therapeutics evidence and decision making

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Therapeutics Evidence And Decision Making

Author : Michael D Rawlins
ISBN : 9781853159473
Genre : Law
File Size : 36. 65 MB
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This book is intended to help decision-makers use, assess and appraise the evidence that underpins decisions about the use of therapeutic interventions. It will inform decision-makers about the nature of evidence, the strengths and weaknesses of the available approaches, and how these can be most effectively distilled for the purpose of reaching reliable conclusions. It aims to encourage decision-makers to base their judgements about the use of therapeutic interventions on an informed appraisal of the totality of the evidence base. Is it reliable? Is it generalisable beyond the context of the environment in which the primary research has been conducted? Do the intervention's benefits outweigh its harms? Is it cost effective as well as clinically effective? Is it, indeed, fit-for-purpose? Ultimately, good judgement is at the heart of decision-making in therapeutics. An invaluable text for all physicians, pharmacists, nurses, health commissioners and purchasers and indeed anyone having to make decisions concerning evidence-based therapeutics.

Real World Evidence Generation And Evaluation Of Therapeutics

Author : National Academies of Sciences, Engineering, and Medicine
ISBN : 9780309455626
Genre : Medical
File Size : 44. 30 MB
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The volume and complexity of information about individual patients is greatly increasing with use of electronic records and personal devices. Potential effects on medical product development in the context of this wealth of real-world data could be numerous and varied, ranging from the ability to determine both large-scale and patient-specific effects of treatments to the ability to assess how therapeutics affect patients’ lives through measurement of lifestyle changes. In October 2016, the National Academies of Sciences, Engineering, and Medicine held a workshop to facilitate dialogue among stakeholders about the opportunities and challenges for incorporating real-world evidence into all stages in the process for the generation and evaluation of therapeutics. Participants explored unmet stakeholder needs and opportunities to generate new kinds of evidence that meet those needs. This publication summarizes the presentations and discussions from the workshop.

Real World Evidence Generation And Evaluation Of Therapeutics

Author : National Academies of Sciences, Engineering, and Medicine
ISBN : 9780309455626
Genre : Medical
File Size : 24. 60 MB
Format : PDF, Kindle
Download : 770
Read : 969

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The volume and complexity of information about individual patients is greatly increasing with use of electronic records and personal devices. Potential effects on medical product development in the context of this wealth of real-world data could be numerous and varied, ranging from the ability to determine both large-scale and patient-specific effects of treatments to the ability to assess how therapeutics affect patients’ lives through measurement of lifestyle changes. In October 2016, the National Academies of Sciences, Engineering, and Medicine held a workshop to facilitate dialogue among stakeholders about the opportunities and challenges for incorporating real-world evidence into all stages in the process for the generation and evaluation of therapeutics. Participants explored unmet stakeholder needs and opportunities to generate new kinds of evidence that meet those needs. This publication summarizes the presentations and discussions from the workshop.

Handbook Of Institutional Pharmacy Practice

Author : Thomas R. Brown
ISBN : 9781585281145
Genre : Medical
File Size : 78. 81 MB
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This comprehensive text provides fundamental information on a broad spectrum of essential topics in health-system pharmacy practice. From an overview of health delivery systems and hospital pharmacy through various practice settings such as home care, long term care, hospice and palliative care, ambulatory care, and managed care this text focuses on various elements important to health-system pharmacies. The Handbook of Institutional Pharmacy Practice is the first step in developing a career in pharmacy and provides opportunities for study in career enhancement. New chapters included in the FOURTH EDITION: Integrity of the Drug Supply Overview of the History of Hospital Pharmacy in the United States Interprofessional Teams/Collaborative Practice Models Development, Implementation and Monitoring Therapeutic Plans and Evidence-Based Medicine

