therapeutics evidence and decision making

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Therapeutics Evidence And Decision Making

Author : Michael D Rawlins
ISBN : 9781853159473
Genre : Law
File Size : 49. 68 MB
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This book is intended to help decision-makers use, assess and appraise the evidence that underpins decisions about the use of therapeutic interventions. It will inform decision-makers about the nature of evidence, the strengths and weaknesses of the available approaches, and how these can be most effectively distilled for the purpose of reaching reliable conclusions. It aims to encourage decision-makers to base their judgements about the use of therapeutic interventions on an informed appraisal of the totality of the evidence base. Is it reliable? Is it generalisable beyond the context of the environment in which the primary research has been conducted? Do the intervention's benefits outweigh its harms? Is it cost effective as well as clinically effective? Is it, indeed, fit-for-purpose? Ultimately, good judgement is at the heart of decision-making in therapeutics. An invaluable text for all physicians, pharmacists, nurses, health commissioners and purchasers and indeed anyone having to make decisions concerning evidence-based therapeutics.

Real World Evidence Generation And Evaluation Of Therapeutics

Author : National Academies of Sciences, Engineering, and Medicine
ISBN : 9780309455626
Genre : Medical
File Size : 37. 47 MB
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The volume and complexity of information about individual patients is greatly increasing with use of electronic records and personal devices. Potential effects on medical product development in the context of this wealth of real-world data could be numerous and varied, ranging from the ability to determine both large-scale and patient-specific effects of treatments to the ability to assess how therapeutics affect patients’ lives through measurement of lifestyle changes. In October 2016, the National Academies of Sciences, Engineering, and Medicine held a workshop to facilitate dialogue among stakeholders about the opportunities and challenges for incorporating real-world evidence into all stages in the process for the generation and evaluation of therapeutics. Participants explored unmet stakeholder needs and opportunities to generate new kinds of evidence that meet those needs. This publication summarizes the presentations and discussions from the workshop.

Handbook Of Institutional Pharmacy Practice

Author : Thomas R. Brown
ISBN : 9781585281145
Genre : Medical
File Size : 64. 57 MB
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This comprehensive text provides fundamental information on a broad spectrum of essential topics in health-system pharmacy practice. From an overview of health delivery systems and hospital pharmacy through various practice settings such as home care, long term care, hospice and palliative care, ambulatory care, and managed care this text focuses on various elements important to health-system pharmacies. The Handbook of Institutional Pharmacy Practice is the first step in developing a career in pharmacy and provides opportunities for study in career enhancement. New chapters included in the FOURTH EDITION: Integrity of the Drug Supply Overview of the History of Hospital Pharmacy in the United States Interprofessional Teams/Collaborative Practice Models Development, Implementation and Monitoring Therapeutic Plans and Evidence-Based Medicine

Clinical Pharmacy And Therapeutics E Book

Author : Roger Walker
ISBN : 9780702048487
Genre : Medical
File Size : 21. 62 MB
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Now in its fifth edition, this best-selling, multidisciplinary textbook continues to draw on the skills of pharmacists and clinicians to present optimal drug regimens. The authors integrate an understanding of the disease processes with an appreciation of pathophysiological processes, clinical pharmacy and the evidence base. New to this edition: Stronger emphasis on understanding both the prescribing process and the clinical pharmacy process. All chapters completely revised and updated. Thirty-eight leading new authors. Features: Key points boxes at the beginning of every chapter Case study tests at the end of every chapter Chapters co-authored by pharmacists and clinicians Organised by body system Consistent, clearly signposted chapter layout ‘...a unique and valuable support for all those involved or interested in drug therapy. This is a textbook that no university or pharmacy department, particularly those with employees studying at any level, and no pharmacist trying to develop their knowledge base should be without." Dr Chris Green and John Sexton, The Pharmaceutical Journal Now in its fifth edition, this best-selling, multidisciplinary textbook continues to draw on the skills of pharmacists and clinicians to present optimal drug regimens. The authors integrate an understanding of the disease processes with an appreciation of pathophysiological processes, clinical pharmacy and the evidence base. New to this edition: Stronger emphasis on understanding both the prescribing process and the clinical pharmacy process. All chapters completely revised and updated. Thirty-eight leading new authors. Features: Key points boxes at the beginning of every chapter Case study tests at the end of every chapter Chapters co-authored by pharmacists and clinicians Organised by body system Consistent, clearly signposted chapter layout ‘...a unique and valuable support for all those involved or interested in drug therapy. This is a textbook that no university or pharmacy department, particularly those with employees studying at any level, and no pharmacist trying to develop their knowledge base should be without." Dr Chris Green and John Sexton, The Pharmaceutical Journal Stronger emphasis on understanding both the prescribing process and the clinical pharmacy process. All chapters completely revised and updated. Thirty-eight leading new authors.

