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Theoretical And Applied Aspects Of Systems Biology

Author : Fabricio Alves Barbosa da Silva
ISBN : 9783319749747
Genre : Computers
File Size : 28. 69 MB
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This book presents the theoretical foundations of Systems Biology, as well as its application in studies on human hosts, pathogens and associated diseases. This book presents several chapters written by renowned experts in the field. Some topics discussed in depth in this book include: computational modeling of multiresistant bacteria, systems biology of cancer, systems immunology, networks in systems biology.

User Friendly Tools Applied To Genetics Or Systems Biology

Author : Helder Nakaya
ISBN : 9782889661336
Genre : Science
File Size : 27. 11 MB
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Networks In Systems Biology

Author : Fabricio Alves Barbosa da Silva
ISBN : 9783030518622
Genre : Computers
File Size : 76. 17 MB
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This book presents a range of current research topics in biological network modeling, as well as its application in studies on human hosts, pathogens, and diseases. Systems biology is a rapidly expanding field that involves the study of biological systems through the mathematical modeling and analysis of large volumes of biological data. Gathering contributions from renowned experts in the field, some of the topics discussed in depth here include networks in systems biology, the computational modeling of multidrug-resistant bacteria, and systems biology of cancer. Given its scope, the book is intended for researchers, advanced students, and practitioners of systems biology. The chapters are research-oriented, and present some of the latest findings on their respective topics.

Emerging Trends In Computational Biology Bioinformatics And Systems Biology

Author : Quoc Nam Tran
ISBN : 0128025085
Genre : Computers
File Size : 60. 33 MB
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Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology discusses the latest in all aspects of computational biology, bioinformatics, and systems biology and the application of data-analytical and algorithms, mathematical modeling and simulation techniques. Part I: Computational Biology discusses the development and application of data-analytical and theoretical methods, mathematical modeling and computational simulation techniques. Part II: Bioinformatics: Databases, Data Mining and Pattern Discovery focuses on how to use methods for storing, retrieving, organizing and analyzing biological data which are fundamentally extensions of techniques used in computing. Part III: Systems Biology explains how to obtain, integrate and analyze complex data sets from multiple experimental sources using interdisciplinary tools while taking into consideration the evolving nature of the field. Part IV: Big Data and Data Analytics in Computational Biology and Informatics presents strategies and techniques using robust Big Data tools for dealing with the collection of data sets so large and complex that they are difficult to process using conventional database management systems or traditional data processing applications. Discusses the development and application of data-analytical and theoretical methods, mathematical modeling and computational simulation techniques to the study of biological and behavioral systems. Presents a systematic approach for storing, retrieving, organizing and analyzing biological data using software tools with applications. Provides a systems biology perspective including general guidelines and techniques for obtaining, integrating and analyzing complex data sets from multiple experimental sources using computational tools and software.

Emerging Trends In Computational Biology Bioinformatics And Systems Biology

Author : Hamid R Arabnia
ISBN : 9780128026465
Genre : Computers
File Size : 29. 48 MB
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Emerging Trends in Computational Biology, Bioinformatics, and Systems Biology discusses the latest developments in all aspects of computational biology, bioinformatics, and systems biology and the application of data-analytics and algorithms, mathematical modeling, and simu- lation techniques. • Discusses the development and application of data-analytical and theoretical methods, mathematical modeling, and computational simulation techniques to the study of biological and behavioral systems, including applications in cancer research, computational intelligence and drug design, high-performance computing, and biology, as well as cloud and grid computing for the storage and access of big data sets. • Presents a systematic approach for storing, retrieving, organizing, and analyzing biological data using software tools with applications to general principles of DNA/RNA structure, bioinformatics and applications, genomes, protein structure, and modeling and classification, as well as microarray analysis. • Provides a systems biology perspective, including general guidelines and techniques for obtaining, integrating, and analyzing complex data sets from multiple experimental sources using computational tools and software. Topics covered include phenomics, genomics, epigenomics/epigenetics, metabolomics, cell cycle and checkpoint control, and systems biology and vaccination research. • Explains how to effectively harness the power of Big Data tools when data sets are so large and complex that it is difficult to process them using conventional database management systems or traditional data processing applications. Discusses the development and application of data-analytical and theoretical methods, mathematical modeling and computational simulation techniques to the study of biological and behavioral systems. Presents a systematic approach for storing, retrieving, organizing and analyzing biological data using software tools with applications. Provides a systems biology perspective including general guidelines and techniques for obtaining, integrating and analyzing complex data sets from multiple experimental sources using computational tools and software.

