medicinal natural products

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Medicinal Natural Products

Author : Paul M. Dewick
ISBN : 9781119964575
Genre : Science
File Size : 40. 82 MB
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Medicinal Natural Products: A Biosynthetic Approach, Third Edition, provides a comprehensive and balanced introduction to natural products from a biosynthetic perspective, focussing on the metabolic sequences leading to various classes of natural products. The book builds upon fundamental chemical principles and guides the reader through a wealth of diverse natural metabolites with particular emphasis on those used in medicine. There have been rapid advances in biosynthetic understanding over the past decade through enzymology, gene isolation and genetic engineering. Medicinal Natural Products has been extended and fully updated in this new edition to reflect and explain these developments and other advances in the field. It retains the user-friendly style and highly acclaimed features of previous editions: a comprehensive treatment of plant, microbial, and animal natural products in one volume extensive use of chemical schemes with annotated mechanistic explanations cross-referencing to emphasize links and similarities boxed topics giving further details of medicinal materials, covering sources, production methods, use as drugs, semi-synthetic derivatives and synthetic analogues, and modes of action Medicinal Natural Products: A Biosynthetic Approach, Third Edition, is an invaluable textbook for students of pharmacy, pharmacognosy, medicinal chemistry, biochemistry and natural products chemistry.

Medicinal Natural Products

Author : Paul M. Dewick
ISBN : 0471496413
Genre : Medical
File Size : 52. 10 MB
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Medicinal Natural Products, Second Edition is a comprehensive guide providing information on all classes of natural products in medicine. It builds upon fundamental chemical principles and demonstrates a unique integration of plant, microbial and animal natural products in one volume. The text guides the reader through a wealth of diverse natural metabolites used in medicine with sources, production methods, use as drugs and modes of action all extensively covered. Taking a chemistry based approach it combines traditional pharmacognosy with medicinal chemistry. The structure is user-friendly and includes the acclaimed grey boxes on groups of products and detailed mechanistic explanations. * Adopts a novel biosynthetic theme rather than a traditional descriptive approach * Includes extensive further reading at the end of the chapter * Thoroughly revised and updated to incorporate comprehensive coverage of plant, microbial and animal products * Includes the latest developments in the field * New material on genetic manipulation of biosynthetic pathways and non-mevalonate pathway to terpanoids * User-friendly format including extensive use of chemical schemes with annotated mechanistic explanations

Natural Product Chemistry For Drug Discovery

Author : Antony D. Buss
ISBN : 9780854041930
Genre : Medical
File Size : 26. 40 MB
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This up-to-date summary of natural product chemistry in drug discovery will appeal to scientists, professionals, postgraduates and industrial chemists.

Medicinal Natural Products A Disease Focused Approach

Author :
ISBN : 9780128210208
Genre : Science
File Size : 79. 39 MB
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Medicinal Natural Products: A Disease-Focused Approach, Volume 55 of the Annual Reports in Medicinal Chemistry series, highlights the applications of natural products as medicines or prospective medicinal leads for the treatment of various human ailments. Each chapter covers a particular disease area or medical condition – for example, the chapter on anticancer natural products will look into the contributions of natural products in cancer chemotherapy, including the discovery and development of taxol, vincristine and vinblastine as cancer chemotherapeutic agents, and also explore the recent developments in anticancer drug discovery and development from various natural products. All 16 chapters will cover the history, current status and future opportunities of natural products in the treatment and prevention of any particular ailment or medical conditions. Whist the primary focus will be on the medicinal chemistry aspects of these natural products with therapeutic applications, structural modifications and in silico approaches will also be covered. Additionally all chapters will review recent literature of last ten years or so, and present an overview on the developments in respective areas. Disease-focused Medicinal chemistry of natural products In silico approaches Natural products drug discovery

Plant Derived Natural Products

Author : Anne E. Osbourn
ISBN : 0387854983
Genre : Science
File Size : 62. 14 MB
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Plants produce a huge array of natural products (secondary metabolites). These compounds have important ecological functions, providing protection against attack by herbivores and microbes and serving as attractants for pollinators and seed-dispersing agents. They may also contribute to competition and invasiveness by suppressing the growth of neighboring plant species (a phenomenon known as allelopathy). Humans exploit natural products as sources of drugs, flavoring agents, fragrances and for a wide range of other applications. Rapid progress has been made in recent years in understanding natural product synthesis, regulation and function and the evolution of metabolic diversity. It is timely to bring this information together with contemporary advances in chemistry, plant biology, ecology, agronomy and human health to provide a comprehensive guide to plant-derived natural products. Plant-derived natural products: synthesis, function and application provides an informative and accessible overview of the different facets of the field, ranging from an introduction to the different classes of natural products through developments in natural product chemistry and biology to ecological interactions and the significance of plant-derived natural products for humans. In the final section of the book a series of chapters on new trends covers metabolic engineering, genome-wide approaches, the metabolic consequences of genetic modification, developments in traditional medicines and nutraceuticals, natural products as leads for drug discovery and novel non-food crops.

