fusion protein technologies for biopharmaceuticals

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Fusion Protein Technologies For Biopharmaceuticals

Author : Stefan R. Schmidt
ISBN : 9781118354582
Genre : Medical
File Size : 59. 32 MB
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The state of the art in biopharmaceutical FUSION PROTEINDESIGN Fusion proteins belong to the most lucrative biotechdrugs—with Enbrel® being one of the best-sellingbiologics worldwide. Enbrel® represents a milestone of moderntherapies just as Humulin®, the first therapeutic recombinantprotein for human use, approved by the FDA in 1982 andOrthoclone® the first monoclonal antibody reaching the marketin 1986. These first generation molecules were soon followed by aplethora of recombinant copies of natural human proteins, and in1998, the first de novo designed fusion protein was launched. Fusion Protein Technologies for Biopharmaceuticalsexamines the state of the art in developing fusion proteins forbiopharmaceuticals, shedding light on the immense potentialinherent in fusion protein design and functionality. A widepantheon of international scientists and researchers deliver acomprehensive and complete overview of therapeutic fusion proteins,combining the success stories of marketed drugs with the dynamicpreclinical and clinical research into novel drugs designed for asyet unmet medical needs. The book covers the major types of fusionproteins—receptor-traps, immunotoxins, Fc-fusions andpeptibodies—while also detailing the approaches fordeveloping, delivering, and improving the stability of fusionproteins. The main body of the book contains three large sectionsthat address issues key to this specialty: strategies for extendingthe plasma half life, the design of toxic proteins, and utilizingfusion proteins for ultra specific targeting. The book concludeswith novel concepts in this field, including examples of highlyrelevant multifunctional antibodies. Detailing the innovative science, commercial realities, andbrilliant potential of fusion protein therapeutics, FusionProtein Technologies for Biopharmaceuticals is a must forpharmaceutical scientists, biochemists, medicinal chemists,molecular biologists, pharmacologists, and genetic engineersinterested in determining the shape of innovation in the world ofbiopharmaceuticals.

Current Developments In Biotechnology And Bioengineering

Author : Vanete Thomaz Soccol
ISBN : 9780444636713
Genre : Science
File Size : 38. 69 MB
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Current Developments in Biotechnology and Bioengineering: Human and Animal Health Applications provides extensive coverage of new developments, state-of-the-art technologies, and potential future trends, presenting data-based scientific knowledge and information on medical biotechnological interventions for human and animal health. Drawing on the key development areas in this field, the book reviews biotechnological advances and applications in immunotechnology, vaccines and vaccinology, combinatorial libraries, gene and cell therapy, tissue engineering, and parasite and infectious disease diagnostics. This title outlines why biotechnological techniques in these areas are useful in a clinical context and considers their potential uses, limitations, and the ethical considerations surrounding their use. Provides development in human and animal health due to biotechnology Includes immunotechnology and vaccinology Outlines diagnostic techniques based on tissue and metabolic engineering principles Considers potential uses of the various biotechnology based techniques and the ethical issues raised in their use

Manufacturing Of Pharmaceutical Proteins

Author : Stefan Behme
ISBN : 9783527683086
Genre : Science
File Size : 23. 76 MB
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Structured like a textbook, the second edition of this reference covers all aspects of biopharmaceutical manufacturing, including legal and regulatory issues, production facility design, and quality assurance, with a focus on supply chain management and regulations in emerging markets and cost control. The author has longstanding industrial expertise in biopharmaceutical production and years of experience teaching at universities. As such, this practical book is ideal for use in academia as well as for internal training within companies.

Delivery Technologies For Biopharmaceuticals

Author : Lene Jorgensen
ISBN : 9780470688403
Genre : Science
File Size : 79. 60 MB
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Advances in biotechnology have provided scientists with anincreasing number of biopharmaceuticals such as novel peptide andprotein drugs as well as nucleic acid based drugs for gene therapy.However, successful delivery of these biopharmaceuticals is a majorchallenge because their molecular properties lead to poor physicaland chemical stability in the body and limited membranepermeability. Therefore researchers are developing a range of newdelivery technologies and materials to enable these new drugs to bedelivered intact to their target sites. Delivery Technologies forBiopharmaceuticals describes strategies to overcome themain barriers for successful delivery of therapeutic peptides,proteins, and nucleic acid-based drugs or vaccines related to thesite of administration and the target site. Many of the approachesdescribed are reported in formulations in current clinical trialsas well as in marketed products. Contents include: challenges in delivery of biopharmaceuticals novel formulation approaches for peptide and proteininjectables non-viral chemical vectors and viral technology for delivery ofnucleic acid based drugs immune response, adjuvants and delivery systems forvaccines several examples of delivery systems for differentbiopharmaceuticals a critical assessment of delivery technologies forbiopharmaceuticals Delivery Technologies for Biopharmaceuticals is anessential single-volume introduction to the technologies used byresearchers to ensure efficient delivery of this exciting new classof drugs. It will be of value to researchers and students workingin drug delivery, formulation, biopharmaceuticals, medicinalchemistry, and new materials development.