International Conference On Theory And Application In Nonlinear Dynamics Icand 2012

Author : Visarath In
ISBN : 9783319029252
Genre : Technology & Engineering
File Size : 51. 49 MB
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A collection of different lectures presented by experts in the field of nonlinear science provides the reader with contemporary, cutting-edge, research works that bridge the gap between theory and device realizations of nonlinear phenomena. Representative examples of topics covered include: chaos gates, social networks, communication, sensors, lasers, molecular motors, biomedical anomalies, stochastic resonance, nano-oscillators for generating microwave signals and related complex systems. A common theme among these and many other related lectures is to model, study, understand, and exploit the rich behavior exhibited by nonlinear systems to design and fabricate novel technologies with superior characteristics. Consider, for instance, the fact that a shark’s sensitivity to electric fields is 400 times more powerful than the most sophisticated electric-field sensor. In spite of significant advances in material properties, in many cases it remains a daunting task to duplicate the superior signal processing capabilities of most animals. Since nonlinear systems tend to be highly sensitive to perturbations when they occur near the onset of a bifurcation, there are also lectures on the general topic of bifurcation theory and on how to exploit such bifurcations for signal enhancements purposes. This manuscript will appeal to researchers interested in both theory and implementations of nonlinear systems.

Theoretical And Applied Aspects Of Health Psychology

Author : Lothar R. Schmidt
ISBN : 3718650533
Genre : Medical
File Size : 81. 93 MB
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First Published in 1990. Routledge is an imprint of Taylor & Francis, an informa company.

Algebraic And Combinatorial Computational Biology

Author : Raina Robeva
ISBN : 9780128140697
Genre : Mathematics
File Size : 68. 46 MB
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Algebraic and Combinatorial Computational Biology introduces students and researchers to a panorama of powerful and current methods for mathematical problem-solving in modern computational biology. Presented in a modular format, each topic introduces the biological foundations of the field, covers specialized mathematical theory, and concludes by highlighting connections with ongoing research, particularly open questions. The work addresses problems from gene regulation, neuroscience, phylogenetics, molecular networks, assembly and folding of biomolecular structures, and the use of clustering methods in biology. A number of these chapters are surveys of new topics that have not been previously compiled into one unified source. These topics were selected because they highlight the use of technique from algebra and combinatorics that are becoming mainstream in the life sciences. Integrates a comprehensive selection of tools from computational biology into educational or research programs Emphasizes practical problem-solving through multiple exercises, projects and spinoff computational simulations Contains scalable material for use in undergraduate and graduate-level classes and research projects Introduces the reader to freely-available professional software Supported by illustrative datasets and adaptable computer code

Computational Systems Biology

Author : Paola Lecca
ISBN : 9780081001158
Genre : Science
File Size : 87. 21 MB
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Computational Systems Biology: Inference and Modelling provides an introduction to, and overview of, network analysis inference approaches which form the backbone of the model of the complex behavior of biological systems. This book addresses the challenge to integrate highly diverse quantitative approaches into a unified framework by highlighting the relationships existing among network analysis, inference, and modeling. The chapters are light in jargon and technical detail so as to make them accessible to the non-specialist reader. The book is addressed at the heterogeneous public of modelers, biologists, and computer scientists. Provides a unified presentation of network inference, analysis, and modeling Explores the connection between math and systems biology, providing a framework to learn to analyze, infer, simulate, and modulate the behavior of complex biological systems Includes chapters in modular format for learning the basics quickly and in the context of questions posed by systems biology Offers a direct style and flexible formalism all through the exposition of mathematical concepts and biological applications

Systems Biology

Author : Fred Boogerd
ISBN : 0080475272
Genre : Computers
File Size : 71. 61 MB
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Systems biology is a vigorous and expanding discipline, in many ways a successor to genomics and perhaps unprecedented in its combination of biology with a great many other sciences, from physics to ecology, from mathematics to medicine, and from philosophy to chemistry. Studying the philosophical foundations of systems biology may resolve a longer standing issue, i.e., the extent to which Biology is entitled to its own scientific foundations rather than being dominated by existing philosophies. * Answers the question of what distinguishes the living from the non-living * An in-depth look to a vigorous and expanding discipline, from molecule to system * Explores the region between individual components and the system

