virus dynamics mathematical principles of immunology and virology

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Virus Dynamics Mathematical Principles Of Immunology And Virology

Author : Martin Nowak
ISBN : 0191588512
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File Size : 54. 95 MB
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This groundbreaking book describes the emerging field of theoretical immunology, in particular the use of mathematical models to describe the spread of infectious diseases within patients. It reveals fascinating insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. Structured around the examples of HIV/AIDS and hepatitis B, Nowak and May show how mathematical models can help researchers to understand the detailed dynamics of infection and the effects of antiviral therapy. Models are developed to describe the dynamics of drug resistance, immune responses, viral evolution and mutation, and to optimise the design of therapy and vaccines. - ;We know, down to the tiniest details, the molecular structure of the human immunodeficiency virus (HIV). Yet despite this tremendous accomplishment, and despite other remarkable advances in our understanding of individual viruses and cells of the immune system, we still have no agreed understanding of the ultimate course and variability of the pathogenesis of AIDS. Gaps in our understanding like these impede our efforts towards developing effective therapies and preventive vaccines. Martin Nowak and Robert M May describe the emerging field of theoretical immunology in this accessible and well- written text. Using mathematical modelling techniques, the authors set out their ideas about how populations of viruses and populations of immune system cells may interact in various circumstances, and how infectious diseases spread within patients. They explain how this approach to understanding infectious diseases can reveal insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. The book is structured around the examples of HIV/AIDS and Hepatitis B virus, although the approaches described will be more widely applicable. The authors use mathematical tools to uncover the detailed dynamics of the infection and the effects of antiviral therapy. Models are developed to describe the emergence of drug resistance, and the dynamics of immune responses, viral evolution, and mutation. The practical implications of this work for optimisation of the design of therapy and vaccines are discussed. The book concludes with a glance towards the future of this fascinating, and potentially highly useful, field of study. - ;... an excellent introduction to a field that has the potential to advance substantially our understanding of the complex interplay between virus and host - Nature

Virus Dynamics

Author : Martin Nowak
ISBN : 0198504179
Genre : Science
File Size : 24. 8 MB
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This groundbreaking book describes the emerging field of theoretical immunology, in particular the use of mathematical models to describe the spread of infectious diseases within patients. It reveals fascinating insights into the dynamics of viral and other infections, and the interactions between infectious agents and immune responses. Structured around the examples of HIV/AIDS and hepatitis B, Nowak and May show how mathematical models can help researchers to understand the detailed dynamics of infection and the effects of antiviral therapy. Models are developed to describe the dynamics of drug resistance, immune responses, viral evolution and mutation, and to optimise the design of therapy and vaccines.

Evolution Games And God

Author : Martin A. Nowak
ISBN : 9780674075535
Genre : Science
File Size : 57. 50 MB
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Evolution, Games, and God explores how cooperation and altruism, alongside mutation and natural selection, play a critical role in evolution, from microbes to human societies. Inheriting a tendency to cooperate and self-sacrifice on behalf of others may be as beneficial to a population’s survival as the self-preserving instincts of individuals.

Supercooperators

Author : Martin Nowak
ISBN : 9781451626636
Genre : Mathematics
File Size : 43. 45 MB
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Examines the importance of cooperation in human beings and in nature, arguing that this social tool is as an important aspect of evolution as mutation and natural selection.

Insect Infection And Immunity

Author : Jens Rolff
ISBN : 9780199551354
Genre : Science
File Size : 77. 74 MB
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The study of insect immune systems has accelerated rapidly in recent years & is now becoming an important interdisciplinary field. This book provides a coherent synthesis & is clearly structured around three broadly themed sections: mechanisms, interactions, & evolutionary ecology.

An Introduction To Mathematical Modeling In Physiology Cell Biology And Immunology

Author : James Sneyd
ISBN : 0821867644
Genre : Medical
File Size : 34. 25 MB
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In many respects, biology is the new frontier for applied mathematicians. This book demonstrates the important role mathematics plays in the study of some biological problems. It introduces mathematicians to the biological sciences and provides enough mathematics for bioscientists to appreciate the utility of the modelling approach. The book presents a number of diverse topics, such as neurophysiology, cell biology, immunology, and human genetics. It examines how research is done,what mathematics is used, what the outstanding questions are, and how to enter the field. Also given is a brief historical survey of each topic, putting current research into perspective. The book is suitable for mathematicians and biologists interested in mathematical methods in biology.

