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Fundamentals Of Contemporary Mass Spectrometry

Author : Chhabil Dass
ISBN : 9780470118481
Genre : Science
File Size : 63. 7 MB
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Modern mass spectrometry - the instrumentation and applications in diverse fields Mass spectrometry has played a pivotal role in a variety of scientific disciplines. Today it is an integral part of proteomics and drug discovery process. Fundamentals of Contemporary Mass Spectrometry gives readers a concise and authoritative overview of modern mass spectrometry instrumentation, techniques, and applications, including the latest developments. After an introduction to the history of mass spectrometry and the basic underlying concepts, it covers: Instrumentation, including modes of ionization, condensed phase ionization techniques, mass analysis and ion detection, tandem mass spectrometry, and hyphenated separation techniques Organic and inorganic mass spectrometry Biological mass spectrometry, including the analysis of proteins and peptides, oligosaccharides, lipids, oligonucleotides, and other biological materials Applications to quantitative analysis Based on proven teaching principles, each chapter is complete with a concise overview, highlighted key points, practice exercises, and references to additional resources. Hints and solutions to the exercises are provided in an appendix. To facilitate learning and improve problem-solving skills, several worked-out examples are included. This is a great textbook for graduate students in chemistry, and a robust, practical resource for researchers and scientists, professors, laboratory managers, technicians, and others. It gives scientists in diverse disciplines a practical foundation in modern mass spectrometry.

Fundamentals Of Mass Spectrometry

Author : Kenzo Hiraoka
ISBN : 9781461472339
Genre : Science
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Most research and all publications in mass spectrometry address either applications or practical questions of procedure. This book, in contrast, discusses the fundamentals of mass spectrometry. Since these basics (physics, chemistry, kinetics, and thermodynamics) were worked out in the 20th century, they are rarely addressed nowadays and young scientists have no opportunity to learn them. This book reviews a number of useful methods in mass spectrometry and explains not only the details of the methods but the theoretical underpinning.

Fundamentals And Applications Of Fourier Transform Mass Spectrometry

Author : Philippe Schmitt-Kopplin
ISBN : 9780128140147
Genre : Science
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Fundamentals and Applications of Fourier Transform Mass Spectrometry is the first book to delve into the underlying principles on the topic and their linkage to industrial applications. Drs. Schmitt-Kopplin and Kanawati have brought together a team of leading experts in their respective fields to present this technique from many different perspectives, describing, at length, the pros and cons of FT-ICR and Orbitrap. Numerous examples help researchers decide which instruments to use for their particular scientific problem and which data analysis methods should be applied to get the most out of their data. Covers FT-ICR-MS and Orbitrap’s fundamentals, enhancing researcher knowledge Includes details on ion sources, data processing, chemical analysis and imaging Provides examples across the wide spectrum of applications, including omics, environmental, chemical, pharmaceutical and food analysis

Fundamentals Of Integrated Gc Ms Mass Spectrometry

Author : Benjamin J. Gudzinowicz
ISBN : MINN:31951D00129115A
Genre : Chromatographic analysis
File Size : 21. 38 MB
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Inorganic Mass Spectrometry

Author : Christopher Barshick
ISBN : 0824702433
Genre : Science
File Size : 28. 68 MB
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Providing a theoretical background for inorganic mass spectrometry, this text describes classical applications of four modern mass spectrometers - magnetic sector, quadrupole, time-of-flight, and ion trap - and illustrates how they have impacted elemental and isotopic analysis. The book features examples that concentrate on routine and non-routine applications of inorganic analysis techniques.

Handbook Of Gc Ms

Author : Hans-Joachim Hübschmann
ISBN : 9783527334742
Genre : Science
File Size : 60. 11 MB
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The only comprehensive reference on this popular and rapidly developing technique provides a detailed overview, ranging from fundamentals to applications, including a section on the evaluation of GC-MS analyses. As such, it covers all aspects, including the theory and principles, as well as a broad range of real-life examples taken from laboratories in environmental, food, pharmaceutical and clinical analysis. It also features a glossary of approximately 300 terms and a substance index that facilitates finding a specific application. For this new edition the work has been now extended to two volumes, reflecting the latest developments in the technique and related instrumentation, while also incorporating several new examples of applications in many fields. The first two editions were very well received, making this handbook a must-have in all analytical laboratories using GC-MS.

