cytokine-knockouts

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Cytokine Knockouts

Author : Scott K. Durum
ISBN : 9781475727531
Genre : Medical
File Size : 31. 35 MB
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My personal history in the field of cytokines had an initial period of several years during which my student and then colleague, Werner Muller, tried in vain to attract me to them. My interest always vanished when I was confronted with complex data pointing to func tional redundancy of cytokines in cell culture systems. When gene targeting in the mouse germline became possible, this frustration came to an end. We and others immediately embarked on analyzing the in vivo function of cytokines and the problem of functional redundancy with this powerful new approach. The early cytokine gene knockouts performed by colleagues in Wiirzburg (IL-2) and by ourselves (IL-4 and IL-l 0) seemed to give clear answers and at the same time led to surprises: Each of these cytokines apparently had its own special and irreplaceable function, and this function could be quite distinct from what had been anticipated from functional experiments in vitro. Al though the latter finding is of course a wonderful incentive for fur ther research, the former is pleasing in a general sense since it highlights the value of each of those one hundred thousand genes or so in our genome, cherished by evolution to become respectable mem bers of the community. Even in the present era of "genomics" there will be no way around the careful functional analysis of each gene by itself.

Cytokine Knockouts

Author : Giamila Fantuzzi
ISBN : 9781592594054
Genre : Medical
File Size : 43. 14 MB
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Carrying on the high standards of the much praised first edition (Durum and Muegge, Cytokine Knockouts, 1998), Giamila Fantuzzi and a panel of experts have generated completely new chapters to reflect the use of many novel mouse strains and the hundreds of recent studies on cytokine physiology. Comprehensive reviews of the numerous often-surprising results obtained using cytokine knockout mice are provided, along with much important information about cytokine biology and physiology. For those not familiar with cytokine research, the authors present a critical discussion of the advantages and disadvantages of using cytokine knockout mice in various fields of research.

Index Medicus

Author :
ISBN : OSU:32436011091731
Genre : Medicine
File Size : 55. 34 MB
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Clinical Applications Of Cytokines And Growth Factors

Author : John R. Wingard
ISBN : 0792384865
Genre : Medical
File Size : 44. 47 MB
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The hematopoietic system plays roles that are crucial for survival of the host: delivery of oxygen to tissues, arrest of accidental blood leaking from blood vessels, and fending off of invading microbes by humoral, cell-mediated, and phagocytic immunity. The activity of the hematopoietic system is staggering: daily, a normal adult produces approximately 2.5 billion erythrocytes, 2.5 billion platelets, and 1 billion granulocytes per kilogram of body weight. This production is adjusted in a timely fashion to changes in actual needs and can vary from nearly none to many times the normal rate depending on needs which vary from day to day, or even minute to minute. In response to a variety of stimuli, the cellular components of the blood are promptly increased or decreased in production to maintain appropriate numbers to optimally protect the host from hypoxia, infection, and hemorrhage. How does this all happen and happen without over or under responding? There has been extraordinary growth in our understanding ofhematopoiesis over the last two decades. Occupying center stage is the pluripotent stern cell and its progeny. Hematopoietic stern cells have been characterized by their capacity for self renewal and their ability to proliferate and differentiate along multiple lineages. Few in number, the stern cell gives rise to all circulating neutrophils, erythrocytes, lymphoid cells, and platelets. In hematopoietic transplantation, the stern cell is capable of restoring long-term hematopoiesis in a lethally irradiated host.

Cytokines And Cytokine Receptors

Author : Giorgio Trinchieri
ISBN : NWU:35557000187938
Genre : Cytokines
File Size : 38. 16 MB
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Bacteria Cytokine Interactions In Health And Disease

Author : Brian Henderson
ISBN : WISC:89065347601
Genre : Bacteria
File Size : 35. 74 MB
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This volume brings together the current literature on bacterial virulence and on cytokines to produce a synthesis that attempts to explain how infectious and commensal bacteria interact with man. An explanation is provided for this failure to respond to normal microflora.

Environmental Health Perspectives

Author :
ISBN : UCR:31210012361885
Genre : Environmental health
File Size : 76. 4 MB
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The Journal Of Immunology

Author :
ISBN : UIUC:30112077266259
Genre : Immunology
File Size : 30. 54 MB
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Biochemicals And Reagents For Life Science Research

Author : Sigma Chemical Company
ISBN : UCLA:L0078493749
Genre : Biological reagents
File Size : 75. 75 MB
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Cytokines In Liver Injury And Repair

Author : A.M. Gressner
ISBN : 0792387759
Genre : Medical
File Size : 21. 68 MB
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This book, the proceedings of Falk Symposium No. 125 on 'Cytokines in Liver Injury and Repair' (Progress in Gastroenterology and Hepatology Part II), held in Hannover, Germany, on September 30 - October 1, 2001, provides an update of our current knowledge on the role of cytokines in various human and experimental liver diseases and on their present and prospective use in therapeutic trials. The book contains chapters by most well-known experts in the field who have contributed significantly to our present knowledge on cytokines in liver injury and repair.