Manual Of Evidence Based Admitting Orders And Therapeutics

Author : Karen McDonough
ISBN : 1416031960
Genre : Medical
File Size : 60. 12 MB
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Here's all the guidance you need to write clear, concise, safe, and effective medical orders! Whether you've had training in order writing or not, and whether you use an electronic order system or not, this handy guide offers you strategies, templates, decision-making guidelines, and a systematic, evidence-based approach to reinforce what you know...simplify and improve communication with your colleagues...and thus reduce confusion, unnecessary steps, and costly mistakes. Includes sample admitting orders for almost 100 illnesses and conditions. Offers valuable guidelines for revising original orders. Provides special procedures for handling verbal orders given in fast-paced, intense situations. Thoroughly reviewed by a large number of experienced clinicians for optimal "real-world" practicality. Is now fully evidence based, giving you the benefit of the latest knowledge on reducing error and costs. Incorporates new information about computerized patient order entry (CPOE) and how order writing fits into clinical information systems. Features a major new emphasis on discharge planning and outpatient followup, in light of the trend toward reduced length of stay and the increasing importance of effective handoff and followup.

The Pharmacist S Guide To Evidence Based Medicine For Clinical Decision Making

Author : Patrick J. Bryant
ISBN : 1585282707
Genre : Medical
File Size : 80. 13 MB
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While most practicing pharmacists are familiar with the term and the general concept of evidence-based medicine, few are adequately trained in the clinical application of these skills. Developed to give clinical pharmacists an edge, this book provides a practical approach for applying sound EBM principles to your clinical decision making process. Decision making based on personal experience alone, without knowledge from well-designed, controlled, randomized trials with adequate sample size, often overestimates the efficacy and underestimates the safety risks associated with drugs. This book provides a roadmap that is instructional and, most importantly, practical for the pharmacist so these new skills can be applied immediately in practice. Based on a five-step process perfected over ten years at the University of Missouri, Kansas City, School of Pharmacy, this exciting new approach will: · Reduce complexity · Shorten time for decision making support · Maintain rigor · Categorize quality of the evidence in a simple, straightforward, and logical manner · Provide a process designed specifically for pharmacists making drug therapy decisions Use of examples, tables, diagrams, and key points highlighted throughout the book and summarized at the end of each chapter provide the pharmacist with skills they can implement the next day to begin applying EBM principles to their practice.

Clinical Pharmacy And Therapeutics E Book

Author : Roger Walker
ISBN : 9780702048487
Genre : Medical
File Size : 63. 14 MB
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Now in its fifth edition, this best-selling, multidisciplinary textbook continues to draw on the skills of pharmacists and clinicians to present optimal drug regimens. The authors integrate an understanding of the disease processes with an appreciation of pathophysiological processes, clinical pharmacy and the evidence base. New to this edition: Stronger emphasis on understanding both the prescribing process and the clinical pharmacy process. All chapters completely revised and updated. Thirty-eight leading new authors. Features: Key points boxes at the beginning of every chapter Case study tests at the end of every chapter Chapters co-authored by pharmacists and clinicians Organised by body system Consistent, clearly signposted chapter layout ‘...a unique and valuable support for all those involved or interested in drug therapy. This is a textbook that no university or pharmacy department, particularly those with employees studying at any level, and no pharmacist trying to develop their knowledge base should be without." Dr Chris Green and John Sexton, The Pharmaceutical Journal Now in its fifth edition, this best-selling, multidisciplinary textbook continues to draw on the skills of pharmacists and clinicians to present optimal drug regimens. The authors integrate an understanding of the disease processes with an appreciation of pathophysiological processes, clinical pharmacy and the evidence base. New to this edition: Stronger emphasis on understanding both the prescribing process and the clinical pharmacy process. All chapters completely revised and updated. Thirty-eight leading new authors. Features: Key points boxes at the beginning of every chapter Case study tests at the end of every chapter Chapters co-authored by pharmacists and clinicians Organised by body system Consistent, clearly signposted chapter layout ‘...a unique and valuable support for all those involved or interested in drug therapy. This is a textbook that no university or pharmacy department, particularly those with employees studying at any level, and no pharmacist trying to develop their knowledge base should be without." Dr Chris Green and John Sexton, The Pharmaceutical Journal Stronger emphasis on understanding both the prescribing process and the clinical pharmacy process. All chapters completely revised and updated. Thirty-eight leading new authors.