Electrospray And Maldi Mass Spectrometry

Author : Richard B. Cole
ISBN : 9781118211557
Genre : Science
File Size : 78. 91 MB
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Discover how advances in mass spectrometry are fueling newdiscoveries across a broad range of research areas Electrospray and MALDI Mass Spectrometry brings both veteranpractitioners and beginning scientists up to date with the mostrecent trends and findings in electrospray ionization andmatrix-assisted laser desorption/ionization (MALDI) massspectrometry. In particular, this Second Edition highlights howadvances in electrospray and MALDI mass spectrometry are supportingimportant discoveries in new and emerging fields such as proteomicsand metabolomics as well as in traditional areas of chemistry andphysics research. Electrospray AND MALDI Mass Spectrometry, SECOND EDITION isdivided into five parts: Part A, Fundamentals of ES, explains the fundamental phenomenaunderlying the electrospray process, including selectivity inionization and inherent electrochemistry, and concludes with achapter offering a comparative inventory of source hardware Part B, Fundamentals of MALDI, confronts ionization mechanisms,instrument development, and matrix selection, and includes a finalchapter that explores the special application of MALDI to obtaintwo-dimensional images of spatial distributions of compounds onsurfaces Part C, ES and MALDI Coupling to Mass SpectrometryInstrumentation, examines the coupling of these ionizationtechniques to various mass analyzers, including quadrupole iontrap, time-of-flight, Fourier transform ion cyclotron resonance,and ion mobility mass spectrometers Part D, Practical Aspects of ES and MALDI, investigatesanalytical issues including quantification, charge-statedistributions, noncovalent interactions in solution that arepreserved as gas-phase ions, and various means of ion excitation inpreparation for tandem mass spectrometry, and offers a guide to theinterpretation of even-electron mass spectra Part E, Biological Applications of ES and MALDI, examines therole of mass spectrometry in such areas as peptide and proteincharacterization, carbohydrate analysis, lipid analysis, and drugdiscovery Written by a team of leading experts, the book not only providesa critical review of the literature, but also presents key conceptsin tutorial fashion to help readers take full advantage of thelatest technological breakthroughs and applications. As a result,Electrospray and MALDI Mass Spectrometry will help researchersfully leverage the power of electrospray and MALDI massspectrometry. The judicious compartmentalization of chapters, andthe pedagogic presentation style throughout, render the book highlysuitable for use as a text for graduate-level courses in advancedmass spectrometry.

Inorganic Mass Spectrometry

Author : Sabine Becker
ISBN : 0470517204
Genre : Science
File Size : 79. 77 MB
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Providing an exhaustive review of this topic, Inorganic Mass Spectrometry: Principles and Applications provides details on all aspects of inorganic mass spectrometry, from a historical overview of the topic to the principles and functions of mass separation and ion detection systems. Offering a comprehensive treatment of inorganic mass spectrometry, topics covered include: Recent developments in instrumentation Developing analytical techniques for measurements of trace and ultratrace impurities in different materials This broad textbook in inorganic mass spectrometry, presents the most important mass spectrometric techniques used in all fields of analytical chemistry. By covering recent developments and advances in all fields of inorganic mass spectrometry, this text provides researchers and students with information to answer any questions on this topic as well as providing the basic fundamentals for understanding this potentially complex, but increasingly relevant subject.

Advances In Ion Mobility Mass Spectrometry Fundamentals Instrumentation And Applications

Author :
ISBN : 9780444641557
Genre : Science
File Size : 44. 57 MB
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Ion Mobility Spectrometry, Volume 83 will focuses on new trends, methods and instrumentation in the field, starting from the innovations of each technique, to the most progressive challenges of IM-MS. Chapters includes section on Recent advances in IM-MS, IM-MS Principles and Theory, IM-MS Applications and Instrumentation, and the Future of IM-MS. Presents the latest advancements in IM-MS that are essential for new applications Helps readers understand the state-of-the-art in the currently available IM-MS interfaces and their principle uses Provides information on different IM-MS instrumentation Delves into key applications of IM-MS

