essential-oncology-of-the-lymphocyte

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Essential Oncology Of The Lymphocyte

Author : Ian J. Forbes
ISBN : 9781447114673
Genre : Medical
File Size : 79. 47 MB
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This book has been written from two points of view: firstly, from the viewpoint of those who are involved in the diagnosis and treatment of lymphoid malignancies, who must meet the challenge of integrating the new biological insights into their knowledge of these diseases; and secondly, from the viewpoint of those who are involved in basic biological approaches to malignancy and immunology, who wish to know more about the function of the lymphoid tissues and their malignant diseases. Neoplasia of lymphocytes is a focus for considering many of the most important biological advances impinging on cancer in the past two or three decades, because malignant lymphoproliferative diseases offer unequalled opportunities for studying many aspects of cancer. We probably know more about lymphocytes than other normal cells because of the ease with which they can be obtained. For the same reason we probably know more about malignant lymphocytes. One or other aspect of most of the momentous advances in biology of the past two or three decades has implications for lymphoid malignancies: hybridoma technology and the use of monoclonal antibodies, gene technology, the understanding of oncogenes and growth factors in the control of growth and differentiation, insights into causation of cancer by potent tumour promoters such as the phorbol esters and by viruses, and knowledge of the control of growth function of lymphocytes themselves. Conversely, many of the advances in understanding lym phocytic leukaemias and lymphomas have implications for other cancers.

Essential Oncology Of The Lymphocyte

Author : Ian J Forbes
ISBN : 144711468X
Genre :
File Size : 60. 73 MB
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The Biology Of Cancer

Author : Janice Ann Gabriel
ISBN : 0470518170
Genre : Medical
File Size : 71. 22 MB
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Advances in research and the treatment of cancer mean that more patients and their carers are asking healthcare professionals about the latest treatments and how they may be of benefit. It is essential that staff working with cancer patients understand fully how these new treatments work in order to disseminate timely and appropriate information to patients. The application of biology to the delivery of cancer care is playing an ever-increasing role in the management of these diseases. The Biology of Cancer: Second Edition provides details of the most recent developments in cancer care and is divided into three sections: Understanding Cancer – examines predisposing factors to developing cancer, diagnosis and its implications on the individual and society. The Science of Cancer – a closer look at the cell, genetics, the immune system, tumour markers and monoclonal antibodies. Research and Treatment – exploring translational oncology, applying research methodology to cancer research and research ethics relating to cancer. This fully updated edition also looks at evidence-based research that can be translated directly to patient care and gives details recent developments. Written by experienced, practicing healthcare professionals, The Biology of Cancer: Second Edition can easily be applied to patient care. It is an informative text for students, newly qualified nurses and practising oncology/palliative care nurses.

Lymphocyte Updates

Author : Gheorghita Isvoranu
ISBN : 9789535133438
Genre : Medical
File Size : 79. 59 MB
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This book represents a synergic effort of an international team of specialists in immunology to expand the scientific achievements in the field of lymphocytes. It offers important and specific updated information to researchers, students, teachers, and medical professionals. Moreover, considering the remarkable dynamics of immunology and immunotherapy, this book "Lymphocyte Updates - Cancer, Autoimmunity, and Infection" aims to represent a significant source of concise scientific data and advancement of knowledge in this field. The chapters offer new insights into the latest scientific progress on lymphocyte roles in protective immunity, as well as their involvement in pathogenesis of various disorders.

Research Awards Index

Author :
ISBN : MINN:30000008789061
Genre : Medicine
File Size : 70. 40 MB
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Lymphocytes In Immunotherapy Of Cancer

