trace amines and neurological disorders potential mechanisms and risk factors

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Trace Amines And Neurological Disorders

Author : Tahira Farooqui
ISBN : 9780128036167
Genre : Medical
File Size : 79. 45 MB
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Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders. Focuses on recent findings on trace amines, providing insights into the functional significance, molecular mechanisms, and biological relevance of TAARS in neurological disorders Edited work with chapters authored by leaders in the field from around the globe, the broadest, most expert coverage available Provides cutting-edge research on trace amines-mediated signaling in vertebrate model systems

Neurochemical Aspects Of Alzheimer S Disease

Author : Akhlaq A. Farooqui
ISBN : 9780128099384
Genre : Science
File Size : 29. 57 MB
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Neurochemical Aspects of Alzheimer's Disease provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies. The book focuses on molecular mechanisms and signal transduction processes associated with the pathogenesis, biomarkers, and therapeutic strategies of AD. The comprehensive and cutting edge information in this monograph may not only help in early detection of AD, but also promote discovery of new drugs to treat this chronic disease. Chapters discuss involvement of neural membrane phospholipids, sphingolipids, and cholesterol-derived lipid mediators, abnormal APP processing, and nucleic acid damage, risk factors, biomarker, and therapeutic strategies of Alzheimer's disease. This book is written for neurologists, neuroscientists, neurochemists, neuropharmacologists, and clinicianswho are interested in molecular mechanisms associated with the pathogenesis of age-related neurological disorders. Provides a comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies for Alzheimer's disease Written for researchers, clinicians, and advanced graduate students in neurology, neuroscience, neurochemistry, and neuropharmacology Acts as the first book to provide a comprehensive description of the signal transduction processes associated with pathogenesis of Alzheimer's disease

Ischemic And Traumatic Brain And Spinal Cord Injuries

Author : Akhlaq A. Farooqui
ISBN : 9780128135976
Genre : Medical
File Size : 70. 12 MB
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Considerable progress has been made on the pathogenesis and therapeutic strategies of neurotraumatic diseases recent years. Ischemic and Traumatic Brain and Spinal Cord Injuries: Mechanisms and Potential Therapies presents readers with comprehensive and cutting edge information on molecular mechanisms, including signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries. The book also covers the molecular mechanisms of drugs used for the treatment of neurotraumatic disease. Chapters are organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy. The author aims to integrate and consolidate knowledge on neurotraumatic diseases and hopes that it will provide the basis of more dramatic advances and developments not only on molecular mechanisms, but also on causes and treatment of neurotraumatic diseases. Offers a clearly written and logically organized and comprehensive overview of molecular aspects of risk factors, pathogenesis, biomarkers, and therapeutic strategies for ischemic, spinal cord, severe and mild brain injuries Provides cutting edge research information on signal transduction processes associated with neurodegeneration and neuroprotection in ischemic, spinal cord, severe and mild brain injuries Chapters organized by molecular aspects and neuroprotective strategies by disease, including ischemic injury, spinal cord injury, traumatic brain injury, and chronic traumatic encephalopathy

Taste And Smell

Author : Dietmar Krautwurst
ISBN : 9783319489278
Genre : Science
File Size : 46. 71 MB
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Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Cognitive Communication Disorders Second Edition

Author : Michael L. Kimbarow
ISBN : 9781597569132
Genre : Medical
File Size : 51. 91 MB
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Drug Discovery Approaches For The Treatment Of Neurodegenerative Disorders

Author : Adeboye Adejare
ISBN : 9780128028117
Genre : Medical
File Size : 53. 10 MB
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Drug Discovery Approaches for the Treatment of Neurodegenerative Disorders: Alzheimer’s Disease examines the drug discovery process for neurodegenerative diseases by focusing specifically on Alzheimer’s Disease and illustrating the paradigm necessary to ensure future research and treatment success. The book explores diagnosis, epidemiology, drug discovery strategies, current therapeutics, and much more to provide a holistic approach to the discovery, development, and treatment of Alzheimer’s Disease. Through its coverage of the latest research in targeted drug design, preclinical studies, and mouse and rat models, the book is a must-have resource for all pharmaceutical scientists, pharmacologists, neuroscientists, and clinical researchers working in this area. It illustrates why these drugs tend to fail at the clinical stage, and examines Alzheimer’s Disease within the overall context of improving the drug discovery process for the treatment of other neurodegenerative disorders. Provides a compilation of chemical considerations required in drug discovery for the treatment of neurodegenerative disorders Examines different classes of compounds currently being used in discovery and development stages Explores in vitro and in vivo models with respect to their ability to translate these models to human conditions Distills the most significant information across multiple areas of Alzheimer’s disease research to provide a single, comprehensive, and balanced resource

A Spectrum Approach To Mood Disorders Not Fully Bipolar But Not Unipolar Practical Management

