the exposome a primer

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The Exposome

Author : Gary W Miller
ISBN : 9780124172180
Genre : Science
File Size : 25. 63 MB
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The Exposome: A Primer is the first book dedicated to exposomics, detailing the purpose and scope of this emerging field of study, its practical applications and how it complements a broad range of disciplines. Genetic causes account for up to a third of all complex diseases. (As genomic approaches improve, this is likely to rise.) Environmental factors also influence human disease but, unlike with genetics, there is no standard or systematic way to measure the influence of environmental exposures. The exposome is an emerging concept that hopes to address this, measuring the effects of life-long environmental exposures on health and how these exposures can influence disease. This systematic introduction considers topics of managing and integrating exposome data (including maps, models, computation, and systems biology), "-omics"-based technologies, and more. Both students and scientists in disciplines including toxicology, environmental health, epidemiology, and public health will benefit from this rigorous yet readable overview.

Social Ecology In The Digital Age

Author : Daniel Stokols
ISBN : 9780128031148
Genre : Psychology
File Size : 86. 30 MB
Format : PDF
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Social Ecology in the Digital Age: Solving Complex Problems in a Globalized World provides a comprehensive overview of social ecological theory, research, and practice. Written by renowned expert Daniel Stokols, the book distills key principles from diverse strands of ecological science, offering a robust framework for transdisciplinary research and societal problem-solving. The existential challenges of the 21st Century - global climate change and climate-change denial, environmental pollution, biodiversity loss, food insecurity, disease pandemics, inter-ethnic violence and the threat of nuclear war, cybercrime, the Digital Divide, and extreme poverty and income inequality confronting billions each day - cannot be understood and managed adequately from narrow disciplinary or political perspectives. Social Ecology in the Digital Age is grounded in scientific research but written in a personal and informal style from the vantage point of a former student, current teacher and scholar who has contributed over four decades to the field of social ecology. The book will be of interest to scholars, students, educators, government leaders and community practitioners working in several fields including social and human ecology, psychology, sociology, anthropology, criminology, law, education, biology, medicine, public health, earth system and sustainability science, geography, environmental design, urban planning, informatics, public policy and global governance. The book traces historical origins and conceptual foundations of biological, human, and social ecology Offers a new conceptual framework that brings together earlier approaches to social ecology and extends them in novel directions Highlights the interrelations between four distinct but closely intertwined spheres of human environments: our natural, built, sociocultural, and virtual (cyber-based) surroundings Spans local to global scales and individual, organizational, community, regional, and global levels of analysis Applies core principles of social ecology to identify multi-level strategies for promoting personal and public health, resolving complex social problems, managing global environmental change, and creating resilient and sustainable communities Underscores social ecology’s vital importance for understanding and managing the environmental and political upheavals of the 21st Century Highlights descriptive, analytic, and transformative (or moral) concerns of social ecology Presents strategies for educating the next generation of social ecologists emphasizing transdisciplinary, team-based, translational, and transcultural approaches

Guide To Big Data Applications

Author : S. Srinivasan
ISBN : 9783319538174
Genre : Technology & Engineering
File Size : 41. 39 MB
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This handbook brings together a variety of approaches to the uses of big data in multiple fields, primarily science, medicine, and business. This single resource features contributions from researchers around the world from a variety of fields, where they share their findings and experience. This book is intended to help spur further innovation in big data. The research is presented in a way that allows readers, regardless of their field of study, to learn from how applications have proven successful and how similar applications could be used in their own field. Contributions stem from researchers in fields such as physics, biology, energy, healthcare, and business. The contributors also discuss important topics such as fraud detection, privacy implications, legal perspectives, and ethical handling of big data.

