the biosynthesis of mycotoxins a study in secondary metabolism

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The Biosynthesis Of Mycotoxins

Author : Pieter Steyn
ISBN : 9780323149938
Genre : Nature
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The Biosynthesis of Mycotoxins: A Study in Secondary Metabolism focuses on the biosynthetic analysis of mycotoxins, which are inherently a heterogeneous group of metabolites that are formed along the terpene route and the route polyketide, as well as from amino acids. This book discusses the unique biological properties and structural complexity of the highly specialized secondary microbial metabolites. Organized into 12 chapters, this book starts with an overview of the characteristics of secondary metabolites, including their problematic function and the combination of their structural diversity with their restricted biological occurrence. This text then explains the sporadic occurrence of the mycotoxins as fungal metabolites. Other chapters explore ergochromes, which are a group of light yellow mycotoxins that are isolated from ergot, mold fungi, and lichens. The final chapter discusses the biosynthesis of several unrelated fungal metabolites for which toxicological data are reported. Biochemists, organic chemists, mycologists, enzymologists, plant pathologists, toxicologists, and graduate students will find this book useful.

Biosynthesis And Molecular Genetics Of Fungal Secondary Metabolites

Author : Susanne Zeilinger
ISBN : 9781493925315
Genre : Science
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​Fungi produce many chemically diverse secondary metabolites whose biological roles largely remain elusive. Within the increasing number of sequenced fungal genomes several important genes involved in secondary metabolite formation have been identified. Most of these genes are clustered and their coordinated transcription is controlled in a complex way by both narrow pathway-specific regulators as well as broad global transcription factors responsive to environmental cues. In recent years it was discovered many of the newly identified gene clusters are silent under laboratory conditions suggesting that the biosynthetic potential of fungi is far from being exploited. Besides identifying novel bioactive metabolites from still unexplored sources, the activation of these gene clusters by several approaches may result in the discovery of new substances with antibiotic and pharmaceutical benefits. This book covers recent advances in the field of fungal secondary metabolisms ranging from methodologies to biological aspects and will include the latest knowledge on fungal molecular biology, genomics, and metabolomics. With the related volume by Professor Juan-Francisco Martin, where the most relevant and well-studied fungal secondary metabolites are compiled, this book provides a comprehensive overview of the state-of-the-art of research on fungal secondary metabolites.

The Genus Aspergillus

Author : Keith A. Powell
ISBN : 9781489909817
Genre : Science
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Proceedings of a symposium held in Canterbury, United Kingdom, April 5-8, 1993.

Modern Methods In The Analysis And Structural Elucidation Of Mycotoxins

Author : Richard J. Cole
ISBN : 9780323148535
Genre : Science
File Size : 64. 30 MB
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Modern Methods in the Analysis and Structural Elucidation of Mycotoxins presents available methods of analysis and structural elucidation of mycotoxins by recognized experts in the various disciplines. The approach in each chapter of the book is to present each method initially in theoretical terms and then to review the method as it specifically applies to the analysis and/or structural elucidation of mycotoxins. Comprised of 15 chapters, the book's opening chapters deal with screening, sampling, and survey methods for mycotoxins and toxigenic fungi. This is followed by chapters dealing mostly with methods for structural elucidation, such as NMR and X-ray crystallography and IR and UV spectroscopy, as well as biosynthetic techniques. Significant chapters consider the analytical methods for mycotoxin analyses, including enzyme-linked immunosorbent assay system and tandem mass spectrometry. The concluding chapter examines the mycotoxin analytical problem in taxonomic or ecological terms. This book is of value to food and feed researchers, scientists, and manufacturers who are interested in product contamination control.

Structural And Functional Studies Of Secondary Metabolite Acyltransferase Superfamily Members From The Trichothecene Mycotoxin Biosynthetic Pathway

Author : Graeme S. Garvey
ISBN : WISC:89099670630
Genre :
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In Chapter four, the results of a collaborative project to functionally characterize PrpF are presented. PrpF is an enzyme involved in the 2-methyl citrate catabolic pathway. The X-ray crystallographic study revealed strong structural homology of PrpF to the non-PLP dependent diaminopimelate epimerase, which allowed an activity of epimerization to be hypothesized and experimentally validated.

Mycotoxins Advances In Research And Application 2011 Edition

Author :
ISBN : 1464926166
Genre : Science
File Size : 27. 75 MB
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Mycotoxins: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Mycotoxins. The editors have built Mycotoxins: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Mycotoxins in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Mycotoxins: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

R Mpp Encyclopedia Natural Products 1st Edition 2000

Author : Burkhard Fugmann
ISBN : 9783131795519
Genre : Science
File Size : 90. 90 MB
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Compiled by German natural products chemist Wolfgang Steglich and his co-editors Burkhard Fugmann and Susanne Lang-Fugmann, RÖMPP Encyclopedia Natural Products provides highly reliable and comprehensive information on the 6,000 most relevant natural substances, including 15,000 cross references and 2,200 formulas. The book contains descriptions of the different substance classes and important analytical methods, comprehensive indices of Latin Species names and molecular formulas as well as a vast amount of cross referencing. It has been compiled by 40 leaders in their respective fields. Written in a clear, consistent style and thoroughly copy edited, this is a must-have reference work for chemists, biochemists working with natural products, researchers in plant protection, pharmacists and medical researchers, biologists working in drug research as well as microbiologists and botanists working on microorganisms, plants or marine organisms, and interested layman.

Mycotoxins And Animal Foods

Author : DUPLICATE Smith
ISBN : 0849349044
Genre : Nature
File Size : 80. 73 MB
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The ingestion of feed containing mycotoxins has serious adverse effects on the health of farm animals, contributing to reduced weight gain, lower reproductivity, damage to the immune system, severe illnesses, and even death. Mycotoxins formed in animal feedstuffs depend on the presence of specific strains of filamentous fungi or molds and are strongly influenced by environmental factors such as temperature and humidity. This book considers the biological nature of mycotoxin formation, the chemical and biological methods of analysis, as well as the extensive range of substrates capable of supporting the growth of toxigenic fungi. The book also provides extensive coverage of the mycotoxicoses of farmed animals and the current state of research into the control and detoxification of mycotoxins. All researchers interested in mycotoxins and their effects on animals will find important information in this book.

Fungal Jewels Secondary Metabolites

Author : Nancy Keller
ISBN : 9782889451364
Genre :
File Size : 31. 44 MB
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Fungal natural products are friends and foes of humans such as deleterious mycotoxins, cytotoxic, carcinogenic compounds or beneficial compounds such as antibiotics, fungicides, insecticides, antiviral and antitumor metabolites. Understanding fungal diversity and estimation of fungal species on our planet poses a great challenge to researchers. This complexity is further multiplied by secondary metabolite diversity of fungi, which requires interdisciplinary studies. It is extremely important to understand the fungal secondary metabolism to stop human, animal and plant diseases caused by fungi and harvest their valuable metabolites. Furthermore, many secondary metabolite gene clusters are silenced under laboratory conditions. It is vital to develop effective methods to activate those clusters in order to discover novel potent metabolites. This e-book is a compilation of original review articles contributed by leading fungal secondary metabolite researchers with a wide range of expertise. Important aspects of fungal secondary metabolism, including regulation, genome mining, evolution, synthetic biology and novel methods have been discussed. This book will be a great source to those people, who are interested in understanding overall structure, diversity and regulation of production of these tiny but precious chemicals.

Journal Of Food Protection

Author :
ISBN : CHI:24811370
Genre : Food adulteration and inspection
File Size : 77. 65 MB
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