the philadelphia chromosome a genetic mystery a lethal cancer and the improbable invention of a lifesaving treatment

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The Philadelphia Chromosome

Author : Jessica Wapner
ISBN : 9781615191659
Genre : Health & Fitness
File Size : 75. 27 MB
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Philadelphia, 1959: A scientist scrutinizing a single human cell under a microscope detects a missing piece of DNA. That scientist, David Hungerford, had no way of knowing that he had stumbled upon the starting point of modern cancer research— the Philadelphia chromosome. It would take doctors and researchers around the world more than three decades to unravel the implications of this landmark discovery. In 1990, the Philadelphia chromosome was recognized as the sole cause of a deadly blood cancer, chronic myeloid leukemia, or CML. Cancer research would never be the same. Science journalist Jessica Wapner reconstructs more than forty years of crucial breakthroughs, clearly explains the science behind them, and pays tribute—with extensive original reporting, including more than thirty-five interviews—to the dozens of researchers, doctors, and patients with a direct role in this inspirational story. Their curiosity and determination would ultimately lead to a lifesaving treatment unlike anything before it. The Philadelphia Chromosome chronicles the remarkable change of fortune for the more than 70,000 people worldwide who are diagnosed with CML each year. It is a celebration of a rare triumph in the battle against cancer and a blueprint for future research, as doctors and scientists race to uncover and treat the genetic roots of a wide range of cancers.

Magic Cancer Bullet

Author : Daniel Vasella, M.D.
ISBN : 9780060010300
Genre : Business & Economics
File Size : 78. 13 MB
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The CEO of Novartis discusses the development and potential of cancer drug Gleevec, tracing its laboratory successes, the company's efforts to acquire the drug's FDA approval, and the stories of patients with cancer whose lives have been positively impacted.

Brain Surgeon

Author : Keith Black
ISBN : 9780446544528
Genre : Health & Fitness
File Size : 46. 75 MB
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Welcome to tiger country: the treacherous territory where a single wrong move by a brain surgeon can devastate-or end-a patient's life. This is the terrain world-renowned neurosurgeon Keith Black, MD, enters every day to produce virtual medical miracles. Now, in BRAIN SURGEON, Dr. Black invites readers to shadow his breathtaking journeys into the brain as he battles some of the deadliest and most feared tumors known to medical science. Along the way, he shares his unique insights about the inner workings of the brain, his unwavering optimism for the future of medicine, and the extraordinary stories of his patients-from ministers and rock stars to wealthy entrepreneurs and uninsured students-whom he celebrates as the real heroes. BRAIN SURGEON offers a window into one man's remarkable mind, revealing the anatomy of the unflinching confidence of this master surgeon, whose personal journey brought him from life as a young African-American boy growing up in the civil rights era South to the elite world of neurosurgery. Through Dr. Black's white-knuckle descriptions of some of the most astonishing medical procedures performed today, he reveals the beauty and marvel of the human brain and the strength and heroism of his patients who refuse to see themselves as victims. Ultimately, BRAIN SURGEON is an inspiring story of the struggle to overcome odds-whether as a man, a doctor, or a patient. "BRAIN SURGEON is an inspirational book about true heroes-readers will marvel at Keith Black's achievements both as a doctor and as a man, and will be in awe of his patients' courage and will to survive." --Denzel Washington I often get asked who the best doctor is in the world for various ailments. Truth is, it's a hard question. When it comes to brain tumors, however, the answer is pretty clear: Keith Black. He is the doctor people find when all the other doctors have given up. He is that guy. This book is about the heroic patients he has already helped and saved. If you want a rare, behind-the-curtain look at the life of one of the most pre-eminent neurosurgeons in the world, pick up Brain Surgeon. And Keith, from one brain surgeon to another: thank you for honoring our profession. Well done. --Sanjay Gupta, MD, Chief Medical Correspondent, CNN and New York Times bestselling author of Chasing Life