Biotechnology And Biopharmaceutical Manufacturing Processing And Preservation

Author : Kenneth E. Avis
ISBN : 1574910167
Genre : Medical
File Size : 31. 73 MB
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In this unique book, experts describe practices applicable to the large-scale processing of biotechnological products. Beginning with processing and bulk storage preservation techniques, the book provides strategies for improving efficiency of process campaigns of multiple products and manufacturing facilities for such processing techniques. Large-scale chromatography for the purification of biomolecules in manufacturing and lyophilization of protein pharmaceuticals are discussed. Includes a case study on blow-fill-seal processing technology and a chapter on economic and cost factors for bioprocess engineering.

Therapeutic Proteins

Author : Roland Kontermann
ISBN : 9783527644780
Genre : Science
File Size : 29. 89 MB
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For this ready reference, the internationally renowned authority in the field, Roland Kontermann, has assembled a team of outstanding contributors from industry and academia to convey the worldwide knowledge on modifying therapeutic proteins in order to optimize their pharmacological potential. The result is a comprehensive work covering all approaches and aspects of the topic in one handy volume, making this indispensable reading for companies and research institutions working on the development of biopharmaceuticals.

Biophysical Characterization Of Proteins In Developing Biopharmaceuticals

Author : Damian J. Houde
ISBN : 9780444595904
Genre : Science
File Size : 60. 14 MB
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Biophysical Characterization of Proteins in Developing Biopharmaceuticals is concerned with the analysis and characterization of the higher-order structure (HOS) or conformation of protein based drugs. Starting from the very basics of protein structure this book takes the reader on a journey on how to best achieve this goal using the key relevant and practical methods commonly employed in the biopharmaceutical industry today as well as up and coming promising methods that are now gaining increasing attention. As a general resource guide this book has been written with the intent to help today’s industrial scientists working in the biopharmaceutical industry or the scientists of tomorrow who are planning a career in this industry on how to successfully implement these biophysical methodologies. In so doing a keen focus is placed on understanding the capability of these methodologies in terms of what information they can deliver. Aspects of how to best acquire this biophysical information on these very complex drug molecules, while avoiding potential pitfalls, in order to make concise, well informed productive decisions about their development are key points that are also covered. Presents the reader with a clear understanding of the real world issues and challenges in using these methods. Highlights the capabilities and limitations of each method. Discusses how to best analyze the data generated from these methods. Points out what one needs to look for to avoid making faulty conclusions and mistakes. In total it provides a check list or road map that empowers the industrial scientists as to what they need to be concerned with in order to effectively do their part in successfully developing these new drugs in an efficient and cost effective manner.

Genetic Engineering News

Author :
ISBN : STANFORD:36105121623628
Genre : Genetic engineering
File Size : 75. 89 MB
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Cell Technology For Cell Products

Author : Rodney Smith
ISBN : 9781402054761
Genre : Science
File Size : 61. 73 MB
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The 19th ESACT meeting was to highlight the novel capabilities of the industry to move the products towards the clinic. It was attended by a wide range of workers in the industry and for many it was their first ESACT meeting. The proceedings here include the short papers adding the knowledge of the previous meetings and provide a reference for the researcher entering, or continuing in the field of Animal Cell Technology.

Molecular Farming

Author : Rainer Fischer
ISBN : 9783527605811
Genre : Science
File Size : 28. 11 MB
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Here, authors from academia and industry provide an exciting overview of current production technologies and the fascinating possibilities for future applications. Topics include chloroplast-derived antibodies, biopharmaceuticals and edible vaccines, production of antibodies in plants and plant cell suspension cultures, production of spider silk proteins in plants, and glycosylation of plant produced proteins. The whole is rounded off by chapters on the demands and expectations made on molecular farming by pharmaceutical corporations and the choice of crop species in improving recombinant protein levels. Of interest to biotechnologists, gene technologists, molecular biologists and protein biochemists in university as well as the biotechnological and pharmaceutical industries.

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