the philadelphia chromosome a genetic mystery a lethal cancer and the improbable invention of a lifesaving treatment

Download Book The Philadelphia Chromosome A Genetic Mystery A Lethal Cancer And The Improbable Invention Of A Lifesaving Treatment in PDF format. You can Read Online The Philadelphia Chromosome A Genetic Mystery A Lethal Cancer And The Improbable Invention Of A Lifesaving Treatment here in PDF, EPUB, Mobi or Docx formats.

The Philadelphia Chromosome

Author : Jessica Wapner
ISBN : 9781615191659
Genre : Health & Fitness
File Size : 83. 91 MB
Format : PDF, Kindle
Download : 532
Read : 804

Download Now


Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research— the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same. Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute—with extensive original reporting, including more than thirty-five interviews—to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it. The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

Cancer Genomics

Author : Graham Dellaire
ISBN : 9780123972743
Genre : Medical
File Size : 49. 37 MB
Format : PDF, Kindle
Download : 471
Read : 929

Download Now


Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics. Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.

Magic Cancer Bullet

Author : Daniel Vasella, M.D.
ISBN : 9780060010300
Genre : Business & Economics
File Size : 43. 76 MB
Format : PDF, Mobi
Download : 892
Read : 865

Download Now


The CEO of Novartis discusses the development and potential of cancer drug Gleevec, tracing its laboratory successes, the company's efforts to acquire the drug's FDA approval, and the stories of patients with cancer whose lives have been positively impacted.

The Cancer Chronicles

Author : George Johnson
ISBN : 9781448156979
Genre : Medical
File Size : 39. 51 MB
Format : PDF, Kindle
Download : 446
Read : 716

Download Now


When the woman he loved was diagnosed with a metastatic cancer, science-writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is that a revolution is now under way – an explosion of new ideas about what cancer really is and where it comes from. He combs through the realms of epidemiology, clinical trials, laboratory experiments and scientific hypotheses, to reveal what we know and don’t know about cancer, showing why a cure remains such a slippery concept. His luminous accounts describe tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them against the body. Throughout his pursuit, Johnson illuminates the human experience with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies and other treatments. Provocative and intellectually vibrant, The Cancer Chronicles will challenge everything you thought you knew about the disease – and provide hope for tomorrow and the future.

The Language Of God

Author : Francis S. Collins
ISBN : 0743293576
Genre : Religion
File Size : 24. 88 MB
Format : PDF
Download : 652
Read : 1210

Download Now


Does science necessarily undermine faith in God? Or could it actually support faith? Beyond the flashpoint debates over the teaching of evolution, or stem-cell research, most of us struggle with contradictions concerning life's ultimate question. We know that accidents happen, but we believe we are on earth for a reason. Until now, most scientists have argued that science and faith occupy distinct arenas. Francis Collins, a former atheist as a science student who converted to faith as he became a doctor, is about to change that. Collins's faith in God has been confirmed and enhanced by the revolutionary discoveries in biology that he has helped to oversee. He has absorbed the arguments for atheism of many scientists and pundits, and he can refute them. Darwinian evolution occurs, yet, as he explains, it cannot fully explain human nature -- evolution can and must be directed by God. He offers an inspiring tour of the human genome to show the miraculous nature of God's instruction book. Sure to be compared with C.S. Lewis's Mere Christianity, this is a stunning document, whether you are a believer, a seeker, or an atheist.

The Emperor Of All Maladies

Author : Siddhartha Mukherjee
ISBN : 9781439170915
Genre : History
File Size : 26. 51 MB
Format : PDF, Docs
Download : 909
Read : 472

Download Now


An assessment of cancer addresses both the courageous battles against the disease and the misperceptions and hubris that have compromised modern understandings, providing coverage of such topics as ancient-world surgeries and the development of present-day treatments. Reprint. Best-selling winner of the Pulitzer Prize. Includes reading-group guide.

The Already Dead

Author : Eric Cazdyn
ISBN : 9780822352280
Genre : Philosophy
File Size : 37. 78 MB
Format : PDF, Kindle
Download : 650
Read : 467

Download Now


This book considers how a culture of crisis management&—what Cazdyn calls "the new chronic"&— has come to dominate all aspects of contemporary life, from biomedicine to economics to politics. Drawing from his own experiences battling leukemia and the subsequent effects of his illness on the process of becoming a Canadian citizen, Cazdyn unravels the logic of the new chronic where people find themselves suspended in a space between life and death.

Top Download:

Best Books