Author : Paul Koldovsky
ISBN : 3540504575
Genre : Medical
File Size : 56. 36 MB
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In the past, research in cancer immunology has produced informa tion important for other medical disciplines. It helped, for example, in formulating the laws of immunogenetics and in achieving a better understanding of the mechanism governing the fate of allotrans planted tissue. Cancer has often been considered a foreign body, and therefore many attempts have been made to cure it on the basis of the immunological principles applicable to parasitic, bacterial, or viral diseases. Vaccination has been investigated clinically for its po tential to prevent cancer [1], and clinical research into the cure of cancer has included active immunization [2], nonspecific stimulation of defense mechanisms [3], and transfer of passive immunity by cells [4] or by antibodies [5]. These experiments have been of limited value and in some cases have even had an adverse effect. The reputation of cancer immunology has suffered, and the concept has often been severely criticized. However, the basic postulate that cancer must originate from the body's own cells, and that the immune system belongs to the principal regulatory mechanisms, remains valid. In recent years new research into clinical cancer immunotherapy has included critical appraisal of all its potential benefits, and also of the risks and limitations. It is dangerous to make unrealistic promises or to speak or think in terms of "miracle weapons" or a "magic bul let.

Essential General Surgical Oncology

Author : Irving Taylor
ISBN : UOM:39015038444116
Genre : Cancer
File Size : 48. 16 MB
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This practical text on surgical oncology is aimed at surgical trainees and practising general surgeons. It covers the principles of cancer treatment, the application of diagnostic methods, clinical practice for all the different areas of the body, and miscellaneous topics such as pain management.

Cancer Immunology Immunotherapy

Author :
ISBN : NWU:35558001826722
Genre :
File Size : 66. 51 MB
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Medical Oncology

Author : Paul Calabresi
ISBN : NWU:35558004775736
Genre : Medical
File Size : 38. 46 MB
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The first edition pioneered new territory in the literature as the only definitive text-reference devoted to cancer management by the internist or primary care physician. Now as more & more cancer patients are being managed by this group, the second edition of Medical Oncology: Basic Principles & Clinical Management comes at the ideal time. The book is completely revised with new material on: Cancer & Pregnancy, AIDS, integration of molecular biology of cancer & new biologic response modifiers, plus timely coverage of how to effectively manage the cancer patient in the office setting; expanded coverage of nursing in cancer & completely revamped section on supportive care.

Detection Of Lymphocyte Sensitization In Cancer Patients To Encephalitogenic Factor Ef And Cancer Basic Proteins Cabp Using The Technique Of Cytophoresis

Author : Basil Chiu
ISBN : OCLC:10610224
Genre :
File Size : 40. 64 MB
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Research Grants Index

Author : National Institutes of Health (U.S.). Division of Research Grants
ISBN : UOM:39015072175246
Genre : Medicine
File Size : 20. 72 MB
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Cancer Immunotherapy Principles And Practice Second Edition

Author : Lisa H. Butterfield, PhD
ISBN : 9780826137432
Genre : Medical
File Size : 85. 47 MB
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Thoroughly updated to reflect major advances in the field of immuno-oncology, this second edition of Cancer Immunotherapy Principles and Practice, from the Society for Immunotherapy of Cancer (SITC), remains the definitive resource for information on tumor immunology and cancer immunotherapy treatments. An essential reference for both novice and experienced cancer researchers, oncologists, and related practitioners alike, the book not only guides readers through the fundamental scientific principles of the field all the way to translational and practical clinical applications for treating and managing oncologic disease, but also provides a comprehensive understanding of the regulatory processes that support the safe and effective delivery of immunotherapy to patients with cancer. The expanded and updated second edition now spans 68 chapters, including 12 new chapters, covering major topics and innovations that have shaped the rapid development of immunotherapy and its ascension into the standard of care as first-line treatment for a growing number of disease settings. New to this edition are chapters with deeper insight into our understanding of cancer genomics and determinants of response, immunogenic cell death, cancer and stromal cell-intrinsic pathways of immune resistance, cancer immune exclusion, adoptive cell therapy, metabolomics, tumor mutation burden, immunotherapy in combination with radiation therapy, synthetic biology, and more. Complete with detailed illustrations, tables, and key points for targeted reference, Cancer Immunotherapy Principles and Practice, Second Edition is the most comprehensive and authoritative resource for scientists and clinicians looking to expand their knowledge base of this dynamic field. Key Features: Offers key insights and perspectives on cancer immunology and immunotherapy treatments from renowned experts in the field Covers the basic principles and science behind cancer immunotherapy and tumor immunology Includes treatment strategies for a vast array of available immunotherapy classes and agents, such as cytokine therapies, oncolytic viruses, cancer vaccines, CAR T therapies, and combination immunotherapies Provides essential information on FDA-approved immunotherapies, including clinical management and outcome data related to response rates, risks, and toxicities Discusses special considerations for immunotherapy in the context of specific disease settings, including skin cancers, genitourinary cancers, gastrointestinal cancers, hepatocellular carcinomas, gynecologic malignancies, breast cancers, lung cancers, head and neck cancers, brain tumors, sarcomas, pediatric cancers, and treatments combined with radiation therapy Clarifies the complex regulatory aspects behind the development and approval of immunotherapy drugs

