botulinum-neurotoxin

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Botulinum Neurotoxin Injection Manual

Author : Katharine E. Alter, MD
ISBN : 9781617052095
Genre : Medical
File Size : 74. 79 MB
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The Essential Guide for Clinicians Who Prescribe and Inject BoNTs This is a detailed and practical guide to botulinum neurotoxin therapy (BoNT) and the wide range of applications for neurological and pain disorders. A unique reference source for new injectors and experienced clinicians alike, this indispensable manual provides information on dose, dilution, and indications for all four FDA-approved toxins in one handy text. Following a brief review of relevant pharmacology, the book provides product information and comparative distinctions between the four FDA-approved toxins (BotoxÆ, MyoblocÆ, XeominÆ, and DysportÆ), along with indications and doses for FDA-approved conditions, guidance techniques, and common and emerging clinical applications. The heart of the book is an injection manual, organized anatomically and by condition and covering all applications for medical treatment. For each condition or site, information is provided on typical muscle pattern or muscle groups involved, dosing guidelines and dilution for the applicable toxins, number of injection sites, and potential risks and benefits. Targeting techniques are organized in table format for quick retrieval. Anatomic illustrations and cross-sections are provided to orient injectors and help identify optimal insertion points. An appendix with useful clinical rating scales is also included. Key Features: Presents state-of-the-art information about current indications for all four FDA-approved botulinum neurotoxins Compares and contrasts the four toxins along with common and emerging clinical applications Provides dosing guidelines for various indications and injection sites for each muscle Includes anatomic drawings and cross-sections to illustrate muscle relationships and insertion points Serves as a practical, portable, how-to guide for new and experienced clinicians

Clinical Applications Of Botulinum Neurotoxin

Author : Keith A. Foster
ISBN : 9781493902613
Genre : Science
File Size : 37. 64 MB
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Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins and is both up to date and authoritative.

Botulinum Neurotoxin And Tetanus Toxin

Author : Lance Simpson
ISBN : 9780323141604
Genre : Health & Fitness
File Size : 20. 6 MB
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Botulinum Neurotoxin and Tetanus Toxin covers the mechanism of action, pathogenesis, and treatment of clostridial neurotoxins. The book is organized into four parts encompassing 18 chapters that discuss the origin, structure, pharmacology, toxicology, immunology, assays, and clinical issues of botulinum and tetanus neurotoxins. The introductory part of the book discusses the discovery and production of neurotoxins in various strains of Clostridium bacteria. This text also describes how specific bacteriophages and plasmids mediate the pathogenicity of some types of Clostridium botulinum and Clostridium tetani. The subsequent part provides an overview of issues related to toxin binding, including toxins that may serve as models for botulinum and tetanus neurotoxins. Discussions on the peripheral and central aspects of poisoning transport in the central nervous system and on the antagonistic drugs for clostridial neurotoxins are provided. The third part of the book addresses the antibodies against botulinum neurotoxin. Bioassay in mice and highly sensitive immunoassays, such as reversed passive hemagglutination, reversed passive latex agglutination, radioimmunoassay, and enzyme-linked immunosorbent assay, are presented. The concluding part covers the animal models for these toxins and discusses the diagnosis and treatment of botulism and tetanus in human. The clinical use of Clostridium botulinum toxin type A in ocular and neuromuscular disease is also examined. This book will be of value to protein chemists, microbiologists, virologists, pharmacologists, immunologists, and clinicians.

Botulinum Neurotoxins

Author : Andreas Rummel
ISBN : 9783642335709
Genre : Medical
File Size : 84. 50 MB
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The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion. Also basic scientists value the botulinum neurotoxin as molecular tool for dissecting mechanisms of exocytosis. This book will cover the most recent molecular details of botulinum neurotoxin, its mechanism of action as well as its detection and application.

Molecular Aspects Of Botulinum Neurotoxin

Author : Keith A. Foster
ISBN : 9781461494546
Genre : Science
File Size : 75. 24 MB
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Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation with a focus on clinical application. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins and is both up to date and authoritative.

