histophysiology-of-the-circulating-platelet

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Histophysiology Of The Circulating Platelet

Author : Laurenz J. Wurzinger
ISBN : WISC:89031854664
Genre : Medical
File Size : 42. 74 MB
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1. 1 Platelets in Hemostasis and Thrombosis: A Brief Overview For more than 100 years the dominant role of blood platelets in hemostasis and thrombosis has been well documented. Seven years before their identification as a distinct class of blood corpuscles by Bizzozero (1882), Zahn (1875), using intravital microscopic observations, described the growth of an arterial thrombus as the result of "continued apposition of colorless blood corpuscles along the direction of blood flow. " A hallmark still valid today was set by Eberth and Schimmel busch (1888), who clearly divided the formation of the hemostatic plug into the result of the "conglutination of preformed blood corpuscles," followed by the "plasmatic coagulation as the formation of fibrin from substances dissolved in blood," as two distinct processes taking place in the described order. In spite of technical shortcomings, by approaching the limits of the light microscopic techniques of their time, Eberth and Schimmel busch discovered a change in the morphology of the platelets, paralleled by a presumptive change in their functional state, which was a prerequisite for the formation of a platelet plug. Their meticulous description implicitly anticipated the modern terminology of the "smooth disk" as the resting form of the circulating platelet and the activated "spiny sphere" as a result of a change in shape following stimulation.

The Circulating Platelet

Author : Shirley A. Johnson
ISBN : 9780323144322
Genre : Medical
File Size : 77. 23 MB
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The Circulating Platelet focuses on the biochemistry and physiology of platelets. Composed of contributions of authors, the compilation starts with the discussions on the origin, discovery, production, and life span of blood platelets. The discussions continue with the morphology of platelets. Concerns include peripheral, sol-gel, and organelle zones and the membrane systems. The book also looks at the energy metabolism of thrombocytes and highlights the presence of glycoproteins in blood platelets. These include polysaccharides, glucosaminoglycans, and glycoproteins. The text also discusses the properties, functions, and the physiological value of thrombosthenin. The compilation further discusses platelet aggregation and functions of platelets. Concerns include collection and processing of platelets; preparation of homogenates; and the agents that influence platelet aggregation. The role of platelets in blood clots and fibrinolysis is emphasized. The selection ends with discussions on the immunological reactions of platelets; the clinical diseases related to blood platelets; and blood transfusion and preservation. The text is vital for researchers interested in studying blood platelets.

Manual Of Blood Platelets Morphology Physiology And Pharmacology

Author : Gundu HR Rao
ISBN : 9789352702022
Genre : Medical
File Size : 80. 2 MB
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Platelets are tiny blood cells that help the body form clots to stop bleeding. Antiplatelet medications, such as aspirin and clopidogrel, are commonly used to thin the blood which limits clotting and reduces the risk of heart attack. This book is a comprehensive guide to blood platelets for haematologists. Beginning with discussion on platelet structure, morphology, function and physiology, the next chapters cover the role of calcium in platelet activation and calcium modulation by cyclic nucleotides. The following sections explain the pharmacology of antiplatelet drugs, antiplatelet therapies, aspirin resistance, and the association of diabetes mellitus with major platelet dysfunction. The book concludes with chapters on acute coronary problems, interaction between endothelial cells and platelets, and blood biocompatibility studies. Authored by a Minneapolis-based expert in the field, the text is further enhanced by clinical photographs, diagrams and tables. Key points Comprehensive guide to blood platelets for haematologists Extensive coverage of antiplatelet drugs and resistance Recognised author from University of Minnesota Highly illustrated with clinical photographs, diagrams and tables

Platelets

Author : Alan D. Michelson
ISBN : 9780123878373
Genre : Medical
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PLATELETS is the definitive current source of state-of-the-art knowledge about platelets and covers the entire field of platelet biology, pathophysiology, and clinical medicine. Recently there has been a rapid expansion of knowledge in both basic biology and the clinical approach to platelet-related diseases including thrombosis and hemorrhage. Novel platelet function tests, drugs, blood bank storage methods, and gene therapies have been incorporated into patient care or are in development. This book draws all this information into a single, comprehensive and authoritative resource. · First edition won Best Book in Medical Science Award from the Association of American Publishers · Contains fourteen new chapters on topics such as platelet genomics and proteomics, inhibition of platelet function by the endothelium, clinical tests of platelet function, real time in vivo imaging of platelets, and inherited thrombocytopenias · A comprehensive full color reference comprising over 70 chapters, 1400 pages, and 16,000 references