Cardiovascular Therapeutics

Author : Elliott M. Antman
ISBN : 9781437710939
Genre : Medical
File Size : 81. 70 MB
Format : PDF, Kindle
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This companion to Braunwald's Heart Disease equips you with all of today's most effective therapeutic guidelines and management solutions for the full range of heart disease patients. It reflects the most recent standards for drug management as well as the latest in new technologies. Reorganized to mirror your changing practice, each cardiovascular-problem-based section offers a chapter on pharmacologic treatment (with a minimum of pathophysiology)...a chapter on catheter-based or minimally invasive interventions...and a discussion of surgical options. You'll also find a brand-new chapter on gene therapy and stem cell therapy, plus new chapters on many other rapidly developing areas of practice. The result is an outstanding single-volume source for state-of-the-art, clinically oriented guidance on both common and unusual areas of cardiovascular treatment. Facilitates the decision-making process clinicians face when choosing among various cardiovascular therapeutic options. covers the latest concepts in pathophysiology, evaluation, and management of patients with cardiovascular disorders Addresses pharmacological, interventional, and surgical management approaches for each type of cardiovascular disease, putting advice on the full range of therapeutic options at your disposal. Keeps you current with brand-new chapters on gene therapy and stem cell therapy * unstable and chronic stable angina * management of unstable angina and non-ST-elevation myocardial infarction * devices for heart failure and arrhythmias * prevention of ischemic disease * the regulatory approval process for new cardiovascular drugs and devices * and more. Delivers a fully revised section on "Heart Failure" that explores cardiac resynchronization therapy, surgical interventions, ambulatory management, hospital management, and cardiac transplantation and circulatory support devices. Offers a completely updated section on "Other Cardiovascular Conditions" that addresses issues such as pharmacologic treatment of cardiovascular disease during pregnancy * care for adults with congenital heart disease * treatment of primary pulmonary hypertension * prevention and treatment of infective endocarditis * treatment of pericardial disease * and rehabilitation of the patient with cardiovascular disease. Reflects a new emphasis on the role of diet and exercise in the management of cardiovascular problems in conformity with ACC/AHA/ESC guidelines.

Clinical Pharmacology

Author : Morris J. Brown
ISBN : 9780702051135
Genre : Medical
File Size : 44. 58 MB
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A thorough knowledge of pharmacological and therapeutic principles is vital if drugs are to be used safely and effectively for increasingly informed patients. Those who clearly understand how drugs get into the body, how they produce their effects, what happens to them in the body, and how evidence of their therapeutic effect is assessed, will choose drugs more skilfully, and use them more safely and successfully than those who do not. Now in a fully revised 11th edition, Clinical Pharmacology is essential reading for undergraduate medical students, junior doctors and anyone concerned with evidence-based drug therapy. Introductory first three sections cover general principle of clinical pharmacology; five subsequent sections cover drug treatment of disease organised by body system. Retains approachable style set by the original author, Professor Laurence. Emphasis throughout is on evidence-based and safe drug prescribing. Indian Advisory Board will ensure content reflects the needs of the devloping world.

Multiple Sclerosis Therapeutics Third Edition

Author : Jeffrey A. Cohen
ISBN : 0203012054
Genre : Medical
File Size : 55. 20 MB
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Since the publication of the previous edition of this volume, there has been substantial progress in a number of areas of multiple sclerosis (MS) research. Although immunosuppressive treatments continue to be developed and refined, more targeted immunomodulatory therapies are surfacing as we learn more about how the immune system works in health and disease. Multiple Sclerosis Therapeutics, Third Edition provides a comprehensive review of clinical trial methodology and therapeutic modalities in MS. This edition reflects current understanding of the pathophysiology of the disease and includes popular and emerging treatments. Topics include: Biomarkers in MS Pharmacogenomics Emerging therapeutic modalities such as natalizumab, T-cell-based and B-cell-based therapies, cytokine/chemokine-based therapies, statins, and 4-aminopyridine Neuroprotection The use of OCT and MRI to guide disease therapy Within the next several years, we will begin to discover the utility and the limitations of stem cells in the treatment of MS. It is likely that the next edition of this text will include clinical trial data that evaluate early attempts at nervous system regeneration in MS. Until that time occurs, this volume remains an essential resource for neurologists and anyone involved in the treatment of MS.