Emerging Concepts Targeting Immune Checkpoints In Cancer And Autoimmunity

Author : Akihiko Yoshimura
ISBN : 9783319689296
Genre : Medical
File Size : 85. 5 MB
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This volume reviews the current state of research on immune checkpoints and offers novel concepts. It discusses the two most important immune checkpoints: T lymphocyte-associated antigen-4 (CTLA-4) and programmed cell death-1 (PD-1). It shows that antagonistic antibodies against these two molecules are highly effective in the treatment of various cancers and that PD-1 and CTLA-4 have been linked to the suppression of T-cell receptor signaling and co-stimulatory molecules. Further, the volume examines other agents, a number of cells, receptors and signaling molecules, that are also involved in the regulation of T-cell activation and extends the concept of immune checkpoints to “molecules and cells that negatively regulate T-cell activation”. Playing essential roles in immune homeostasis, they could offer new targets for cancer immunotherapy, and for the therapy of autoimmune diseases. Written by internationally respected scientists, this book will appeal to basic scientists, clinicians, drug development researchers, and advanced students alike.

Lymphocyte Sparing Radiation Therapy For Stage Iii Nsclc A Dosimetric Study

Author : Patrícia Henriques Fernandes
ISBN : OCLC:1293441634
Genre :
File Size : 64. 94 MB
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The influence of the immune system on the outcome of cancer patients is becoming clear in the past years, with the increasing role of immunotherapy in oncology. Radiotherapy (RT) plays a crucial role in cancer treatment but is also one of the main causes of lymphocytopenia, a phenomenon that has been linked to worse clinical outcomes. Despite all these recent findings, lymphocyte related organs at risk (LOAR) are usually not considered for treatment plan optimization or approval. The aim of this work is to study the feasibility of including the LOAR in the treatment plan optimization for stage III Non-Small Cells Lung Carcinoma (NSCLC) and determine if it is possible to reduce the dose to these organs while guarantying target coverage, respecting conventional organs at risk dose constraints as well as plan quality.*****The influence of the immune system on the outcome of cancer patients is becoming clear in the past years, with the increasing role of immunotherapy in oncology. Radiotherapy (RT) plays a crucial role in cancer treatment but is also one of the main causes of lymphocytopenia, a phenomenon that has been linked to worse clinical outcomes. Despite all these recent findings, lymphocyte related organs at risk (LOAR) are usually not considered for treatment plan optimization or approval. The aim of this work is to study the feasibility of including the LOAR in the treatment plan optimization for stage III Non-Small Cells Lung Carcinoma (NSCLC) and determine if it is possible to reduce the dose to these organs while guarantying target coverage, respecting conventional organs at risk dose constraints as well as plan quality.

Archives Of Virology

Author :
ISBN : UCAL:B4884488
Genre : Virology
File Size : 80. 29 MB
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Subject Index Of Current Extramural Research Administered By The National Cancer Institute

Author : National Cancer Institute (U.S.)
ISBN : UOM:39015010012675
Genre : Cancer
File Size : 55. 55 MB
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Provides information concerning research grants and contracts supported by the National Cancer Institute.