Platelets As Immune Cells In Physiology And Immunopathology

Author : Olivier Garraud
ISBN : 9782889197408
Genre :
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Are platelets cells? (Not everyone agrees, since they are non-nucleate). And if platelets are cells - which all specialists consider at the time being - are they immune cells? The issue that platelets participate in immunity is no longer debated; however, the issue that they are key cells in immunity is challenged. It has even been proposed a couple of years ago that platelets can present antigen to T-lymphocytes by using their HLA class I molecules. No one has the same functional definition of platelets. The ‘Frontiers Research Topic’- coordinators’ own view is that platelets are primarily repairing cells, what they do in deploying tools of physiological inflammation. This function is better acknowledged as primary hemostasis, i.e. platelet adherence to injured or wounded vessels, followed by activation, aggregation, and constitution of the initial clot. Platelets would thus repair damaged vascular endothelium; so doing, as they patrol to detect damages, they sense danger along the vascular arborescence. As the latter is immense, platelets get close to tissues, which are not allowed to them under ‘physiological’ conditions but are readily accessible in pathology. Platelets are equipped with a variety of Pathogen Recognition Receptors such as TLRs; they have a complete signalosome, which is functional until the phosphorylation of NFkB; they have been proved to retro-transcribe RNA and synthesize de novo proteins; etc. Platelets participate to inflammation along the whole spectrum: from physiological (tissue repair, healing) to acute/severe inflammation (as can be seen in e.g. sepsis). In general, platelets engage complex interactions with most infectious pathogens. We propose there to cover those topics - from physiology to pathology, that put platelets within cells that not only take place in-, but also are key players of-, innate immunity. The relation of platelets with adaptive immunity is even more complex. Not everyone is convinced that platelets present antigens; however, platelets influence adaptive immunity since they have mutual interactions with Dendritic cells, Monocytes/Macrophages, and B-lymphocytes (the key players of antigen presentation); they also have mutual interactions with T-lymphocytes, though is issue is less clearly deciphered. We propose to also cover these topics - or to present the forum. There is another issue which is medically relevant - speaking of physiology/physiopathology-: this is fetal maternal incompatibility of platelet specific antigens (the HPA system) and the likely formation of maternal antibodies that often injure the newborn with risks of severe thrombocytopenia and intracranial hemorrhage. We propose an update on this issue as well. Last, platelets are very special because they can be directly therapeutic (by transfusion), even when being offered by a generous blood donor displaying given genetic and phenotypic parameters to a patient/recipient in need, who also display his/her own genetic and phenotypic parameters, which - for a large part - differ from the donor's ones. Besides immunization - via mechanisms probably close to the fetal maternal platelet incompatibility, but likely not similar -, transfusion has allowed the identification of the tremendous capacity of platelets to mediate inflammation: we propose to conclude the Topics with this item/forum.

Platelet Kinetics Imaging

Author : Anthon du P. Heyns
ISBN : 0849354412
Genre : Medical
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Handbook Of Platelet Physiology And Pharmacology

Author : Gundu H.R. Rao
ISBN : 9781461550495
Genre : Science
File Size : 24. 67 MB
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This is the first comprehensive work to review blood platelet biochemistry, physiology, pharmacology, and function. It provides up-to-date information on how platelets function, the biochemical mechanisms that modulate their physiology and function, as well as the pharmacology of platelet inhibitory drugs.

