toxicology and risk assessment

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Environmental Toxicology And Risk Assessment

Author : David A. Bengtson
ISBN : 0803120311
Genre : Biochemical markers
File Size : 50. 91 MB
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Papers presented at symposium as in title, held 3-5 April 1995, Denver, Colo.

Environmental Toxicology And Risk Assessment

Author : Wayne G. Landis
ISBN : 0803118600
Genre : Environmental health.
File Size : 89. 72 MB
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Toxicology And Risk Assessment

Author : Anna M. Fan
ISBN : 9789814613392
Genre : Medical
File Size : 89. 17 MB
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The presence of chemicals in our environment is a subject of intense interest owing to the many potential adverse health effects to humans following exposure to these chemicals. The principles and practices of risk assessment are used to assess the associated health risks to provide a scientific and health basis for guidance or regulatory standards development and risk management decision making for public health protection. This book compiles, discusses, and presents cutting-edge research data and methodology in performing risk assessment of some major chemicals of concern in our environment. It also discusses the complexity of the scientific databases, the available and updated methodology, emerging issues, limitations in knowledge and methods, considerations of developmental and age sensitivities, use of defaults, case samples on results in risk assessment and risk management, and current and future perspectives. The editors are prominent in the field of environmental toxicology, risk assessment, and chemical regulations. This book will appeal to those interested in evaluating the human health effects of exposure to chemicals in the environment and the associated assessments and findings.

Toxicological Risk Assessment For Beginners

Author : Jose Torres
ISBN : 9783319127514
Genre : Medical
File Size : 28. 97 MB
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This book serves as a comprehensive introductory guide to the practical aspects of risk assessment. Chapters include clearly defined objectives and summaries. The book includes: hazard identification, dose-response, exposure assessment, risk characterization, chemical mixtures, epidemiology, emerging issues and global perspectives with accessible language. The book concludes with a set of hypothetical case studies. Toxicological Risk Assessment for Beginners aims not to create an expert, but rather to provide readers with their first understanding of the risk assessment topic. This book was designed with the student in mind. We simplify a complex process for beginners and balance theory with practical aspects, but remain fluid enough to increase difficulty with case studies. By incorporating an action based, step by step approach to learning the risk assessment process, this book provides its readers with an elementary understanding of how the risk assessment process is initiated, developed and finished, making it a valuable guide for graduate students, post-doctoral fellows and early career scientists in industry.

Environmental Risk Assessment

Author : Ted Simon
ISBN : 9781466598294
Genre : Medical
File Size : 43. 88 MB
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The purpose of risk assessment is to support science-based decisions about how to solve complex societal problems. The problems we face in the twenty-first century have many social, political, and technical complexities. Environmental risk assessment in particular is of increasing importance as a means of seeking to address the potential effects of chemicals in the environment in both the developed and developing world. Environmental Risk Assessment: A Toxicological Approach examines various aspects of problem formulation, exposure, toxicity, and risk characterization that apply to both human health and ecological risk assessment. The book is aimed at the next generation of risk assessors and students who need to know more about developing, conducting, and interpreting risk assessments. It delivers a comprehensive view of the field, complete with sufficient background to enable readers to probe for themselves the science underlying the key issues in environmental risk. Written in an engaging and lively style by a highly experienced risk assessment practitioner, the text: Introduces the science of risk assessment—past, present, and future Covers problem formation and the development of exposure factors Explains how human epidemiology and animal testing data are used to determine toxicity criteria Provides environmental sampling data for conducting practice risk assessments Examines the use of in vitro and ‘omics methods for toxicity testing Describes the political and social aspects of science-based decisions in the twenty-first century Includes fully worked examples, case studies, discussion questions, and links to legislative hearings Readers of this volume will not only learn how to execute site-specific human health and ecological risk assessments but also gain a greater understanding of how science is used in deciding environmental regulations.

