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Molecular Biology Of Aging

Author : Leonard Guarente
ISBN : 9780879698249
Genre : Medical
File Size : 45. 74 MB
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This volume covers the major threads in the molecular genetics of aging, including genes that regulate aging, causes of aging, evolutionary theories of aging, and the relationship between diet and aging. Among specific topics covered are calorie restriction, mitochondria, sirtuins, telomeres, stem cells, and cancer.

Molecular Biology Of Aging

Author : University of California, Los Angeles
ISBN : UOM:39015017993919
Genre : Science
File Size : 52. 73 MB
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This broad ranging study explores the recent findings in the dynamic field of molecular biogerontology. It examines the numerous molecular changes which occur during senescence and pinpoints the basic biological pacemakers of aging. Investigators examine the importance of DNA damage and the extent of differential gene expression during aging. There are discussions of attempts to manipulate the lifespans of various model organisms through gene transfer and regulated gene expression. Throughout, the contributors stress that the genome holds the ultimate key to understanding the limits of lifespan and the determinants of senescence.

Molecular Biology Of Aging

Author :
ISBN : 9780128115336
Genre : Science
File Size : 67. 36 MB
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Molecular Biology of Aging, the latest volume in the Progress in Molecular Biology and Translational Science series, focuses on placental development and disease. Contains contributions from leading authorities on the topic Publishes cutting-edge reviews in molecular biology

The Molecular Genetics Of Aging

Author : Siegfried Hekimi
ISBN : 9783540480037
Genre : Science
File Size : 38. 87 MB
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The molecular genetics of aging or life-span determination is an expanding field. One reason is because many people would consider it desirable if hu man life span could be extended. Indeed, it is difficult not to be fascinated by tales of the life and death of people who have succeeded in living a very long life. Because of this, we have placed at the head of this book the chapter by Perls et al. on Centenerians and the Genetics of Longevity. Perls and his coauthors convincingly argue that, while the average life expectancy might be mostly determined by environmental factors because the average person has an average genotype, extremely long life spans are genetically determined. Of course, studying humans to uncover the genetics of aging is not ideal, not so much because one cannot easily perform experiments as because they live such a long time. This is why most of this book describes the current state of research with model organisms such as yeast, worms, flies, and mice. J aswinski focuses on yeast and how metabolic activity and stress resistance affect the longevity of Saccharomyces cerevisiae. In the process, he discusses the concept of aging as applied to a unicellular organism such as yeast and the importance of metabolism and stress resistance for aging in all organisms.

Aging At The Molecular Level

Author : Thomas von Zglinicki
ISBN : 1402017383
Genre : Medical
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During the last 40 years, the study of the biological basis of aging has progressed tremendously, and is now an independent field of study and research. This volume brings together contributions to the field from an international team of authors.

Evolutionary Biology Of Aging

Author : Michael R. Rose
ISBN : 0198022727
Genre : Science
File Size : 81. 50 MB
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This unique book looks at the biology of aging from a fundamentally new perspective, one based on evolutionary theory rather than traditional concepts which emphasize molecular and cellular processes. The basis for this approach lies in the fact that natural selection, as a powerful determining force, tends to decline in importance with age. Many of the characteristics we associate with aging, the author argues, are more the result of this decline than any mechanical imperative contained within organic structures. This theory in turn yields the most fruitful avenues for seeking answers to the problem of aging, and should be recognized as the intellectual core of gerontology and the foundation for future research. The author ably surveys the vast literature on aging, presenting mathematical, experimental, and comparative findings to illustrate and support the central thesis. The result is the first complete synthesis of this vital field. Evolutionary biologists, gerontologists, and all those concerned with the science of aging will find it a stimulating, strongly argued account.