Multiple Sclerosis Therapeutics Third Edition

Author : Jeffrey A. Cohen
ISBN : 0203012054
Genre : Medical
File Size : 65. 43 MB
Format : PDF
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Since the publication of the previous edition of this volume, there has been substantial progress in a number of areas of multiple sclerosis (MS) research. Although immunosuppressive treatments continue to be developed and refined, more targeted immunomodulatory therapies are surfacing as we learn more about how the immune system works in health and disease. Multiple Sclerosis Therapeutics, Third Edition provides a comprehensive review of clinical trial methodology and therapeutic modalities in MS. This edition reflects current understanding of the pathophysiology of the disease and includes popular and emerging treatments. Topics include: Biomarkers in MS Pharmacogenomics Emerging therapeutic modalities such as natalizumab, T-cell-based and B-cell-based therapies, cytokine/chemokine-based therapies, statins, and 4-aminopyridine Neuroprotection The use of OCT and MRI to guide disease therapy Within the next several years, we will begin to discover the utility and the limitations of stem cells in the treatment of MS. It is likely that the next edition of this text will include clinical trial data that evaluate early attempts at nervous system regeneration in MS. Until that time occurs, this volume remains an essential resource for neurologists and anyone involved in the treatment of MS.

Clinical Pharmacology

Author : Morris J. Brown
ISBN : 9780702051135
Genre : Medical
File Size : 80. 72 MB
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A thorough knowledge of pharmacological and therapeutic principles is vital if drugs are to be used safely and effectively for increasingly informed patients. Those who clearly understand how drugs get into the body, how they produce their effects, what happens to them in the body, and how evidence of their therapeutic effect is assessed, will choose drugs more skilfully, and use them more safely and successfully than those who do not. Now in a fully revised 11th edition, Clinical Pharmacology is essential reading for undergraduate medical students, junior doctors and anyone concerned with evidence-based drug therapy. Introductory first three sections cover general principle of clinical pharmacology; five subsequent sections cover drug treatment of disease organised by body system. Retains approachable style set by the original author, Professor Laurence. Emphasis throughout is on evidence-based and safe drug prescribing. Indian Advisory Board will ensure content reflects the needs of the devloping world.

Comparative Effectiveness Research

Author : Carol M. Ashton
ISBN : 9780199969579
Genre : Medical
File Size : 84. 48 MB
Format : PDF
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For all its costs, flaws, and inequities, American health care is fundamentally rooted in a belief that treatment should be based on solid scientific research. To this end, between 2003 and 2010, three different federal laws were enacted, the most recent being the Affordable Care Act of 2010, that mandated new federal investments in a type of clinical research called comparative effectiveness research (CER) -- research into what works best in medical care. Comparative Effectiveness Research: Evidence, Medicine, and Policy provides the first complete account of how -- and why -- the federal government decided to make CER an important feature of health reform. Despite earlier legislative uptake of policy proposals on CER, support for federal mandates took dramatic twists and turns, with eventual compromises forged amid failing bipartisan alliances, special interests, and mobilized public opinion. Based on exhaustive research and first-hand interviews, the authors examine where CER fits in the production of scientific evidence about the benefits and harms of treatments for human diseases and conditions. Their work offers sobering confirmation that contemporary American medical care falls, not surprisingly, well short of the evidence-based ideal. Comparative Effectiveness Research demonstrates that dealing constructively with the vast uncertainties inherent to medical care requires policies to make the generation of high-quality evidence an inseparable part of routine health care.

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