Author : James Phelps
ISBN : 9780393711479
Genre : Psychology
File Size : 22. 62 MB
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How to understand your clients' true illnesses, not just their DSM checklists. Though the DSM discusses the criteria for mood disorders in absolute terms—either present or absent—professionals are aware that while such dichotomies are useful for teaching, they are not always true in practice. Recent genetic data support clinicians' longstanding recognition that a continuum of mood disorders between unipolar and bipolar better matches reality than a yes/no, bipolar-or-not approach. If we acknowledge that continuum, how does this affect our approach to diagnosis and treatment? In A Spectrum Approach to Mood Disorders, nationally recognized expert James Phelps provides an in-depth exploration of the signs, symptoms, and nuanced presentations of the mood disorder spectrum, focusing on the broad gray area between Major Depression and Bipolar I. Combining theoretical understanding and real-world scenarios, Phelps offers practical treatment guidelines for clinicians to better understand the subtle ways mood disorders can show up, and how to find the most beneficial path for treatment based on the patient's individual pattern of symptoms. Is it trauma, or is it bipolar? Borderline? Both? Phelps's expertise and wealth of personal experience provides readers with unparalleled insight into a subject that is by nature challenging to define. His emphasis on non-medication approaches, as well as chapters on all the major pill-based treatments (from fish oil to lithium to the avoidance of atypical antipsychotics and antidepressants), creates a comprehensive resource for any clinician working with patients on the mood spectrum. Appendices on the relationship between bipolar diagnosis, politics, and religion; and a plain-English approach to the statistical perils of bipolar screening, offer further value. Phelps has written an invaluable guide of the critical information professionals need to treat patients on the mood disorder spectrum, as well as a useful tool for highly motivated families and patients to better understand the mood disorder that effects their lives. This book seeks to alter the black and white language surrounding these mood disorders to influence a shift in how patients are diagnosed—to insure that treatment matches their specific needs.

Diet And Exercise In Cognitive Function And Neurological Diseases

Author : Akhlaq A. Farooqui
ISBN : 9781118840566
Genre : Medical
File Size : 55. 5 MB
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Diet and exercise have long been recognized as important components of a healthy lifestyle, as they have a great impact on improving cardiovascular and cerebrovascular functions, lowering the risk of metabolic disorders, and contributing to healthy aging. As a greater proportion of the world’s population is living longer, there has been increased interest in understanding the role of nutrition and exercise in long-term neurological health and cognitive function. Diet and Exercise in Cognitive Function and Neurological Diseases discusses the role and impact that nutrition and activity have on cognitive function and neurological health. The book is divided into two sections. The first section focuses on diet and its impact on neurobiological processes. Chapters focus on the impacts of specific diets, such as the Mediterranean, ketogenic and vegan diets, as well as the role of specific nutrients, fats, fatty acids, and calorie restriction on neurological health and cognitive function. The second section of the book focuses on exercise, and its role in maintaining cognitive function, reducing neuroinflammatory responses, regulating adult neurogenesis, and healthy brain aging. Other chapters look at the impact of exercise in the management of specific neurological disorders such Multiple Sclerosis and Parkinson’s Disease. Diet and Exercise in Cognitive Function and Neurological Diseases is a timely reference on the neurobiological interplay between diet and exercise on long-term brain health and cognitive function.

The Science Of Fitness

Author : Greg LeMond
ISBN : 9780128010709
Genre : Science
File Size : 63. 60 MB
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The Science of Fitness: Power, Performance, and Endurance clearly explains the vital connection between diet and exercise in the human body. With this knowledge, you can use the right exercise and nutrition to obtain a higher quality life, prevent disease, and slow the aging process. Authored in a straightforward style and with color images throughout, this book explores the cellular science behind fitness, protein synthesis, and healthy living. With it you will learn the most recent and important discoveries in the relationships between physical fitness, nutrition, weight loss, and weight management. It provides key information on the body’s mitochondrial processes and their role in aging, along with well-informed discussions on general nutrition, sports nutrition, exercise physiology, how to enhance athletic performance, and how exercise strengthens the mind. Whether you are interested in how to eat healthy, train for your first (or next) marathon, take your fitness to the next level, find the best super foods, or simply want to improve your vitality through healthy, doable practices, this book will help you on your journey regardless of age or fitness level. Presents the connection between exercise, nutrition, and physiology in a way that is ideal for both experienced athletes and newcomers Provides the scientific basis for mitochondrial functions and their relationship to fitness, protein synthesis, quality of life, and the aging process Synthesizes the latest research on nutrition, sports nutrition, super foods, and the brain/body connection Co-Authored by legendary cyclist Greg LeMond, who illustrates key points using his own athletic journey

Neuropathology Of Drug Addictions And Substance Misuse Volume 2

Author : Victor R. Preedy
ISBN : 9780128003756
Genre : Psychology
File Size : 34. 11 MB
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Neuropathology of Drug Addictions and Substance Misuse, Volume 2: Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects is the second of three volumes in this informative series and offers a comprehensive examination of the adverse consequences of the most common drugs of abuse. Each volume serves to update the reader’s knowledge on the broader field of addiction as well as to deepen understanding of specific addictive substances. Volume 2 addresses stimulants, club and dissociative drugs, hallucinogens, and inhalants and solvents. Each section provides data on the general, molecular and cellular, and structural and functional neurological aspects of a given substance, with a focus on the adverse consequences of addictions. Research shows that the neuropathological features of one addiction are often applicable to those of others, and understanding these commonalties provides a platform for studying specific addictions in more depth and may ultimately lead researchers toward new modes of understanding, causation, prevention, and treatment. However, marshalling data on the complex relationships between addictions is difficult due to the myriad material and substances. Offers a modern approach to understanding the pathology of substances of abuse, offering an evidence-based ethos for understanding the neurology of addictions Fills an existing gap in the literature by serving as a “one-stop-shopping synopsis of everything to do with the neuropathology of drugs of addiction and substance misuse Includes in each chapter: list of abbreviations, abstract, introduction, applications to other addictions and substance misuse, mini-dictionary of terms, summary points, 6+ figures and tables, and full references Offers coverage of preclinical, clinical, and population studies, from the cell to whole organs, and from the genome to whole body

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