the theory and practical application of adjuvants

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The Theory And Practical Application Of Adjuvants

Author : Duncan E. S. Stewart-Tull
ISBN : 0471951706
Genre : Medical
File Size : 23. 78 MB
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For many years, a small group of research workers worldwide has been responsible for the development of adjuvants or immunoprotectors for use in experimental vaccines and in the routine production of antisera. Adjuvants interact with cells of the immune system and trigger a number of biological effects, some of which are desirable and some less so. There is a need to keep the latter under control, although it is doubtful if there is such a thing as an innocuous adjuvant. Studies have also included such problems as isolation, preparation, dose responses, adverse reactions and practical applications. Much of this information is spread throughout the literature over the last 25 years, and this book aims, therefore, to bring the information together through contributions from a group of internationally renowned scientists. This book deals with the well-documented adjuvant or immuno-potentiating preparations which have been developed by leading groups throughout the world. Among others these preparations include: aluminum absorbents; black copolymers; Freund’s complete and incomplete adjuvants; muramyl dipeptide and its synthetic derivatives; ISCOMs; lipid A; liposomes; and saponins. The benefits and pitfalls associated with the use of each of these different adjuvants are described which will help to prevent their misuse in laboratory studies and the potential use of adjuvants in AIDS vaccines is also covered. The book also aims to provide a source of practical hints for and uses by immunologists, microbiologists, parasitologists and vaccinologists. In addition those interested in developing new adjuvant preparations, either natural or synthetic, will find details within the book on the types of assay required to authenticate an adjuvant effect. The book may also enable regulatory bodies to assess the validity of tests for a variety of possible contraindications associated with the more reactive preparations when formulating quality control regulations.

Immunology Of Infection

Author : Stefan H.E. Kaufmann
ISBN : 0125215320
Genre : Medical
File Size : 30. 87 MB
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Immunology of Infection, 2nd Edition, edited by two leading experts in the field, presents the most appropriate up-to-date experimental approaches in the detail required for modern microbiological research. Focusing on the methods most useful for the Microbiologist interested in analysing host-pathogen relationships, this volume will be essential reading for all researchers working in microbiology, immunology, virology, mycology and parasitology. This new edition of Immunology of Infection provides ready-to-use "recipes", and the latest emerging techniques as well as novel approaches to the tried and tested, established methods included in the successful first edition. Methods in Microbiologyis the most prestigious series devoted to techniques and methodology in the field. Established for over 30 years, Methods in Microbiology will continue to provide you with tried and tested, cutting edge protocols to directly benefit your research. Includes techniques for genome-wide expression profiling of both the pathogen and host and of the host response to infection Cytometric analysis of cytokine secretion by immune cells Describes tetramer technology for the quantitative analysis of antigen specific T cell responses Analysis of host cells and pathogens involved in the host-microbe interplay Covers techniques useful for the analysis of human and murine systems Includes techniques for the prediction and determination of MHC ligands and T cell epitopes Covers the fundamentals and practice of DNA vaccines Describes methods for the isolation and propagation of human dendritic cells

Vaccine Adjuvants

Author : Derek T. O’Hagan
ISBN : 0896037355
Genre : Medical
File Size : 25. 51 MB
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Annotation Vaccinologists and pharmacologists describe the preparation, characterization, and evaluation of alternative vaccine adjuvants for use in preclinical studies. Each chapter reviews a single, adjuvant and suggests why it might be preferred for a given antigen, depending on what type of immune response is desired. Alternate adjuvant choices are also presented. Methods are described in full detail and range from simple to complex preparation processes. Methods are presented by scientists who originally invented or developed them.

Vaccine Protocols

Author : Andrew Robinson
ISBN : 9781592593996
Genre : Medical
File Size : 75. 22 MB
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This extensively revised, updated, and expanded second edition of a classic laboratory manual applies new understanding of molecular mechanisms to the rational design and development of vaccines. Here the working researcher will find readily reproducible techniques for the development and production of live attenuated vaccines, and vaccines based on inactivated toxins, peptides, and polysaccharide conjugates.

The Iacuc Handbook Second Edition

Author : Jerald Silverman
ISBN : 0849340101
Genre : Medical
File Size : 22. 51 MB
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Since its establishment by USDA regulation in the mid-1980s, the Institutional Animal Care and Use Committee (IACUC) has evolved as the premier instrument of animal welfare oversight within research institutions in the United States. By addressing questions and problems that often confront institutions, The IACUC Handbook, Second Edition provides accurate, succinct answers. It features comprehensive updates for all pertinent federal laws, regulations, and policies. It also contains an expanded survey of IACUC practices from institutions around the nation. With accessible information, this new editionprovides a foundation for those attempting to understand and implement the many and varied responsibilities of these committees.

Handbook Of Laboratory Animal Science

Author : Jann Hau
ISBN : 9781420040913
Genre : Medical
File Size : 41. 92 MB
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The second edition of an international bestseller, this book provides veterinary specialists as well as veterinary and biomedical researchers with detailed information about laboratory animal genetics, diseases, health monitoring, nutrition, and environmental impact on animal experiments. Completely revised and updated, Volume I now contains expanded coverage of topics such as procedures in genetic engineering, surgical techniques, and humane endpoints and the treatment of pain and suffering in laboratory animals. It includes a new, streamlined chapter that combines the review of alternative techniques to animal experimentation such as the use of isolated organs, cell cultures, and computer simulations.

Handbook Of Cancer Vaccines

Author : Michael A. Morse
ISBN : 9781592596805
Genre : Medical
File Size : 47. 29 MB
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An authoritative survey of the scientific background for therapeutic cancer vaccines, the challenges to their development, and their current uses in treating cancer. The authors examine the basic issues that effect all vaccines (such as immune adjuvants and prime-boost strategies), describe the methods for antigen discovery, and review the preclinical development phases for each major vaccine strategy. They also spell out the clinical results for cancer vaccines now beginning to be used in the treatment of many common cancers.

A Practical Guide To Monoclonal Antibodies

Author : J. Eryl Liddell
ISBN : 0471929050
Genre : Medical
File Size : 68. 28 MB
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Includes all of the information required to produce monoclonal antibodies in the laboratory and to prepare them for use in a multitude of given applications. Production procedures are treated in chronological order, beginning with basic tissue culture techniques, immunization strategies and screening test design, followed by production of hybridoma cell lines and basic antibody characterization, purification and labeling. Each chapter contains explanatory text on each step with comparative analysis of methods where appropriate. All necessary experimental protocols are presented in a self-contained format that is easy to follow in the laboratory. Alternative protocols are provided where relevant; for others not included in full, source references are presented. Surveys the current status of human hybridoma production and antibody engineering using molecular biology techniques.

New Researches On The Therapeutic Use Of Manganese As An Adjuvant Of Iron

Author : Joseph Eléonor Pétrequin
ISBN : STANFORD:24501743290
Genre :
File Size : 38. 74 MB
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Synthetic Adjuvants

Author : Arlette Adam
ISBN : 0471864501
Genre : Medical
File Size : 89. 84 MB
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A comprehensive account of the main classes of synthetic adjuvants, presenting the findings and experimental data needed to evaluate these substances for use in medicine and immunoregulation research. Classifies synthetic adjuvants according to chemical structure, namely: muramylpeptides, nucleic acid derivatives, sulfur-containing compounds, polymers, heterocyclic and aromatic compounds and lipids. Stressses the main pharmacological properties of adjuvants as well as their effects on nonspecific immune processes. Also reviews the potential use of adjuvants in clinical and veterinary applications.

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