Exposure Science

Author : Paul Lioy
ISBN : 9780124202382
Genre : Technology & Engineering
File Size : 21. 59 MB
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Exposure Science: Basic Principles and Applications provides a concise overview of the field of exposure science, from its origins in sanitation and occupational health, to its exciting involvement with emerging scientific concepts. Written by world-leading experts in the field of exposure science, this book provides all the basic understanding you need to employ the best tools and methods for measurement, analysis, and modeling of exposure. Exposure Science: Basic Principles and Applications is an invaluable introduction to exposure science for anyone working in the fields of environmental health, risk assessment, toxicology, or epidemiology. Focuses on and highlights the basic fundamentals, scientific goals, theories and tools of exposure science Examines the use of the exposome and eco-exposome concepts within the field of exposure science

The Telomere Effect

Author : Dr. Elizabeth Blackburn
ISBN : 9781455587964
Genre : Health & Fitness
File Size : 54. 13 MB
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NEW YORK TIMES BESTSELLER The revolutionary book coauthored by the Nobel Prize winner who discovered telomerase and telomeres' role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life. Have you wondered why some sixty-year-olds look and feel like forty-year-olds and why some forty-year-olds look and feel like sixty-year-olds? While many factors contribute to aging and illness, Dr. Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage. Dr. Blackburn and Dr. Elissa Epel's research shows that the length and health of one's telomeres are a biological underpinning of the long-hypothesized mind-body connection. They and other scientists have found that changes we can make to our daily habits can protect our telomeres and increase our health spans (the number of years we remain healthy, active, and disease-free). THE TELOMERE EFFECT reveals how Blackburn and Epel's findings, together with research from colleagues around the world, cumulatively show that sleep quality, exercise, aspects of diet, and even certain chemicals profoundly affect our telomeres, and that chronic stress, negative thoughts, strained relationships, and even the wrong neighborhoods can eat away at them. Drawing from this scientific body of knowledge, they share lists of foods and suggest amounts and types of exercise that are healthy for our telomeres, mind tricks you can use to protect yourself from stress, and information about how to protect your children against developing shorter telomeres, from pregnancy through adolescence. And they describe how we can improve our health spans at the community level, with neighborhoods characterized by trust, green spaces, and safe streets. THE TELOMERE EFFECT will make you reassess how you live your life on a day-to-day basis. It is the first book to explain how we age at a cellular level and how we can make simple changes to keep our chromosomes and cells healthy, allowing us to stay disease-free longer and live more vital and meaningful lives.

Cancer Epidemiology And Prevention

Author : Michael Thun
ISBN : 9780190238667
Genre : Medical
File Size : 50. 75 MB
Format : PDF, ePub
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Since its initial publication in 1982, CANCER EPIDEMIOLOGY AND PREVENTION has served as the premier reference work for students and professionals working to understand the causes and prevention of cancer in humans. Now revised for the first time in more than a decade, this fourth edition provides a comprehensive summary of the global patterns of cancer incidence and mortality, current understanding of the major causal determinants, and a rationale for preventive interventions. Special attention is paid tomolecular epidemiologic approaches that address the wider role of genetic predisposition and gene-environment interactions in cancer etiology and pathogenesis. New and timely chapters on environmental and social-epidemiologic factors include: * The role of social class disparities* The role of obesity and physical inactivity* The potential effects of electromagnetic fields and radiofrequency radiation* The principles of cancer chemopreventionFor both seasoned professionals and newer generations of students and researchers, this fourth edition of CANCER EPIDEMIOLOGY AND PREVENTION remains the authority in the field - a work of distinction that every lab, library, student, professional, or researcher should have close at hand.

Applying Big Data Analytics In Bioinformatics And Medicine

Author : Lytras, Miltiadis D.
ISBN : 9781522526087
Genre : Computers
File Size : 51. 56 MB
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Many aspects of modern life have become personalized, yet healthcare practices have been lagging behind in this trend. It is now becoming more common to use big data analysis to improve current healthcare and medicinal systems, and offer better health services to all citizens. Applying Big Data Analytics in Bioinformatics and Medicine is a comprehensive reference source that overviews the current state of medical treatments and systems and offers emerging solutions for a more personalized approach to the healthcare field. Featuring coverage on relevant topics that include smart data, proteomics, medical data storage, and drug design, this publication is an ideal resource for medical professionals, healthcare practitioners, academicians, and researchers interested in the latest trends and techniques in personalized medicine.