The Physiology Of Hemostasis

Author : Derek. Ogston
ISBN : 9781468473193
Genre : Juvenile Nonfiction
File Size : 81. 28 MB
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The current widespread interest in the hemostatic mechanism stems largely from the probability that its inappropriate function may lead to thrombosis, but also for its relevance to the causation and manage ment of bleeding disorders. Our understanding of the pathological events leading to thrombus formation or abnormal bleeding depends on knowledge of the basic physiology of the hemostatic system. A number of excellent multiauthor texts are available on the general area of hemostasis and thrombosis, and many symposia proceedings on specific topics in hemostasis have been published. The present volume aims to cover the normal function of hemostasis and ex plicitly excludes consideration of disease states and therapy. In addition, it is concerned with human hemostasis only although reference is made to studies on other mammalian species when the information supplements that available on man. The book is divided broadly into two sections. The first covers the current knowledge of the principal components contributing to the hemostatic process; the second examines the changes in these com ponents induced by physiological events, and details an accumula tion of information not previously brought together in a single text. An introductory chapter, intended for the non-specialist, outlines the whole hemostatic process and provides an orientation for the later detailed information on individual components.

A Textbook Of Practical Physiology

Author : CL Ghai
ISBN : 9789350259320
Genre : Medical
File Size : 55. 50 MB
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Pdq Physiology

Author : Uwe Ackermann
ISBN : 1550091484
Genre : Medical
File Size : 90. 43 MB
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PDQ Physiology offers a concise, up-to-date summary of human physiology. It is an ideal resource for the more advanced physiology specialist and health professional requiring a quick view or review. Its perspective is one of integration while incorporating the current understanding in molecular and cellular physiology and offering up-to-date explanations of physiological phenomena. The reader will greatly benefit from the coverage of topics not found in most comprehensive physiology books. PDQ Physiology is more focused on significant points; more current in cardiac, renal, and muscle functions; and is more descriptive in sexuality, reproduction and birth.

The Physiology Of Growth

Author : Richard Goss
ISBN : 9780323149785
Genre : Nature
File Size : 70. 58 MB
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The Physiology of Growth focuses on the physiological mechanisms underlying the growth of organs and tissues such as the epidermis, connective tissues, bone and cartilage, blood cells, and the heart. The atrophy and hypertrophy of muscle, adaptive plasticity of the nervous system, and neural regulation of salivary glands are also explored. Comprised of 24 chapters, this book opens with an overview of the nature of growth, ways to measure growth, and theories of growth. The discussion then turns to the renewal of epidermis; the growth of connective tissues such as collagen and keloids; physical regulation of bone growth and cartilage regrowth; and turnover of blood cells. The following chapters focus on the link between hypertension and heart growth; expansion of arteries and veins; muscle atrophy and hypertrophy; and intraocular regulation of lens development. The effect of lactation on the growth of the mammary glands is also considered, along with liver degeneration and experimental regulation of the testis. This monograph is intended for physiologists, developmental biologists, and students of histology.

Basics Of Medical Physiology

Author : HH Sudhakar D Venkatesh
ISBN : 9789387506534
Genre : Medical
File Size : 88. 83 MB
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About the Book This book explains the basic concepts of medical physiology in a clear and concise style. The fourth edition presents revised and updated text with numerous new diagrams. The Applied Physiology aspect has been suitably emphasized.

National Library Of Medicine Current Catalog

Author : National Library of Medicine (U.S.)
ISBN : OSU:32435027430727
Genre : Medicine
File Size : 81. 94 MB
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Concise Textbook Of Physiology For Dental Students

Author : Tripathi
ISBN : 9788131225318
Genre :
File Size : 83. 56 MB
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Principles Of Sex Based Differences In Physiology

Author : Virginia M. Miller
ISBN : 044451497X
Genre : Science
File Size : 79. 45 MB
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Differences in physiology between men and women extend far beyond differences in reproductive functions. Medical literature abounds in descriptions of differences in prevalence, symptoms and severity of diseases between men and women including heart attack, rheumatic diseases, gastrointestinal disease and osteoporosis. Much of the information is descriptive rather than mechanistic and scattered throughout a variety of books, review articles and original papers. This book provides a single source that summarizes current basic mechanisms of gene/hormone interactions and their subsequent impact on physiological functions. It is an ideal source material to be used in training the next generation of physician/scientists who will develop a more individualized approach to prevention, diagnosis and therapeutic medical practice.