Computational Toxicology

Author : Sean Ekins
ISBN : 0470145889
Genre : Science
File Size : 48. 26 MB
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A comprehensive analysis of state-of-the-art molecular modeling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing experimental and computational approaches in detail, with: * An introduction to toxicology methods and an explanation of computational methods * In-depth reviews of QSAR methods applied to enzymes, transporters, nuclear receptors, and ion channels * Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena * Chapters written by leading international experts * Figures that illustrate computational models and references for further information This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET, drug discovery, and technology and software development.

Developmental Toxicology

Author : CaroleAKimmel
ISBN : 0781701376
Genre : Medical
File Size : 20. 2 MB
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The Second Edition of this highly regarded work provides a state-of-the-art review of developmental toxicology from basic science, clinical, epidemiological, and regulatory perspectives. This new edition highlights the latest approaches to understanding the mechanisms of developmental toxicity, testing pharmaceutical and environmental agents, and interpreting developmental toxicity data.; The contributors demonstrate how new information on molecular embryology and cell biology is being applied to problems in developmental toxicology. Chapters describe the effects of toxic exposure on the functional development of various organs, examine the relationship between maternal and developmental toxicity, and discuss current techniques for studying chemical disposition, metabolism, and placental transfer. Close attention is given to the use of mathematical and statistical techniques in data interpretation, as well as to the regulatory aspects of testing and risk assessment. Other chapters focus on pre- and post conceptional clinical care and on genetic factors in clinical developmental toxicology.

Lu S Basic Toxicology

Author : Byung-Mu Lee
ISBN : 9781841849546
Genre : Medical
File Size : 73. 41 MB
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This new edition of our bestselling book, Lu’s Basic Toxicology, provides a number of key benefits that make it a must-read for toxicology specialists worldwide, including: Revision of a Bestseller - the new Sixth Edition provides the critical updates toxicologists need to keep up with the changing times New Information - on over-the-counter preparations, lactation, and occupational toxicology, providing clarity and insight into a rapidly evolving subject Comprehensive - Updated, topical additions - new chapters on Nanotoxicology and Toxicity of Endocrine System provide you with information not currently available elsewhere Expert Editors - Kacew & Lee offers a distillation of decades and research and teaching experience in toxicology, providing authoritative guidance for both students and practicing professionals Practical- Easy to read information at your fingertips - In-depth, yet concise presentation of material – split into four key sections that include separate subject and chemical indexes all while in the 6 x 9 format makes this a useful, quick pocket-guide for the more experienced researcher.

Calculated Risks

Author : Joseph V. Rodricks
ISBN : 0521423317
Genre : Medical
File Size : 74. 79 MB
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Public concern regarding environmental pollution and chemicals present in foods, consumer products, and the work place are at an all time high. While there is widespread awareness, confusion still reigns, aggravated by conflicting reports concerning carcinogens in food and drinking water, or about chemicals present in medicines and household products that may cause birth defects. The central purpose of this book is to describe how scientists come to understand the toxic properties of such chemicals and the health risks they may pose. Rather than attempting to expose governmental and corporate ignorance, negligence or corruption, this book explores the underlying scientific issues.

Fundamentals Of Aquatic Toxicology

Author : Gary M. Rand
ISBN : 1560320915
Genre : Science
File Size : 51. 68 MB
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This text is divided into three parts. The first part describes basic toxicological concepts and methodologies used in aquatic toxicity testing, including the philosophies underlying testing strategies now required to meet and support regulatory standards. The second part of the book discusses various factors that affect transport, transformation, ultimate distribution, and accumulation of chemicals in the aquatic environment, along with the use of modelling to predict fate.; The final section of the book reviews types of effects or endpoints evaluated in field studies and the use of structure-activity relationships in aquatic toxicology to predict biological activity and physio-chemical properties of a chemical. This section also contains an extensive background of environmental legislation in the USA and within the European Community, and an introduction to hazard/risk assessment with case studies.

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