progress in medicinal chemistry 49

Download Book Progress In Medicinal Chemistry 49 in PDF format. You can Read Online Progress In Medicinal Chemistry 49 here in PDF, EPUB, Mobi or Docx formats.

Progress In Medicinal Chemistry

Author :
ISBN : 0123812933
Genre : Science
File Size : 39. 43 MB
Format : PDF
Download : 556
Read : 663

Get This Book

Progress in Medicinal Chemistry provides a review of eclectic developments in medicinal chemistry. This volume continues in the serial's tradition of providing an insight into the skills required of the modern medicinal chemist; in particular, the use of an appropriate selection of the wide range of tools now available to solve key scientific problems. Presents the latest research in the field of drug discovery Publishes on a twice yearly basis to bring you the most innovative updates in medicinal chemistry Available as an online resource via ScienceDirect

Progress In Medicinal Chemistry 7

Author : Gwynn Pennant Ellis
ISBN : 9780408700139
Genre : Pharmaceutical chemistry
File Size : 28. 61 MB
Format : PDF, ePub
Download : 456
Read : 548

Get This Book

Drug Discovery And Development E Book

Author : Raymond G Hill
ISBN : 9780702053160
Genre : Medical
File Size : 65. 40 MB
Format : PDF, Kindle
Download : 535
Read : 976

Get This Book

The modern pharmacopeia has enormous power to alleviate disease, and owes its existence almost entirely to the work of the pharmaceutical industry. This book provides an introduction to the way the industry goes about the discovery and development of new drugs. The first part gives a brief historical account from its origins in the mediaeval apothecaries’ trade, and discusses the changing understanding of what we mean by disease, and what therapy aims to achieve, as well as summarising case histories of the discovery and development of some important drugs. The second part focuses on the science and technology involved in the discovery process: the stages by which a promising new chemical entity is identified, from the starting point of a medical need and an idea for addressing it. A chapter on biopharmaceuticals, whose discovery and development tend to follow routes somewhat different from synthetic compounds, is included here, as well as accounts of patent issues that arise in the discovery phase, and a chapter on research management in this environment. The third section of the book deals with drug development: the work that has to be undertaken to turn the drug candidate that emerges from the discovery process into a product on the market. The definitive introduction to how a pharmaceutical company goes about its business of discovering and developing drugs. The second edition has a new editor: Professor Raymond Hill ● non-executive director of Addex Pharmaceuticals, Covagen and of Orexo AB ● Visiting Industrial Professor of Pharmacology in the University of Bristol ● Visiting Professor in the School of Medical and Health Sciences at the University of Surrey ● Visiting Professor in Physiology and Pharmacology at the University of Strathclyde ● President and Chair of the Council of the British Pharmacological Society ● member of the Nuffield Council on Bioethics and the Advisory Council on Misuse of Drugs. New to this edition: Completely rewritten chapter on The Role of Medicinal Chemistry in the Drug Discovery Process. New topic - DMPK Optimization Strategy in drug discovery. New chapter on Scaffolds: Small globular proteins as antibody substitutes. Totally updated chapters on Intellectual Property and Marketing 50 new illustrations in full colour Features Accessible, general guide to pharmaceutical research and development. Examines the interfaces between cost and social benefit, quality control and mass production, regulatory bodies, patent management, and all interdisciplinary intersections essential to effective drug development. Written by a strong team of scientists with long experience in the pharmaceutical industry. Solid overview of all the steps from lab bench to market in an easy-to-understand way which will be accessible to non-specialists. From customer reviews of the previous edition: ‘... it will have everything you need to know on this module. Deeply referenced and, thus, deeply reliable. Highly Commended in the medicine category of the BMA 2006 medical book competition Winner of the Royal Society of Medicine Library Prize for Medical Book of the Year

Medicinal Chemistry

Author : Thomas Nogrady
ISBN : 0198026455
Genre : Medical
File Size : 68. 45 MB
Format : PDF, Kindle
Download : 856
Read : 837

