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Cell Biology Of The B Cell Receptor

Author : Hidde Ploegh
ISBN : 9780128003633
Genre : Science
File Size : 38. 82 MB
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Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future. Contributions from leading authorities Informs and updates on all the latest developments in the field

T Cell Protocols

Author : Kelly P. Kearse
ISBN : 9781592596829
Genre : Medical
File Size : 68. 84 MB
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The purpose of T Cell Protocols: Development and Activation is to c- lect a series of protocols, particularly those that have been developed within the past few years, to help investigators master new techniques (or improve existing ones) for the study of T-cell Biology. Invariably, in putting together a book like this it is difficult to decide which methods to include and which to leave out. To this end methods were selected from a variety of disciplines, including cellular immunology, b- chemistry, and molecular biology, to try to provide something of interest for everyone who works on T-cell development and activation. I would like to mention that my primary reason for agreeing to put this book together is that, when I was a graduate student, I purchased a copy of Selected Methods in Cellular Immunology by Mishell and Shigii which proved a tremendous help in learning the basics of one-and two- dimensional gel te- niques (and other methods). The cover has long since fallen off, but it still remains one of my most valued reference books for the laboratory. It is my hope that T Cell Protocols: Development and Activation will prove similarly useful to current and future scientists wishing to learn new methods for expl- ing the development and activation of T cells.

Mechanisms Of Lymphocyte Activation And Immune Regulation Xi

Author : Sudhir Gupta
ISBN : 9780387465302
Genre : Medical
File Size : 73. 8 MB
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In recent years, major developments have increased understanding of various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.

Molecular Biology Of B Cell And T Cell Development

Author : John G. Monroe
ISBN : 9781475727784
Genre : Science
File Size : 66. 80 MB
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Despite the tremendous diversity of the cells of the hematopoietic system, they are all derived from common precursor cells that are generated in the fetus and persist into adult life. In this regard, Band T lymphocytes, which comprise the two arms of the antigen-specific and inducible immune system, though functionally very different, are descendants of the same stem cell precursor. In the past several years, we have witnessed an explosion of information regarding the process by which differentiation of B-and T-cells from stem cells occurs. This information, like the answers to most important biological questions, has come from multiple and diverse directions. Because all hematopoietic cells arise from common precursors, complex regulatory processes must be involved in determining commitment to various lineages. Understanding commitment to the B- or T-cell lineage remains incomplete; however, identification of transcription factors necessary for progression along specific B-and T-cell pathways suggests that we are on the verge of understanding the molecules involved in the initial fate-determining steps. Studies of this type previously could be accomplished only in nonmammalian systems that are more amenable to genetic approaches. However, new technologies allow increasingly elegant and informative studies in mammalian systems, particularly for cells of the hematopoietic system.

Lymphocytes

Author : Erman Salih Istifli
ISBN : 9781789849196
Genre : Medical
File Size : 86. 68 MB
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Although all the features of the immune system have not been fully resolved yet, the knowledge we have gained from studies on lymphocytes, the basic elements of the immune system, is quite lucid. For this reason, the significance of lymphocytes (the cells that are the source of most of the information we have obtained about the human genome, the negative effects of drugs on the genetic system, the development and behavior of immune system, antigen-antibody association, cytotoxic adaptive immunity, antibody-driven adaptive immunity, cancer and autoimmune diseases) is clear. Studies on lymphocytes will not only help us develop tools to combat human diseases more effectively in the future, but will also help us understand how evolution shapes the immune system in living organisms.

Lymphocyte Activation And Immune Regulation Ix

Author : Sudhir Gupta
ISBN : 1461352266
Genre : Science
File Size : 20. 22 MB
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This volume is divided into three sections. Section I deals with factors that regulate the development and maturation of T cells and B cells and lymphocyte traffic. The significance of C-kit, Bcl-6, IL-7, and Vav in the development of T and B lymphocytes is discussed. A role of lymphotoxins and VAP-I in trafficking of leucocytes is reviewed. Finally, the trafficking and homing characteristics of T cell and B cell subsets, and the regulation of these processes during the immune response, is presented. Section II discusses various aspects of naive and memory T cell biology, including clonal expansion, reprogramming of genes including those encoding cytokines and cytotoxic granules, changes in the expression of cell surface proteins involved in cell-cell adhesion, homing of naive and memory T cells, the role of MHC and cytokines in the maintenance of naive and memory T cells, and the characterization and differentiation of virus-specific memory T cell heterogeneity in mice and humans. Novel methods of visualization of immune cells and immune systems are reviewed in Section III.

Molecular Biology Of B Cells

Author : Tasuku Honjo
ISBN : 9780123984906
Genre : Science
File Size : 61. 22 MB
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Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics. Covers signaling mechanisms regulating B cell differentiation Provides information on the development of therapeutics using monoclonal antibodies and clinical application of Ab Contains studies on B cell tumors from various stages of B lymphocytes Offers an integrated view of all aspects of B cells to produce a normal immune response

Molecular Biology Of The Cell

Author : Bruce Alberts
ISBN : 9781317563754
Genre : Science
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As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts.As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced.Protein structures better illustrate structure–function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing openended questions highlighting “What We Don’t Know,” introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text, and these problems have been expanded to all chapters by adding questions on developmental biology, tissues and stem cells, pathogens, and the immune system.

