the biosynthesis of mycotoxins a study in secondary metabolism

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The Biosynthesis Of Mycotoxins

Author : Pieter Steyn
ISBN : 9780323149938
Genre : Nature
File Size : 80. 84 MB
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The Biosynthesis of Mycotoxins: A Study in Secondary Metabolism focuses on the biosynthetic analysis of mycotoxins, which are inherently a heterogeneous group of metabolites that are formed along the terpene route and the route polyketide, as well as from amino acids. This book discusses the unique biological properties and structural complexity of the highly specialized secondary microbial metabolites. Organized into 12 chapters, this book starts with an overview of the characteristics of secondary metabolites, including their problematic function and the combination of their structural diversity with their restricted biological occurrence. This text then explains the sporadic occurrence of the mycotoxins as fungal metabolites. Other chapters explore ergochromes, which are a group of light yellow mycotoxins that are isolated from ergot, mold fungi, and lichens. The final chapter discusses the biosynthesis of several unrelated fungal metabolites for which toxicological data are reported. Biochemists, organic chemists, mycologists, enzymologists, plant pathologists, toxicologists, and graduate students will find this book useful.

Mycotoxins And Animal Foods

Author : DUPLICATE Smith
ISBN : 0849349044
Genre : Nature
File Size : 90. 20 MB
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The ingestion of feed containing mycotoxins has serious adverse effects on the health of farm animals, contributing to reduced weight gain, lower reproductivity, damage to the immune system, severe illnesses, and even death. Mycotoxins formed in animal feedstuffs depend on the presence of specific strains of filamentous fungi or molds and are strongly influenced by environmental factors such as temperature and humidity. This book considers the biological nature of mycotoxin formation, the chemical and biological methods of analysis, as well as the extensive range of substrates capable of supporting the growth of toxigenic fungi. The book also provides extensive coverage of the mycotoxicoses of farmed animals and the current state of research into the control and detoxification of mycotoxins. All researchers interested in mycotoxins and their effects on animals will find important information in this book.

The Genus Aspergillus

Author : Keith A. Powell
ISBN : 9781489909817
Genre : Science
File Size : 82. 76 MB
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Proceedings of a symposium held in Canterbury, United Kingdom, April 5-8, 1993.

Modern Methods In The Analysis And Structural Elucidation Of Mycotoxins

Author : Richard J. Cole
ISBN : 9780323148535
Genre : Science
File Size : 54. 83 MB
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Modern Methods in the Analysis and Structural Elucidation of Mycotoxins presents available methods of analysis and structural elucidation of mycotoxins by recognized experts in the various disciplines. The approach in each chapter of the book is to present each method initially in theoretical terms and then to review the method as it specifically applies to the analysis and/or structural elucidation of mycotoxins. Comprised of 15 chapters, the book's opening chapters deal with screening, sampling, and survey methods for mycotoxins and toxigenic fungi. This is followed by chapters dealing mostly with methods for structural elucidation, such as NMR and X-ray crystallography and IR and UV spectroscopy, as well as biosynthetic techniques. Significant chapters consider the analytical methods for mycotoxin analyses, including enzyme-linked immunosorbent assay system and tandem mass spectrometry. The concluding chapter examines the mycotoxin analytical problem in taxonomic or ecological terms. This book is of value to food and feed researchers, scientists, and manufacturers who are interested in product contamination control.

Biosynthesis And Molecular Genetics Of Fungal Secondary Metabolites

Author : Juan-Francisco Martín
ISBN : 9781493911912
Genre : Science
File Size : 77. 9 MB
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This volume describes the more relevant secondary metabolites of different fungi with current information on their biosynthesis and molecular genetics. Bolstered with color illustrations and photographs, the book describes the possible application of molecular genetics to directed strain improvement in great detail. The needs for future developments in this field are also discussed at length Written by authorities in the field, Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites provides a cutting-edge perspective on fungal secondary metabolism and underlying genetics and is a valuable resource for scientists, researchers, and educators in the field of fungal biology.

Structural And Functional Studies Of Secondary Metabolite Acyltransferase Superfamily Members From The Trichothecene Mycotoxin Biosynthetic Pathway

Author : Graeme S. Garvey
ISBN : WISC:89099670630
Genre :
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In Chapter four, the results of a collaborative project to functionally characterize PrpF are presented. PrpF is an enzyme involved in the 2-methyl citrate catabolic pathway. The X-ray crystallographic study revealed strong structural homology of PrpF to the non-PLP dependent diaminopimelate epimerase, which allowed an activity of epimerization to be hypothesized and experimentally validated.

Canadian Journal Of Botany

Author :
ISBN : WISC:89048692875
Genre : Botany
File Size : 72. 25 MB
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R Mpp Encyclopedia Natural Products 1st Edition 2000

Author : Burkhard Fugmann
ISBN : 9783131795519
Genre : Science
File Size : 47. 47 MB
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Compiled by German natural products chemist Wolfgang Steglich and his co-editors Burkhard Fugmann and Susanne Lang-Fugmann, RÖMPP Encyclopedia Natural Products provides highly reliable and comprehensive information on the 6,000 most relevant natural substances, including 15,000 cross references and 2,200 formulas. The book contains descriptions of the different substance classes and important analytical methods, comprehensive indices of Latin Species names and molecular formulas as well as a vast amount of cross referencing. It has been compiled by 40 leaders in their respective fields. Written in a clear, consistent style and thoroughly copy edited, this is a must-have reference work for chemists, biochemists working with natural products, researchers in plant protection, pharmacists and medical researchers, biologists working in drug research as well as microbiologists and botanists working on microorganisms, plants or marine organisms, and interested layman.

Journal Of Food Protection

Author :
ISBN : CHI:24811370
Genre : Food adulteration and inspection
File Size : 61. 58 MB
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Fungal Jewels Secondary Metabolites

Author : Nancy Keller
ISBN : 9782889451364
Genre :
File Size : 46. 32 MB
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Fungal natural products are friends and foes of humans such as deleterious mycotoxins, cytotoxic, carcinogenic compounds or beneficial compounds such as antibiotics, fungicides, insecticides, antiviral and antitumor metabolites. Understanding fungal diversity and estimation of fungal species on our planet poses a great challenge to researchers. This complexity is further multiplied by secondary metabolite diversity of fungi, which requires interdisciplinary studies. It is extremely important to understand the fungal secondary metabolism to stop human, animal and plant diseases caused by fungi and harvest their valuable metabolites. Furthermore, many secondary metabolite gene clusters are silenced under laboratory conditions. It is vital to develop effective methods to activate those clusters in order to discover novel potent metabolites. This e-book is a compilation of original review articles contributed by leading fungal secondary metabolite researchers with a wide range of expertise. Important aspects of fungal secondary metabolism, including regulation, genome mining, evolution, synthetic biology and novel methods have been discussed. This book will be a great source to those people, who are interested in understanding overall structure, diversity and regulation of production of these tiny but precious chemicals.

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