transgenic plants a production system for industrial and pharmaceutical proteins

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Transgenic Plants

Author : Meran R. L. Owen
ISBN : 0471964433
Genre : Science
File Size : 37. 54 MB
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Transgenic Plants: A Production System for Industrial and Pharmaceutical Proteins provides a detailed guide to the principles and practice of using transgenic plants as a system for the production of heterologous proteins. It is unique in that it covers the complete process of heterologous protein production in plants, from the initial transformation of the plant, through to transcription, transgene stability and finally the downstreaming processing events for protein purification. Written by an international team of industrialists and academics, this book describes: * the fundamental issues associated with expressing heterologous proteins in plants; * a number of detailed examples of the successful small-and large-scale production of proteins; * the essentials of patenting; and * the commercial exploitation. Transgenic Plants: A Production System for Industrial and Pharmaceutical Proteins will be of interest to plant biotechnologists, molecular biologists and protein biochemists in the biotechnology and pharmaceutical industries.

Molecular Farming

Author : Rainer Fischer
ISBN : 9783527605811
Genre : Science
File Size : 80. 9 MB
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Here, authors from academia and industry provide an exciting overview of current production technologies and the fascinating possibilities for future applications. Topics include chloroplast-derived antibodies, biopharmaceuticals and edible vaccines, production of antibodies in plants and plant cell suspension cultures, production of spider silk proteins in plants, and glycosylation of plant produced proteins. The whole is rounded off by chapters on the demands and expectations made on molecular farming by pharmaceutical corporations and the choice of crop species in improving recombinant protein levels. Of interest to biotechnologists, gene technologists, molecular biologists and protein biochemists in university as well as the biotechnological and pharmaceutical industries.

Molecular Farming In Plants Recent Advances And Future Prospects

Author : Aiming Wang
ISBN : 9400722176
Genre : Science
File Size : 45. 12 MB
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Molecular farming in plants is a relatively young subject of sciences. As plants can offer an inexpensive and convenient platform for the large-scale production of recombinant proteins with various functions, the driven force from the giant market for recombinant protein pharmaceuticals and industrial enzymes makes this subject grow and advance very quickly. To summarize recent advances, current challenges and future directions in molecular farming, international authorities were invited to write this book for researchers, teachers and students who are interested in this subject. This book, with the focus on the most advanced cutting-edge breakthroughs, covers all the essential aspects of the field of molecular farming in plants: from expression technologies to downstream processing, from products to safety issues, and from current advances and holdups to future developments.

Plant Biotechnology

Author : J. Hammond
ISBN : 9783642602344
Genre : Science
File Size : 34. 52 MB
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The title of this volume, Plant Biotechnology: Nell' Products and Applications, may look a little out of place among previous vol umes of Current Topics in Microbiology and Immunology that have focused mostly on issues related to human health and ani mal biology, However, plant biology has always been of immense and has enjoyed an intimate relationship practical importance, with medicine and other biological sciences for centuries, In creasing scientific specialization and the dramatic advances in the medical and chemical sciences during this century have left many persons with the impression that plant biology and plant bio technology is important only in relation to the agricultural sci ences, This is no longer true. Within the past year a genetically engineered plant virus has been used to vaccinate and protect against an animal disease (see the chapter by Lomonossoff and Hamilton), the first human trials of a potential transgenic plant based oral vaccine against cholera have been conducted (see the chapter by Richter and Kipp), and the first human trial of an injectable transgenic plant-derived therapeutic protein is under way (discussed in the chapter by Russell et al. ). Today plant biotechnology is being used in new and creative ways to produce therapeutic products for medicine and plastics for industry as well as new disease-and stress-resistant crops for agriculture.

Progress In Botany

Author : Karl Esser
ISBN : 9783642188190
Genre : Science
File Size : 90. 90 MB
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With one volume each year, this series keeps scientists and advanced students informed of the latest developments and results in all areas of the plant sciences. The present volume includes reviews on genetics, cell biology, physiology, comparative morphology, systematics, ecology, and vegetation science.

Molecular Farming Of Plants And Animals For Human And Veterinary Medicine

Author : L. Erickson
ISBN : 9789401723176
Genre : Science
File Size : 20. 13 MB
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Molecular farming has been hailed as the "third wave" of genetically-modified organisms produced through biotechnology for the bio-based economy of the future. Unlike products of the first wave, such as herbicide resistant crop plants, which were perceived to benefit only the farmers who used them and the agrochemical companies who developed them, products of molecular farming are designed specifically for the benefit of the consumer. Such products could be purified from food or non-food organisms for a range of applications in industry, as well as animal and human health. Alternatively, the products of this technology could be consumed more directly in some edible format, such as milk, eggs, fruits or vegetables. There is a rapidly-growing interest Qn the part of the public as well as in the medical community in the role food plays in health, especially in the immunophysiological impact of food over and above the role of basic nutrition.