Advances In Immunology

Author : Frederick W. Alt
ISBN : 9780323989459
Genre : Medical
File Size : 56. 1 MB
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Advances in Immunology, Volume 155, the latest release in this ongoing serial, highlights new advances in the field with this new volume presenting interesting chapters written by an international board of authors. Sections of note cover B cell/GC material. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Advances in Immunology serials Includes groundbreaking updates from immunology, including a section on B cell/GC material

The Molecular Basis Of Cellular Defence Mechanisms

Author : Gregory R. Bock
ISBN : 9780470515297
Genre : Science
File Size : 90. 86 MB
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The field of lymphokine research has grown in parallel to the exciting developments around the two sets of cells which defend the body. While lymphokines are the "property" of immunologists, the molecular regulators of hemopoiesis (CSFs) belong to the hematologists. This book offers the rare opportunity to examine these separate fields of expertise together.

Romanian Journal Of Biochemistry

Author :
ISBN : CORNELL:31924101484628
Genre : Biochemistry
File Size : 22. 80 MB
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Ir Genes

Author : Carl W. Pierce
ISBN : UCAL:B5136524
Genre : Medical
File Size : 84. 60 MB
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The Fifth Ir Gene Workshop was held at the Chase-Park Plaza Hotel, St. Louis, MO, August 28-31, 1982; 240 scientists participated in the Workshop. The man uscripts compiled in this book describe the state of the art concerning Ir genes. Although the notion of Ir Genes: Past, Present, and Future has not been ad dressed specifically by each author, the reader is certain to get this flavor from the contributions. In this Preface, we have tried to summarize some of the salient ob servations and discussions from the Workshop. The mUltiple genes of the I region have been defined traditionally by serolog ical analysis of intra-H-2 recombinant mice and the pattern of immune responses to certain antigens developed by these recombinant mice. The application of sev eral new techniques, such as gene cloning and DNA sequencing, production of T and B cell hybridomas, and development of cloned T cell lines has changed this tradition and introduced a new phase into the analysis of the I region, Ia antigens, and Ir genes.

Molecular Biology And Biotechnology

Author : John M. Walker
ISBN : 9780854041251
Genre : Science
File Size : 28. 30 MB
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This popular textbook has been revised and updated to provide a comprehensive overview and to reflect the latest developments in this rapidly developing area. Continuing with the broad base style of both current molecular and traditional biotechnology, chapters have been updated to reflect current interest and include new areas such as stem cell technology and important areas in drug discovery such as IP and patents. By presenting information in an easily assimilated form, this book makes an ideal undergraduate text for students of biology and chemistry, as well as to postgraduates.

Molecular Biology Of Long Non Coding Rnas

Author : Ahmad M. Khalil
ISBN : 9783030170868
Genre : Medical
File Size : 48. 27 MB
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This second edition shows how long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Advances in the field also include better characterization of human long non-coding RNAs, novel insights into their roles in human development and disease, their diverse mechanisms of action and novel technologies to study them.

Molecular And Cellular Biology Of The Allergic Response

Author : Arnold I. Levinson
ISBN : 0824788761
Genre : Medical
File Size : 58. 12 MB
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Providing a thorough overview of the fundamental elements of the human allergic immune response, this up-to-date reference focuses on the unique molecular and cellular features of the IgE-mediated immune response-relating these features to current knowledge of the immune response to protein antigens. Written by over 20 internationally renowned experts, Molecular and Cellular Biology of the Allergic Response describes T- and B-cell development and activation examines important genetic and structural features of the major histocompatibility complex details antigen processing and presentation explores the molecular and cellular biology of mast cells and basophils analyzes the processes underlying the synthesis of IgE in humans explains the cellular components and soluble factors that mediate IgE inflammation investigates the molecular characterization and immune recognition of allergenic peptides and more!

Biomedical Index To Phs Supported Research

Author :
ISBN : UOM:39015020571777
Genre : Medicine
File Size : 22. 87 MB
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Fundamental Immunology

Author : William E. Paul
ISBN : 0781714125
Genre : Immunity
File Size : 58. 2 MB
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This revised sourcebook on immunology seeks to reflect research and the improved understanding of immunoglobulins, B lymphocytes and T cells. There are new illustrations and chapters covering lymphocyte development and biology, lymphocyte activation, autoimmunity, apoptosis, regulatory cytokines, control of T cell phenotype, affinity maturation, cytotoxic T cells, immunotherapy, mucosal immunity, and the immunology of ageing.

The Biology And Therapeutic Application Of Mesenchymal Cells 2 Volume Set

Author : Kerry Atkinson
ISBN : 9781118907511
Genre : Science
File Size : 26. 36 MB
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The Biology and Therapeutic Application of Mesenchymal Cells comprehensively describes the cellular and molecular biology of mesenchymal stem cells and mesenchymal stromal cells, describing their therapeutic potential in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models. Chapters also discuss the current status of the use of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues. Provides coverage on both the biology of mesenchymal stem cells and stromal cells, and their therapeutic applications Describes the therapeutic potential of mesenchymal stem and stromal cells in a wide variety of preclinical models of human diseases and their mechanism of action in these preclinical models Discusses the current status of mesenchymal stem and stromal cells in clinical trials in a wide range of human diseases and disorders, for many of which there are limited, or no other, therapeutic avenues Written and edited by leaders in the field The Biology and Therapeutic Application of Mesenchymal Cells is an invaluable resource for those studying stem cells, cell biology, genetics, gene or cell therapy, or regenerative medicine.

Research Awards Index

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ISBN : UOM:39015014022589
Genre : Medicine
File Size : 49. 4 MB
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The Encylopedia Of Molecular Biology

Author : Sir John Kendrew
ISBN : 9781444313840
Genre : Science
File Size : 30. 55 MB
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The Encylopaedia of Molecular Biology is a truly unique work of reference. 6000 definitions cover the entire spectrum of molecular life science The complete one-volume guide to understanding the way molecular biology is transforming medicine and agriculture Long and short entries written by over 300 of the world's finest researchers For rapid research or detailed study ... this is the A to Z of the New Biology

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