Seduced By Logic

Author : Robyn Arianrhod
ISBN : 9780199931613
Genre : Mathematics
File Size : 37. 94 MB
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Newton's explanations of natural laws shattered the way mankind perceived the universe, and hence were not immediately embraced. How can anyone warm to a force that could not be seen or touched? But for two women, separated by time and space but joined in their passion for Newtonian physics,that force drove them to great achievements. Brilliant, determined, and almost entirely self-taught, they dedicated their lives to explaining and disseminating Newton's discoveries.Robyn Arianrhod's Seduced by Logic tells the dual biography of Emilie du Chatelet and Mary Somerville, who, despite living a century apart, were connected by their love for mathematics and their places at the heart of the most advanced scientific society of their age. When Newton published hisrevolutionary theory of gravity in 1687, most of his Continental peers rejected it for its reliance on physical observation and mathematical insight and its lack of religious or metaphysical hypotheses. But the brilliant French aristocrat and intellectual Emilie du Chatelet and some of her earlyeighteenth-century Enlightenment colleagues - including her lover, Voltaire - realized the Principia Mathematica had changed everything, marking the beginning of theoretical science as a predictive, quantitative, and secular discipline. Emilie devoted herself to furthering Newton's ideas in France,and her translation of the Principia became the accepted French version of his work. Almost a century later, in Scotland, Mary Somerville taught herself mathematics and rose from genteel poverty to become a world authority on Newtonian physics. Living in France, she became acquainted with the workof one of Newton's proteges, Pierre Simon Laplace, and translated his six-volume Celestial Mechanics into English. It remained the standard astronomy text for the next century, and was considered the most influential work since Principia. Combining biography and history of science, Seduced by Logic not only reveals the fascinating story of two incredibly talented women, but also brings to life a period of dramatic political and scientific change. With lucidity and skill, Arianrhod reveals the intimate links between the unfoldingNewtonian revolution and the origins of intellectual and political liberty.

The Cancer Chronicles

Author : George Johnson
ISBN : 9780385349710
Genre : Medical
File Size : 90. 40 MB
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When the woman he loved was diagnosed with a metastatic cancer, science writer George Johnson embarked on a journey to learn everything he could about the disease and the people who dedicate their lives to understanding and combating it. What he discovered is a revolution under way—an explosion of new ideas about what cancer really is and where it comes from. In a provocative and intellectually vibrant exploration, he takes us on an adventure through the history and recent advances of cancer research that will challenge everything you thought you knew about the disease. Deftly excavating and illuminating decades of investigation and analysis, he reveals what we know and don’t know about cancer, showing why a cure remains such a slippery concept. We follow him as he combs through the realms of epidemiology, clinical trials, laboratory experiments, and scientific hypotheses—rooted in every discipline from evolutionary biology to game theory and physics. Cogently extracting fact from a towering canon of myth and hype, he describes tumors that evolve like alien creatures inside the body, paleo-oncologists who uncover petrified tumors clinging to the skeletons of dinosaurs and ancient human ancestors, and the surprising reversals in science’s comprehension of the causes of cancer, with the foods we eat and environmental toxins playing a lesser role. Perhaps most fascinating of all is how cancer borrows natural processes involved in the healing of a wound or the unfolding of a human embryo and turns them, jujitsu-like, against the body. Throughout his pursuit, Johnson clarifies the human experience of cancer with elegiac grace, bearing witness to the punishing gauntlet of consultations, surgeries, targeted therapies, and other treatments. He finds compassion, solace, and community among a vast network of patients and professionals committed to the fight and wrestles to comprehend the cruel randomness cancer metes out in his own family. For anyone whose life has been affected by cancer and has found themselves asking why?, this book provides a new understanding. In good company with the works of Atul Gawande, Siddhartha Mukherjee, and Abraham Verghese, The Cancer Chronicles is endlessly surprising and as radiant in its prose as it is authoritative in its eye-opening science.

The Death Of Cancer

Author : Vincent T. DeVita, Jr., M.D.
ISBN : 9780374714178
Genre : Medical
File Size : 37. 7 MB
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Cancer touches everybody’s life in one way or another. But most of us know very little about how the disease works, why we treat it the way we do, and the personalities whose dedication got us where we are today. For fifty years, Dr. Vincent T. DeVita Jr. has been one of those key players: he has held just about every major position in the field, and he developed the first successful chemotherapy treatment for Hodgkin’s lymphoma, a breakthrough the American Society of Clinical Oncologists has called the top research advance in half a century of chemotherapy. As one of oncology’s leading figures, DeVita knows what cancer looks like from the lab bench and the bedside. The Death of Cancer is his illuminating and deeply personal look at the science and the history of one of the world’s most formidable diseases. In DeVita’s hands, even the most complex medical concepts are comprehensible. Cowritten with DeVita’s daughter, the science writer Elizabeth DeVita-Raeburn, The Death of Cancer is also a personal tale about the false starts and major breakthroughs, the strong-willed oncologists who clashed with conservative administrators (and one another), and the courageous patients whose willingness to test cutting-edge research helped those oncologists find potential treatments. An emotionally compelling and informative read, The Death of Cancer is also a call to arms. DeVita believes that we’re well on our way to curing cancer but that there are things we need to change in order to get there. Mortality rates are declining, but America’s cancer patients are still being shortchanged—by timid doctors, by misguided national agendas, by compromised bureaucracies, and by a lack of access to information about the strengths and weaknesses of the nation’s cancer centers. With historical depth and authenticity, DeVita reveals the true story of the fight against cancer. The Death of Cancer is an ambitious, vital book about a life-and-death subject that touches us all.