Biology Of Aging

Author : Roger B. McDonald
ISBN : 9780429638190
Genre : Science
File Size : 29. 50 MB
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Biology of Aging, Second Edition presents the biological principles that have led to a new understanding of the causes of aging and describes how these basic principles help one to understand the human experience of biological aging, longevity, and age-related disease. Intended for undergraduate biology students, it describes how the rate of biological aging is measured; explores the mechanisms underlying cellular aging; discusses the genetic pathways that affect longevity in various organisms; outlines the normal age-related changes and the functional decline that occurs in physiological systems over the lifespan; and considers the implications of modulating the rate of aging and longevity. The book also includes end-of-chapter discussion questions to help students assess their knowledge of the material. Roger McDonald received his Ph.D. from the University of Southern California and is Professor Emeritus in the Department of Nutrition at the University of California, Davis. Dr. McDonald’s research focused on mechanisms of cellular aging and the interaction between nutrition and aging. His research addressed two key topics in the field: the relationship between dietary restriction and lifespan, and the effect of aging on circadian rhythms and hypothalamic regulation. You can contact Dr. McDonald at [email protected] Related Titles Ahmad, S. I., ed. Aging: Exploring a Complex Phenomenon (ISBN 978-1-1381-9697-1) Moody, H. R. & J. Sasser. Gerontology: The Basics (ISBN 978-1-1387-7582-4) Timiras, P. S. Physiological Basis of Aging and Geriatrics (ISBN 978-0-8493-7305-3)

Handbook Of The Biology Of Aging

Author : Edward J. Masoro
ISBN : 9780120883875
Genre : Psychology
File Size : 88. 87 MB
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This volume is a collection of 21 papers comprising conceptual and technical issues, non-mammalian models and mammalian models and including issues such as aging of the female reproductive system and computer modelling in the study of aging.

Molecular Biology Of Aging

Author : Avril D. Woodhead
ISBN : 0306420848
Genre : Psychology
File Size : 84. 78 MB
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It is delightful but humbling to find my face at the start of these Proceedings--there are innumerable other faces which could equally weIl stand there, from among the band who have fore gathered at every gerontology conference since the subject was launched in its present form; but I deeply appreciate being there. Gerontology d. id not grow by accident. Its present standing is the fruit of careful planning, undertaken by European and American scientists back in the 1950's. In those days it was still a "fringe" science, and the conspirators had much the standing of the 1920's Interplanetary Society. The United States itself is the offspring of conspiracy, for when the results of conspiracy are beneficent, the conspirators become Founding Fathers. This has been the case with gerontology. The present meeting is especially gratifying because the papers have been recitals of normal, hard-science investigation. We had to get through the rigors of a long period of semantic argument and a long period of one-shot general theories before this kind of meeting, normal in all other research fields, could take place. It was also necesssary to breed in the menagerie a generation of excellent investigators aware of the theoretical background but unintimidated by it, who share our conviction that human aging is comprehensible and probably controllable, and who go into the laboratory to attack specifics.

Biological Aging

Author : Trygve O. Tollefsbol
ISBN : 9781597453615
Genre : FAMILY & RELATIONSHIPS
File Size : 67. 28 MB
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The goal of Biological Aging: Methods and Protocols is to present some of the most promising and important tools that are currently used in biological aging research. These tools include established protocols such as aging cell culture as well as many more contemporary approaches such as nuclear transfer, microarray and proteomics technologies and the use of ribozymes in aging research. Collectively, these powerful tools combined with the many other techniques that are presented are rapidly advancing the exciting and expanding field of biological aging.

Biology Of Aging

Author : Robert Arking
ISBN : UOM:39015025382295
Genre : Science
File Size : 52. 48 MB
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Arking (Institute of Gerontology, Wayne State U.) presents an overview of the biological processes underlying aging at the cellular, organism, and population levels. A textbook for the college or graduate level. Annotation copyright Book News, Inc. Portland, Or.

Molecular Basis Of Aging

Author : A Roy
ISBN : 9780323151559
Genre : Science
File Size : 65. 4 MB
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Molecular Basis of Aging is a collection of papers that discuss the molecular aspects of aging in the light of molecular biology, biochemical gerontology, and genetics. Each chapter of the book contains a different study about the topic, which includes the effects of aging on DNA synthesis; the amplification of extrachromosomal circular copies and mitochondrial DNA during aging; and the altered actions of hormones and neurotransmitters during aging. The book also encompasses the loss of responsiveness to growth factors in cell senescence; the integration of cellular-molecular and neuroendocrine concepts of aging; changes and inactivation of enzymes during aging; and the relationship of aging with free radicals. The text is recommended for molecular biologists, biochemists, and gerontologists who wish to study further the effects of aging on the body on a molecular level.