Understanding Cancer From A Systems Biology Point Of View

Author : Irina Kareva
ISBN : 9780128136744
Genre : Medical
File Size : 27. 26 MB
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Understanding Cancer from a Systems Biology Point of View: From Observation to Theory and Back starts with a basic question, why do we sometimes observe accelerated metastatic growth after resection of primary tumors? Next, it helps readers understand the systemic nature of cancer and how it affects treatment approaches and decisions. The book puts together aspects of cancer that many readers have most likely never combined, using unfamiliar, novel methods. It is a valuable resource for cancer researchers, cancer biologists, mathematicians and members of the biomedical field who are interested in applying systems biology methodologies for understanding and treating cancer. Explains the systemic nature of cancer and how it affects decisions on treatment Brings a variety of methods together, showing, in detail, the logical approach to finding answers to complex questions Discusses the theoretical underpinnings of cancer as a systemic disease, providing the reader with valuable information on applicable cases

Systems Biology

Author : Andreas Kremling
ISBN : 9781466567900
Genre : Mathematics
File Size : 37. 66 MB
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Drawing on the latest research in the field, Systems Biology: Mathematical Modeling and Model Analysis presents many methods for modeling and analyzing biological systems, in particular cellular systems. It shows how to use predictive mathematical models to acquire and analyze knowledge about cellular systems. It also explores how the models are sy

Information Processing And Biological Systems

Author : Samuli Niiranen
ISBN : 3642196217
Genre : Computers
File Size : 24. 82 MB
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Living beings require constant information processing for survival. In cells, information is being processed and propagated at various levels, from the gene regulatory network to chemical pathways, to the interaction with the environment. How this is achieved and how information is coded is still poorly understood. For example, what a cell interprets as information in the temporal level of an mRNA and what is interpreted as noise remains an open question. Recently, information theoretical methods and other tools, developed in the context of engineering and natural sciences, have been applied to study diverse biological processes. This book covers the latest findings on how information is processed in various biological processes, ranging from information processing and propagation in gene regulatory networks to information processing in natural language. An overview is presented of the state-of-the-art in information processing in biological systems and the opinion of current leaders in this research field on future research directions.

Systems Biology

Author : Lilia Alberghina
ISBN : 3540742697
Genre : Computers
File Size : 29. 85 MB
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For life to be understood and disease to become manageable, the wealth of postgenomic data now needs to be made dynamic. This development requires systems biology, integrating computational models for cells and organisms in health and disease; quantitative experiments (high-throughput, genome-wide, living cell, in silico); and new concepts and principles concerning interactions. This book defines the new field of systems biology and discusses the most efficient experimental and computational strategies. The benefits for industry, such as the new network-based drug-target design validation, and testing, are also presented.

Emerging Trends In Applications And Infrastructures For Computational Biology Bioinformatics And Systems Biology

Author : Hamid Arabnia
ISBN : 0128042036
Genre :
File Size : 55. 49 MB
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Emerging Trends in Applications and Infrastructures for Computational Biology, Bioinformatics, and Systems Biology: Systems and Applications covers the latest trends in the field with special emphasis on their applications. The first part covers the major areas of computational biology, development and application of data-analytical and theoretical methods, mathematical modeling, and computational simulation techniques for the study of biological and behavioral systems. The second part covers bioinformatics, an interdisciplinary field concerned with methods for storing, retrieving, organizing, and analyzing biological data. The book also explores the software tools used to generate useful biological knowledge. The third part, on systems biology, explores how to obtain, integrate, and analyze complex datasets from multiple experimental sources using interdisciplinary tools and techniques, with the final section focusing on big data and the collection of datasets so large and complex that it becomes difficult to process using conventional database management systems or traditional data processing applications. Explores all the latest advances in this fast-developing field from an applied perspective Provides the only coherent and comprehensive treatment of the subject available Covers the algorithm development, software design, and database applications that have been developed to foster research

Control Theory And Systems Biology

Author : Pablo A. Iglesias
ISBN : 9780262013345
Genre : Science
File Size : 58. 14 MB
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A survey of how engineering techniques from control and systems theory can be used tohelp biologists understand the behavior of cellular systems.

