trace amines and neurological disorders potential mechanisms and risk factors

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Trace Amines And Neurological Disorders

Author : Tahira Farooqui
ISBN : 9780128036167
Genre : Medical
File Size : 71. 24 MB
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Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders. Focuses on recent findings on trace amines, providing insights into the functional significance, molecular mechanisms, and biological relevance of TAARS in neurological disorders Edited work with chapters authored by leaders in the field from around the globe, the broadest, most expert coverage available Provides cutting-edge research on trace amines-mediated signaling in vertebrate model systems

Drug Discovery Approaches For The Treatment Of Neurodegenerative Disorders

Author : Adeboye Adejare
ISBN : 9780128028117
Genre : Medical
File Size : 70. 33 MB
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Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource

The Science Of Fitness

Author : Greg LeMond
ISBN : 9780128010709
Genre : Science
File Size : 51. 81 MB
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The Science of Fitness: Power, Performance, and Endurance clearly explains the vital connection between diet and exercise in the human body. With this knowledge, you can use the right exercise and nutrition to obtain a higher quality life, prevent disease, and slow the aging process. Authored in a straightforward style and with color images throughout, this book explores the cellular science behind fitness, protein synthesis, and healthy living. With it you will learn the most recent and important discoveries in the relationships between physical fitness, nutrition, weight loss, and weight management. It provides key information on the body’s mitochondrial processes and their role in aging, along with well-informed discussions on general nutrition, sports nutrition, exercise physiology, how to enhance athletic performance, and how exercise strengthens the mind. Whether you are interested in how to eat healthy, train for your first (or next) marathon, take your fitness to the next level, find the best super foods, or simply want to improve your vitality through healthy, doable practices, this book will help you on your journey regardless of age or fitness level. Presents the connection between exercise, nutrition, and physiology in a way that is ideal for both experienced athletes and newcomers Provides the scientific basis for mitochondrial functions and their relationship to fitness, protein synthesis, quality of life, and the aging process Synthesizes the latest research on nutrition, sports nutrition, super foods, and the brain/body connection Co-Authored by legendary cyclist Greg LeMond, who illustrates key points using his own athletic journey

Color And Vision

Author : Steve Parker
ISBN : 1770858296
Genre : Color
File Size : 37. 99 MB
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A highly readable guide to the evolution of color and vision in the natural world.

The Sexual Abuse Victim And Sexual Offender Treatment Planner With Dsm 5 Updates

Author : Arthur E. Jongsma, Jr.
ISBN : 9781119074816
Genre : Psychology
File Size : 74. 27 MB
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This timesaving resource features: Treatment plan components for 27 behaviorally based presenting problems Over 1,000 prewritten treatment goals, objectives, and interventions—plus space to record your own treatment plan options A step-by-step guide to writing treatment plans that meet the requirements of most insurance companies and third-party payors The Sexual Abuse Victim and Sexual Offender Treatment Planner provides all the elements necessary to quickly and easily develop formal treatment plans that satisfy the demands of HMOs, managed care companies, third-party payors, and state and federal review agencies. Saves you hours of time-consuming paperwork, yet offers the freedom to develop customized treatment plans for clients who are sexual abuse victims and/or sexual offenders Organized around 27 main presenting problems, including such offender issues as anger difficulties, deviant sexual arousal, and legal issues; such victim issues as eating disorders, self-blame, and social withdrawal; and such offender and victim issues as family reunification and self-esteem and stress-management deficits Over 1,000 well-crafted, clear statements describe the behavioral manifestations of each relational problem, long-term goals, short-term objectives, and clinically tested treatment options Easy-to-use reference format helps locate treatment plan components by behavioral problem Includes a sample treatment plan that conforms to the requirements of most third-party payors and accrediting agencies (including HCFA, JCAHO, and NCQA)

Molecular Microbiology

Author : David H. Persing
ISBN : 1555814972
Genre : Medical
File Size : 65. 61 MB
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The second edition of Molecular Microbiology: Diagnostic Principles and Practice presents the latest molecular diagnostic techniques to support clinical care and basic and clinical research. the authors -- all experienced researchers and diagnosticians -- have conducted a comprehensive review and evaluation of this rapidly evolving field and provide the new material in an easy-to-read summary format. Moreover, the book offers a broad range of practical advice, such as determining the appropriate type and quantity of a specimen, releasing and concentrating the targets, and eliminating inhibitor