Forks Over Knives

Author : Gene Stone
ISBN : 9781615191468
Genre : Health & Fitness
File Size : 90. 57 MB
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The #1 New York Times bestseller answers: What if one simple change could save you from heart disease, diabetes, and cancer? For decades, that question has fascinated a small circle of impassioned doctors and researchers—and now, their life-changing research is making headlines in the hit documentary Forks Over Knives. Their answer? Eat a whole-foods, plant-based diet—it could save your life. It may overturn most of the diet advice you’ve heard—but the experts behind Forks Over Knives aren’t afraid to make waves. In his book Prevent and Reverse Heart Disease, Dr. Caldwell Esselstyn explained that eating meat, dairy, and oils injures the lining of our blood vessels, causing heart disease, heart attack, or stroke. In The China Study, Dr. Colin Campbell revealed how cancer and other diseases skyrocket when eating meat and dairy is the norm—and plummet when a traditional plant-based diet persists. And more and more experts are adding their voices to the cause: There is nothing else you can do for your health that can match the benefits of a plant-based diet. Now, as Forks Over Knives is introducing more people than ever before to the plant-based way to health, this accessible guide provides the information you need to adopt and maintain a plant-based diet. Features include: Insights from the luminaries behind the film—Dr. Neal Barnard, Dr. John McDougall, The Engine 2 Diet author Rip Esselstyn, and many others Success stories from converts to plant-based eating—like San’Dera Prude, who no longer needs to medicate her diabetes, has lost weight, and feels great! The many benefits of a whole-foods, plant-based diet—for you, for animals and the environment, and for our future A helpful primer on crafting a healthy diet rich in unprocessed fruits, vegetables, legumes, and whole grains, including tips on transitioning and essential kitchen tools 125 recipes from 25 champions of plant-based dining—from Blueberry Oat Breakfast Muffins and Sunny Orange Yam Bisque to Garlic Rosemary Polenta and Raspberry-Pear Crisp—delicious, healthy, and for every meal, every day.

The Goldilocks Enigma

Author : Paul Davies
ISBN : 9780547348469
Genre : Science
File Size : 85. 35 MB
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An acclaimed physicist and cosmologist considers the multiverse and more: “Very readable indeed . . . This is Doctor Who, but for real.” —TheGuardian The Goldilocks Enigma is Paul Davies’s eagerly awaited return to cosmology, the successor to his critically acclaimed bestseller The Mind of God. Here he tackles all the “big questions,” including the biggest of them all: Why does the universe seem so well adapted for life? In his characteristically clear and elegant style, Davies shows how recent scientific discoveries point to a perplexing fact: many different aspects of the cosmos, from the properties of the humble carbon atom to the speed of light, seem tailor-made to produce life. A radical new theory says it’s because our universe is just one of an infinite number of universes, each one slightly different. Our universe is bio-friendly by accident—we just happened to win the cosmic jackpot. While this “multiverse” theory is compelling, it has bizarre implications, such as the existence of infinite copies of each of us and Matrix-like simulated universes. And it still leaves a lot unexplained. Davies believes there’s a more satisfying solution to the problem of existence: the observations we make today could help shape the nature of reality in the remote past. If this is true, then life—and, ultimately, consciousness—aren’t just incidental byproducts of nature, but central players in the evolution of the universe. Whether he’s elucidating dark matter or dark energy, M-theory or the multiverse, Davies brings the leading edge of science into sharp focus, provoking us to think about the cosmos and our place within it in new and thrilling ways.

Pandora S Lab

Author : Paul A. Offit
ISBN : 9781426217982
Genre : HEALTH & FITNESS
File Size : 32. 62 MB
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Exploring the most fascinating and significant scientific missteps, the author presents seven cautionary lessons to separate good science from bad.

To Live And To Die When Why And How

Author : R.H. Williams
ISBN : 9781475743692
Genre : Psychology
File Size : 59. 25 MB
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In the 1960's marked changes occurred throughout the world in philosophies and policies related to man's role in life. These changes, prompted predominantly by extensive increases in knowledge and popula tion density, have produced increased pleasures as well as problems. The rising number of people and improved methods of communication and transportation have caused more relationships among people, with their pleasures, competitions, jealousies, conflicts of interest, oppressions, and crimes. Large assortments of drugs have been developed and are easily obtained. There are drugs to speed us up, slow us down, make us sleep, change our perspectives on life, promote propagation of life or prevent it, prolong life or terminate it, and modify the course of life in many ways. Also, numerous mechanical devices have been developed that influence the propagation of life, the termination of life, and the manner in which we live. Many people have changed their overall goals in life, and in par ticular have experienced major changes in attitudes and policies applying to sexual activity, marriage, birth control, abortion, welfare, children, old people, criminals, economics, social status, careers, education, euthanasia, and suicide. There also has been marked enlightenment concerning the effect of the chemical and physical status of the brain upon normal and abnormal thinking and behavior.

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