the philadelphia chromosome a genetic mystery a lethal cancer and the improbable invention of a lifesaving treatment

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The Philadelphia Chromosome

Author : Jessica Wapner
ISBN : 9781615191659
Genre : Health & Fitness
File Size : 87. 7 MB
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Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research— the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same. Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute—with extensive original reporting, including more than thirty-five interviews—to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it. The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

P53

Author : Sue Armstrong
ISBN : 9781472910530
Genre : Health & Fitness
File Size : 48. 51 MB
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All of us have lurking in our DNA a most remarkable gene, which has a crucial job ? it protects us from cancer. Known simply as p53, this gene constantly scans our cells to ensure that they grow and divide without mishap, as part of the routine maintenance of our bodies. If a cell makes a mistake in copying its DNA during the process of division, p53 stops it in its tracks, summoning a repair team before allowing the cell to carry on dividing. If the mistake is irreparable and the rogue cell threatens to grow out of control, p53 commands the cell to commit suicide. Cancer cannot develop unless p53 itself is damaged or prevented from functioning normally. Perhaps unsurprisingly, p53 is the most studied single gene in history. This book tells the story of medical science's mission to unravel the mysteries of this crucial gene, and to get to the heart of what happens in our cells when they turn cancerous. Through the personal accounts of key researchers, p53: The Gene that Cracked the Cancer Code reveals the fascination of the quest for scientific understanding, as well as the huge excitement of the chase for new cures ? the hype, the enthusiasm, the lost opportunities, the blind alleys, and the thrilling breakthroughs. And as the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms begins to take off at last, p53 remains at the cutting edge. This timely tale of scientific discovery highlights the tremendous recent advances made in our understanding of cancer, a disease that affects more than one in three of us at some point in our lives.

Magic Cancer Bullet

Author : Daniel Vasella, M.D.
ISBN : 9780060010300
Genre : Business & Economics
File Size : 81. 73 MB
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The CEO of Novartis discusses the development and potential of cancer drug Gleevec, tracing its laboratory successes, the company's efforts to acquire the drug's FDA approval, and the stories of patients with cancer whose lives have been positively impacted.

One Renegade Cell

Author : Robert A. Weinberg
ISBN : 0786724013
Genre : Science
File Size : 23. 44 MB
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Cancer research has reached a major turning point, and no one is better qualified to explain the past two deacades' dramatic leaps forward in understanding this disease than world-renowned molecular biologist Robert Weinberg, director of the Oncology Research Laboratory at the Whitehead Institute in Cambridge, Massachusetts. In One Renegade Cell, Weinberg presents a state-of-the-art account of how cancer begins and how, one day, it will be cured.

The Death Of Cancer

Author : Vincent T. DeVita, Jr., M.D.
ISBN : 9780374714178
Genre : Medical
File Size : 87. 94 MB
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Cancer touches everybody’s life in one way or another. But most of us know very little about how the disease works, why we treat it the way we do, and the personalities whose dedication got us where we are today. For fifty years, Dr. Vincent T. DeVita Jr. has been one of those key players: he has held just about every major position in the field, and he developed the first successful chemotherapy treatment for Hodgkin’s lymphoma, a breakthrough the American Society of Clinical Oncologists has called the top research advance in half a century of chemotherapy. As one of oncology’s leading figures, DeVita knows what cancer looks like from the lab bench and the bedside. The Death of Cancer is his illuminating and deeply personal look at the science and the history of one of the world’s most formidable diseases. In DeVita’s hands, even the most complex medical concepts are comprehensible. Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged—by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers. With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.

The Cancer Chronicles

Author : George Johnson
ISBN : 9780385349710
Genre : Medical
File Size : 78. 4 MB
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When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way—an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease. Deftly excavating and illuminating decades of investigation and analysis, he reveals what we know and don’t know about cancer, showing why a cure remains such a slippery concept. We follow him as he combs through the realms of epidemiology, clinical trials, laboratory experiments, and scientific hypotheses—rooted in every discipline from evolutionary biology to game theory and physics. Cogently extracting fact from a towering canon of myth and hype, he describes tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them, jujitsu-like, against the body. Throughout his pursuit, Johnson clarifies the human experience of cancer with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies, and other treatments. He finds compassion, solace, and community among a vast network of patients and professionals committed to the fight and wrestles to comprehend the cruel randomness cancer metes out in his own family. For anyone whose life has been affected by cancer and has found themselves asking why?, this book provides a new understanding. In good company with the works of Atul Gawande, Siddhartha Mukherjee, and Abraham Verghese, The Cancer Chronicles is endlessly surprising and as radiant in its prose as it is authoritative in its eye-opening science.