Hydrogen Exchange Mass Spectrometry Of Proteins

Author : David D. Weis
ISBN : 9781118616499
Genre : SCIENCE
File Size : 30. 45 MB
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Hydrogen exchange mass spectrometry is widely recognized for its ability to probe the structure and dynamics of proteins. The application of this technique is becoming widespread due to its versatility for providing structural information about challenging biological macromolecules such as antibodies, flexible proteins and glycoproteins. Although the technique has been around for 25 years, this is the first definitive book devoted entirely to the topic. Hydrogen Exchange Mass Spectrometry of Proteins: Fundamentals, Methods and Applications brings into one comprehensive volume the theory, instrumentation and applications of Hydrogen Exchange Mass Spectrometry (HX-MS) - a technique relevant to bioanalytical chemistry, protein science and pharmaceuticals. The book provides a solid foundation in the basics of the technique and data interpretation to inform readers of current research in the method, and provides illustrative examples of its use in bio- and pharmaceutical chemistry and biophysics In-depth chapters on the fundamental theory of hydrogen exchange, and tutorial chapters on measurement and data analysis provide the essential background for those ready to adopt HX-MS. Expert users may advance their current understanding through chapters on methods including membrane protein analysis, alternative proteases, millisecond hydrogen exchange, top-down mass spectrometry, histidine exchange and method validation. All readers can explore the diversity of HX-MS applications in areas such as ligand binding, membrane proteins, drug discovery, therapeutic protein formulation, biocomparability, and intrinsically disordered proteins.

The Encyclopedia Of Mass Spectrometry

Author : Michael L. Gross
ISBN : UCSD:31822034188235
Genre : Mass spectrometry
File Size : 47. 81 MB
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Electrospray Ionization Mass Spectrometry

Author : Richard B. Cole
ISBN : UOM:39015056304408
Genre : Science
File Size : 43. 51 MB
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Comprehensive, up-to-date coverage of a revolutionary technique Electrospray ionization mass spectrometry (ESI-MS) has completely changed the way physicists, chemists, and biologists view the study of large molecules. The technique derives detailed information about molecular weights and structures from extremely small sample quantities. ESI-MS can create highly charged forms of very high molecular weight compounds, it is naturally compatible with many types of separation techniques, and it allows noncovalent interactions between molecules in solution to be preserved in the gas phase. But many researchers may not use the technique to its full potential because they are unfamiliar with the different perspectives of its underlying processes, the varied approaches to implementation, and the wide-ranging utility of the technique. In this book, Richard B. Cole and an assemblage of leading researchers present a single-volume compilation of different approaches to the understanding and exploitation of ESI-MS. This comprehensive guide: * Examines the physical and chemical aspects of the electrospray process and describes the events involved in ion formation as well as the electro-chemical phenomena that are central to charged droplet formation during the process * Explores the coupling of electrospray ionization to various mass spectrometers, including quadrupole, magnetic, time-of-flight, quadrupole ion trap, and Fourier transform ion cyclotron resonance instruments * Describes recent progress in interfacing ESI with solution-based separation techniques, including liquid chromatography and capillary electrophoresis * Charts the rapid development of ESI applications and categorizes them by compound type: peptides and proteins, nucleic acids and their constituents, carbohydrates and lipids, small molecules related to pharmacology and drug metabolism, and organometallics and inorganic compounds Electrospray Ionization Mass Spectrometry is the indispensable handbook and reference for anyone who wishes to understand, implement, or apply this technique, including researchers in chemistry, metallochemistry, biochemistry, biology, pharmacology, and physics.

Understanding Mass Spectra

Author : R. Martin Smith
ISBN : 9780471479345
Genre : Science
File Size : 60. 60 MB
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Understanding Mass Spectra: A Basic Approach, Second Editioncombines coverage of the principles underlying mass spectralanalysis with clear guidelines on how to apply them in a laboratorysetting. Completely revised from the first edition, an updated andunified approach to mass spectral interpretation emphasizes theapplication of basic principles from undergraduate organic,analytical, and physical chemistry courses. A detailed overview of theory and instrumentation, this usefulguide contains step-by-step descriptions of interpretativestrategies and convenient lists and tables detailing theinformation needed to solve unknowns. Other features includereal-world case studies and examples, skill-building problems withclearly explained answers, and easy-to-follow explanations of theimportant mathematical derivations.

Ion Mobility Mass Spectrometry

Author : Alison E. Ashcroft
ISBN : 1839161663
Genre :
File Size : 23. 13 MB
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Providing a comprehensive guide to the technique, each chapter is written by an internationally recognised expert and will help the end users understand the practicalities of using different instruments for different ion mobility purposes.

Advanced Mass Spectrometry

Author : Urs P. Schlunegger
ISBN : 9781483188874
Genre : Science
File Size : 34. 73 MB
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Advanced Mass Spectrometry: Applications in Organic and Analytical Chemistry discusses the concepts that are essential in the effective utilization of mass spectrometry. The title particularly covers the fundamentals of the modern techniques, along with the technological concerns of mass spectrometry. The opening chapter of the selection introduces mass spectrometry, while the subsequent chapters cover the fundamentals and hardware. The next chapters talk about the analytical chemistry consequences and the ion-genetic relationships. The remaining chapter covers the application of mass spectrometry, which includes structural, mechanistic, chemical, and biochemical applications. The book will be of great use to organic and analytical chemists. Chemists from other branch of chemistry, along with practitioners of related fields such as chemical engineering will also benefit from the text.