Multiple Sclerosis Therapeutics

Author : Richard Rudick
ISBN : 0415805821
Genre : Medical
File Size : 59. 79 MB
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This textbook examines the most important aspects of multiple sclerosis that impact on clinical trial design, on the development of new disease therapies and on patient care. The international team of contributors discuss the clinical course of multiple sclerosis, its clinical heterogeneity, the presence of subclinical disease activity which occurs during the early stages of the disease. Multiple sclerosis presents clinical challenges: from unexpected and irregular relapses to profressive deterioration.

Pharmacology For The Primary Care Provider E Book

Author : Marilyn Winterton Edmunds
ISBN : 9780323087919
Genre : Medical
File Size : 65. 17 MB
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Written by and for nurse practitioners, and also suitable for physician’s assistants, Pharmacology for the Primary Care Provider, 4th Edition focuses on what you need to know to safely and effectively prescribe drugs for primary care. An emphasis on patient teaching helps you gain patient adherence to prescribed drug regimens, and guidelines for health promotion help in maintaining and improving your patients’ health. Now in full color, this edition expands the book's emphasis on the QSEN priorities of safety and evidence-based practice, and adds coverage of new drugs, new drug classes, and new therapeutic drug uses. Written by leading nurse practitioner authorities Marilyn Winterton Edmunds and Maren Stewart Mayhew, Pharmacology for the Primary Care Provider teaches principles of pharmacotherapeutics using today’s most commonly used drugs. A Key Drugs focus highlights the most commonly used and most representative drugs of each major drug class — with particular emphasis on the top 100 most commonly prescribed drugs. Emphasis on patient teaching helps you communicate with patients and family caregivers to promote adherence to the drug regimen. Emphasis on health promotion describes how to help patients stay well and improve their health, including coverage of immunizations and biologicals, vitamins, weight management, and smoking cessation. Evidence-Based Decision-Making and Treatment Guidelines chapter (11) provides practical guidelines for using the best current research evidence to make decisions about the care of individual patients. Extensive coverage of drug therapy for special populations such as geriatric and pediatric patients includes considerations related to age, pregnancy, race, and other factors. UNIQUE! Coverage of prescriptive practice includes topics such as prescriptive authority, role implementation, and the role of nurses (NPs, CNMs, CRNAs, and CNSs) and physician assistants in writing prescriptions. NEW! Full-color design and illustrations highlight the most important content. DRUG UPDATES reflect the latest FDA-approved drugs, drug classes, and therapeutic uses. Expanded emphasis on the QSEN priorities of safety and evidence-based practice helps you eliminate drug prescribing errors with color-highlighted Safety Alerts! and NEW Clinical Practice Alerts! NEW section on male hormone replacement therapies adds coverage of men to that for women. Updated evidence-based prescribing information reflects the latest national clinical practice guidelines and evidence-based treatment guidelines, including the latest clinical treatment guidelines for diabetes. NEW! Complementary and Alternative Products tables highlight interactions with drugs, and are emphasized with a distinctive icon. Updated Drug Overview tables are enhanced with color as well as Top 100 icons that highlight the most commonly prescribed drugs.

Comparative Effectiveness Research

Author : Carol M. Ashton
ISBN : 9780199969579
Genre : Medical
File Size : 37. 84 MB
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For all its costs, flaws, and inequities, American health care is fundamentally rooted in a belief that treatment should be based on solid scientific research. To this end, between 2003 and 2010, three different federal laws were enacted, the most recent being the Affordable Care Act of 2010, that mandated new federal investments in a type of clinical research called comparative effectiveness research (CER) -- research into what works best in medical care. Comparative Effectiveness Research: Evidence, Medicine, and Policy provides the first complete account of how -- and why -- the federal government decided to make CER an important feature of health reform. Despite earlier legislative uptake of policy proposals on CER, support for federal mandates took dramatic twists and turns, with eventual compromises forged amid failing bipartisan alliances, special interests, and mobilized public opinion. Based on exhaustive research and first-hand interviews, the authors examine where CER fits in the production of scientific evidence about the benefits and harms of treatments for human diseases and conditions. Their work offers sobering confirmation that contemporary American medical care falls, not surprisingly, well short of the evidence-based ideal. Comparative Effectiveness Research demonstrates that dealing constructively with the vast uncertainties inherent to medical care requires policies to make the generation of high-quality evidence an inseparable part of routine health care.

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