Medicinal Chemistry Of Bioactive Natural Products

Author : Xiao-Tian Liang
ISBN : 9780471739333
Genre : Science
File Size : 85. 70 MB
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Current discoveries and research into bioactive naturalproducts Medicinal Chemistry of Bioactive Natural Products provides amuch-needed survey of bioactive natural products and theirapplications in medicinal chemistry. This comprehensive referencefeatures articles by some of the world's leading scientists in thefield on discovery, structure elucidation, and elegant syntheticstrategies--developed for natural products--with an emphasis on thestructure activity relationship of bioactive natural products. Thetopics have been carefully chosen on the basis of relevance tocurrent research and to importance as clinicially usefulagents. Rather than attempting to be a comprehensive encyclopedia ofbioactive natural products, Medicinal Chemistry of BioactiveNatural Products guides the reader to the key developments in thefield. By providing not only practical detail but a historicalperspective on the chemistry and biology of the compounds underconsideration, the book serves as a handy resource for researchersin their own work developing pharmaceuticals, and as an inspiringintroduction for young scientists to the dynamic field of bioactivenatural products research. Enhanced by examples with updated research results, the discussioncovers such topics as: * The chemistry and biology of epothilones * Vancomycin and other glycopeptide antibiotic derivates * Antitumor and other related activities of Taxol and itsanalogs * The antimalarial properties of the traditional Chinese medicine,Quinghaosu (artemisinin) * Huperzine A: A natural drug for the treatment of Alzheimer'sdisease * The medicinal chemistry of ginkgolides from Ginkgo biloba * Recent progress in Calophyllum coumarins as potent anti-HIVagents * Plant-derived anti-HIV agents and analogs * Chemical synthesis of annonaceous acetogenins and theirstructurally modified mimics

Natural Products In Medicinal Chemistry

Author : Stephen Hanessian
ISBN : 9783527676569
Genre : Medical
File Size : 64. 71 MB
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The inspiration provided by biologically active natural products to conceive of hybrids, congeners, analogs and unnatural variants is discussed by experts in the field in 16 highly informative chapters. Using well-documented studies over the past decade, this timely monograph demonstrates the current importance and future potential of natural products as starting points for the development of new drugs with improved properties over their progenitors. The examples are chosen so as to represent a wide range of natural products with therapeutic relevance among others, as anticancer agents, antimicrobials, antifungals, antisense nucleosides, antidiabetics, and analgesics. From the content: * Part I: Natural Products as Sources of Potential Drugs and Systematic Compound Collections * Part II: From Marketed Drugs to Designed Analogs and Clinical Candidates * Part III: Natural Products as an Incentive for Enabling Technologies * Part IV: Natural Products as Pharmacological Tools * Part V: Nature: The Provider, the Enticer, and the Healer

Progress In The Chemistry Of Organic Natural Products 109

Author : A. Douglas Kinghorn
ISBN : 9783030128586
Genre : Science
File Size : 41. 8 MB
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This volume comprises three reviews. The first describes isolation, structure determination, syntheses, and biochemistry of the low molecular weight compounds of the secretion of exocrine glands of termies with emphasis to pheromones and defensive compounds. The second review describes recent studies on isolation and structure elucidation of bioactive compounds involved in the life cycle and determination of the molecular mechanisms of the developmental events observed in higher plants. The third contribution reports on the current body of knowledge of African propolis, with a particular emphasis on its chemistry and biological activity.

Pharmaceutical Medicinal And Natural Product Chemistry

Author : P. S. Kalsi
ISBN : 1842655981
Genre : Science
File Size : 78. 97 MB
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PHARMACEUTICAL, MEDICINAL AND NATURAL PRODUCT CHEMISTRY provides an overview of structural features and functional groups of different classes of pharmacologically active natural products, synthetic drugs and drugs from microorganisms, animals and plants and their biological activities. The text presents the concepts which are central to the study of drug action of the natural materials themselves and as lead compounds and drug production (DNA Recombinant Technology) supported by logical chemical, biochemical and mechanistic principles. The material presented guides the reader through biosynthetic and metabolic pathways, which demonstrates their unique integration. The book also contains material on the synthesis of some drugs structure, synthesis, biosynthesis and conformational analysis of some of the more important members of terpenoids, steroids, carotenoid alkaloids, flavanoids, purine and pyrimidines along with their medicinal significance. Students of organic chemistry, pharmacy and medicinal chemistry will find this book an invaluable source.

Foye S Principles Of Medicinal Chemistry

Author : Thomas L. Lemke
ISBN : 9781609133450
Genre : Medical
File Size : 46. 65 MB
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Acclaimed by students and instructors alike, Foye's Principles of Medicinal Chemistry is now in its Seventh Edition, featuring updated chapters plus new material that meets the needs of today's medicinal chemistry courses. This latest edition offers an unparalleled presentation of drug discovery and pharmacodynamic agents, integrating principles of medicinal chemistry with pharmacology, pharmacokinetics, and clinical pharmacy. All the chapters have been written by an international team of respected researchers and academicians. Careful editing ensures thoroughness, a consistent style and format, and easy navigation throughout the text.

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