the evolution of the immune system conservation and diversification

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The Evolution Of The Immune System

Author : Davide Malagoli
ISBN : 9780128020135
Genre : Medical
File Size : 24. 85 MB
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The Evolution of the Immune System: Conservation and Diversification is the first book of its kind that prompts a new perspective when describing and considering the evolution of the immune system. Its unique approach summarizes, updates, and provides new insights on the different immune receptors, soluble factors, and immune cell effectors. Helps the reader gain a modern idea of the evolution of the immune systems in pluricellular organisms Provides a complete overview of the most studied and hot topics in comparative and evolutionary immunology Reflects the organisation of the immune system (cell-based, humoral [innate], humoral [adaptive]) without introducing further and misleading levels of organization Brings concepts and ideas on the evolution of the immune system to a wide readership

Origin And Evolution Of The Vertebrate Immune System

Author : L. Du Pasquier
ISBN : 9783642596742
Genre : Medical
File Size : 35. 65 MB
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The comparative approach to immunology can be traced to the era of Pasteur and Metchnikov in which observations regarding foreign recognition in invertebrates was a factor in the develop ment of the principal concepts that created the foundation of what now is the broad field of immunology. With each major experimental and conceptual breakthrough, the classical, albeit essential, question has been asked "are the immune systems of phylogenetically primitive vertebrates and invertebrates similar to that of mammals?" Somewhat surprisingly for the jawed verte brates, the general answer has been a qualified form of "yes", whereas for agnathans and invertebrate phyla it has been "no" so far. The apparent abruptness in the appearance of the immune system of vertebrates is linked to the introduction of the somatic generation of the diversity of its antigen specific receptors. Therefore the questions regarding the origin and evolution of the specific immune system revolve around this phenomenon. With respect to the origin of the system (aside from the or igin of the rearranging machinery itself, the study of which is still in its infancy) one can ask questions about the cellular and mo lecular contexts in which the mechanism was introduced.

Encyclopedia Of Immunobiology

Author :
ISBN : 9780080921525
Genre : Medical
File Size : 48. 24 MB
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Encyclopedia of Immunobiology provides the largest integrated source of immunological knowledge currently available. It consists of broad ranging, validated summaries on all of the major topics in the field as written by a team of leading experts. The large number of topics covered is relevant to a wide range of scientists working on experimental and clinical immunology, microbiology, biochemistry, genetics, veterinary science, physiology, and hematology. The book is built in thematic sections that allow readers to rapidly navigate around related content. Specific sections focus on basic, applied, and clinical immunology. The structure of each section helps readers from a range of backgrounds gain important understanding of the subject. Contains tables, pictures, and multimedia features that enhance the learning process In-depth coverage allows readers from a range of backgrounds to benefit from the material Provides handy cross-referencing between articles to improve readability, including easy access from portable devices

Self And Nonself

Author : Carlos López-Larrea
ISBN : 9781461416807
Genre : Medical
File Size : 75. 6 MB
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In 1960 Sir Frank Macfarlane Burnet received the Noble Prize in Physiology and Medicine. He titled his Nobel Lecture “Immunological Recognition of Self” emphasizing the central argument of immunological tolerance in “How does the vertebrate organism recognize self from nonself in this the immunological sense—and how did the capacity evolve.” The concept of self is linked to the concept of biological self identity. All organisms, from bacteria to higher animals, possess recognition systems to defend themselves from nonself. Even in the context of the limited number of metazoan phyla that have been studied in detail, we can now describe many of the alternative mechanism of immune recognition that have emerged at varying points in phylogeny. Two different arms—the innate and adaptive immune system—have emerged at different moments in evolution, and they are conceptually different. The ultimate goals of immune biology include reconstructing the molecular networks underlying immune processes.

Current Topics In Microbiology And Immunology

Author : Louis Du Pasquier
ISBN : CORNELL:31924084952971
Genre : Immune system
File Size : 62. 32 MB
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Somatic Diversification Of Immune Responses

Author : Garnett Kelsoe
ISBN : 9783642719844
Genre : Medical
File Size : 73. 19 MB
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Discovery of the mechanism for V(D)J hypermutation remains a basic goal of immunology despite the best efforts of many labo ratories. The existence of catalyzed, site-specific mutation and its exploitation for the somatic evolution of lymphocytes are re markable adaptations, yet since the discovery of hypermutation in 1970 (see cover), much hard work has generated little. Indeed, our knowledge of what is probably absolutely required for the mutator's action can be succinctly expressed: /g gene enhancers. Table 1 of Winter et a!.'s chapter puts into a historical perspec tive how our notions of the mutator have changed over the years. Despite these modest gains, most of us feel that this is the best of times. Our work has not only shown us what the mutator is not, it has also, like an artist's preliminary sketch, defined the questions and experiments we must face without diminishing the potential for new biology. In short, it is great fun to toil against a significant and enigmatic problem.

Insect Infection And Immunity

Author : Jens Rolff
ISBN : 9780191579141
Genre : Science
File Size : 65. 24 MB
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Under continual attack from both microbial pathogens and multicellular parasites, insects must cope with immune challenges every day of their lives. However, this has not prevented them from becoming the most successful group of animals on the planet. Insects possess highly-developed innate immune systems which have been fine-tuned by an arms race with pathogens spanning hundreds of millions of years of evolutionary history. Recent discoveries are revealing both an unexpected degree of specificity and an indication of immunological memory - the functional hallmark of vertebrate immunity. The study of insect immune systems has accelerated rapidly in recent years and is now becoming an important interdisciplinary field. Furthermore, insects are a phenomenally rich and diverse source of antimicrobial chemicals. Some of these are already being seriously considered as potential therapeutic agents to control microbes such as MRSA. Despite a burgeoning interest in the field, this is the first book to provide a coherent synthesis and is clearly structured around two broadly themed sections: mechanisms of immunity and evolutionary ecology. This novel text adopts an interdisciplinary and concept-driven approach, integrating insights from immunology, molecular biology, ecology, evolutionary biology, parasitology, and epidemiology. It features contributions from an international team of leading experts. Insect Infection and Immunity is suitable for both graduate students and researchers interested in insect immunity from either an evolutionary, genetical, physiological or molecular perspective. Due to its interdisciplinary and concept-driven approach, it will also appeal to a broader audience of immunologists, parasitologists and evolutionary biologists requiring a concise overview.

Evolutionary Conservation Of Developmental Mechanisms

Author : Allan C. Spradling
ISBN : CHI:36830203
Genre : Science
File Size : 30. 50 MB
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An overview of the fundamental mechanisms of multicellular development, focusing on unifying themes in the study of developmental biology. Topics discussed include the role of highly conserved transcription factors in embryonic patterning, generation of distinct germline and soma, transmission and interpretation of information between cells, and evolutionary patterns of sex determination.

Evolutionary Conservation Of Developmental Mechanisms

Author : Society for Developmental Biology. Symposium
ISBN : WISC:89037909389
Genre : Science
File Size : 35. 53 MB
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An overview of the fundamental mechanisms of multicellular development, focusing on unifying themes in the study of developmental biology. Topics discussed include the role of highly conserved transcription factors in embryonic patterning, generation of distinct germline and soma, transmission and interpretation of information between cells, and evolutionary patterns of sex determination.

Primitive Immune Systems

Author : Jules Hoffmann
ISBN : NWU:35557000119584
Genre : Drosophila melanogaster
File Size : 89. 85 MB
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