Author : Robert A. Meyers
ISBN : 3527316086
Genre : Medical
File Size : 57. 34 MB
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With three Nobel Laureates contributing to this invaluable collection of high-quality articles, carefully selected from the highly praised R.A. Meyer's Encyclopedia, these two volumes cover a wide range of topics in protein research. Clearly divided into sections on structure, modeling, expression, analysis and others, the chapters are designed to aid readers of all levels of expertise: Each chapter includes a glossary of the most important keywords, a concise summary of the article concerned and comprehensive references for further reading. Similarly, the uniform structure of the articles makes them very easy to use, resulting in a ready reference for molecular and cell biologists, biochemists, biophysicists, and biotechnologists, as well as those working in the pharmaceutical and biotechnological industries.

Molecular Pharming

Author : Allison R. Kermode
ISBN : 9781118801482
Genre : Science
File Size : 66. 16 MB
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A single volume collection that surveys the exciting field of plant-made pharmaceuticals and industrial proteins This comprehensive book communicates the recent advances and exciting potential for the expanding area of plant biotechnology and is divided into six sections. The first three sections look at the current status of the field, and advances in plant platforms and strategies for improving yields, downstream processing, and controlling post-translational modifications of plant-made recombinant proteins. Section four reviews high-value industrial and pharmacological proteins that are successfully being produced in established and emerging plant platforms. The fifth section looks at regulatory challenges facing the expansion of the field. The final section turns its focus toward small molecule therapeutics, drug screening, plant specialized metabolites, and plants as model organisms to study human disease processes. Molecular Pharming: Applications, Challenges and Emerging Areas offers in-depth coverage of molecular biology of plant expression systems and manipulation of glycosylation processes in plants; plant platforms, subcellular targeting, recovery, and downstream processing; plant-derived protein pharmaceuticals and case studies; regulatory issues; and emerging areas. It is a valuable resource for researchers that are in the field of plant molecular pharming, as well as for those conducting basic research in gene expression, protein quality control, and other subjects relevant to molecular and cellular biology. Broad ranging coverage of a key area of plant biotechnology Describes efforts to produce pharmaceutical and industrial proteins in plants Provides reviews of recent advances and technology breakthroughs Assesses realities of regulatory and cost hurdles Forward looking with coverage of small molecule technologies and the use of plants as models of human disease processes Providing wide-ranging and unique coverage, Molecular Pharming: Applications, Challenges and Emerging Areas will be of great interest to the plant science, plant biotechnology, protein science, and pharmacological communities.

Biopharmaceuticals In Plants

Author : Kathleen Laura Hefferon
ISBN : 1439804753
Genre : Medical
File Size : 22. 94 MB
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Transgenic plants present enormous potential to become one of the most cost-effective and safe systems for large-scale production of proteins for industrial, pharmaceutical, veterinary, and agricultural uses. Over the past decade, much progress has been made with respect to the development of vaccines, antibodies, and other therapeutic proteins. Biopharmaceuticals in Plants: Toward the Next Century of Medicine provides a comprehensive survey of all major aspects of the development and production of plant-made biopharmaceuticals. Accompanied by an exhaustive list of references to facilitate further study, this critical volume: Describes the theory and practice of modern plant transformation techniques with respect to nuclear and plastic genomes Outlines the steps involved in the generation of transgenic plants Discusses the engineering of plant virus expression vectors for transient expression of vaccine proteins and other therapeutics in plant tissue Addresses the significant role of glycosylation in the production of plant-made mammalian proteins Investigates the basis of mucosal immunity using plant-based oral vaccines Examines the scale-up of plant-derived vaccine and therapeutic proteins in entire crops or in large batch cell suspension cultures Explores the development of clinical trials utilizing plant-derived biopharmaceutical proteins Evaluates risks and biosafety concerns regarding plant-derived pharmaceuticals The book concludes with a discussion of the future of plant-based vaccines and other therapeutic proteins with respect to commercial viability and as a tool to improve global public health. Far-reaching in its scope, this text is a baseline reference that students and researchers in a broad range of fields such as medicine, plant science, biotechnology, crop science, natural products chemistry, and engineering will consult regularly. It will also serve as a useful tool for individuals and companies seeking to invest in this dynamic area.

Plant Biotechnology And Agriculture

Author : Arie Altman
ISBN : 9780123814661
Genre : Medical
File Size : 25. 3 MB
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As the oldest and largest human intervention in nature, the science of agriculture is one of the most intensely studied practices. From manipulation of plant gene structure to the use of plants for bioenergy, biotechnology interventions in plant and agricultural science have been rapidly developing over the past ten years with immense forward leaps on an annual basis. This book begins by laying the foundations for plant biotechnology by outlining the biological aspects including gene structure and expression, and the basic procedures in plant biotechnology of genomics, metabolomics, transcriptomics and proteomics. It then focuses on a discussion of the impacts of biotechnology on plant breeding technologies and germplasm sustainability. The role of biotechnology in the improvement of agricultural traits, production of industrial products and pharmaceuticals as well as biomaterials and biomass provide a historical perspective and a look to the future. Sections addressing intellectual property rights and sociological and food safety issues round out the holistic discussion of this important topic. Includes specific emphasis on the inter-relationships between basic plant biotechnologies and applied agricultural applications, and the way they contribute to each other Provides an updated review of the major plant biotechnology procedures and techniques, their impact on novel agricultural development and crop plant improvement Takes a broad view of the topic with discussions of practices in many countries

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