Cognitive Communication Disorders Second Edition

Author : Michael L. Kimbarow
ISBN : 9781597569132
Genre : Medical
File Size : 42. 31 MB
Format : PDF, ePub
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Mechatronics And Control Of Electromechanical Systems

Author : Sergey Edward Lyshevski
ISBN : 9781351651462
Genre : Science
File Size : 47. 5 MB
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Due to the enormous impact of mechatronics systems, we encounter mechatronics and micromechatronic systems in our daily activities. Recent trends and novel technologies in engineering have increased the emphasis on integrated analysis, design, and control. This book examines motion devices (actuators, motors, transducers and sensors), power electronics, controllers, and electronic solutions with the main emphasis placed on high-performance mechatronic systems. Analysis, design, optimization, control, and implementation issues, as well as a variety of enabling mechatronic systems and devices, are also covered. The results extend from the scope of mechatronic systems to the modern hardware-software developments, utilizing enabling solutions and placing the integrated system perspectives in favor of consistent engineering solutions. Mechatronics and Control of Electromechanical Systems facilitates comprehensive studies and covers the design aspects of mechatronic systems with high-performance motion devices. By combining traditional engineering topics and subjects with the latest technologies and developments, new advances are stimulated in design of state-of-the-art mechatronic systems. This book provides a deep understanding of the engineering underpinnings of integrated technologies.

Biopesticides Handbook

Author : Leo M.L. Nollet
ISBN : 9781466596535
Genre : Nature
File Size : 41. 71 MB
Format : PDF
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The need to feed an ever-growing global population combined with increasing demand for sustainable agricultural practices has generated a significant rise in demand for biopesticides. By responding concurrently to the interests of farming, forestry, and industrial sectors, biopesticides offer a considerable potential for utilization in sustainable agriculture. The Biopesticides Handbook details the benefits of biopesticides all along the food chain, offering a full spectrum and review of the range of organisms and organic products that may be used in the biological control of insects. Exploring not only the benefits but all aspects of biopesticides, the book discusses the uses and abuses of biopesticides that have been in circulation for more than 50 years, as well as more recent advances in this area. It describes the metabolism of these biopesticides and offers the best mode of action to prove environmental safety, detailing the present status of biopesticide residue in foodstuffs, soil, and water. The chapters review the regulatory schemes worked out by different countries and/or supranational authorities for biopesticides, the possible uses of pheromones, oil, plant extracts, wastes, and fungi as biopesticides. When all the features are added, the advantages of biopesticides in crop protection suggest that utilization of this class of pesticides can be a highly attractive proposition. In view of the potential environmental problems associated with the use of chemicals in crop protection, EPA and other agencies may consider establishing centers for large-scale production of biopesticides and for the training of the users (farmers) and suppliers. This book helps you select the appropriate biopesticides for your uses and explore future biopesticides and their uses.

Neuropathology Of Drug Addictions And Substance Misuse Volume 2

Author : Victor R. Preedy
ISBN : 9780128003756
Genre : Medical
File Size : 60. 82 MB
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Neuropathology of Drug Addictions and Substance Misuse, Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects is the second of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader’s knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 2 addresses stimulants, club and dissociative drugs, hallucinogens, and inhalants and solvents. Each section provides data on the general, molecular and cellular, and structural and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention, and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad material and substances. Offers a modern approach to understanding the pathology of substances of abuse, offering an evidence-based ethos for understanding the neurology of addictions Fills an existing gap in the literature by serving as a “one-stop-shopping synopsis of everything to do with the neuropathology of drugs of addiction and substance misuse Includes in each chapter: list of abbreviations, abstract, introduction, applications to other addictions and substance misuse, mini-dictionary of terms, summary points, 6+ figures and tables, and full references Offers coverage of preclinical, clinical, and population studies, from the cell to whole organs, and from the genome to whole body

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