the exposome a primer

Download Book The Exposome A Primer in PDF format. You can Read Online The Exposome A Primer here in PDF, EPUB, Mobi or Docx formats.

The Exposome

Author : Gary W Miller
ISBN : 9780124172180
Genre : Science
File Size : 24. 90 MB
Format : PDF, Kindle
Download : 255
Read : 1121

Get This Book


The Exposome: A Primer is the first book dedicated to exposomics, detailing the purpose and scope of this emerging field of study, its practical applications and how it complements a broad range of disciplines. Genetic causes account for up to a third of all complex diseases. (As genomic approaches improve, this is likely to rise.) Environmental factors also influence human disease but, unlike with genetics, there is no standard or systematic way to measure the influence of environmental exposures. The exposome is an emerging concept that hopes to address this, measuring the effects of life-long environmental exposures on health and how these exposures can influence disease. This systematic introduction considers topics of managing and integrating exposome data (including maps, models, computation, and systems biology), "-omics"-based technologies, and more. Both students and scientists in disciplines including toxicology, environmental health, epidemiology, and public health will benefit from this rigorous yet readable overview.

Computational Metabolomics

Author : Nabil Semmar
ISBN : 1617616087
Genre : Medical
File Size : 50. 2 MB
Format : PDF, ePub
Download : 618
Read : 1088

Get This Book


Metabolism represents a complex system characterised by a high variability in metabolites' structure, concentration and regulation ratio. Such variability is observed at different metabolic scales going from metabolites to metabolic profiles via chemical reactions and metabolic pathways, as well as under static or dynamic aspects. Variations in these components are due to apparition-disappearance, level increase-decrease and/or relative changes in weights or contributions leading to different structural, functional and evolutive states of the metabolic system. This book presents a variety of different computational approaches of the variability in metabolic systems.

A First Course In Systems Biology

Author : Eberhard Voit
ISBN : 9781351332941
Genre : Computers
File Size : 81. 25 MB
Format : PDF, ePub, Docs
Download : 231
Read : 754

Get This Book


A First Course in Systems Biology is an introduction for advanced undergraduate and graduate students to the growing field of systems biology. Its main focus is the development of computational models and their applications to diverse biological systems. The book begins with the fundamentals of modeling, then reviews features of the molecular inventories that bring biological systems to life and discusses case studies that represent some of the frontiers in systems biology and synthetic biology. In this way, it provides the reader with a comprehensive background and access to methods for executing standard systems biology tasks, understanding the modern literature, and launching into specialized courses or projects that address biological questions using theoretical and computational means. New topics in this edition include: default modules for model design, limit cycles and chaos, parameter estimation in Excel, model representations of gene regulation through transcription factors, derivation of the Michaelis-Menten rate law from the original conceptual model, different types of inhibition, hysteresis, a model of differentiation, system adaptation to persistent signals, nonlinear nullclines, PBPK models, and elementary modes. The format is a combination of instructional text and references to primary literature, complemented by sets of small-scale exercises that enable hands-on experience, and large-scale, often open-ended questions for further reflection.

Social Ecology In The Digital Age

Author : Daniel Stokols
ISBN : 9780128031148
Genre : Psychology
File Size : 28. 96 MB
Format : PDF, ePub, Docs
Download : 627
Read : 1184

Get This Book


Social Ecology in the Digital Age: Solving Complex Problems in a Globalized World provides a comprehensive overview of social ecological theory, research, and practice. Written by renowned expert Daniel Stokols, the book distills key principles from diverse strands of ecological science, offering a robust framework for transdisciplinary research and societal problem-solving. The existential challenges of the 21st Century - global climate change and climate-change denial, environmental pollution, biodiversity loss, food insecurity, disease pandemics, inter-ethnic violence and the threat of nuclear war, cybercrime, the Digital Divide, and extreme poverty and income inequality confronting billions each day - cannot be understood and managed adequately from narrow disciplinary or political perspectives. Social Ecology in the Digital Age is grounded in scientific research but written in a personal and informal style from the vantage point of a former student, current teacher and scholar who has contributed over four decades to the field of social ecology. The book will be of interest to scholars, students, educators, government leaders and community practitioners working in several fields including social and human ecology, psychology, sociology, anthropology, criminology, law, education, biology, medicine, public health, earth system and sustainability science, geography, environmental design, urban planning, informatics, public policy and global governance. The book traces historical origins and conceptual foundations of biological, human, and social ecology Offers a new conceptual framework that brings together earlier approaches to social ecology and extends them in novel directions Highlights the interrelations between four distinct but closely intertwined spheres of human environments: our natural, built, sociocultural, and virtual (cyber-based) surroundings Spans local to global scales and individual, organizational, community, regional, and global levels of analysis Applies core principles of social ecology to identify multi-level strategies for promoting personal and public health, resolving complex social problems, managing global environmental change, and creating resilient and sustainable communities Underscores social ecology’s vital importance for understanding and managing the environmental and political upheavals of the 21st Century Highlights descriptive, analytic, and transformative (or moral) concerns of social ecology Presents strategies for educating the next generation of social ecologists emphasizing transdisciplinary, team-based, translational, and transcultural approaches

Primary Immunodeficiency Diseases

Author : Hans D. Ochs,
ISBN : 9780195389838
Genre : Health & Fitness
File Size : 58. 98 MB
Format : PDF, Kindle
Download : 332
Read : 773

Get This Book


This third edition of Primary Immunodeficiency Diseases provides readers with the historic and scientific background, clinical presentations, immunologic characteristics, and the molecular/genetic underpinnings of this rapidly enlarging class of diseases.