Big Mechanisms In Systems Biology

Author : Bor-Sen Chen
ISBN : 9780128097076
Genre : Medical
File Size : 59. 61 MB
Format : PDF
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Big Mechanisms in Systems Biology: Big Data Mining, Network Modeling, and Genome-Wide Data Identification explains big mechanisms of systems biology by system identification and big data mining methods using models of biological systems. Systems biology is currently undergoing revolutionary changes in response to the integration of powerful technologies. Faced with a large volume of available literature, complicated mechanisms, small prior knowledge, few classes on the topics, and causal and mechanistic language, this is an ideal resource. This book addresses system immunity, regulation, infection, aging, evolution, and carcinogenesis, which are complicated biological systems with inconsistent findings in existing resources. These inconsistencies may reflect the underlying biology time-varying systems and signal transduction events that are often context-dependent, which raises a significant problem for mechanistic modeling since it is not clear which genes/proteins to include in models or experimental measurements. The book is a valuable resource for bioinformaticians and members of several areas of the biomedical field who are interested in an in-depth understanding on how to process and apply great amounts of biological data to improve research. Written in a didactic manner in order to explain how to investigate Big Mechanisms by big data mining and system identification Provides more than 140 diagrams to illustrate Big Mechanism in systems biology Presents worked examples in each chapter

Stochastic Approaches For Systems Biology

Author : Mukhtar Ullah
ISBN : 1461404789
Genre : Mathematics
File Size : 86. 30 MB
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This textbook focuses on stochastic analysis in systems biology containing both the theory and application. While the authors provide a review of probability and random variables, subsequent notions of biochemical reaction systems and the relevant concepts of probability theory are introduced side by side. This leads to an intuitive and easy-to-follow presentation of stochastic framework for modeling subcellular biochemical systems. In particular, the authors make an effort to show how the notion of propensity, the chemical master equation and the stochastic simulation algorithm arise as consequences of the Markov property. The text contains many illustrations, examples and exercises to illustrate the ideas and methods that are introduced. Matlab code is also provided where appropriate. Additionally, the cell cycle is introduced as a more complex case study. Senior undergraduate and graduate students in mathematics and physics as well as researchers working in the area of systems biology, bioinformatics and related areas will find this text useful.

Systems Biology For Traditional Chinese Medicine

Author : Guoan Luo
ISBN : 9780470637975
Genre : Medical
File Size : 57. 93 MB
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The application of systems biology methods to Traditional Chinese Medicine Emphasizing the harmony of the human body with the environment, Traditional Chinese Medicine (TCM) has evolved over thousands of years. It is a systemic theory derived from clinical experience, the philosophy of holism and systematology, and the belief that man is an integral part of nature. Systems Biology for Traditional Chinese Medicine describes how the latest methods in systems biology can be applied to TCM, providing a comprehensive resource for the modernization and advancement of TCM as well as general drug discovery efforts. It is the first comprehensive work to propose a system-to-system research methodology to study the interaction between TCM and the human body and its applications in drug research and development. Using three popular traditional Chinese medicines—Shuanglongfang, Qingkailing, and Liushenwan—as examples, the authors set forth case examples demonstrating how to find material groups, perform efficacy screenings, and conduct safety evaluations of TCM. The book also: Describes the mechanisms of TCM at the molecular and systems levels using chemomics, genomics, proteomics, metabolomics, and bioinformatics Places modern scientific technologies within the context of TCM, helping drug researchers improve experimental designs and strategies Illustrates how a systems biology approach is compatible with TCM's traditional, holistic therapeutic strategies and treatment modalities Presents topics of current interest, such as integrated global systems biology and the application of chemometrics research to herbal medicines This book not only opens a new pathway for the continued development of TCM, but also for systems biology. In addition, it fosters collaboration and discussion among Eastern and Western scientists by applying systems biology to TCM.

Biophysics

Author : Roland Glaser
ISBN : 9783642252129
Genre : Science
File Size : 61. 4 MB
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Biophysics is the science of physical principles underlying all processes of life, including the dynamics and kinetics of biological systems. This fully revised 2nd English edition is an introductory text that spans all steps of biological organization, from the molecular, to the organism level, as well as influences of environmental factors. In response to the enormous progress recently made, especially in theoretical and molecular biophysics, the author has updated the text, integrating new results and developments concerning protein folding and dynamics, molecular aspects of membrane assembly and transport, noise-enhanced processes, and photo-biophysics. The advances made in theoretical biology in the last decade call for a fully new conception of the corresponding sections. Thus, the book provides the background needed for fundamental training in biophysics and, in addition, offers a great deal of advanced biophysical knowledge.

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