Transactions Of The Annual Meeting Of The Orthopaedic Research Society

Author : Orthopaedic Research Society. Meeting
ISBN : UOM:39015045495507
Genre : Orthopedics
File Size : 64. 49 MB
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Consists of the transactions of the 22nd- annual meeting of the society.

Cytokine Therapeutics In Infectious Diseases

Author : Steven Matthew Holland
ISBN : UOM:39015051434457
Genre : Medical
File Size : 67. 88 MB
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Cytokine Therapeutics in Infectious Diseases provides a comprehensive analysis of the role cytokines fulfill in fighting infectious diseases. Structured to disclose clinical discoveries with clarity and accessibility, the information on therapeutic cytokines is linked to specific diseases. The book closes with a discussion about future directions for research, applications, and studies.

European Cytokine Network

Author :
ISBN : UCLA:L0098849011
Genre :
File Size : 76. 88 MB
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Icn

Author : ICN Pharmaceuticals, inc
ISBN : STANFORD:36105011581159
Genre : Biotechnology
File Size : 63. 82 MB
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Overexpression And Knockout Of Cytokines In Transgenic Mice

Author : Chaim O. Jacob
ISBN : UOM:39015031823753
Genre : Medical
File Size : 44. 58 MB
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The intricate ways in which they act, often with the exhibition of pleiotropic or synergistic effects, make the study of cytokine biology complicated, and the results potentially ambiguous using conventional systems. As a consequence, many investigators are now utilizing the powerful tools of transgenic technology to address some of these questions.

Neuroimmunomodulation

Author :
ISBN : UCLA:L0081604233
Genre : Immune response
File Size : 45. 39 MB
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Inflammatory Bowel Disease

Author : Joseph B. Kirsner
ISBN : UOM:39015048934429
Genre : Inflammatory bowel diseases
File Size : 45. 28 MB
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World-renowned experts present state-of-the-art information in the clinical understanding of inflammatory bowel disease in the 5th Edition of this best-selling text. Scholarly and pragmatic, this text features authoritative information on the medical and surgical management of IBD with the support of over 390 illustrations. Features many new chapters, including those covering intestinal permeability in health and disease, the intestinal response to acute inflammation and injuries, and current concepts of IBD etiology and pathogenesis.

Neuroimmunomodulation

Author : Ario Conti
ISBN : UVA:X004521489
Genre : Medical
File Size : 32. 51 MB
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These proceedings focus on different areas of research, with special emphasis on relating the state of the art (basic) neuroimmunomodulation research to its potential practical application in specific fields. Among these, the role of pro-and anti-inflammatory cytokines in the central nervous system; peripheral mechanisms of neuroimmunomodulation; behavioural studies and immunity; and neuroimmunomodulation correlates in autoimmune disease represent areas of particular interest. Also highlighted are studies related to the role of melatonin as an immunomodulatory hormone (an area of explosive growth), as well as the emerging field of neuroendocrine regulation of haematopoiesis. Clinical studies in cancer, allergy, AIDs and other infectious diseases will focus upon neuroimmunomodulation-based mechanisms, and suggest new therapeutic approaches.

The Cytokine Handbook

Author : Michael T Lotze
ISBN : UOM:39015047074433
Genre : Science
File Size : 27. 23 MB
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The Third Edition of the Cytokine Handbook provides encyclopedic coverage of the hemopoietic growth factors and the interleukin and interferon families of molecules, cytokine by cytokine. This new edition is completely revised to bring the reader the most up-to-date information on all of the important cytokines and cytokine receptors with the inclusion of new members of the interleukin family (up to IL-18), in depth treatment of cytokine receptors, as well as individual chapters on stem cell factor and flt3 ligand, gene therapy, and the chemokines. The Cytokine Handbook explains in detail the immunology and molecular biology of these molecules and their receptors, and discusses in additional chapters their therapeutic potential, assay systems, and phylogeny. It is written in an easy-to-follow style and includes an extensive bibliography. This book is a must for the library of any researcher or clinician interested in, or bewildered by, the diversity of cytokines. Key Features * Up-to-date material includes new members of the interleukin family (up to IL-18) * In-depth treatment of cytokine receptors * Individual chapters on stem cell factor and flt3 ligand, gene therapy, and the chemokines

Seltzer And Bender S Dental Pulp

Author : Israel B. Bender
ISBN : UOM:39015055598885
Genre : Medical
File Size : 50. 80 MB
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Nearly three decades ago, Samuel Seltzer and I. B. Bender pioneered the concept of developing biologically based recommendations for the clinical practice of endodontics and restorative dentistry. This concept was the cornerstone of their classic textbook, "The Dental Pulp". "Seltzer and Bender's Dental Pulp" represents the evolution of that book and of the philosophical principles on which it was based. Today we know that pulp tissue plays a central role in both local and systemic health. This book presents the latest research on the dental pulp and its interaction with other tissues. Each chapter provides an introduction to its major themes for the busy clinician or dental student, as well as a set of biologically based clinical recommendations for restorative and endodontic procedures. Practicing clinicians need this information to provide accurate diagnoses and effective treatment to their patients.

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