Botulinum Neurotoxins For Head And Neck Disorders

Author : Andrew Blitzer
ISBN : 9781604065862
Genre : Medical
File Size : 31. 71 MB
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Learn expert injection techniques with this multimedia reference guide to the therapeutic uses of botulinum neurotoxin Containing detailed injection instructions, Botulinum Neurotoxin for Head and Neck Disorders and the associated how-to videos offer otolaryngologists, neurologists, pain specialists, and others a complete guide to the management of motor, sensory and autonomic disorders of the head and neck region with botulinum neurotoxin. It covers treatment methods for conditions ranging from hyperfunctional motor disorders (dystonia, tremor, dysphagia), to afferent pain disorders (temporomandibular joint disorder, migraine, trigeminal neuralgia) to autonomic disorders (hypersalivation, Frey's syndrome). In each of the indications, the written material reviews the effects of the toxin on the nervous system, central pain thresholds, and central motor pathways. Special Features: Reviews the pharmacology, indications, mechanisms of action, and technique for each use of botulinum neurotoxin Provides detailed information on the anatomy, treatment methods, follow-up care, and possible complications for each disorder Includes online access to professionally produced videos in which Dr. Blitzer demonstrates injection techniques for the disorders in the book Contains vivid, full color illustrations and photographs that clarify information in the text Focusing specifically on injection techniques for the therapeutic uses of botulinum neurotoxin for treating head and neck disorders, this manual fills an important gap in the literature. It gives clinicians current, authoritative, and in-depth information on administering botulinum neurotoxin most effectively for the head and neck disorders of their patients.

Botulinum Toxins In Dermatology

Author : Joel L. Cohen
ISBN : 9781444338256
Genre :
File Size : 58. 46 MB
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Manual Of Botulinum Toxin Therapy

Author : Daniel Truong
ISBN : 9781107025356
Genre : Medical
File Size : 32. 7 MB
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"This book tries to answer many of the questions posed above with the contributions of a team of international experts. As in the first edition, the emphasis in this book is on technique, so it is richly endowed with illustrations concerning accurate access techniques to help physicians become facile and fully competent"--Provided by publisher.

Botulinum Neurotoxin Complex

Author : Jiarong Flora Chen
ISBN : UCAL:C3409179
Genre :
File Size : 24. 9 MB
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Botulinum And Tetanus Neurotoxins

Author : B.R. DasGupta
ISBN : 9781475795424
Genre : Medical
File Size : 73. 49 MB
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Three days in Madison have thoroughly modified my view on clostridial neurotoxins. While still realizing the numerous activating, modifying and protective inputs, I cannot judge the meaningfulness of the meeting impartially. Neither may the reader expect a complete summary of all presentations. Collected in this volume, they speak for themselves without requiring an arbiter. Instead I shall write down my very personal opinions as a researcher who has studied clostridial neurotoxins for nearly 25 years. Comparable conferences have been rare during this time. A comprehensive symposium 4 on C. botulinum neurotoxins has been organized at Ft. Detrick. International conferences on tetanus have been held regularly under the auspices of the Wodd Health Organization. One or maximally two days of these meetings have been devoted to tetanus toxin and its actions whereas the sponsor and the majority of the participants have been interested mainly in epidemiology, prevention and treatment of tetanus as a disease (see refs. 5,6). Some aspects of clostridial neurotoxins have been addressed in the context of bacterial toxins, in particular in the biennial European workshops. 1-3,7,8 The Madison meeting differed from the previous ones in three aspects. First, it covered both tetanus and botulinum neurotoxins. The fusion was justified because of their huge similarities in primary structure, in their mode of action and in their cellular targets. Second, the meeting was not limited to toxins but drew some lines on which modern neurobiology might proceed.

