trace amines and neurological disorders potential mechanisms and risk factors

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Trace Amines And Neurological Disorders

Author : Tahira Farooqui
ISBN : 9780128036167
Genre : Medical
File Size : 23. 27 MB
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Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders. Focuses on recent findings on trace amines, providing insights into the functional significance, molecular mechanisms, and biological relevance of TAARS in neurological disorders Edited work with chapters authored by leaders in the field from around the globe, the broadest, most expert coverage available Provides cutting-edge research on trace amines-mediated signaling in vertebrate model systems

Research Awards Index

Author :
ISBN : MINN:31951000193627T
Genre : Medicine
File Size : 46. 63 MB
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Chemical Abstracts

Author :
ISBN : UOM:39015057324090
Genre : Chemistry
File Size : 42. 55 MB
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Adams And Victor S Principles Of Neurology Ninth Edition

Author : Allan H. Ropper
ISBN : 9780071702812
Genre : Medical
File Size : 45. 2 MB
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The definitive guide to the full spectrum of neurology Adams and Victor's Principles of Neurology provides all the information you will need to confidently handle any neurologic problem, from disorders of motility, and derangements of intellect, behavior, and language, to the degenerative and neuromuscular diseases. Having this gold standard text on your reference shelf is like being able to consult with skilled clinicians on a daily basis. More than a compilation of facts, Adams and Victor's delivers expert insights not found in any other resource that help you understand every aspect of neurological disease. Written in a conversational style, the text offers practical, yet in-depth, coverage of both common and rare illnesses. Adams and Victor's Principles of Neurology also includes timely, complete, and accessible treatment and clinical management strategies. FEATURES Balanced presentation of evidence-based research coupled with the perspectives and experience of world-renowned expert neurologists Logical six-part organization reviews the clinical method, cardinal presentations, diseases of the central nervous system, diseases of the peripheral nervous system, and psychiatric disorders A-to-Z coverage of cardinal manifestations, including disorders of the special senses; epilepsy and disorders of consciousness; disorders of energy, mood, autonomic, and endocrine functions; and neuromuscular, spinal cord, and psychiatric disease Focus on symptoms, etiology, diagnosis, and treatment offers complete, practical guidance in clinical practice Special section on growth, development, and aging related to neurologic disease presents the latest, cutting-edge research in this integral area

Pharmacology And Pharmacologists

Author : Oxford University Press
ISBN : UOM:39015004399708
Genre : Biography & Autobiography
File Size : 23. 77 MB
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Biomedical Index To Phs Supported Research Project Number Listing Investigator Listing

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ISBN : STANFORD:36105003101123
Genre : Medicine
File Size : 28. 12 MB
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Index Medicus

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ISBN : NYPL:33433062652684
Genre : Medicine
File Size : 58. 74 MB
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Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Mao The Mother Of All Amine Oxidases

Author : J. P. M. Finberg
ISBN : 3211830383
Genre : Medical
File Size : 46. 93 MB
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Monoamine oxidase (MAO) is linked to psychiatric and neurological disorders, because inhibitors of the enzyme are used clinically for treatment of affective disorders and Parkinsona (TM)s disease. One of the interesting new aspects of MAO is the occurrence in the human population of deletions of genes coding for one or the other enzyme subtype (A or B). This leads to the possibility of a genetic basis for psychiatric disorders based on MAO. Subjects with deletions of type A or B, and combined deletions, have been described. In the first group of 6 papers in this book, the occurrence and characterization of these phenotypes, as well as the structure of MAO genes, is explored. Advances in the biochemistry of MAO subtypes and their physiological function and localization in brain and periphery is included. Other sections of the book deal with the neuroprotective action of MAO inhibitors and their pharmacology, especially the pharmacology of new MAO-B inhibitors.

Der K Rper Vergi T Nicht

Author : Bessel van der Kolk
ISBN : 3944476131
Genre :
File Size : 34. 35 MB
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Der Stumme Fr Hling

Author : Rachel Carson
ISBN : 3406547605
Genre :
File Size : 69. 65 MB
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