Comprehensive Coordination Chemistry Ii Fundamentals Physical Methods Theoretical Analysis And Case Studies

Author : Jon A. McCleverty
ISBN : 0080443249
Genre : Coordination compounds
File Size : 82. 53 MB
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Computational Methods For Mass Spectrometry Proteomics

Author : Ingvar Eidhammer
ISBN : 0470724293
Genre : Medical
File Size : 74. 35 MB
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Proteomics is the study of the subsets of proteins present in different parts of an organism and how they change with time and varying conditions. Mass spectrometry is the leading technology used in proteomics, and the field relies heavily on bioinformatics to process and analyze the acquired data. Since recent years have seen tremendous developments in instrumentation and proteomics-related bioinformatics, there is clearly a need for a solid introduction to the crossroads where proteomics and bioinformatics meet. Computational Methods for Mass Spectrometry Proteomics describes the different instruments and methodologies used in proteomics in a unified manner. The authors put an emphasis on the computational methods for the different phases of a proteomics analysis, but the underlying principles in protein chemistry and instrument technology are also described. The book is illustrated by a number of figures and examples, and contains exercises for the reader. Written in an accessible yet rigorous style, it is a valuable reference for both informaticians and biologists. Computational Methods for Mass Spectrometry Proteomics is suited for advanced undergraduate and graduate students of bioinformatics and molecular biology with an interest in proteomics. It also provides a good introduction and reference source for researchers new to proteomics, and for people who come into more peripheral contact with the field.

Fundamentals And Applications Of Gas Phase Ion Chemistry

Author : K.R. Jennings
ISBN : 079235463X
Genre : Science
File Size : 66. 7 MB
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Proceedings of the NATO Advanced Study Institute, Grainau, Germany, 7-8 August 1995

Gas Chromatography And Mass Spectrometry A Practical Guide

Author : O. David Sparkman
ISBN : 0080920152
Genre : Science
File Size : 69. 69 MB
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The second edition of Gas Chromatography and Mass Spectrometry: A Practical Guide follows the highly successful first edition by F.G. Kitson, B.S. Larsen, and C.N. McEwen (1996), which was designed as an indispensible resource for GC/MS practitioners regardless of whether they are a novice or well experienced. The Fundamentals section has been extensively reworked from the original edition to give more depth of an understanding of the techniques and science involved with GC/MS. Even with this expansion, the original brevity and simple didactic style has been retained. Information on chromatographic peak deconvolution has been added along with a more in-depth understanding of the use of mass spectral databases in the identification of unknowns. Since the last edition, a number of advances in GC inlet systems and sample introduction techniques have occurred, and they are included in the new edition. Other updates include a discussion on fast GC and options for combining GC detectors with mass spectrometry. The section regarding GC Conditions, Derivatization, and Mass Spectral Interpretation of Specific Compound Types has the same number of compound types as the original edition, but the information in each section has been expanded to not only explain some of the spectra but to also explain why certain fragmentations take place. The number of Appendices has been increased from 12 to 17. The Appendix on Atomic Masses and Isotope Abundances has been expanded to provide tools to aid in determination of elemental composition from isotope peak intensity ratios. An appendix with examples on "Steps to follow in the determination of elemental compositions based on isotope peak intensities" has been added. Appendices on whether to use GC/MS or LC/MS, third-party software for use in data analysis, list of information required in reporting GC/MS data, X+1 and X+2 peak relative intensities based on the number of atoms of carbon in an ion, and list of available EI mass spectral databases have been added. Others such as the ones on derivatization, isotope peak patterns for ions with Cl and/or Br, terms used in GC and in mass spectrometry, and tips on setting up, maintaining and troubleshooting a GC/MS system have all been expanded and updated. Covers the practical instruction necessary for successful operation of GC/MS equipment Reviews the latest advances in instrumentation, ionization methods, and quantitation Includes troubleshooting techniques and a variety of additional information useful for the GC/MS practitioner A true benchtop reference A guide to a basic understanding of the components of a Gas Chromatograph-Mass Spectrometer (GC-MS) Quick References to data interpretation Ready source for information on new analyses

Fundamentals Of Integrated Gc Ms Gas Chromatography

Author : Benjamin J. Gudzinowicz
ISBN : MINN:31951000465039X
Genre : Science
File Size : 88. 43 MB
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