Botulinum Toxin Dosing Manual

Author : Katharine E. Alter, MD
ISBN : 9780826147660
Genre : Medical
File Size : 56. 35 MB
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Configured for quick point-of-care consult, Botulinum Toxin Dosing Manual is the must-have resource for practitioners and trainees at any level. This practical compendium provides comprehensive information on applications and dosing guidelines for all four FDA-approved toxins, and also includes agency-approved indications and ranges for Canada, the UK, and selected EU countries. Detailed botulinum toxin (or neurotoxin) (BoNT) dosage information is presented in an easy-to-navigate table format. The tables are organized by clinical indication along with each agency-approved dosage where available and the published dosage ranges per treatment session and per structure injected. Covering applications for neurological, urological, neurosecretory, and pain conditions with side-by-side product dosing comparisons, the guide allows clinicians to quickly calculate the dosage of a given BoNT product for a particular indication and/or structure and choose the best option for treatment. Anatomical illustrations are provided at the end of the book to enhance the localization of muscles and other target structures during the injection planning process. This handy manual is indispensable for new injectors and experienced clinicians alike, who need to stay current with the ever-expanding indications and dosage recommendations to create effective treatment plans for their patients. Key Features: Up-to-date guidelines and dosage ranges for FDA-approved botulinum toxins and applications for adults and children; includes agency-approved ranges for Canada, the UK, and EU Current information on published dosage ranges from studies for FDA-approved botulinum toxins fit for adults and children for most clinical applications Information organized in user-friendly table format to speed dosage calculation for clinicians treating patients with BoNT Published dosing recommendations for a wide variety of indications by muscle or group, dilution, injection sites, and more Anatomic drawings illustrate muscle relationships and insertion points

Mechanism Of Botulinum Neurotoxin B Entry Into Cells And Novel Ways To Detect Botulinum Neurotoxin Activity

Author : Min Dong
ISBN : WISC:89090640707
Genre :
File Size : 57. 81 MB
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Botulinum Toxin E Book

Author : Joseph Jankovic
ISBN : 9781437711196
Genre : Medical
File Size : 47. 5 MB
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The new, therapeutically-focused Botulinum Toxin presents comprehensive, cross-disciplinary guidance on current practices, covering more than 100 non-cosmetic conditions that occur in neurology, physical medicine and rehabilitation, pain medicine, ophthalmology, gastroenterology, urology, orthopedics, and surgery. International contributors review the current understanding of the biology and cellular mechanisms along with relevant research so you can easily apply them to the pathophysiology of the numerous disorders that botulinum toxin is used to treat—such as botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. With discussions of the latest in approved treatment practices as well as new and emerging uses, you’ll get in-depth management guidance on the application of the toxin. Provides clinical applications of botulinum toxin for over 100 disorders for immediate access and easy reference during practice and treatment. Covers a broad array of hot topics, including botulinum toxin applications for the treatment of cranial-cervical dystonias, motor disorders in cerebral palsy, bruxism and temporomandibular disorders, headache, overactive bladder, chronic pelvic pain syndromes, arthritis joint pain, and wound healing. Focuses on approved uses with expert advice on thoroughly tested applications but also discusses new and emerging applications to expose you to additional treatment options. Presents the most comprehensive and up-to-date material available so you get all the information you need from this one resource. Offers the cross-disciplinary guidance of the best world-class expertise through an authoritative, international group of authors who demonstrate the applications of botulinum toxin across various specialties.

Botulinum Neurotoxin Production By Clostridium Botulinum Strain Loch Maree

Author : Sherly Bellevue
ISBN : WISC:89095899480
Genre :
File Size : 51. 28 MB
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Characterization And Stabilization Of Clostridium Botulinum Neurotoxin For Medical Use

Author : Michael Charles Goodnough
ISBN : WISC:89052289881
Genre :
File Size : 65. 61 MB
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Botulinum Toxin E Book

