the philadelphia chromosome a genetic mystery a lethal cancer and the improbable invention of a lifesaving treatment

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The Philadelphia Chromosome

Author : Jessica Wapner
ISBN : 9781615191659
Genre : Health & Fitness
File Size : 25. 35 MB
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Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research— the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same. Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute—with extensive original reporting, including more than thirty-five interviews—to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it. The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

P53

Author : Sue Armstrong
ISBN : 1472910516
Genre : Science
File Size : 40. 58 MB
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All of us have lurking in our DNA a most remarkable gene. Its job is to protect us from cancer. This gene-known simply as p53-constantly scans our cells to ensure that when they grow and divide as part of the routine maintenance of our bodies, they do so without mishap. If a cell makes a mistake in copying its DNA during the process of division, p53 stops it in its tracks, sending in the repair team before allowing the cell to carry on dividing. If the mistake is irreparable and the rogue cell threatens to grow out of control (as happens in cancer), p53 commands the cell to commit suicide. Cancer cannot develop unless p53 itself is damaged or handicapped by some other fault in the system. Not surprisingly, p53 is the most studied single gene in history. p53: The Gene that Cracked the Cancer Code tells the story of the discovery of the gene and of medical science's mission to unravel its mysteries and get to the heart of what happens in our cells when they turn cancerous. Through the personal accounts of key researchers, the book reveals the excitement of the hunt for new cures -- the hype, the enthusiasm, the lost opportunities, the blind alleys and the thrilling breakthroughs. As the long-anticipated revolution in cancer treatment tailored to each individual patient's symptoms starts to take off at last, p53 is at the cutting edge. This is a timely tale of scientific discovery and advances in our understanding of a disease that still affects more than one in three of us at some point in our lives.

Cancer Genomics

Author : Graham Dellaire
ISBN : 9780123972743
Genre : Medical
File Size : 76. 32 MB
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Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics. Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.

The Biology Of Cancer Second Edition

Author : Robert Weinberg
ISBN : 9781317963462
Genre : Science
File Size : 56. 84 MB
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Thoroughly updated and incorporating the most important advances in the fast-growing field of cancer biology, The Biology of Cancer, Second Edition, maintains all of its hallmark features admired by students, instructors, researchers, and clinicians around the world. The Biology of Cancer is a textbook for students studying the molecular and cellular bases of cancer at the undergraduate, graduate, and medical school levels. The principles of cancer biology are presented in an organized, cogent, and in-depth manner. The clarity of writing, supported by an extensive full-color art program and numerous pedagogical features, makes the book accessible and engaging. The information unfolds through the presentation of key experiments that give readers a sense of discovery and provide insights into the conceptual foundation underlying modern cancer biology.

Magic Cancer Bullet

Author : Daniel Vasella, M.D.
ISBN : 9780060010300
Genre : Business & Economics
File Size : 90. 95 MB
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The CEO of Novartis discusses the development and potential of cancer drug Gleevec, tracing its laboratory successes, the company's efforts to acquire the drug's FDA approval, and the stories of patients with cancer whose lives have been positively impacted.

Human Genes And Genomes

Author : Leon E. Rosenberg
ISBN : 9780123852137
Genre : Science
File Size : 33. 55 MB
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In the nearly 60 years since Watson and Crick proposed the double helical structure of DNA, the molecule of heredity, waves of discoveries have made genetics the most thrilling field in the sciences. The study of genes and genomics today explores all aspects of the life with relevance in the lab, in the doctor’s office, in the courtroom and even in social relationships. In this helpful guidebook, one of the most respected and accomplished human geneticists of our time communicates the importance of genes and genomics studies in all aspects of life. With the use of core concepts and the integration of extensive references, this book provides students and professionals alike with the most in-depth view of the current state of the science and its relevance across disciplines. Bridges the gap between basic human genetic understanding and one of the most promising avenues for advances in the diagnosis, prevention and treatment of human disease. Includes the latest information on diagnostic testing, population screening, predicting disease susceptibility, pharmacogenomics and more Explores ethical, legal, regulatory and economic aspects of genomics in medicine. Integrates historical (classical) genetics approach with the latest discoveries in structural and functional genomics

The Cancer Chronicles

Author : George Johnson
ISBN : 9780385349710
Genre : Medical
File Size : 20. 89 MB
Format : PDF
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When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way—an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease. Deftly excavating and illuminating decades of investigation and analysis, he reveals what we know and don’t know about cancer, showing why a cure remains such a slippery concept. We follow him as he combs through the realms of epidemiology, clinical trials, laboratory experiments, and scientific hypotheses—rooted in every discipline from evolutionary biology to game theory and physics. Cogently extracting fact from a towering canon of myth and hype, he describes tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them, jujitsu-like, against the body. Throughout his pursuit, Johnson clarifies the human experience of cancer with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies, and other treatments. He finds compassion, solace, and community among a vast network of patients and professionals committed to the fight and wrestles to comprehend the cruel randomness cancer metes out in his own family. For anyone whose life has been affected by cancer and has found themselves asking why?, this book provides a new understanding. In good company with the works of Atul Gawande, Siddhartha Mukherjee, and Abraham Verghese, The Cancer Chronicles is endlessly surprising and as radiant in its prose as it is authoritative in its eye-opening science.

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