Exposure Assessment In Occupational And Environmental Epidemiology

Author : Mark J. Nieuwenhuijsen
ISBN : 0191015687
Genre : Medical
File Size : 45. 37 MB
Format : PDF, Mobi
Download : 237
Read : 429

Get This Book


Set against a background of growing public, media and political concern about occupational and environmental health issues, and a scientific need to better understand and explain the effects of pollutants on human health, this book is a unique resource. Contributions from an expert panel of international practitioners provide a comprehensive reference on the state of the art methods and applications in the field of occupational and environmental pollution and the adverse health effects, particularly the exposure assessment in epidemiological studies. Risks associated with occupational and environmental exposure are generally small, but the exposed population, and hence the population attributable risk, may be large. To detect small risk, the exposure assessment needs to be very refined. Exposure assessment is the study of the distribution and determinants of potentially hazardous agents, and includes the estimation of intensity, duration and frequency of exposure, the variation in these indices and their determinants. The aim of this book is to develop an understanding and knowledge of exposure assessment methods and their application to substantive issues in occupational and environmental epidemiology. The emphasis is on methodological principles and good practice. It is focused on exposure assessment in both occupational and environmental epidemiology since there are many similarities but also some interesting differences. The book outlines the basic principles of exposure assessment, and examines the current status and research questions in the exposure assessment of occupational and environmental epidemiological studies of allergens, particulate matter, chlorination disinfection by-products, agricultural pesticides and radiofrequencies. The book will be of interest to all concerned with exposure assessment and epidemiology. It will be a valuable source for undergraduate and postgraduate courses in exposure assessment, occupational hygiene, environmental science, epidemiology, toxicology, biostatistics, occupational and environmental health, health risk assessment and related disciplines and a useful resource of reference for policy makers and regulators.

Guide To Big Data Applications

Author : S. Srinivasan
ISBN : 9783319538174
Genre : Technology & Engineering
File Size : 44. 45 MB
Format : PDF, ePub, Mobi
Download : 727
Read : 812

Get This Book


This handbook brings together a variety of approaches to the uses of big data in multiple fields, primarily science, medicine, and business. This single resource features contributions from researchers around the world from a variety of fields, where they share their findings and experience. This book is intended to help spur further innovation in big data. The research is presented in a way that allows readers, regardless of their field of study, to learn from how applications have proven successful and how similar applications could be used in their own field. Contributions stem from researchers in fields such as physics, biology, energy, healthcare, and business. The contributors also discuss important topics such as fraud detection, privacy implications, legal perspectives, and ethical handling of big data.

Skin Aging

Author : Barbara A. Gilchrest
ISBN : 9783540329534
Genre : Medical
File Size : 68. 22 MB
Format : PDF, ePub, Mobi
Download : 810
Read : 358

Get This Book


The topic of skin aging is of growing importance to all working in the field of dermatology, aesthetic medicine and cosmetic medicine. Two internationally well-known and leading experts in the field present a comprehensive state-of-the-art review on all aspects of skin aging. With its clear, concise and reader-friendly format this book has all the potential to become the Bible of skin aging. Every specialist interested in dermatology, aesthetic medicine, cosmetic science, cutaneous biology and aging research will find indispensable information of great value for his or her daily work.

Applying Big Data Analytics In Bioinformatics And Medicine

Author : Lytras, Miltiadis D.
ISBN : 9781522526087
Genre : Computers
File Size : 63. 13 MB
Format : PDF
Download : 852
Read : 242

Get This Book


Many aspects of modern life have become personalized, yet healthcare practices have been lagging behind in this trend. It is now becoming more common to use big data analysis to improve current healthcare and medicinal systems, and offer better health services to all citizens. Applying Big Data Analytics in Bioinformatics and Medicine is a comprehensive reference source that overviews the current state of medical treatments and systems and offers emerging solutions for a more personalized approach to the healthcare field. Featuring coverage on relevant topics that include smart data, proteomics, medical data storage, and drug design, this publication is an ideal resource for medical professionals, healthcare practitioners, academicians, and researchers interested in the latest trends and techniques in personalized medicine.

Cancer Epidemiology And Prevention

Author : Michael Thun
ISBN : 9780190238667
Genre : Medical
File Size : 39. 98 MB
Format : PDF, ePub, Mobi
Download : 108
Read : 566

Get This Book


Since its initial publication in 1982, CANCER EPIDEMIOLOGY AND PREVENTION has served as the premier reference work for students and professionals working to understand the causes and prevention of cancer in humans. Now revised for the first time in more than a decade, this fourth edition provides a comprehensive summary of the global patterns of cancer incidence and mortality, current understanding of the major causal determinants, and a rationale for preventive interventions. Special attention is paid tomolecular epidemiologic approaches that address the wider role of genetic predisposition and gene-environment interactions in cancer etiology and pathogenesis. New and timely chapters on environmental and social-epidemiologic factors include: * The role of social class disparities* The role of obesity and physical inactivity* The potential effects of electromagnetic fields and radiofrequency radiation* The principles of cancer chemopreventionFor both seasoned professionals and newer generations of students and researchers, this fourth edition of CANCER EPIDEMIOLOGY AND PREVENTION remains the authority in the field - a work of distinction that every lab, library, student, professional, or researcher should have close at hand.

Top Download:

Best Books