treatment refractory schizophrenia a clinical conundrum

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Treatment Refractory Schizophrenia

Author : Peter F. Buckley
ISBN : 9783642452574
Genre : Medical
File Size : 79. 63 MB
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Schizophrenia is often associated with an inadequate response to pharmacological and non-pharmacological treatments. How to treat patients who have an unsatisfactory response to anti-psychotics, including clozapine - which is unequivocally the most powerful antipsychotic medication for this recalcitrant population - remains a clinical conundrum. A range of adjunctive medications have been tried with mixed results; there has also been renewed interest in the role of neuromodulatory strategies, electroconvulsive therapy, and cognitive and vocational approaches. Perhaps a bright spot for the future lies in the evolution of pharmacogenetic approaches for individualized care. In this book, leading experts from Europe, Australia and the Americas provide a timely appraisal of treatments for the most severely ill schizophrenia patients. This clinically focused book is informed by the latest research on the neurobiology and treatment of schizophrenia. It is comprehensive in scope, covering current treatment options, various add-on approaches, and a range of psychosocial treatments. The contributors are respected experts who have combined their clinical experience with cutting-edge research to provide readers with authoritative information on fundamental aspects of clinical care for schizophrenia.

Schizophrenia Advances And Current Management An Issue Of Psychiatric Clinics Of North America

Author : Peter F. Buckley
ISBN : 9780323446334
Genre : Medical
File Size : 85. 54 MB
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This issue of the Psychiatric Clinics, edited by Dr. Peter F. Buckley, examines advances and current management in the treatment of Schizophrenia. The topics covered in this issue include, but are not limited to: Duration of Untreated Psychosis (DUP) and Longitudinal Perspectives on DUP; Neuroinflammation and Schizophrenia; Emerging Treatments for Schizophrenia; Treatment-Resistant Schizophrenia; Comorbidities and Schizophrenia; Recovery from Schizophrenia; and the latest in schizophrenia research.

Care Of The Mentally Disordered Offender In The Community

Author : Alec Buchanan
ISBN : 9780198804567
Genre : Medical
File Size : 53. 46 MB
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The thoroughly revised second edition of Care of the Mentally Disordered Offender in the Community is a comprehensive, evidence-based guide to the latest developments in the social context, management, and treatment of offenders in mental health care. In recent years there has been significant changes in the public perception of crime and the mentally ill offender, enhanced by research into causal links between violence and mental illness, and the increased publicity of the risk mentally disordered offenders could pose to the community. These, and other various factors, have significantly increased service development and research into psychological and pharmacological treatments and the rate of re-offending. Over three sections this essential guide explores key topics for discussion in the field. Part One critically examines the social, administrative and clinical context within which care is given in the modern day. Part Two discusses treatment and the evaluation of risk when determining the most appropriate treatment, whilst Part Three explores psychiatric services and their relationship with other agencies. Fully updated to ensure new areas for discussion are included, this book includes new chapters on relevant debates in the field such as US provision for the mentally disordered leaving prison, community management of sexual offending, the relationships between care and coercion, and the treatment of personality disorders. Written and edited by a global team of experts in the field, this book provides readers with useful insight into the social, clinical, and institutional contexts of this complex and relevant issue.

Complex Clinical Conundrums In Psychiatry

Author : Kuppuswami Shivakumar
ISBN : 9783319703114
Genre : Medical
File Size : 38. 65 MB
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This book provides the readers with a series of complex cases that are organized by psychiatric disorder. Written by experts in the field, the cases offer insight on how to navigate care in delicate situations while considering preexisting medical conditions. Topics cover pharmacological concerns in women who are pregnant or nursing, working with dementia patients suffering from HIV, assessing and treating ADHD in special populations, monitoring medication use in patience recovering from Substance Use Disorder, and working with patients suffering from personality disorders. Each chapter offers guidance through the maze of classifications, clinical features, diagnosis and various complex interventions. The book also covers new information on the advances in research and management aspects. Complex Clinical Conundrums in Psychiatry is a valuable resource for psychiatrists, psychologists, family physicians, geriatricians, counselors, social workers, nurses, and all medical professionals working with complex psychiatric patients.