Skin Aging

Author : Barbara A. Gilchrest
ISBN : 9783540329534
Genre : Medical
File Size : 33. 35 MB
Format : PDF, Kindle
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The topic of skin aging is of growing importance to all working in the field of dermatology, aesthetic medicine and cosmetic medicine. Two internationally well-known and leading experts in the field present a comprehensive state-of-the-art review on all aspects of skin aging. With its clear, concise and reader-friendly format this book has all the potential to become the Bible of skin aging. Every specialist interested in dermatology, aesthetic medicine, cosmetic science, cutaneous biology and aging research will find indispensable information of great value for his or her daily work.

Exposure Assessment In Occupational And Environmental Epidemiology

Author : Mark J. Nieuwenhuijsen
ISBN : 0191015687
Genre : Medical
File Size : 25. 62 MB
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Set against a background of growing public, media and political concern about occupational and environmental health issues, and a scientific need to better understand and explain the effects of pollutants on human health, this book is a unique resource. Contributions from an expert panel of international practitioners provide a comprehensive reference on the state of the art methods and applications in the field of occupational and environmental pollution and the adverse health effects, particularly the exposure assessment in epidemiological studies. Risks associated with occupational and environmental exposure are generally small, but the exposed population, and hence the population attributable risk, may be large. To detect small risk, the exposure assessment needs to be very refined. Exposure assessment is the study of the distribution and determinants of potentially hazardous agents, and includes the estimation of intensity, duration and frequency of exposure, the variation in these indices and their determinants. The aim of this book is to develop an understanding and knowledge of exposure assessment methods and their application to substantive issues in occupational and environmental epidemiology. The emphasis is on methodological principles and good practice. It is focused on exposure assessment in both occupational and environmental epidemiology since there are many similarities but also some interesting differences. The book outlines the basic principles of exposure assessment, and examines the current status and research questions in the exposure assessment of occupational and environmental epidemiological studies of allergens, particulate matter, chlorination disinfection by-products, agricultural pesticides and radiofrequencies. The book will be of interest to all concerned with exposure assessment and epidemiology. It will be a valuable source for undergraduate and postgraduate courses in exposure assessment, occupational hygiene, environmental science, epidemiology, toxicology, biostatistics, occupational and environmental health, health risk assessment and related disciplines and a useful resource of reference for policy makers and regulators.

Younger

Author : Dr. Sara Gottfried
ISBN : 9780062316295
Genre : Health & Fitness
File Size : 63. 44 MB
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The New York Times bestselling author of The Hormone Cure and The Hormone Reset Diet shows every woman how to create a lifestyle that will help her look great, feel energized, and slow down the effects of aging. Feel destined for cellulite, saddle bags, and belly fat? Does your family come from a long line of Alzheimer's, cancer, or heart disease? Will nothing help your aging skin or declining libido or flagging energy? This book is for you. The body is magnificent but it doesn't come with a lifetime warranty, or an operating manual. You're the result of millions of years of evolution, but many of the adaptations that helped your ancestors survive are now working overtime to accelerate the aging process. The assumption here is that we are our genes and therefore trapped by the past. The good news is that your genetic code—the DNA sequence that is the biochemical basis of heredity—can play a minor role in the way you age. The scientific reality is that 90 percent of the signs of aging and disease are caused by lifestyle choices, not your genes. In other words, you have the capability to overcome and transform your genetic history and tendencies. Harvard/MIT—trained physician Sara Gottfried, M.D. has created a revolutionary 7-week program that empowers us to make the critical choices necessary to not just look young, but also feel young. Dr. Gottfried identifies and builds this book around the five-key factors that lead to accelerated aging -the muscle factor, the brain factor, the hormone factor, the gut factor, and the toxic fat factor. The 7-week program addresses these factors and treats them in an accessible and highly practical protocol and is as follows: Feed—Week 1 Sleep—Week 2 Move—Week 3 Release—Week 4 Expose—Week 5 Soothe—Week 6 Think—Week 7 Younger increases not only your lifespan, but also your healthspan. Dr. Gottfried's program makes it possible to change the way you age, stay younger longer, and remain healthy and vibrant for all of your days.

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