Free Radicals In Molecular Biology Aging And Disease

Author : Donald Armstrong
ISBN : UOM:39015007152831
Genre : Science
File Size : 90. 27 MB
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Handbook Of Cell Biology Of Aging

Author : Chemical Rubber Company (Cleveland, Ohio)
ISBN : UOM:39015010656240
Genre : Science
File Size : 51. 75 MB
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Comparative Biology Of Aging

Author : Norman S. Wolf
ISBN : 904813465X
Genre : Medical
File Size : 46. 1 MB
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determined by an inability to move in response to touch. C. elegans develop through four larval stages following hatching and prior to adulthood. Adult C. elegans are reproductive for about the rst week of adulthood followed by approximately two weeks of post-reproductive adulthood prior to death. Life span is most commonly measured in the laboratory by maintaining the worms on the surface of a nutrie- agar medium (Nematode Growth Medium, NGM) with E. coli OP50 as the bacterial food source (REF). Alternative culture conditions have been described in liquid media; however, these are not widely used for longevity studies. Longevity of the commonly used wild type C. elegans hermaphrodite (N2) varies ? from 16 to 23 days under standard laboratory conditions (20 C, NGM agar, E. coli OP50 food source). Life span can be increased by maintaining animals at lower ambient temperatures and shortened by raising the ambient temperature. Use of a killed bacterial food source, rather than live E. coli, increases lifespan by 2–4 days, and growth of adult animals in the absence of bacteria (axenic growth or bac- rial deprivation) increases median life span to 32–38 days [3, 23, 24]. Under both standard laboratory conditions and bacterial deprivation conditions, wild-derived C. elegans hermaphrodites exhibit longevity comparable to N2 animals [25].

Disciplinary Approaches To Aging Biology Of Aging

Author : Donna Lind Infeld
ISBN : 0415938961
Genre : Social Science
File Size : 72. 59 MB
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This volume is a comprehensive collection of critical essays on The Taming of the Shrew, and includes extensive discussions of the play's various printed versions and its theatrical productions. Aspinall has included only those essays that offer the most influential and controversial arguments surrounding the play. The issues discussed include gender, authority, female autonomy and unruliness, courtship and marriage, language and speech, and performance and theatricality.

Biology Of Aging

Author : Alvaro Macieira-Coelho
ISBN : 3540438270
Genre : Medical
File Size : 56. 7 MB
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The survival of the human species has improved significantly in modern times. During the last century, the mean survival of human populations in developed countries has increased more than during the preceding 5000 years. This improvement in survival was accompanied by an increase in the number of active years. In other words, the increase in mean life span was accompanied by an increase in health span. This is now accentuated by progress in medicine reducing the impact of physiologic events such as menopause and of patho logical processes such as atherosclerosis. Up to now,research on aging, whether theoretical or experimental, has not contributed to improvement in human survival. Actually, there is a striking contrast between these significant modifications in survival and the present knowledge of the mechanisms of human aging. Revealed by this state of affairs are the profound disagreements between gerontologists in regard to the way oflooking at the aging process. The definition of aging itself is difficult to begin with because of the variability of how it occurs in different organisms.

Handbook Of The Biology Of Aging

Author : Finchc
ISBN : UOM:39015009553549
Genre : Science
File Size : 38. 12 MB
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The Evolution Of Progress

Author : C. Owen Paepke
ISBN : UCAL:B4386095
Genre : Business & Economics
File Size : 59. 78 MB
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A look at the end of economic growth and the coming revolution in human engineering draws on history, economics, science, and literature to trace the rise and fall of material progress. 15,000 first printing.

Aging

Author : Joseph Panno
ISBN : 0816049513
Genre : Family & Relationships
File Size : 81. 82 MB
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Discusses the aging process and diseases associated with it, compares human and animal life spans, describes geriatrics and its history, examines ways of extending life, and includes background material on cell biology.

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