Haematology Nursing

Author : Marvelle Brown
ISBN : 9781118276129
Genre : Medical
File Size : 34. 15 MB
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Haematology Nursing is a comprehensive handbook, with a nursing focus, on the care and management of patients with haematological disorders. Divided into four sections, the first provides an introduction to haematology, looking at haemopoiesis, immunology and genetics. Section Two covers non-malignant haematology, including anaemia, haemoglobinopathies and haemochromatosis. Section Three explores the pathophysiology, care and management of myeloproliferative and lymphoproliferative disorders, including leukaemia, myeloma, and lymphoma. The final section provides information on various nursing care interventions, including blood transfusion, venous access devices, and palliative care. Aimed principally at nurses working in a variety of settings including haematology/oncology wards, medical/haematology wards, specialist bone marrow transplant centres, and community settings, Haematology Nursing is an essential and much-needed reference guide.

Subject Index Of Extramural Research Administered By The National Cancer Institute

Author :
ISBN : MINN:31951D03885829Q
Genre : Cancer
File Size : 86. 68 MB
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Current information about research grants and contracts supported by the National Cancer Institute. Subject listing gives contract or grant number and topic. Investigator, grant number, and contract number indexes.

Basic And Clinical Tumor Immunology

Author : Ronald B. Herberman
ISBN : 9781461338734
Genre : Medical
File Size : 26. 78 MB
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Where do you begin to look for a recent, authoritative article on the diagnosis or management of a particular malignancy? The few general onco logy textbooks are generally out of date. Single papers in specialized journals are informative but seldom comprehensive; these are more often prelimi nary reports on a very limited number of patients. Certain general journals frequently publish good indepth reviews of cancer topics, and published symposium lectures are often the best overviews available. Unfortunately, these reviews and supplements appear sporadically, and the reader can never be sure when a topic of special interest will be covered. Cancer Treatment and Research is a series of authoritative volumes which aim to meet this need. It is an attempt to establish a critical mass of oncology literature covering virtually all oncology topics, revised frequently to keep the coverage up to date, easily available on a single library shelf or by a single personal subscription. We have approached the problem in the following fashion. First, by divid ing the oncology literature into specific subdivisions such as lung cancer, genitourinary cancer, pediatric oncology, etc. Second, by asking eminent authorities in each of these areas to edit a volume on the specific topic on an annual or biannual basis. Each topic and tumor type is covered in a volume appearing frequently and predictably, discussing current diagnosis, staging, markers, all forms of treatment modalities, basic biology, and more.

Allogeneic Immunotherapy For Malignant Diseases

Author : John Barrett
ISBN : 9780824746766
Genre : Medical
File Size : 60. 96 MB
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This important reference offers a comprehensive review of the graft-versus-leukemia (GVL) or -tumor (GVT) effect following allogeneic stem cell transplantation and lymphocyte transfusion, covering a wide range of topics from alloimmune responses to clinical applications of GVL, and providing the basics to understand the mechanisms of the GVL effect while demonstrating methods that use the GVL effect to cure a greater number of cancer patients. Presents preliminary data supporting the idea that allogeneic cell therapy can be used not only for the treatment of leukemia but also for metastatic solid tumors! Written by over 40 world renowned experts in the field and containing more than 1450 references for in-depth exploration of the subject, Allogeneic Immunotherapy for Malignant Diseases investigates the capacity of the donor-and the host-to destroy residual leukemia cells by allogeneic immune reaction determines how to direct immune reactions against hematopoietic malignancies safely reveals which other malignant conditions may be responsive to allogeneic-mediated graft-versus-tumor reactions covers the mechanisms that contribute to the development of responses to minor histocompatibility complex (mHC) molecules focuses on the biology of effector cells and their role in mediating GVL reactions in chronic myeloid leukemia (CML) summarizes the putative impact of human mHag on the GVL effect in bone marrow transplantation (BMT) addresses the potential and limitations of oncogene-based immunotherapy examines ways to isolate and control the GVL component of allograft immunity discusses efforts to develop specific anti-leukemic T-cell immunotherapy and more! Attributing the curative effect of allogeneic stem cell transplantation to the GVL or GVT effect, Allogeneic Immunotherapy for Malignant Diseases is an indispensable reference for hematologists, clinical oncologists, immunologists and researchers in the fields of tumor immunology and cancer immunotherapy, internists, residents, and medical school students in these disciplines.

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