Author : Alastair Carruthers
ISBN : 9781455737765
Genre : Medical
File Size : 41. 11 MB
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This title in the PROCEDURES IN COSMETIC DERMATOLOGY SERIES presents up-to-the-minute, practical guidance on botulinum toxin injection techniques shaping today's practice. Succinctly written and lavishly illustrated, it focuses on procedural how-to's and offers step-by-step advice on proper techniques, pitfalls, and tricks of the trade—so you can refine and hone your skills...and expand your surgical repertoire. You'll find current, to-the-point guidance on the cosmetic use of the toxin — edited by pioneers in the field, Drs. Jean and Alastair Carruthers. Implement the newest procedures into your practice immediately and confidently—with the outstanding guidance you'll find in this volume of the PROCEDURES IN COSMETIC DERMATOLOGY SERIES. Covers the hottest topics—including botox aesthetics, facial treatments, neck treatment, adjunctive treatment, pain relief, and facial asymmetry—all in one concise, accessible volume. Features a wealth of color illustrations and photographs that depict cases as they present in practice. Discusses common pitfalls and emphasizes how to optimize outcomes, enabling readers to improve their technique. Highlights emerging topics in the field, with guidance on the newest developments in cosmetic surgery. Includes a comprehensive, instructional DVD containing video clips of techniques and procedures as well as the experts' hints and tips. Use of fillers in combination with Botox to better sculpt the lower face Coverage of new fillers like Juvederm, Evolence, Radiesse and Perlane to keep you on the cutting edge New and expanded coverage of periocular treatment Highest quality video footage of procedures on the bonus DVD

Synthesis Of Mechanism Based Inhibitors Of Botulinum Neurotoxin Serotypes A And B

Author : Matthias Brewer
ISBN : WISC:89084036656
Genre :
File Size : 59. 43 MB
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Botulinum Toxin In Clinical Dermatology

Author : Anthony V. Benedetto
ISBN : 9780203495056
Genre : Medical
File Size : 79. 2 MB
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Botulinum Toxin in Clinical Dermatology explores botulinum toxin, from its early recognition as a food borne toxin to its current form as a pharmaceutical injectible. This high quality, well-illustrated, practical manual presents the latest on the clinical use of the different types of botulinum toxins available and presents in a clear and concise way all the pertinent and up-to-date information on how to inject botulinum toxin and avoid complications. Packed with clinical photographs and scientific drawings, each chapter addresses a different aspect of the topic. This is the most comprehensive and authoritative reference for cosmetic injections of botulinum toxin for removal of facial and neck wrinkles.

Botulinum Neurotoxin

Author : Chong-Tae Kim
ISBN : 0323697151
Genre : Medical
File Size : 26. 67 MB
Format : PDF
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A practical, how-to guide for both new and experienced clinicians, Botulinum Neurotoxin: A Guide to Motor Point Injections identifies the correct motor points for botulinum neurotoxin (BoNT) injections for non-cosmetic purposes such as muscle dystonia, muscle spasticity, teeth grinding, or drooling. Dr. Chong-Tae Kim expertly guides readers through the efficient blocking of neurotransmitters using BoNT, identifying target muscles and clearly demonstrating how to identify optimal insertion points. Covers both the upper and lower extremities and how to select target muscles for specific deformities. Includes illustrations and photographs to illustrate muscle relationships and correct insertion points. Uses consistent labelling and coding throughout to provide an easy-to-follow, image-guided approach. Presents information in two parts: Part 1 covers BoNT injections to individual motor points of muscles of the face, neck, trunk, and extremities, along with superb visual guidance. Part 2 discusses how to select target muscles for BoNT injections to treat deformities caused by muscle hyperactivity. Consolidates today's available information on this timely topic into a single, convenient resource

Hyperhidrosis And Botulinum Toxin In Dermatology

Author : Oliver Philip Kreyden
ISBN : 9783805573061
Genre : Medical
File Size : 75. 2 MB
Format : PDF
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In this publication a comprehensive overview on the pathophysiology and treatment of hyperhidrosis with a focus on the new therapy with botulinum toxin is given by renowned experts from Europe and the USA. In the first part the pathophysiology of hyperhidrosis, rare forms of sweating and their symptoms, as well as the different topical and surgical treatments for focal hyperhidrosis are discussed. The second part deals with botulinum toxin. Besides a historic survey of the drug the reader is introduced to the pharmacological particularities and the different modalities of treatment for focal hyperhidrosis. Complications and side effects of the therapy are presented as well. The final chapter is reserved for other dermatological indications like anal fissure and wrinkles.

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