We Are All Stardust

Author : Stefan Klein
ISBN : 9781615191536
Genre : Science
File Size : 89. 63 MB
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“What distinguishes scientists, in your eyes?”—Stefan Klein “First and foremost, curiosity.”—Roald Hoffmann, Nobel Prize–winning chemist When Stefan Klein, an acclaimed journalist, sits down to talk with 18 of the world’s leading scientists, he finds they’re driven by, above all, curiosity. When they talk about their work, they turn to what’s next, to what they still hope to discover. And they see inspiration everywhere: From the sports car that physicist Steven Weinberg says helped him on his quest for “the theory of everything” to the jazz musicians who gave psychologist Alison Gopnik new insight into raising children, they reveal how their paradigm-changing work entwines with their lives outside the lab. We hear from extraordinary natural and social scientists, including: Evolutionary biologist Richard Dawkins on ego and selflessness Primatologist Jane Goodall on chimpanzee behavior Neuroscientist V. S. Ramachandran on consciousness Geographer Jared Diamond on chance in history Anthropologist Sarah Hrdy on motherhood And cosmologist Martin Rees on how “ultimately we ourselves are stardust.”

Forks Over Knives

Author : Gene Stone
ISBN : 9781615191468
Genre : Health & Fitness
File Size : 25. 25 MB
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The #1 New York Times bestseller answers: What if one simple change could save you from heart disease, diabetes, and cancer? For decades, that question has fascinated a small circle of impassioned doctors and researchers—and now, their life-changing research is making headlines in the hit documentary Forks Over Knives. Their answer? Eat a whole-foods, plant-based diet—it could save your life. It may overturn most of the diet advice you’ve heard—but the experts behind Forks Over Knives aren’t afraid to make waves. In his book Prevent and Reverse Heart Disease, Dr. Caldwell Esselstyn explained that eating meat, dairy, and oils injures the lining of our blood vessels, causing heart disease, heart attack, or stroke. In The China Study, Dr. Colin Campbell revealed how cancer and other diseases skyrocket when eating meat and dairy is the norm—and plummet when a traditional plant-based diet persists. And more and more experts are adding their voices to the cause: There is nothing else you can do for your health that can match the benefits of a plant-based diet. Now, as Forks Over Knives is introducing more people than ever before to the plant-based way to health, this accessible guide provides the information you need to adopt and maintain a plant-based diet. Features include: Insights from the luminaries behind the film—Dr. Neal Barnard, Dr. John McDougall, The Engine 2 Diet author Rip Esselstyn, and many others Success stories from converts to plant-based eating—like San’Dera Prude, who no longer needs to medicate her diabetes, has lost weight, and feels great! The many benefits of a whole-foods, plant-based diet—for you, for animals and the environment, and for our future A helpful primer on crafting a healthy diet rich in unprocessed fruits, vegetables, legumes, and whole grains, including tips on transitioning and essential kitchen tools 125 recipes from 25 champions of plant-based dining—from Blueberry Oat Breakfast Muffins and Sunny Orange Yam Bisque to Garlic Rosemary Polenta and Raspberry-Pear Crisp—delicious, healthy, and for every meal, every day.

Herding Hemingway S Cats

Author : Kat Arney
ISBN : 9781472910066
Genre : Science
File Size : 76. 66 MB
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The language of genes has become common parlance. We know they make your eyes blue, your hair curly or your nose straight. The media tells us that our genes control the risk of cancer, heart disease, alcoholism or Alzheimer's. The cost of DNA sequencing has plummeted from billions of pounds to a few hundred, and gene-based advances in medicine hold huge promise. So we've all heard of genes, but how do they actually work? There are 2.2 metres of DNA inside every one of your cells, encoding roughly 20,000 genes. These are the 'recipes' that tell our cells how to make the building blocks of life, along with myriad control switches ensuring they're turned on and off at the right time and in the right place. But rather than a static string of genetic code, this is a dynamic, writhing biological library. Figuring out how it all works Â? how your genes build your body Â? is a major challenge for researchers around the world. And what they're discovering is that far from genes being a fixed, deterministic blueprint, things are much more random and wobbly than anyone expected. Drawing on stories ranging from six toed cats and stickleback hips to Mickey Mouse mice and zombie genes Â? told by researchers working at the cutting edge of genetics Â? Kat Arney explores the mysteries in our genomes with clarity, flair and wit, creating a companion reader to the book of life itself.

13 Things That Don T Make Sense

Author : Michael Brooks
ISBN : 9781861976475
Genre : Science
File Size : 70. 85 MB
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Science starts to get interesting when things don't make sense.Even today there are experimental results that the most brilliant scientists can neither explain nor dismiss. In the past, similar anomalies have revolutionised our world: in the sixteenth century, a set of celestial irregularities led Copernicus to realise that the Earth goes around the sun and not the reverse. In 13 Things That Don't Make Sense Michael Brooks meets thirteen modern-day anomalies that may become tomorrow's breakthroughs. Is ninety six percent of the universe missing? If no study has ever been able to definitively show that the placebo effect works, why has it become a pillar of medical science? Was the 1977 signal from outer space a transmission from an alien civilization? Spanning fields from chemistry to cosmology, psychology to physics, Michael Brooks thrillingly captures the excitement and controversy of the scientific unknown.

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