Get This Book

Fully updated and rewritten by a basic scientist who is also a practicing physician, the third edition of this popular textbook remains comprehensive, authoritative and readable. Taking a receptor-based, target-centered approach, it presents the concepts central to the study of drug action in a logical, mechanistic way grounded on molecular and principles. Students of pharmacy, chemistry and pharmacology, as well as researchers interested in a better understanding of drug design, will find this book an invaluable resource. Starting with an overview of basic principles, Medicinal Chemistry examines the properties of drug molecules, the characteristics of drug receptors, and the nature of drug-receptor interactions. Then it systematically examines the various families of receptors involved in human disease and drug design. The first three classes of receptors are related to endogenous molecules: neurotransmitters, hormones and immunomodulators. Next, receptors associated with cellular organelles (mitochondria, cell nucleus), endogenous macromolecules (membrane proteins, cytoplasmic enzymes) and pathogens (viruses, bacteria) are examined. Through this evaluation of receptors, all the main types of human disease and all major categories of drugs are considered. There have been many changes in the third edition, including a new chapter on the immune system. Because of their increasingly prominent role in drug discovery, molecular modeling techniques, high throughput screening, neuropharmacology and genetics/genomics are given much more attention. The chapter on hormonal therapies has been thoroughly updated and re-organized. Emerging enzyme targets in drug design (e.g. kinases, caspases) are discussed, and recent information on voltage-gated and ligand-gated ion channels has been incorporated. The sections on antihypertensive, antiviral, antibacterial, anti-inflammatory, antiarrhythmic, and anticancer drugs, as well as treatments for hyperlipidemia and peptic ulcer, have been substantially expanded. One new feature will enhance the book's appeal to all readers: clinical-molecular interface sections that facilitate understanding of the treatment of human disease at a molecular level.

Recent Advances In Receptor Chemistry

Author : C. Melchiorre
ISBN : 0444429654
Genre : Medical
File Size : 37. 98 MB
Format : PDF, Docs
Download : 473
Read : 623

Get This Book

Technical Book Review Index

Author :
ISBN : UCAL:B4260349
Genre : Books
File Size : 20. 93 MB
Format : PDF, Kindle
Download : 113
Read : 1145

Get This Book

British Book News

Author :
ISBN : UCAL:$B224319
Genre : Best books
File Size : 56. 94 MB
Format : PDF, Kindle
Download : 110
Read : 1264

Get This Book

Thermodynamics And Kinetics Of Drug Binding

Author : György Keserü
ISBN : 9783527673056
Genre : Medical
File Size : 60. 84 MB
Format : PDF, Docs
Download : 557
Read : 703

Get This Book

This practical reference for medicinal and pharmaceutical chemists combines the theoretical background with modern methods as well as applications from recent lead finding and optimization projects. Divided into two parts on the thermodynamics and kinetics of drug-receptor interaction, the text provides the conceptual and methodological basis for characterizing binding mechanisms for drugs and other bioactive molecules. It covers all currently used methods, from experimental approaches, such as ITC or SPR, right up to the latest computational methods. Case studies of real-life lead or drug development projects are also included so readers can apply the methods learned to their own projects. Finally, the benefits of a thorough binding mode analysis for any drug development project are summarized in an outlook chapter written by the editors.

The Handbook Of Medicinal Chemistry

Author : Andrew Davis
ISBN : 9781849736251
Genre : Science
File Size : 73. 50 MB
Format : PDF, Mobi
Download : 576
Read : 150

Get This Book

Developed to provide a comprehensive guide, the Handbook of Medicinal Chemistry has been revised and brought up to date to cover the past, present and future of the entire drug development process.

Medicinal Chemistry Of Nucleic Acids

Author : Li-He Zhang
ISBN : 1118092813
Genre : Medical
File Size : 26. 83 MB
Format : PDF, Kindle
Download : 502
Read : 1123

Get This Book

Complete, up-to-date coverage of the broad area of nucleic acidchemistry and biology Assembling contributions from a collection of authors withexpertise in all areas of nucleic acids, medicinal chemistry, andtherapeutic applications, Medicinal Chemistry of NucleicAcids presents a thorough overview of nucleic acidchemistry—a rapidly evolving and highly challengingdiscipline directly responsible for the development of antiviraland antitumor drugs. This reliable resource delves into a multitudeof subject areas involving the study of nucleic acids—such asthe new advances in genome sequencing, and the processes forcreating RNA interference (RNAi) based drugs—to assistpharmaceutical researchers in removing roadblocks that hinder theirability to predict drug efficacy. Offering the latest cutting-edgescience in this growing field, Medicinal Chemistry of Nucleic Acidsincludes: In-depth coverage of the development and application of modifiednucleosides and nucleotides in medicinal chemistry A close look at a large range of current topics on nucleic acidchemistry and biology Essential information on the use of nucleic acid drugs to treatdiseases like cancer A thorough exploration of siRNA for RNAi and the regulation ofmicroRNA, non-coding RNA (ncRNA), a newly developing and excitingresearch area Thorough in its approach and promising in its message,Medicinal Chemistry of Nucleic Acids probes the new domainsof pharmaceutical research—and exposes readers to a wealth ofnew drug discovery opportunities emerging in the dynamic field ofnucleic acid chemistry.

Top Download:

Best Books