trp channels in sensory transduction

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Trp Channels In Sensory Transduction

Author : Rodolfo Madrid
ISBN : 9783319187051
Genre : Medical
File Size : 67. 74 MB
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TRP channels play a key role in sensory physiology and have been the focus of intensive investigation in recent years. The proposed book will be a comprehensive, detailed overview of the ways in which TRP channels are involved in a wide variety of sensory modalities. Authors will explore the involvement of TRP channels in photo transduction (sight), chemotransduction (taste and odor), mechanotransduction (touch and hearing), thermo transduction (the sensation of temperature) and pain perception. Furthermore, the book will include some grounding chapters such as one on the history of TRP channel research, one on the biophysical characteristics of the proteins and one on trafficking and post-translational regulation.

Trp Ion Channel Function In Sensory Transduction And Cellular Signaling Cascades

Author : Wolfgang B. Liedtke, MD, PH.D.
ISBN : 9781420005844
Genre : Science
File Size : 28. 77 MB
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Since the first TRP ion channel was discovered in Drosophila melanogaster in 1989, the progress made in this area of signaling research has yielded findings that offer the potential to dramatically impact human health and wellness. Involved in gateway activity for all five of our senses, TRP channels have been shown to respond to a wide range of stimuli from both within and outside the cell body. How we sense heat and cold, how we taste food, how eggs are fertilized, how the heart expands and contracts is each dependent on the function of these channels. While no single book could possibly cover all the research being undertaken, TRP Ion Channel Function in Sensory Transduction and Cellular Signaling Cascades presents the most advanced compilation of work in this area to date. All 31 chapters are written by international pioneers working at the vanguard of TRP ion channel research. They explain much about the pivotal function and behavior of these channels, which are most exquisitely tuned to their specific tasks, and delve into how researchers are putting this knowledge to use in the development of novel pharmaceuticals, which may well prove effective in ameliorating treatment-resistant conditions including cancer, heart disease, inflammation, and immune system dysfunctions. Individual chapters shed light on selected topics of interest in the TRP arena, such as signal transduction in axonal path-finding, and in vascular, renal, and auditory functions, as well as pain. The text also covers subjects as diverse as mating and fertilization, inflammatory pain, and mechanisms of pheromone detection in mammals. While the book presents much new insight and explores findings that will be of interest to those involved with advanced research, it also includes significant background material for those looking to familiarize themselves with this exceptionally promising path of inquiry.

Transduction Channels In Sensory Cells

Author : Stephan Frings
ISBN : 9783527604975
Genre : Science
File Size : 67. 46 MB
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This is the first book to provide a molecular level explanation of how the senses work, linking molecular biology with sensory physiology to deduce the molecular mechanism of a key step in sensory signal generation. The editors have assembled expert authors from all fields of sensory physiology for an authoritative overview of the mechanisms of sensory signal transduction in both animals and plants. They systematically cover phototransduction, chemosensory transduction, mechanotransduction, temperature and pain perception, as well as specialized receptors for electrical and magnetic signals. Required reading for biologists, physiologists and medical researchers with an interest in sensory physiology.

Transduction Channels In Sensory Cells

Author : Stephan Frings
ISBN : 9783527604975
Genre : Science
File Size : 21. 12 MB
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This is the first book to provide a molecular level explanation of how the senses work, linking molecular biology with sensory physiology to deduce the molecular mechanism of a key step in sensory signal generation. The editors have assembled expert authors from all fields of sensory physiology for an authoritative overview of the mechanisms of sensory signal transduction in both animals and plants. They systematically cover phototransduction, chemosensory transduction, mechanotransduction, temperature and pain perception, as well as specialized receptors for electrical and magnetic signals. Required reading for biologists, physiologists and medical researchers with an interest in sensory physiology.

Trp Channels

Author : Michael X. Zhu
ISBN : 9781439818602
Genre : Medical
File Size : 79. 79 MB
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The rapid expansion of the TRP field has generated a large amount of excellent original work across many different research fields. However, investigators are not necessarily familiar with the pros and cons of the variety of methods used to study TRP channels. Because of functional and genetic diversity, as well as the different physiological roles they play, techniques used for studying TRP channels range from single molecular analysis to behavioral animal studies. Methods in multiple areas, such as molecular biology, fluorescence imaging, electrophysiology, cell biology, genetics, proteomics, pharmacology, system physiology, and behavioral assessment, are employed to investigate various aspects of these channels. Choosing among many possible topics in these broad areas was a daunting task. A comprehensive review of the field, TRP Channels spans the information gap by providing broad coverage of current methods and techniques commonly used in TRP channel research, and detailed protocols with thorough discussions of the advantages and disadvantages across methods. Some topics covered include Mammalian, Drosophila and C. elegans TRP channels Practical protocols for functional studies of TRP channels, including TRPC, TRPV, TRPA, TRPM and the intracellularly localized TRPML channels ThermoTRPs, including the new fast temperature jump apparatus and the high throughput random mutagenesis method for screening critical motifs involved in TRP channel regulation Cell-based high-throughput screening assays for TRP channels and their applications in drug discoveries TRP channel functions in native cells, including smooth muscles, neurons, and cancers Showcasing the current status of the field, TRP Channels covers the major techniques used in various areas of research. The majority of the chapters are protocol oriented, with the goal of providing clear directions for laboratory use. Because of the breadth of the TRP field, the applications of some methods are described in multiple chapters by experts working on a variety of channel types that serve different physiological functions, highlighting distinctive views on how the methodology can be utilized. Some chapters include discussion on the usefulness and pitfalls associated with the use of certain techniques. Together with chapters that offer comprehensive reviews on the functional regulation and other roles of TRP channels, students and investigators new to the field should find this book particularly informative.

