wrong in pathology. The task undertaken by the authors is in equal parts conceptual and methodological, integrative and analytical, experimental and theoretical, qualitative and quantitative, didactic and comprehensive. Essentially, they unravel the spatio-temporal unfolding of interacting mass-energy and information networks at the cellular and organ levels, as well as its modulation through activation or repression by signaling networks to produce a certain phenotype or (patho)physiological response. Starting with the historical roots, in thirteen chapters this work explores the Systems Biology of signaling networks, cellular structures and fluxes, organ and microorganism functions. In doing so, it establishes the basis of a 21st century approach to biological complexity.

Dicing With Death

Author : Stephen Senn
ISBN : 9781139438995
Genre : Mathematics
File Size : 54. 39 MB
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If you think that statistics has nothing to say about what you do or how you could do it better, then you are either wrong or in need of a more interesting job. Stephen Senn explains here how statistics determines many decisions about medical care, from allocating resources for health, to determining which drugs to license, to cause-and-effect in relation to disease. He tackles big themes: clinical trials and the development of medicines, life tables, vaccines and their risks or lack of them, smoking and lung cancer and even the power of prayer. He entertains with puzzles and paradoxes and covers the lives of famous statistical pioneers. By the end of the book the reader will see how reasoning with probability is essential to making rational decisions in medicine, and how and when it can guide us when faced with choices that impact on our health and even life.

Systems Biology In Drug Discovery And Development

Author : Daniel L. Young
ISBN : 9781118016428
Genre : Medical
File Size : 87. 84 MB
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The first book to focus on comprehensive systems biology as applied to drug discovery and development Drawing on real-life examples, Systems Biology in Drug Discovery and Development presents practical applications of systems biology to the multiple phases of drug discovery and development. This book explains how the integration of knowledge from multiple sources, and the models that best represent that integration, inform the drug research processes that are most relevant to the pharmaceutical and biotechnology industries. The first book to focus on comprehensive systems biology and its applications in drug discovery and development, it offers comprehensive and multidisciplinary coverage of all phases of discovery and design, including target identification and validation, lead identification and optimization, and clinical trial design and execution, as well as the complementary systems approaches that make these processes more efficient. It also provides models for applying systems biology to pharmacokinetics, pharmacodynamics, and candidate biomarker identification. Introducing and explaining key methods and technical approaches to the use of comprehensive systems biology on drug development, the book addresses the challenges currently facing the pharmaceutical industry. As a result, it is essential reading for pharmaceutical and biotech scientists, pharmacologists, computational modelers, bioinformaticians, and graduate students in systems biology, pharmaceutical science, and other related fields.

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