Evolutionary Dynamics

Author : Martin A. Nowak
ISBN : 9780674417755
Genre : Science
File Size : 45. 86 MB
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At a time of unprecedented expansion in the life sciences, evolution is the one theory that transcends all of biology. Any observation of a living system must ultimately be interpreted in the context of its evolution. Evolutionary change is the consequence of mutation and natural selection, which are two concepts that can be described by mathematical equations. Evolutionary Dynamics is concerned with these equations of life. In this book, Martin A. Nowak draws on the languages of biology and mathematics to outline the mathematical principles according to which life evolves. His work introduces readers to the powerful yet simple laws that govern the evolution of living systems, no matter how complicated they might seem. Evolution has become a mathematical theory, Nowak suggests, and any idea of an evolutionary process or mechanism should be studied in the context of the mathematical equations of evolutionary dynamics. His book presents a range of analytical tools that can be used to this end: fitness landscapes, mutation matrices, genomic sequence space, random drift, quasispecies, replicators, the Prisoner’s Dilemma, games in finite and infinite populations, evolutionary graph theory, games on grids, evolutionary kaleidoscopes, fractals, and spatial chaos. Nowak then shows how evolutionary dynamics applies to critical real-world problems, including the progression of viral diseases such as AIDS, the virulence of infectious agents, the unpredictable mutations that lead to cancer, the evolution of altruism, and even the evolution of human language. His book makes a clear and compelling case for understanding every living system—and everything that arises as a consequence of living systems—in terms of evolutionary dynamics.

Geometric Mechanics And Symmetry

Author : Darryl D. Holm
ISBN : 9780199212903
Genre : Mathematics
File Size : 60. 51 MB
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Geometric Mechanics and Symmetry is a friendly and fast-paced introduction to the geometric approach to classical mechanics, suitable for a one- or two- semester course for beginning graduate students or advanced undergraduates. It fills a gap between traditional classical mechanics texts and advanced modern mathematical treatments of the subject.The modern geometric approach illuminates and unifies manyseemingly disparate mechanical problems from several areas of science and engineering. In particular, the book concentrates on the similarities between finite-dimensional rigid body motion and infinite-dimensional systems such asfluid flow. The illustrations and examples, together with a large number of exercises, both solved and unsolved, make the book particularly useful.

Quantitative Methods For Hiv Aids Research

Author : Cliburn Chan
ISBN : 9781351647120
Genre : Mathematics
File Size : 28. 81 MB
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Quantitative Methods in HIV/AIDS Research provides a comprehensive discussion of modern statistical approaches for the analysis of HIV/AIDS data. The first section focuses on statistical issues in clinical trials and epidemiology that are unique to or particularly challenging in HIV/AIDS research; the second section focuses on the analysis of laboratory data used for immune monitoring, biomarker discovery and vaccine development; the final section focuses on statistical issues in the mathematical modeling of HIV/AIDS pathogenesis, treatment and epidemiology. This book brings together a broad perspective of new quantitative methods in HIV/AIDS research, contributed by statisticians and mathematicians immersed in HIV research, many of whom are current or previous leaders of CFAR quantitative cores. It is the editors’ hope that the work will inspire more statisticians, mathematicians and computer scientists to collaborate and contribute to the interdisciplinary challenges of understanding and addressing the AIDS pandemic.

Fenner And White S Medical Virology 5

Author : Christopher J. Burrell
ISBN : 9780123751577
Genre : Science
File Size : 43. 96 MB
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Fenner and White's Medical Virology, Fifth Edition provides an integrated view of related sciences, from cell biology, to medical epidemiology and human social behavior. The perspective represented by this book, that of medical virology as an infectious disease science, is meant to provide a starting point, an anchor, for those who must relate the subject to clinical practice, public health practice, scholarly research, and other endeavors. The book presents detailed exposition on the properties of viruses, how viruses replicate, and how viruses cause disease. These chapters are then followed by an overview of the principles of diagnosis, epidemiology, and how virus infections can be controlled. The first section concludes with a discussion on emergence and attempts to predict the next major public health challenges. These form a guide for delving into the specific diseases of interest to the reader as described in Part II. This lucid and concise, yet comprehensive, text is admirably suited to the needs of not only advanced students of science and medicine, but also postgraduate students, teachers, and research workers in all areas of virology. Features updated and expanded coverage of pathogenesis and immunity Contains the latest laboratory diagnostic methods Provides insights into clinical features of human viral disease, vaccines, chemotherapy, epidemiology, and control

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