Chemosensory Transduction

Author : Frank Zufall
ISBN : 9780128017869
Genre : Science
File Size : 45. 60 MB
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Written by leaders in the field of chemosensation, Chemosensory Transduction provides a comprehensive resource for understanding the molecular mechanisms that allow animals to detect their chemical world. The text focuses on mammals, but also includes several chapters on chemosensory transduction mechanisms in lower vertebrates and insects. This book examines transduction mechanisms in the olfactory, taste, and somatosensory (chemesthetic) systems as well as in a variety of internal sensors that are responsible for homeostatic regulation of the body. Chapters cover such topics as social odors in mammals, vertebrate and invertebrate olfactory receptors, peptide signaling in taste and gut nutrient sensing. Includes a foreword by preeminent olfactory scientist Stuart Firestein, Chair of Columbia University’s Department of Biological Sciences in New York, NY. Chemosensory Transduction describes state-of-the-art approaches and key findings related to the study of the chemical senses. Thus, it serves as the go-to reference for this subject for practicing scientists and students with backgrounds in sensory biology and/or neurobiology. The volume will also be valuable for industry researchers engaged in the design or testing of flavors, fragrances, foods and/or pharmaceuticals. Provides a comprehensive overview for all chemosensory transduction mechanisms Valuable for academics focused on sensory biology, neurobiology, and chemosensory transduction, as well as industry researchers in new flavor, fragrance, and food testing Edited by leading experts in the field of olfactory transduction Focuses on mammals, but lower vertebrates and invertebrate model systems are also included

Structural Determinants Of Trp Channel Assembly

Author : Pamela Tsuruda
ISBN : UCAL:X85576
Genre :
File Size : 53. 50 MB
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Transient Receptor Potential (TRP) channels mediate numerous sensory transduction processes and are thought to function as tetrameric complexes. Much is known about TRP channel physiology; however, comparatively little is understood regarding how these channels assemble. Here, we identify an autonomously folded assembly domain from the cold and menthol gated channel TRPM8, and address the importance of several putative assembly motifs of the capsaicin receptor, TRPV1. Several regions are identified for homomeric interaction within the N-terminus of TRPV1, and we detect two cytoplasmic proteins that may also interact with this domain. Additionally, we use electrophysiology and cell biology to identify N- and C-terminal coiled-coils that may play a role in TRPV1 channel stability or trafficking. We show that the TRPM8 cytoplasmic C-terminal domain contains a coiled-coil that is necessary for directing channel assembly and sufficient for mediating tetramer formation using a combination of biochemical, electrophysiological, and cell biological techniques. These data define the first authentic TRP family modular assembly domain, delineate a new tool that should be of general use in dissecting TRPM channel function, and establish a clear role for coiled-coil structures in ion channel assembly.

The Nociceptive Membrane

Author :
ISBN : 0080463622
Genre : Science
File Size : 44. 45 MB
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Membranes are essential cellular organelles. They not only define cells and other organelles, but also are critical in the cell function by selectively regulating the passage of molecules by acting as a matrix for other signaling molecules, and as conduits of information transfer between the external environment and the cell interior. This series was originally added in 1970 and has since provided a systematic, comprehensive, and rigorous approach to specific topics relevant to the study of cellular membranes. Each volume is a guest edited compendium of membrane biology. This series has been a mainstay for practicing scientists and students interested in this critical field of biology. Articles covered in the volume include History of Ion Channels in the Pain Sensory System; Historical Overview; TRPV1, a Polymodal Sensor in the Nociceptor Terminal; Nociceptive Signals to TRPV1 and its Clinical Potential; Gating, Sensitization and Desensitization of TRPV1; TRP Channels as Thermosensors; ASIC Channels; P2X Receptors in Sensory Neurons; Voltage-Gated Sodium Channels and Neuropathic Pain; Voltage-Gated Potassium Channels in Sensory Neurons.

