the philadelphia chromosome a genetic mystery a lethal cancer and the improbable invention of a lifesaving treatment

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The Philadelphia Chromosome

Author : Jessica Wapner
ISBN : 9781615191659
Genre : Health & Fitness
File Size : 22. 37 MB
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Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research— the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same. Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute—with extensive original reporting, including more than thirty-five interviews—to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it. The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

The Philadelphia Chromosome

Author : Jessica Wapner
ISBN : 9781615191970
Genre : Health & Fitness
File Size : 43. 94 MB
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Discusses the history of a genetic mutation, discovered in 1959, that causes chronic myeloid leukemia, and traces the research and breakthroughs that led to the creation of a drug that makes this once-fatal illness now treatable.

One Renegade Cell

Author : Robert A Weinberg
ISBN : 9781780227788
Genre : Science
File Size : 81. 58 MB
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How cancers begin and spread, by the scientist responsible for the major recent research breakthroughs Cancer research has reached a major turning point. The amount of information gathered in the past twenty years about the origins of the disease is without equal in the history of biomedical research. In this book one of America's most eminent scientists explains to the general reader the step-by-step process by which cancers arise, and more importantly, how they spread. Robert Weinberg explains how normal genes control the conventional growth of the cell, how, in their mutated form, they enable cancers to arise, and why these genes have such life-and-death power over us. Drawing from information that simply was not available until recently, One Renegade Cell explains this insidious disease as no other book as ever been able to do.

Magic Cancer Bullet

Author : Daniel Vasella, M.D.
ISBN : 9780060010300
Genre : Business & Economics
File Size : 20. 51 MB
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The CEO of Novartis discusses the development and potential of cancer drug Gleevec, tracing its laboratory successes, the company's efforts to acquire the drug's FDA approval, and the stories of patients with cancer whose lives have been positively impacted.

The Death Of Cancer

Author : Vincent T. DeVita, Jr., M.D.
ISBN : 9780374714178
Genre : Medical
File Size : 71. 82 MB
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Cancer touches everybody’s life in one way or another. But most of us know very little about how the disease works, why we treat it the way we do, and the personalities whose dedication got us where we are today. For fifty years, Dr. Vincent T. DeVita Jr. has been one of those key players: he has held just about every major position in the field, and he developed the first successful chemotherapy treatment for Hodgkin’s lymphoma, a breakthrough the American Society of Clinical Oncologists has called the top research advance in half a century of chemotherapy. As one of oncology’s leading figures, DeVita knows what cancer looks like from the lab bench and the bedside. The Death of Cancer is his illuminating and deeply personal look at the science and the history of one of the world’s most formidable diseases. In DeVita’s hands, even the most complex medical concepts are comprehensible. Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged—by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers. With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.

Herding Hemingway S Cats

Author : Kat Arney
ISBN : 9781472910066
Genre : Science
File Size : 70. 86 MB
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The language of genes has become common parlance. We know they make your eyes blue, your hair curly or your nose straight. The media tells us that our genes control the risk of cancer, heart disease, alcoholism or Alzheimer's. The cost of DNA sequencing has plummeted from billions of pounds to a few hundred, and gene-based advances in medicine hold huge promise. So we've all heard of genes, but how do they actually work? There are 2.2 metres of DNA inside every one of your cells, encoding roughly 20,000 genes. These are the 'recipes' that tell our cells how to make the building blocks of life, along with myriad control switches ensuring they're turned on and off at the right time and in the right place. But rather than a static string of genetic code, this is a dynamic, writhing biological library. Figuring out how it all works Â? how your genes build your body Â? is a major challenge for researchers around the world. And what they're discovering is that far from genes being a fixed, deterministic blueprint, things are much more random and wobbly than anyone expected. Drawing on stories ranging from six toed cats and stickleback hips to Mickey Mouse mice and zombie genes Â? told by researchers working at the cutting edge of genetics Â? Kat Arney explores the mysteries in our genomes with clarity, flair and wit, creating a companion reader to the book of life itself.

Molecular Biology Of Cancer

Author : Lauren Pecorino
ISBN : 9780199577170
Genre : Medical
File Size : 36. 76 MB
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The third edition of The Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics offers a fresh approach to the study of the molecular basis of cancer, by showing how our understanding of the defective mechanisms which drive cancer is leading to the development of new targeted therapeutic agents.

The Cancer Chronicles

Author : George Johnson
ISBN : 9781448156979
Genre : Medical
File Size : 61. 20 MB
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When the woman he loved was diagnosed with a metastatic cancer, science-writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is that a revolution is now under way – an explosion of new ideas about what cancer really is and where it comes from. He combs through the realms of epidemiology, clinical trials, laboratory experiments and scientific hypotheses, to reveal what we know and don’t know about cancer, showing why a cure remains such a slippery concept. His luminous accounts describe tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them against the body. Throughout his pursuit, Johnson illuminates the human experience with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies and other treatments. Provocative and intellectually vibrant, The Cancer Chronicles will challenge everything you thought you knew about the disease – and provide hope for tomorrow and the future.

Every Living Thing

Author : Dr. Rob Dunn
ISBN : 9780061979743
Genre : Science
File Size : 72. 89 MB
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“If you have any interest in life beyond your own, you should read this book.” —Paul R. Ehrlich, author of The Dominant Animal Biologist Rob Dunn’s Every Little Thing is the story of man’s obsessive quest to catalog life, from nanobacteria to new monkeys. In the tradition of E.O. Wilson, this engaging and fascinating work of popular science follows humanity’s unending quest to discover every living thing in our natural world—from the unimaginably small in the most inhospitable of places on earth to the unimaginably far away in the unexplored canals on Mars.

The Family That Couldn T Sleep

Author : D. T. Max
ISBN : 9781588365583
Genre : Health & Fitness
File Size : 82. 35 MB
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For two hundred years a noble Venetian family has suffered from an inherited disease that strikes their members in middle age, stealing their sleep, eating holes in their brains, and ending their lives in a matter of months. In Papua New Guinea, a primitive tribe is nearly obliterated by a sickness whose chief symptom is uncontrollable laughter. Across Europe, millions of sheep rub their fleeces raw before collapsing. In England, cows attack their owners in the milking parlors, while in the American West, thousands of deer starve to death in fields full of grass. What these strange conditions–including fatal familial insomnia, kuru, scrapie, and mad cow disease–share is their cause: prions. Prions are ordinary proteins that sometimes go wrong, resulting in neurological illnesses that are always fatal. Even more mysterious and frightening, prions are almost impossible to destroy because they are not alive and have no DNA–and the diseases they bring are now spreading around the world. In The Family That Couldn’t Sleep, essayist and journalist D. T. Max tells the spellbinding story of the prion’s hidden past and deadly future. Through exclusive interviews and original archival research, Max explains this story’s connection to human greed and ambition–from the Prussian chemist Justus von Liebig, who made cattle meatier by feeding them the flesh of other cows, to New Guinean natives whose custom of eating the brains of the dead nearly wiped them out. The biologists who have investigated these afflictions are just as extraordinary–for example, Daniel Carleton Gajdusek, a self-described “pedagogic pedophiliac pediatrician” who cracked kuru and won the Nobel Prize, and another Nobel winner, Stanley Prusiner, a driven, feared self-promoter who identified the key protein that revolutionized prion study. With remarkable precision, grace, and sympathy, Max–who himself suffers from an inherited neurological illness–explores maladies that have tormented humanity for centuries and gives reason to hope that someday cures will be found. And he eloquently demonstrates that in our relationship to nature and these ailments, we have been our own worst enemy.

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