the philadelphia chromosome a genetic mystery a lethal cancer and the improbable invention of a lifesaving treatment

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The Philadelphia Chromosome

Author : Jessica Wapner
ISBN : 9781615191659
Genre : Health & Fitness
File Size : 29. 18 MB
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Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research— the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same. Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute—with extensive original reporting, including more than thirty-five interviews—to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it. The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

One Renegade Cell

Author : Robert A. Weinberg
ISBN : 9780786724017
Genre : Science
File Size : 48. 60 MB
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Cancer research has reached a major turning point, and no one is better qualified to explain the past two deacades' dramatic leaps forward in understanding this disease than world-renowned molecular biologist Robert Weinberg, director of the Oncology Research Laboratory at the Whitehead Institute in Cambridge, Massachusetts. In One Renegade Cell, Weinberg presents a state-of-the-art account of how cancer begins and how, one day, it will be cured.

The Cancer Chronicles

Author : George Johnson
ISBN : 9781448156979
Genre : Medical
File Size : 20. 73 MB
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When the woman he loved was diagnosed with a metastatic cancer, science-writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is that a revolution is now under way – an explosion of new ideas about what cancer really is and where it comes from. He combs through the realms of epidemiology, clinical trials, laboratory experiments and scientific hypotheses, to reveal what we know and don’t know about cancer, showing why a cure remains such a slippery concept. His luminous accounts describe tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them against the body. Throughout his pursuit, Johnson illuminates the human experience with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies and other treatments. Provocative and intellectually vibrant, The Cancer Chronicles will challenge everything you thought you knew about the disease – and provide hope for tomorrow and the future.

Her 2

Author : Robert Bazell
ISBN : 9780307764980
Genre : Health & Fitness
File Size : 79. 49 MB
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Two years after she underwent a mastectomy and chemotherapy, Barbara Bradfield's aggressive breast cancer had recurred and spread to her lungs. The outlook was grim. Then she took part in Genentech's clinical trials for a new drug. Five years later she remains cancer-free. Her-2 is the biography of Herceptin, the drug that provoked dramatic responses in Barbara Bradfield and other women in the trials and that offers promise for hundreds of thousands of breast cancer patients. Unlike chemotherapy or radiation, Herceptin has no disabling side effects. It works by inactivating Her-2/neu--a protein that makes cancer cells grow especially quickly-- produced by a gene found in 25 to 30 percent of all breast tumors. Herceptin caused some patients' cancers to disappear completely; in others, it slowed the progression of the disease and gave the women months or years they wouldn't otherwise have had. Herceptin is the first treatment targeted at a gene defect that gives rise to cancer. It marks the beginning of a new era of treatment for all kinds of cancers. Robert Bazell presents a riveting account of how Herceptin was born. Her-2 is a story of dramatic discoveries and strong personalities, showing the combination of scientific investigation, money, politics, ego, corporate decisions, patient activism, and luck involved in moving this groundbreaking drug from the lab to a patient's bedside. Bazell's deft portraits introduce us to the remarkable people instrumental in Herceptin's history, including Dr. Dennis Slamon, the driven UCLA oncologist who played the primary role in developing the treatment; Lily Tartikoff, wife of television executive Brandon Tartikoff, who tapped into Hollywood money and glamour to help fund Slamon's research; and Marti Nelson, who inspired the activists who lobbied for a "compassionate use" program that would allow women outside the clinical trials to have access to the limited supplies of Herceptin prior to FDA approval of the drug. And throughout there are the stories of the heroic women with advanced breast cancer who volunteered for the trials, risking what time they had left on an unproven treatment. Meticulously researched, written with clarity and compassion, Her-2 is masterly reporting on cutting-edge science. From the Hardcover edition.

The Death Of Cancer

Author : Vincent T. DeVita, Jr., M.D.
ISBN : 9780374714178
Genre : Medical
File Size : 47. 22 MB
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Cancer touches everybody’s life in one way or another. But most of us know very little about how the disease works, why we treat it the way we do, and the personalities whose dedication got us where we are today. For fifty years, Dr. Vincent T. DeVita Jr. has been one of those key players: he has held just about every major position in the field, and he developed the first successful chemotherapy treatment for Hodgkin’s lymphoma, a breakthrough the American Society of Clinical Oncologists has called the top research advance in half a century of chemotherapy. As one of oncology’s leading figures, DeVita knows what cancer looks like from the lab bench and the bedside. The Death of Cancer is his illuminating and deeply personal look at the science and the history of one of the world’s most formidable diseases. In DeVita’s hands, even the most complex medical concepts are comprehensible. Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged—by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers. With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.

Magic Cancer Bullet

Author : Daniel Vasella, M.D.
ISBN : 9780060010300
Genre : Business & Economics
File Size : 40. 85 MB
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The CEO of Novartis discusses the development and potential of cancer drug Gleevec, tracing its laboratory successes, the company's efforts to acquire the drug's FDA approval, and the stories of patients with cancer whose lives have been positively impacted.

The Biology Of Cancer Second Edition

Author : Robert Weinberg
ISBN : 9781317963462
Genre : Science
File Size : 64. 46 MB
Format : PDF, ePub
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Thoroughly updated and incorporating the most important advances in the fast-growing field of cancer biology, The Biology of Cancer, Second Edition, maintains all of its hallmark features admired by students, instructors, researchers, and clinicians around the world. The Biology of Cancer is a textbook for students studying the molecular and cellular bases of cancer at the undergraduate, graduate, and medical school levels. The principles of cancer biology are presented in an organized, cogent, and in-depth manner. The clarity of writing, supported by an extensive full-color art program and numerous pedagogical features, makes the book accessible and engaging. The information unfolds through the presentation of key experiments that give readers a sense of discovery and provide insights into the conceptual foundation underlying modern cancer biology.

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