Latest Advances In Inductive Logic Programming

Author : Stephen H Muggleton
ISBN : 9781783265107
Genre : Computers
File Size : 77. 99 MB
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This book represents a selection of papers presented at the Inductive Logic Programming (ILP) workshop held at Cumberland Lodge, Great Windsor Park. The collection marks two decades since the first ILP workshop in 1991. During this period the area has developed into the main forum for work on logic-based machine learning. The chapters cover a wide variety of topics, ranging from theory and ILP implementations to state-of-the-art applications in real-world domains. The international contributors represent leaders in the field from prestigious institutions in Europe, North America and Asia. Graduate students and researchers in this field will find this book highly useful as it provides an up-to-date insight into the key sub-areas of implementation and theory of ILP. For academics and researchers in the field of artificial intelligence and natural sciences, the book demonstrates how ILP is being used in areas as diverse as the learning of game strategies, robotics, natural language understanding, query search, drug design and protein modelling. Contents:Applications:Can ILP Learn Complete and Correct Game Strategies? (Stephen H Muggleton and Changze Xu)Induction in Nonmonotonic Causal Theories for a Domestic Service Robot (Jianmin Ji and Xiaoping Chen)Using Ontologies in Semantic Data Mining with g-SEGS and Aleph (Anže Vavpetič and Nada Lavră)Improving Search Engine Query Expansion Techniques with ILP (José Carlos Almeida Santos and Manuel Fonseca de Sam Bento Ribeiro)ILP for Cosmetic Product Selection (Hiroyuki Nishiyama and Fumio Mizoguchi)Learning User Behaviours in Real Mobile Domains (Andreas Markitanis, Domenico Corapi, Alessandra Russo and Emil C Lupu)Discovering Ligands for TRP Ion Channels Using Formal Concept Analysis (Mahito Sugiyama, Kentaro Imajo, Keisuke Otaki and Akihiro Yamamoto)Predictive Learning in Two-Way Datasets (Beau Piccart, Hendrik Blockeel, Andy Georges and Lieven Eeckhout)Model of Double-Strand Break of DNA in Logic-Based Hypothesis Finding (Barthelemy Dworkin, Andrei Doncescu, Jean-Charles Faye and Katsumi Inoue)Probabilistic Logical Learning:The PITA System for Logical-Probabilistic Inference (Fabrizio Riguzzi and Terrance Swift)Learning a Generative Failure-Free PRISM Clause (Waleed Alsanie and James Cussens)Statistical Relational Learning of Object Affordances for Robotic Manipulation (Bogdan Moldovan, Martijn van Otterlo, Plinio Moreno, José Santos-Victor and Luc De Raedt)Learning from Linked Data by Markov Logic (Man Zhu and Zhiqiang Gao)Satisfiability Machines (Filip Železný)Implementations:Customisable Multi-Processor Acceleration of Inductive Logic Programming (Andreas K Fidjeland, Wayne Luk and Stephen H Muggleton)Multivalue Learning in ILP (Orlando Muoz Texzocotetla and Ren Mac Kinney Romero)Learning Dependent-Concepts in ILP: Application to Model-Driven Data Warehouses (Moez Essaidi, Aomar Osmani and Céline Rouveirol)Graph Contraction Pattern Matching for Graphs of Bounded Treewidth (Takashi Yamada and Takayoshi Shoudai)mLynx: Relational Mutual Information (Nicola Di Mauro, Teresa M A Basile, Stefano Ferilli and Floriana Esposito)Theory:Machine Learning Coalgebraic Proofs (Ekaterina Komendantskaya)Can ILP Deal with Incomplete and Vague Structured Knowledge? (Francesca A Lisi and Umberto Straccia)Logical Learning:Towards Efficient Higher-Order Logic Learning in a First-Order Datalog Framework (Niels Pahlavi and Stephen H Muggleton)Automatic Invention of Functional Abstractions (Robert J Henderson and Stephen H Muggleton)Constraints:Using Machine-Generated Soft Constraints for Roster Problems (Yoshihisa Shiina and Hayato Ohwada)Spatial and Temporal:Relational Learning for Football-Related Predictions (Jan Van Haaren and Guy Van den Broeck) Readership: Graduate students and researchers in the field of ILP, and academics and researchers in the fields of artificial intelligence and natural sciences. Key Features:Covers major areas of research in ILPProvides an up-to-date insight into the key sub-areas of implementation and theory of ILPThe papers in this volume do not appear in conference proceedings elsewhere in the literatureKeywords:Machine Learning;Logic Programs;Inductive Inference;Structure Learning;Relational Learning;Statistical Relational Learning

Trp Channels In Drug Discovery

Author : Arpad Szallasi
ISBN : 162703076X
Genre : Medical
File Size : 52. 83 MB
Format : PDF
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Recent findings have implied a distinct therapeutic potential for drugs targeting Transient Receptor Potential (TRP) channels in a wide variety of diseases, many with no existing satisfactory treatment options. Thus, the TRP superfamily of ion channels has attracted a great deal of well-deserved attention. TRP Channels in Drug Discovery provides a thorough collection of the most up-to-date reviews and protocols on the subject, coming from top experts in the field. Volume I presents a series of state-of-the-art minireviews on the most interesting TRP channels (from TRPA1 to TRPV4), as well as TRP-related protocols involving airways and the genitourinary tract. Written for the Methods in Pharmacology and ToxicologyTM series, this work includes the kind of detailed description and key implementation advice that ensures successful results in the lab. Comprehensive and cutting-edge, TRP Channels in Drug Discovery serves as an ideal reference for graduate students in academic laboratories as well as for pharmaceutical scientists developing new drugs and clinicians interested in novel drugs in the pipeline.

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