the philadelphia chromosome a genetic mystery a lethal cancer and the improbable invention of a lifesaving treatment

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The Philadelphia Chromosome

Author : Jessica Wapner
ISBN : 9781615191659
Genre : Health & Fitness
File Size : 57. 45 MB
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Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research— the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same. Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute—with extensive original reporting, including more than thirty-five interviews—to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it. The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

Magic Cancer Bullet

Author : Daniel Vasella, M.D.
ISBN : 9780060010300
Genre : Business & Economics
File Size : 79. 6 MB
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The CEO of Novartis discusses the development and potential of cancer drug Gleevec, tracing its laboratory successes, the company's efforts to acquire the drug's FDA approval, and the stories of patients with cancer whose lives have been positively impacted.

Herding Hemingway S Cats

Author : Kat Arney
ISBN : 9781472910066
Genre : Science
File Size : 45. 84 MB
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The language of genes has become common parlance. We know they make your eyes blue, your hair curly or your nose straight. The media tells us that our genes control the risk of cancer, heart disease, alcoholism or Alzheimer's. The cost of DNA sequencing has plummeted from billions of pounds to a few hundred, and gene-based advances in medicine hold huge promise. So we've all heard of genes, but how do they actually work? There are 2.2 metres of DNA inside every one of your cells, encoding roughly 20,000 genes. These are the 'recipes' that tell our cells how to make the building blocks of life, along with myriad control switches ensuring they're turned on and off at the right time and in the right place. But rather than a static string of genetic code, this is a dynamic, writhing biological library. Figuring out how it all works Â? how your genes build your body Â? is a major challenge for researchers around the world. And what they're discovering is that far from genes being a fixed, deterministic blueprint, things are much more random and wobbly than anyone expected. Drawing on stories ranging from six toed cats and stickleback hips to Mickey Mouse mice and zombie genes Â? told by researchers working at the cutting edge of genetics Â? Kat Arney explores the mysteries in our genomes with clarity, flair and wit, creating a companion reader to the book of life itself.

Pharmocracy

Author : Kaushik Sunder Rajan
ISBN : 9780822373285
Genre : Social Science
File Size : 80. 11 MB
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Continuing his pioneering theoretical explorations into the relationships among biosciences, the market, and political economy, Kaushik Sunder Rajan introduces the concept of pharmocracy to explain the structure and operation of the global hegemony of the multinational pharmaceutical industry. He reveals pharmocracy's logic in two case studies from contemporary India: the controversial introduction of an HPV vaccine in 2010, and the Indian Patent Office's denial of a patent for an anticancer drug in 2006 and ensuing legal battles. In each instance health was appropriated by capital and transformed from an embodied state of well-being into an abstract category made subject to capital's interests. These cases demonstrate the precarious situation in which pharmocracy places democracy, as India's accommodation of global pharmaceutical regulatory frameworks pits the interests of its citizens against those of international capital. Sunder Rajan's insights into this dynamic make clear the high stakes of pharmocracy's intersection with health, politics, and democracy.

I Wish I D Made You Angry Earlier

Author : Max F. Perutz
ISBN : 019859027X
Genre : Creative ability in science
File Size : 49. 27 MB
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This collection of essays from Nobel Laureate Max Perutz explores a wide range of scientific and personal topics with insight and lucidity. It includes lively anecdotes about key figures in 20th-century science.

Dark Remedy

Author : Trent Stephens
ISBN : 9780786731121
Genre : Science
File Size : 81. 87 MB
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In this riveting medical detective story, Trent Stephens and Rock Brynner recount the history of thalidomide, from the epidemic of birth defects in the 1960's to the present day, as scientists work to create and test an alternative drug that captures thalidomide's curative properties without its cruel side effects. A parable about compassion-and the absence of it-Dark Remedy is a gripping account of thalidomide's extraordinary impact on the lives of individuals and nations over half a century.

