trace amines and neurological disorders potential mechanisms and risk factors

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Trace Amines And Neurological Disorders

Author : Tahira Farooqui
ISBN : 9780128036167
Genre : Medical
File Size : 60. 68 MB
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Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders. Focuses on recent findings on trace amines, providing insights into the functional significance, molecular mechanisms, and biological relevance of TAARS in neurological disorders Edited work with chapters authored by leaders in the field from around the globe, the broadest, most expert coverage available Provides cutting-edge research on trace amines-mediated signaling in vertebrate model systems

Drug Discovery Approaches For The Treatment Of Neurodegenerative Disorders

Author : Adeboye Adejare
ISBN : 9780128028117
Genre : Medical
File Size : 38. 40 MB
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Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource

Chemical Abstracts

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ISBN : UOM:39015057324090
Genre : Chemistry
File Size : 27. 22 MB
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Research Awards Index

Author :
ISBN : MINN:31951000193624Z
Genre : Medicine
File Size : 39. 7 MB
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Adams And Victor S Principles Of Neurology Ninth Edition

Author : Allan H. Ropper
ISBN : 9780071702812
Genre : Medical
File Size : 66. 99 MB
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The definitive guide to the full spectrum of neurology Adams and Victor's Principles of Neurology provides all the information you will need to confidently handle any neurologic problem, from disorders of motility, and derangements of intellect, behavior, and language, to the degenerative and neuromuscular diseases. Having this gold standard text on your reference shelf is like being able to consult with skilled clinicians on a daily basis. More than a compilation of facts, Adams and Victor's delivers expert insights not found in any other resource that help you understand every aspect of neurological disease. Written in a conversational style, the text offers practical, yet in-depth, coverage of both common and rare illnesses. Adams and Victor's Principles of Neurology also includes timely, complete, and accessible treatment and clinical management strategies. FEATURES Balanced presentation of evidence-based research coupled with the perspectives and experience of world-renowned expert neurologists Logical six-part organization reviews the clinical method, cardinal presentations, diseases of the central nervous system, diseases of the peripheral nervous system, and psychiatric disorders A-to-Z coverage of cardinal manifestations, including disorders of the special senses; epilepsy and disorders of consciousness; disorders of energy, mood, autonomic, and endocrine functions; and neuromuscular, spinal cord, and psychiatric disease Focus on symptoms, etiology, diagnosis, and treatment offers complete, practical guidance in clinical practice Special section on growth, development, and aging related to neurologic disease presents the latest, cutting-edge research in this integral area

The Science Of Fitness

Author : Greg LeMond
ISBN : 9780128010709
Genre : Science
File Size : 87. 38 MB
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The Science of Fitness: Power, Performance, and Endurance clearly explains the vital connection between diet and exercise in the human body. With this knowledge, you can use the right exercise and nutrition to obtain a higher quality life, prevent disease, and slow the aging process. Authored in a straightforward style and with color images throughout, this book explores the cellular science behind fitness, protein synthesis, and healthy living. With it you will learn the most recent and important discoveries in the relationships between physical fitness, nutrition, weight loss, and weight management. It provides key information on the body’s mitochondrial processes and their role in aging, along with well-informed discussions on general nutrition, sports nutrition, exercise physiology, how to enhance athletic performance, and how exercise strengthens the mind. Whether you are interested in how to eat healthy, train for your first (or next) marathon, take your fitness to the next level, find the best super foods, or simply want to improve your vitality through healthy, doable practices, this book will help you on your journey regardless of age or fitness level. Presents the connection between exercise, nutrition, and physiology in a way that is ideal for both experienced athletes and newcomers Provides the scientific basis for mitochondrial functions and their relationship to fitness, protein synthesis, quality of life, and the aging process Synthesizes the latest research on nutrition, sports nutrition, super foods, and the brain/body connection Co-Authored by legendary cyclist Greg LeMond, who illustrates key points using his own athletic journey

Dissertation Abstracts International

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ISBN : STANFORD:36105110578775
Genre : Science
File Size : 36. 65 MB
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