Medical Physiology For Undergraduate Students 2nd Updated Edition Ebook

Author : Indu Khurana
ISBN : 9788131262580
Genre : Medical
File Size : 50. 14 MB
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Encouraged by the response to the first edition, this edition highlights the essential and relevant content of physiology with complete and balanced exposition of text with absolute clarity. With the balanced amalgamation of pure and applied text, authors aspire it to be an indispensable text for undergraduates and an authentic reference source for candidates preparing for PG entrance. Complete and up-to-date text with recent advances incorporated Illustrated by more than 1000 clear line diagrams Complemented with numerous tables and flowcharts for quick comprehension Balanced amalgamation of pure and applied text Highlights applied aspects of physiology in separate boxes Systematic organization of text to facilitate easy review Additional important information has been highlighted in the form of "Important Notes" Core competencies prescribed by the MCI are covered and competency codes are included in the text

Textbook Of Medical Physiology E Book

Author : Indu Khurana
ISBN : 9788131242544
Genre : Medical
File Size : 26. 37 MB
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Prompted by the acceptance of the first edition, this endeavour of the author (the 2nd edition) incorporates thoroughly revised and updated text, organized into twelve sections arranged in three parts. Part I: General Physiology – covers the text in five chapters of a section. Part II: Systemic Physiology – comprises a total of ten sections, one on each body system. Part III: Specialized Integrated Physiology – includes seven chapters arranged in a section. • Text completed and updated with recent advances to cater the needs of postgraduates in Physiology. • Quick introduction to functional anatomy followed by systematic presentation of the text is unique feature of this book. • Inclusion of additional molecular and applied aspects makes the special features of this edition. • Applied physiology, highlighted in the boxes, has been expanded and updated with recent concepts on pathophysiology and advances in basic and advanced investigations and therapeutic principles. • Text and figures in an attractive four colored format. • Illustrated with more than eleven hundred colored diagrams with many new additions. • Complemented with numerous tables and flowcharts for quick comprehension.

Textbook Of Human Physiology For Dental Students

Author : Khurana
ISBN : 8131205924
Genre :
File Size : 40. 2 MB
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The book fully covers the syllabus prescribed by Dental Council of India and presents a thorough exposition of physiology for undergraduate students. The exposition is systematically divided into eleven sections. Each section begins with a brief overview highlighting the topics covered. The subject is then explained in a graded manner with a large number of diagrams, flowcharts and tables to facilitate an easy understanding. About the Author : - Dr.(Mrs.) Indu Khurana, Associate Professor, Department of Physiology, Postgraduate Institute of Medical Sciences, Rohtak, India. She has a rich experience of more than 25 years of teaching and research. She has to her credit the discovery of a new reflex 'the oculodepressor reflex (ODR)' and three distinct patterns of oculorespiratory reflex (ORR), (British Journal of Ophthalmology, 1997). On account of her contribution to the field, her biographical profile was included in the Marqui's 'Who's Who in Science and Engineering'.

Clinical Physiology

Author : Ashis Banerjee
ISBN : 1139445073
Genre : Medical
File Size : 64. 46 MB
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This is an admirably concise and clear guide to fundamental concepts in physiology relevant to clinical practice. It covers all the body systems in an accessible style of presentation. Bulleted checklists and boxed information provide an easy overview and summary of the essentials. By concentrating on the core knowledge of physiology, it will serve as a useful revision aid for all doctors striving to achieve postgraduate qualification, and for anyone needing to refresh their knowledge base in the key elements of clinical physiology. The author's own experience as an examiner at all levels has been distilled here for the benefit of postgraduate trainees and medical and nursing students.

Textbook Of Medical Physiology

Author : Khurana
ISBN : 8181478509
Genre : Human physiology
File Size : 82. 2 MB
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The book presents an exhaustive and thorough exposition of the fundamentals of medical physiology. The exposition is divided systematically into three sections covering General Physiology, Systemic Physiology and Specialized Integrative Physiology. Each section begins with a brief Introduction highlighting the topics covered. The subject is then explained in a graded manner with a large number of tables, flowcharts and diagrams to aid understanding. The level of exposition in the book is sufficiently detailed for it to serve as a useful text for undergraduate courses as well as for PG entrance examinations About the Author : - Indu Khurana, Associate Professor, Department of Physiology, Postgraduate Institute of Medical Sciences, Rohtak, Haryana, India.

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