The Maudsley Prescribing Guidelines In Psychiatry

Author : David M. Taylor
ISBN : 9781119442585
Genre : Medical
File Size : 27. 51 MB
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The revised 13th edition of the essential reference for the prescribing of drugs for patients with mental health disorders The revised and updated 13th edition of The Maudsley Prescribing Guidelines in Psychiatry provides up-to-date information, expert guidance on prescribing practice in mental health, including drug choice, treatment of adverse effects and how to augment or switch medications. The text covers a wide range of topics including pharmacological interventions for schizophrenia, bipolar disorder, depression and anxiety, and many other less common conditions. There is advice on prescribing in children and adolescents, in substance misuse and in special patient groups. This world-renowned guide has been written in concise terms by an expert team of psychiatrists and specialist pharmacists. The Guidelines help with complex prescribing problems and include information on prescribing psychotropic medications outside their licensed indications as well as potential interactions with other medications and substances such as alcohol, tobacco and caffeine. In addition, each of the book’s 165 sections features a full reference list so that evidence on which guidance is based can be readily accessed. This important text: Is the world’s leading clinical resource for evidence-based prescribing in day-to-day clinical practice and for formulating prescribing policy Includes referenced information on topics such as transferring from one medication to another, prescribing psychotropic medications during pregnancy or breastfeeding, and treating patients with comorbid physical conditions, including impaired renal or hepatic function. Presents guidance on complex clinical problems that may not be encountered routinely Written for psychiatrists, neuropharmacologists, pharmacists and clinical psychologists as well as nurses and medical trainees, The Maudsley Prescribing Guidelines in Psychiatry are the established reference source for ensuring the safe and effective use of medications for patients presenting with mental health problems.

Essential Papers On Object Relations

Author : Peter Buckley
ISBN : 9780814710807
Genre : Psychology
File Size : 29. 65 MB
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Physical Health And Schizophrenia

Author : David J. Castle
ISBN : 9780192539816
Genre : Medical
File Size : 51. 55 MB
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In comparison to the general population, people with schizophrenia and related disorders have poorer physical health and increased mortality. Whilst it is recognised that serious mental illnesses such as schizophrenia carry a reduced life expectancy, it is often assumed that suicide is the main cause of this disparity. In actuality, suicide accounts for no more than a third of the early mortality associated with schizophrenia: the vast majority is due to cardiovascular factors Physical Health and Schizophrenia offers a user-friendly guide to the physical health problems associated with schizophrenia and a clear overview of strategies and interventions to tackle these issues. Spanning eight chapters this resource covers the essential topics in a practical and easy-to-read format to suit the needs of busy clinicians. It also includes an appendix designed specifically for patients and carers, with practical tips on how to be actively involved in monitoring and managing physical health problems. Part of the Oxford Psychiatry Library series, Physical Health and Schizophrenia offers readers a fully up-to-date and valuable insight into this complex issue. With helpful key points at the start of each chapter and a clear layout, this is an essential resource for busy clinicians and researchers in any mental health field as well as those working in primary care.

Therapy Resistant Schizophrenia

Author : H. Elkis
ISBN : 9783805595124
Genre : Medical
File Size : 31. 52 MB
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The psychotic symptoms of up to 30% of schizophrenic patients do not respond adequately to treatment with antipsychotic drugs, other than clozapine. These refractory patients are generally among the most disabled of all people with schizophrenia and require special assessment and treatment. This volume presents the latest research and recommendations on the definition, causes and therapy of treatment-resistant schizophrenia (TRS). Methods for identification and optimal management of TRS are reviewed. Clozapine and other atypical antipsychotic drugs which are the primary treatment for TRS, as well as non-pharmacologic treatments such as transcranial magnetic stimulation, cognitive behavior therapy and ECT are discussed in depth. Potential causative factors and identifying features such as genetic factors, poor premorbid functioning, longer duration of untreated psychosis, and biological measures such as structural and functional brain abnormalities are also reviewed in depth in the present volume.

Genomics Circuits And Pathways In Clinical Neuropsychiatry

Author : Thomas Lehner
ISBN : 9780128005309
Genre : Science
File Size : 24. 68 MB
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This foundational work comprehensively examines the current state of the genetics, genomics and brain circuitry of psychiatric and neurological disorders. It consolidates discoveries of specific genes and genomic regions associated with these conditions, the genetic and anatomic architecture of these syndromes, and addresses how recent advances in genomics are leading to a reappraisal of the biology underlying clinical neuroscience. In doing so, it critically examines the promise and limitations of these discoveries toward treatment, and to the interdisciplinary nature of understanding brain and behavior. Coverage includes new discoveries regarding autism, epilepsy, intellectual disability, dementias, movement disorders, language impairment, disorders of attention, schizophrenia, and bipolar disorder. Genomics, Circuits, and Pathways in Clinical Neuropsychiatry focuses on key concepts, challenges, findings, and methods in genetics, genomics, molecular pathways, brain circuitry, and related neurobiology of neurologic and psychiatric disorders. Provides interdisciplinary appeal in psychiatry, neurology, neuroscience, and genetics Identifies key concepts, methods, and findings Includes coverage of multiple disorders from autism to schizophrenia Reviews specific genes associated with disorders Discusses the genetic architecture of these syndromes Explains how recent findings are influencing the understanding of biology Clarifies the promise of these findings for future treatment

The Handbook Of Clinical Adult Psychology

Author : S. J. E. Lindsay
ISBN : 0415072166
Genre : Psychology
File Size : 58. 25 MB
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The Handbook of Clinical Adult Psychology offers the most comprehensive, authoritative and practical guide for clinical psychologists in practice and in training. Building upon the reputation of the first edition this completely revised and updated edition will rapidly establish itself as the only textbook that clinical psychologists need or want.

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