Seduced By Logic

Author : Robyn Arianrhod
ISBN : 9780199931613
Genre : Mathematics
File Size : 50. 55 MB
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Newton's explanations of natural laws shattered the way mankind perceived the universe, and hence were not immediately embraced. How can anyone warm to a force that could not be seen or touched? But for two women, separated by time and space but joined in their passion for Newtonian physics,that force drove them to great achievements. Brilliant, determined, and almost entirely self-taught, they dedicated their lives to explaining and disseminating Newton's discoveries.Robyn Arianrhod's Seduced by Logic tells the dual biography of Emilie du Chatelet and Mary Somerville, who, despite living a century apart, were connected by their love for mathematics and their places at the heart of the most advanced scientific society of their age. When Newton published hisrevolutionary theory of gravity in 1687, most of his Continental peers rejected it for its reliance on physical observation and mathematical insight and its lack of religious or metaphysical hypotheses. But the brilliant French aristocrat and intellectual Emilie du Chatelet and some of her earlyeighteenth-century Enlightenment colleagues - including her lover, Voltaire - realized the Principia Mathematica had changed everything, marking the beginning of theoretical science as a predictive, quantitative, and secular discipline. Emilie devoted herself to furthering Newton's ideas in France,and her translation of the Principia became the accepted French version of his work. Almost a century later, in Scotland, Mary Somerville taught herself mathematics and rose from genteel poverty to become a world authority on Newtonian physics. Living in France, she became acquainted with the workof one of Newton's proteges, Pierre Simon Laplace, and translated his six-volume Celestial Mechanics into English. It remained the standard astronomy text for the next century, and was considered the most influential work since Principia. Combining biography and history of science, Seduced by Logic not only reveals the fascinating story of two incredibly talented women, but also brings to life a period of dramatic political and scientific change. With lucidity and skill, Arianrhod reveals the intimate links between the unfoldingNewtonian revolution and the origins of intellectual and political liberty.

Genome

Author : Matt Ridley
ISBN : 9780062253460
Genre : Science
File Size : 70. 76 MB
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The genome's been mapped. But what does it mean? Arguably the most significant scientific discovery of the new century, the mapping of the twenty-three pairs of chromosomes that make up the human genome raises almost as many questions as it answers. Questions that will profoundly impact the way we think about disease, about longevity, and about free will. Questions that will affect the rest of your life. Genome offers extraordinary insight into the ramifications of this incredible breakthrough. By picking one newly discovered gene from each pair of chromosomes and telling its story, Matt Ridley recounts the history of our species and its ancestors from the dawn of life to the brink of future medicine. From Huntington's disease to cancer, from the applications of gene therapy to the horrors of eugenics, Matt Ridley probes the scientific, philosophical, and moral issues arising as a result of the mapping of the genome. It will help you understand what this scientific milestone means for you, for your children, and for humankind.

The Man With The Bionic Brain

Author : Jon Mukand
ISBN : 9781613740583
Genre : Medical
File Size : 66. 18 MB
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A behind-the-scenes view of cutting-edge medical research and discoveries that are helping people with disabilities regain control, this book is an insightful look into the possibilities of technology and the associated ethical, political, social, and financial controversies. After he was stabbed and paralyzed from the neck down, Matthew Nagle, a former high school football star, made scientific history when neurosurgeons implanted microelectrodes in his brain that recognized his thought patterns, allowing him to control a computer cursor. With the BrainGate system he was able to use e-mail, manipulate a prosthetic hand, adjust TV settings, and play video games--all just by thinking. Dr. Jon Mukand, his research physician and a rehabilitation specialist, weaves together Matt's story with firsthand accounts of other courageous survivors of stroke, spinal injuries, and brain trauma and the amazing technology that improves their lives. Not only a discussion of scientific advances in the battle against paralysis, The Man with the Bionic Brain is an inspirational book about how biomedicine gives hope to people with disabilities and enables them to take control of their lives. Jon Mukand, MD, PhD, is rehabilitation medicine specialist and medical director of the Southern New England Rehabilitation Center and serves on the clinical faculty of Brown University and Tufts University. He is the editor of Vital Lines: Contemporary Fiction about Medicine, Articulations: The Body and Illness in Poetry, and Rehabilitation for Patients with HIV Disease. He lives in Providence, Rhode Island.

The Death Of Cancer

Author : Vincent T. DeVita, Jr., M.D.
ISBN : 9780374714178
Genre : Medical
File Size : 52. 66 MB
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Cancer touches everybody’s life in one way or another. But most of us know very little about how the disease works, why we treat it the way we do, and the personalities whose dedication got us where we are today. For fifty years, Dr. Vincent T. DeVita Jr. has been one of those key players: he has held just about every major position in the field, and he developed the first successful chemotherapy treatment for Hodgkin’s lymphoma, a breakthrough the American Society of Clinical Oncologists has called the top research advance in half a century of chemotherapy. As one of oncology’s leading figures, DeVita knows what cancer looks like from the lab bench and the bedside. The Death of Cancer is his illuminating and deeply personal look at the science and the history of one of the world’s most formidable diseases. In DeVita’s hands, even the most complex medical concepts are comprehensible. Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged—by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers. With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.

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